公开(公告)号：US20060094980A1

公开(公告)日：2006-05-04

申请号：US11273683

申请日：2005-11-14

申请人： S. Casscells ,  James Willerson

发明人： S. Casscells ,  James Willerson

IPC分类号： A61B5/00

CPC分类号： A61B5/0086 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0073 ,  A61B5/0075 ,  A61B5/01 ,  A61B5/015 ,  A61B5/02007 ,  A61B5/0507 ,  A61B5/413 ,  A61B5/6853 ,  A61B2017/00084 ,  A61B2017/22001

摘要： An infrared, heat-sensing catheter particularly useful for identifying potentially fatal arterial plaques in patients with disease of the coronary or other arteries and its use are detailed. In one embodiment, an infrared fiberoptic system (with or without ultrasound) is employed at the tip of the catheter to locate inflamed, heat-producing, atherosclerotic plaque, which is at greater risk for rupture, fissure, or ulceration, and consequent thrombosis and occlusion of the artery. In another embodiment, a catheter with an infrared detector (with or without ultrasound) employed at its tip will likewise locate inflamed heat-producing atherosclerotic plaque. The devices and methods of the invention may be used to detect abscesses, infection, and cancerous regions by the heat such regions differentially display over the ambient temperature of immediately adjacent tissues. The methods and devices of the invention may also be used to detect regions of cooler than ambient tissue in a vessel or organ which indicate cell death, thrombosis, cell death, hemorrhage, calcium or cholesterol accumulations, or foreign materials.

公开(公告)号：US20050130925A1

公开(公告)日：2005-06-16

申请号：US10972528

申请日：2004-10-25

申请人： Pierre Zoldhelyi ,  Qi Liu ,  George Bobustuc ,  James Willerson

发明人： Pierre Zoldhelyi ,  Qi Liu ,  George Bobustuc ,  James Willerson

IPC分类号： A61K31/202 ,  A61K38/00 ,  A61K48/00 ,  C12N9/02

CPC分类号： C12N9/0083 ,  A61K31/202 ,  A61K38/00 ,  A61K48/00

摘要： Compositions and methods for gene transfer of cyclooxygenase (COX) isoforms alone or in conjunction with administration of one or more fatty acid substrate for the COX isoform (e.g., dihommo-γ-linoleic acid (DGLA)) are disclosed. Methods for enhancing synthesis of the prostaglandins E1 (PGE1) and prostacyclin (PGI2), without marked local production of pro-inflammatory prostaglandin E2 (PGE2) are also disclosed. The compositions and methods are valuable for protection of vascular conduits, kidney function, airway patency, and renal, cardiac, and other allografts, and promoting increased vascular flow, mucus secretion and bicarbonate secretion as protective factors against gastric and duodenal ulcers.

摘要翻译： 公开了单独或与给予一种或多种用于COX同种型的脂肪酸底物（例如二 - γ-亚油酸（DGLA））的环加氧酶（COX）同种型的基因转移的组合物和方法。 用于增强前列腺素E 1（PGE 1）和前列环素（PGI 2 2）的合成的方法，没有明显的局部产生促炎前列腺素 还公开了E 2（PGE 2 2）。 组合物和方法对于保护血管导管，肾功能，气道通畅以及肾，心脏和其他同种异体移植物是有价值的，并且促进增加的血管流动，粘液分泌和碳酸氢盐分泌作为胃和十二指肠溃疡的保护因子。

公开(公告)号：US20070282456A1

公开(公告)日：2007-12-06

申请号：US11571985

申请日：2005-07-13

申请人： Yong-Jian Geng ,  Rosalinda Madonna ,  James Willerson

发明人： Yong-Jian Geng ,  Rosalinda Madonna ,  James Willerson

IPC分类号： A61F2/02 ,  A61K35/12 ,  A61P9/00 ,  C12N15/63 ,  C12N5/00 ,  C12Q1/02

CPC分类号： C12N5/0657 ,  A61K35/12 ,  C12N2500/44 ,  C12N2506/1384

摘要： An in vitro method of producing stem cells with potential to develop into cardiovascular myocytes is disclosed which comprises culturing myogenic stem cells obtained from the stromal or mesenchymal compartment of adult adipose tissue in a medium that favors myogenic development of the cells. These myogenic stem cells highly express telomerase and myocardin. A composition comprising fat-derived myogenic stem cells and/or differentiated cardiovascular myocytes and a method for treating a mammalian subject suffering from a cardiovascular disorder are also disclosed.

摘要翻译： 公开了一种制备潜在发展成心血管心肌细胞的干细胞的体外方法，其包括在有利于细胞的肌原性发育的培养基中培养从成年脂肪组织的间质或间充质隔室获得的成肌干细胞。 这些肌原性干细胞高度表达端粒酶和心肌素。 还公开了包含脂肪衍生的肌原干细胞和/或分化的心血管心肌细胞的组合物和治疗患有心血管疾病的哺乳动物受试者的方法。

公开(公告)号：US20060099183A1

公开(公告)日：2006-05-11

申请号：US11300722

申请日：2005-12-15

申请人： Pierre Zoldhelyi ,  Janet Cunningham ,  James Willerson

发明人： Pierre Zoldhelyi ,  Janet Cunningham ,  James Willerson

IPC分类号： A61K48/00

CPC分类号： C12N15/86 ,  A61K38/1709 ,  A61K38/36 ,  A61K38/57 ,  A61K48/00 ,  A61K48/0075 ,  C07K14/4713 ,  C07K14/62 ,  C12N2750/14143

摘要： A recombinant adeno-associated virus is used to transduce the cells of a tissue graft ex vivo. More specifically, rAAV encoding a therapeutic protein is delivered to a vascular graft to prevent smooth muscle cell proliferation or thrombosis in the graft. The cells are transfected ex vivo with the recombinant virus carrying a gene known to inhibit the proliferation and migration of vascular smooth muscle cells, thrombosis, and atherosclerosis. The methods can be used for the treatment of restenosis, vascular thrombosis, balloon injury or other vascular pathology.