公开(公告)号：US08572279B2

公开(公告)日：2013-10-29

申请号：US13018420

申请日：2011-01-31

Applicant: John M. Payne ,  Tim Von Kaenel ,  Jeffrey Wang ,  Jeffrey Odell ,  David Starr ,  Jason Katz

Inventor： John M. Payne ,  Tim Von Kaenel ,  Jeffrey Wang ,  Jeffrey Odell ,  David Starr ,  Jason Katz

IPC: G06F15/16 ,  G08B5/22

CPC classification number: H04L67/10 ,  G08B25/085 ,  H04L12/18 ,  H04L51/04 ,  H04L51/24 ,  H04L51/36 ,  H04L51/38 ,  H04L67/02 ,  H04L67/04 ,  H04L67/26 ,  H04W4/06 ,  H04W4/12 ,  H04W84/00

Abstract: A system and method for data communication connecting on-line networks with on-line and off-line computers. The present system provides for broadcast of up to the minute notification centric information thereby providing an instant call to action for users who are provided with the ability to instantaneously retrieve further detailed information. The notification centric portions of information is wirelessly broadcast to wireless receiving devices which are attached to computing devices. Upon receipt of the information at the personal computer, the user is notified through different multimedia alerts that there is an incoming message. Wirelessly broadcasted URL's, associated with the data, are embedded in data packets and provide an automated wired or wireless connection back to the information source for obtaining detailed data.

Abstract translation: 用于在线和离线计算机连接在线网络的数据通信系统和方法。 本系统提供广播最多以通知为中心的信息，从而为被提供能够即时检索更多详细信息的用户提供即时呼叫。 将通知中心部分的信息无线地广播到附接到计算设备的无线接收设备。 在个人计算机上接收到信息时，通过不同的多媒体警报通知用户存在传入消息。 与数据相关联的无线广播URL被嵌入在数据分组中，并提供到信息源的自动有线或无线连接以获得详细数据。

公开(公告)号：US20130040933A1

公开(公告)日：2013-02-14

申请号：US13643323

申请日：2011-04-21

Applicant: Brandon Cash ,  Christian Fischer ,  Yudith Garcia ,  Joon Jung ,  Jason Katz ,  June Kim ,  Alexey Rivkin ,  Adam Schell ,  Tony Siu ,  David Witter ,  Hua Zhou

Inventor： Brandon Cash ,  Christian Fischer ,  Yudith Garcia ,  Joon Jung ,  Jason Katz ,  June Kim ,  Alexey Rivkin ,  Adam Schell ,  Tony Siu ,  David Witter ,  Hua Zhou

IPC: A61K31/497 ,  C07D519/00 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/4985 ,  A61P35/00 ,  A61P11/06 ,  A61P37/00 ,  A61P1/04 ,  A61P25/00 ,  A61P3/10 ,  C07D471/04 ,  A61P19/02

CPC classification number: C07D471/04 ,  C07D519/00

Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable salt thereof. Compounds of formula I are inhibitors of Janus kinases and as such are useful for the treatment of various diseases and conditions mediated by said enzymes, such as rheumatoid arthritis, asthma, COPD, ALS, and the like.

Abstract translation: 本发明提供式I化合物或其药学上可接受的盐。 式I化合物是Janus激酶的抑制剂，因此可用于治疗由所述酶介导的各种疾病和病症，例如类风湿性关节炎，哮喘，COPD，ALS等。

公开(公告)号：USD658329S1

公开(公告)日：2012-04-24

申请号：US29396219

申请日：2011-06-27

Applicant: Jason Katz

Designer： Jason Katz

公开(公告)号：US20110207711A1

公开(公告)日：2011-08-25

申请号：US13057325

申请日：2009-07-27

Applicant: Jason Katz ,  James Jewell ,  Joon Jung ,  Solomon Kattar ,  Yongquan Hou ,  Rachel MacCoss ,  Satoru Ito

Inventor： Jason Katz ,  James Jewell ,  Joon Jung ,  Solomon Kattar ,  Yongquan Hou ,  Rachel MacCoss ,  Satoru Ito

IPC: A61K31/397 ,  C07D471/04 ,  A61K31/437 ,  C07D403/14 ,  A61K31/496 ,  C07D413/14 ,  A61K31/5377 ,  C07D401/14 ,  A61K31/517 ,  A61K31/5386 ,  A61P35/00 ,  A61P25/28 ,  A61P19/02 ,  A61P3/10 ,  A61P1/00

CPC classification number: A61K45/06 ,  A61K31/535 ,  C07D471/04 ,  C07D519/00 ,  A61K2300/00

Abstract: The present invention relates to pyrazolopyridines and imidazopyridines which are inhibitors of the kinase PDK1 and are thus useful for the treatment of myeloproliferative disorders or cancer. The compounds are also useful as inhibitors of other kinases such as FGFR3, NTRK3, RP-S6K and WEE1. Furthermore, the present compounds also selectively inhibit microtubule affinity regulating kinase (MARK) and are therefore useful for the treatment or prevention of Alzheimer's disease.

Abstract translation: 本发明涉及作为激酶PDK1的抑制剂的吡唑并吡啶和咪唑并吡啶，因此可用于治疗骨髓增生性疾病或癌症。 该化合物也可用作其它激酶如FGFR3，NTRK3，RP-S6K和WEE1的抑制剂。 此外，本发明化合物还选择性地抑制微管亲和调节激酶（MARK），因此可用于治疗或预防阿尔茨海默氏病。

公开(公告)号：US20060293358A1

公开(公告)日：2006-12-28

申请号：US11473273

申请日：2006-06-22

Applicant: Christopher Dinsmore ,  Ana Gabarda Ortega ,  David Guerin ,  James Jewell ,  Jason Katz ,  Jongwon Lim ,  Michelle Machacek ,  Ryan Otte ,  Jonathan Young

Inventor： Christopher Dinsmore ,  Ana Gabarda Ortega ,  David Guerin ,  James Jewell ,  Jason Katz ,  Jongwon Lim ,  Michelle Machacek ,  Ryan Otte ,  Jonathan Young

IPC: A61K31/473 ,  C07D221/02

CPC classification number: C07D471/04 ,  C07D221/16 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D487/04 ,  C07D491/10 ,  C07D491/113 ,  C07F7/1804

Abstract: The present invention relates to 5H-benzo[4,5]cyclohepta[1,2-b]pyridine compounds, that are useful for treating cellular proliferative diseases, for treating disorders associated with MET activity, and for inhibiting the receptor tyrosine kinase MET. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

公开(公告)号：US07035914B1

公开(公告)日：2006-04-25

申请号：US09350467

申请日：1999-07-09

Applicant: John M. Payne ,  Tim Von Kaenel ,  Jeffrey Wang ,  Jeffrey Odell ,  David Starr ,  Jason Katz

Inventor： John M. Payne ,  Tim Von Kaenel ,  Jeffrey Wang ,  Jeffrey Odell ,  David Starr ,  Jason Katz

IPC: G06F15/16 ,  G08B5/22

CPC classification number: H04L67/10 ,  G08B25/085 ,  H04L12/18 ,  H04L51/04 ,  H04L51/24 ,  H04L51/36 ,  H04L51/38 ,  H04L67/02 ,  H04L67/04 ,  H04L67/26 ,  H04W4/06 ,  H04W4/12 ,  H04W84/00

Abstract: A system and method for data communication connecting on-line networks with on-line and off-line computers. The present system provides for broadcast of up to the minute notification centric information thereby providing an instant call to action for users who are provided with the ability to instantaneously retrieve further detailed information. The notification centric portions of information is wirelessly broadcast to wireless receiving devices which are attached to computing devices. Upon receipt of the information at the personal computer, the user is notified through different multimedia alerts that there is an incoming message. Wirelessly broadcasted URL's, associated with the data, are embedded in data packets and provide an automated wired or wireless connection back to the information source for obtaining detailed data.

公开(公告)号：US20110138021A1

公开(公告)日：2011-06-09

申请号：US13018421

申请日：2011-01-31

Applicant: John M. Payne ,  Tim Von Kaenel ,  Jeffrey Wang ,  Jeffrey Odell ,  David Starr ,  Jason Katz

Inventor： John M. Payne ,  Tim Von Kaenel ,  Jeffrey Wang ,  Jeffrey Odell ,  David Starr ,  Jason Katz

IPC: G06F15/16

CPC classification number: H04L67/10 ,  G08B25/085 ,  H04L12/18 ,  H04L51/04 ,  H04L51/24 ,  H04L51/36 ,  H04L51/38 ,  H04L67/02 ,  H04L67/04 ,  H04L67/26 ,  H04W4/06 ,  H04W4/12 ,  H04W84/00

Abstract: A system and method for data communication connecting on-line networks with on-line and off-line computers. The present system provides for broadcast of up to the minute notification centric information thereby providing an instant call to action for users who are provided with the ability to instantaneously retrieve further detailed information. The notification centric portions of information is wirelessly broadcast to wireless receiving devices which are attached to computing devices. Upon receipt of the information at the personal computer, the user is notified through different multimedia alerts that there is an incoming message. Wirelessly broadcasted URL's, associated with the data, are embedded in data packets and provide an automated wired or wireless connection back to the information source for obtaining detailed data.

公开(公告)号：US20060195554A1

公开(公告)日：2006-08-31

申请号：US11409396

申请日：2006-05-15

Applicant: John Payne ,  Tim Von Kaenel ,  Jeffrey Wang ,  Jeffrey Odell ,  David Starr ,  Jason Katz

Inventor： John Payne ,  Tim Von Kaenel ,  Jeffrey Wang ,  Jeffrey Odell ,  David Starr ,  Jason Katz

IPC: G06F15/16

CPC classification number: H04L67/10 ,  G08B25/085 ,  H04L12/18 ,  H04L51/04 ,  H04L51/24 ,  H04L51/36 ,  H04L51/38 ,  H04L67/02 ,  H04L67/04 ,  H04L67/26 ,  H04W4/06 ,  H04W4/12 ,  H04W84/00

Abstract: A system and method for data communication connecting on-line networks with on-line and off-line computers. The present system provides for broadcast of up to the minute notification centric information thereby providing an instant call to action for users who are provided with the ability to instantaneously retrieve further detailed information. The notification centric portions of information is wirelessly broadcast to wireless receiving devices which are attached to computing devices. Upon receipt of the information at the personal computer, the user is notified through different multimedia alerts that there is an incoming message. Wirelessly broadcasted URL's, associated with the data, are embedded in data packets and provide an automated wired or wireless connection back to the information source for obtaining detailed data.

公开(公告)号：US20240076285A1

公开(公告)日：2024-03-07

申请号：US18266199

申请日：2021-12-16

Applicant: Shankar VENKATRAMAN ,  Jason KATZ ,  William R. ROUSH ,  Hans Martin SEIDEL ,  IFM Due, Inc.

Inventor： Shankar Venkatraman ,  Jason Katz ,  William R. Roush ,  Hans Martin Seidel

IPC: C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D417/14

CPC classification number: C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D417/14

Abstract: This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Said chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also features compositions containing the same as well as methods of using and making the same.

公开(公告)号：US10336028B1

公开(公告)日：2019-07-02

申请号：US15222258

申请日：2016-07-28

Applicant: Andrew Jason Katz ,  Craig Lusk

Inventor： Andrew Jason Katz ,  Craig Lusk

IPC: B32B3/06 ,  B32B3/26 ,  B32B7/08 ,  B32B7/05 ,  E04B1/34 ,  E04B1/66 ,  B62D29/04 ,  F16L11/12

Abstract: The first objective of this paper is to take an existing design for a shape-shifting surface (SSS) and make it waterproof, making it an effective barrier to fluid flow. The second objective is to minimize internal stresses in the device during operation, by optimizing the kinematic geometry of the SSS. The first objective was achieved by adding a waterproof membrane between the layers of the SSS, where the membrane had an origami fold pattern that enables the membrane to mimic the kinematics of the SSS. The second objective was achieved by creating a two objective optimization routine, which determined the kinematic geometry of the SSS which would minimize the internal stresses due to compression/tension of the flexure portion of the SSS during operation. The resulting SSS is easier to operate due to lower stresses, and has a membrane which prevents transverse fluid flow and mimics its motion.