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    TUMOR ERADICATION BY INOSITOL-TRIPYROPHOSPHATE
    2.
    发明申请
    TUMOR ERADICATION BY INOSITOL-TRIPYROPHOSPHATE 审中-公开
    肿瘤坏死因子 - 磷酸二氢钙

    公开(公告)号：US20120094961A1

    公开(公告)日：2012-04-19

    申请号：US13247418

    申请日：2011-09-28

    申请人： Claude NICOLAU ,  Jean-Marie Lehn

    发明人： Claude NICOLAU ,  Jean-Marie Lehn

    IPC分类号： A61K31/6615 ,  A61P35/00

    CPC分类号： A61K31/6615 ,  A61K31/665 ,  C07F9/65746

    摘要： The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.

    摘要翻译： 本发明涉及三水合磷酸肌醇的各种盐，包括三水合磷酸肌醇的钙，锂，铍，镁，钾，锶，钡，铷和铯盐，包含这些盐的组合物，制备各种盐的方法和使用方法 的上述盐。 使用方法包括在个体中施用有效量的上述盐用于治疗各种类型的癌症，阿尔茨海默氏病，中风和骨质疏松症。

    Compositions and methods for treating cancer and other diseases characterized by abnormal cell proliferation
    6.
    发明申请
    Compositions and methods for treating cancer and other diseases characterized by abnormal cell proliferation 审中-公开
    用于治疗以异常细胞增殖为特征的癌症和其他疾病的组合物和方法

    公开(公告)号：US20080119492A1

    公开(公告)日：2008-05-22

    申请号：US11374312

    申请日：2006-07-28

    申请人： Jean-Marie Lehn ,  Jean-Louis Mergny ,  Anne Petitjean ,  Maia-Paule Teulade-Fichou ,  Andrei Tchirkov ,  Pierre Verrelle

    发明人： Jean-Marie Lehn ,  Jean-Louis Mergny ,  Anne Petitjean ,  Maia-Paule Teulade-Fichou ,  Andrei Tchirkov ,  Pierre Verrelle

    IPC分类号： A61K31/506 ,  C07D403/14

    CPC分类号： A61K31/506 ,  C07D401/14

    摘要： The present invention relates to compositions and methods for treating cancer and other disease states characterized by abnormal cell proliferation. In particular, the present invention relates to certain novel non-nucleoside pharmacologically active compounds that alter telomere and telomerase functions, regulate cell proliferation and/or treat cancer and other diseases characterized by abnormal cell proliferation. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit telomerase, to regulate cell proliferation, and to treat cancer or to inhibit the proliferation of the rumor cells, and to treat other proliferative conditions.

    摘要翻译： 本发明涉及用于治疗以异常细胞增殖为特征的癌症和其他疾病状态的组合物和方法。 特别地，本发明涉及改变端粒和端粒酶功能，调节细胞增殖和/或治疗癌症和以异常细胞增殖为特征的其它疾病的某些新型非核苷药物活性化合物。 本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制端粒酶，调节细胞增殖，以及治疗癌症或抑制肿瘤细胞的增殖 ，并治疗其他增殖性疾病。

    USE OF DYNAMIC MIXTURES FOR A CONTROLLED RELEASE OF FRAGRANCES
    7.
    发明申请
    USE OF DYNAMIC MIXTURES FOR A CONTROLLED RELEASE OF FRAGRANCES 有权
    使用动态混合物进行控制释放

    公开(公告)号：US20070141011A1

    公开(公告)日：2007-06-21

    申请号：US11669560

    申请日：2007-01-31

    申请人： Jean-Marie Lehn ,  Andreas Herrmann

    发明人： Jean-Marie Lehn ,  Andreas Herrmann

    IPC分类号： A61K8/73 ,  A61K8/42

    CPC分类号： A01N25/18 ,  A61L9/01 ,  C11D3/50 ,  C11D3/507

    摘要： The present invention relates to a delivery system in the form of a dynamic mixture obtained by reacting together, in the presence of water, at least one hydrazine derivative with at least one perfuming, flavoring, insect repellent or attractant, bactericide or fungicide aldehyde or ketone. The inventive mixture is capable of releasing in a controlled and prolonged manner the aldehyde or ketone in the surrounding environment. Furthermore, the present invention concerns also the use of these dynamic mixtures as perfuming ingredients as well as the perfuming compositions or perfumed articles that include such mixtures.

    摘要翻译： 本发明涉及一种动态混合物形式的递送系统，其通过在水存在下使至少一种肼衍生物与至少一种加香，调味剂，驱虫剂或引诱剂，杀菌剂或杀真菌剂醛或酮 。 本发明的混合物能够以受控和延长的方式释放在周围环境中的醛或酮。 此外，本发明还涉及这些动态混合物作为加香成分以及包含这些混合物的加香组合物或香料制品的用途。

    Rare earth macrocyclic complexes and use thereof for reduction of disturbances in an assay using fluorescence
    10.
    发明授权
    Rare earth macrocyclic complexes and use thereof for reduction of disturbances in an assay using fluorescence 失效
    稀土大环络合物及其用于减少使用荧光的测定中的扰动的用途

    公开(公告)号：US5457184A

    公开(公告)日：1995-10-10

    申请号：US199135

    申请日：1994-02-25

    申请人： Jean-Marie Lehn ,  Christine O. Roth ,  Gerard Mathis

    发明人： Jean-Marie Lehn ,  Christine O. Roth ,  Gerard Mathis

    IPC分类号： C07D471/08 ,  C07D471/22 ,  C07D498/18 ,  C07F5/00 ,  G01N21/78 ,  G01N33/533 ,  G01N33/58 ,  C07D225/00 ,  C07D245/00

    CPC分类号： C07D471/22 ,  C07F5/003 ,  G01N33/533 ,  G01N33/58 ,  G01N2458/40

    摘要： The invention relates to macrocyclic rare earth complexes which consist of at least one rare earth salt complexed by a macrocyclic compound of formula (I): ##STR1## in which: the bivalent radicals A, B, C and D, which are identical or different, are hydrocarbon chains optionally containing one or more heteroatoms, at least one of said radicals containing at least one molecular unit or essentially consisting of a molecular unit possessing a triplet energy greater than the energy of the emission level of the complexed rare earth ion, at least one of said radicals consisting of a substituted or unsubstituted nitrogen-containing heterocyclic system in which at least one of the nitrogen atoms carries an oxy group, and it being possible for one of the radicals C or D not to exist; andX.sub.1 and X.sub.2, which are identical or different, are hydrogen or a hydrocarbon chain (CH.sub.2).sub.n optionally interrupted by 1 or more heteroatoms, n being an integer from 1 to 10, with the proviso that if the radicals A and/or B are a nitrogen-containing heterocyclic system in which at least one of the nitrogen atoms carries an oxy group, the radicals C and/or D are selected from biquinolines, biisoquinolines, bipyridines, terpyridines, coumarins, bipyrazines, bipyrimidines and pyridines, and to their use for reducing the perturbations in a fluorescent assay.

    摘要翻译： PCT No.PCT / FR92 / 00832 Sec。 371日期1994年2月25日 102（e）日期1994年2月25日PCT提交1992年8月28日PCT公布。 公开号WO93 / 05049 日本1993年3月18日。本发明涉及由至少一种由式（I）的大环化合物络合的稀土盐组成的大环稀土配合物：其中：二价基团+ E， crc / A /，+ E，crc / B /，+ E，crc / C /和+ E，crc / C /和相同或不同的C C，C C，D C是任选含有一个或多个杂原子的烃链， 含有至少一个分子单元或基本上由具有大于复合稀土离子的发射能级的能量的三重态能量的分子单元组成的基团，至少一个所述基团由取代或未取代的含氮杂环体系 其中至少一个氮原子携带氧基，并且不存在自由基+ E，crc / C /或+ E，crc / D /中的一种。 和相同或不同的X 1和X 2是氢或烃链（CH 2）n，其任选地被1个或多个杂原子间隔，n是1至10的整数，条件是如果基团+ E，crc / A /和/或+ E，crc / B /是其中至少一个氮原子携带氧基的含氮杂环体系，基团+ E，crc / C和/或+ E，crc / D /选自二喹啉，双异喹啉，联吡啶，三联吡啶，香豆素，联吡啶，联嘧啶和吡啶，以及它们用于减少荧光测定中的扰动的用途。