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公开(公告)号：US20080103296A1
公开(公告)日：2008-05-01
申请号：US11725596
申请日：2007-03-19
Applicant: Xiaojian David Zhao , Jeffrey D. Randall , Bijit Kundu , Jessica Kesty , Steven R. Gullans , Eugene Y. Chan , Martin Fuchs , Jenny E. Rooke
Inventor： Xiaojian David Zhao , Jeffrey D. Randall , Bijit Kundu , Jessica Kesty , Steven R. Gullans , Eugene Y. Chan , Martin Fuchs , Jenny E. Rooke
IPC: C07H21/04
CPC classification number: C12Q1/6827 , B82Y5/00 , B82Y10/00 , C07H21/02 , C07H21/04 , C12Q1/6818 , C12Q1/6825 , C12Q1/6834 , C12Q2565/101 , C12Q2565/601 , C12Q2521/301 , C12Q2563/107 , C12Q2565/619 , C12Q2565/629 , C12Q2535/125 , C12Q2537/143
Abstract: The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.
Abstract translation: 本发明涉及用于分析和表征单一聚合物如核酸分子的方法。 在优选的实施方案中，使用单分子检测和分析系统分析单分子。
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2.发明申请METHODS OF DETERMINING A TREATMENT PROTOCOL FOR AND/OR A PROGNOSIS OF A PATIENT'S RECOVERY FROM A BRAIN INJURY 审中-公开确定患者恢复脑损伤的治疗方案和/或预防方法公开(公告)号：US20140302532A1
公开(公告)日：2014-10-09
申请号：US14111326
申请日：2012-04-12
Applicant: David Wilson , John Henrik Zetterber , Kaj Blennow , Jeffrey D. Randall
Inventor： David Wilson , John Henrik Zetterber , Kaj Blennow , Jeffrey D. Randall
IPC: G01N33/543
CPC classification number: G01N33/6896 , G01N33/54306 , G01N2333/47 , G01N2333/4709 , G01N2800/28 , G01N2800/52
Abstract: The present invention, in some embodiments, generally relates to methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury. In some embodiments, the brain injury results from a hypoxic event. In some embodiments, methods are provided for determining a measure of the concentration of tau protein in a patient sample containing or suspected of containing tau protein.
Abstract translation: 在一些实施方案中，本发明一般涉及确定患者从脑损伤恢复的治疗方案和/或预后的方法。 在一些实施方案中，脑损伤是由缺氧事件引起的。 在一些实施方案中，提供了用于确定含有或怀疑含有tau蛋白的患者样品中tau蛋白浓度的量度的方法。
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3.发明申请ULTRA-SENSITIVE DETECTION OF ENZYMES BY CAPTURE-AND-RELEASE FOLLOWED BY QUANTIFICATION 审中-公开通过定量检测和释放对酶的超敏感检测公开(公告)号：US20100075355A1
公开(公告)日：2010-03-25
申请号：US12236490
申请日：2008-09-23
Applicant: David C. Duffy , Evan Ferrell , Jeffrey D. Randall , David M. Rissin , David R. Walt
Inventor： David C. Duffy , Evan Ferrell , Jeffrey D. Randall , David M. Rissin , David R. Walt
CPC classification number: G01N33/543 , G01N33/54306 , G01N33/54393
Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.
Abstract translation: 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括固定多个分析物分子或颗粒以形成多个复合物，释放所述多个复合物中的至少一部分，确定所述多个复合物的至少一部分被释放，并且确定 测量流体样品中分析物分子或颗粒的浓度。
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Patent Agency Ranking
公开(公告)号：US08846415B2
公开(公告)日：2014-09-30
申请号：US13527210
申请日：2012-06-19
Applicant: David C. Duffy , Evan Ferrell , Jeffrey D. Randall , David M. Rissin , David R. Walt
Inventor： David C. Duffy , Evan Ferrell , Jeffrey D. Randall , David M. Rissin , David R. Walt
IPC: G01N33/543
CPC classification number: G01N33/54313 , C12Q1/6825 , G01N33/54326 , G01N33/54386
Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.
Abstract translation: 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括固定多个分析物分子或颗粒以形成多个复合物，释放所述多个复合物中的至少一部分，确定所述多个复合物的至少一部分被释放，并且确定 测量流体样品中分析物分子或颗粒的浓度。
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公开(公告)号：US20140243223A1
公开(公告)日：2014-08-28
申请号：US13527210
申请日：2012-06-19
Applicant: David C. Duffy , Evan Ferrell , Jeffrey D. Randall , David M. Rissin , David R. Walt
Inventor： David C. Duffy , Evan Ferrell , Jeffrey D. Randall , David M. Rissin , David R. Walt
IPC: G01N33/543 , C12Q1/68
CPC classification number: G01N33/54313 , C12Q1/6825 , G01N33/54326 , G01N33/54386
Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.
Abstract translation: 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括固定多个分析物分子或颗粒以形成多个复合物，释放所述多个复合物中的至少一部分，确定所述多个复合物的至少一部分被释放，并且确定 测量流体样品中分析物分子或颗粒的浓度。
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公开(公告)号：US07371520B2
公开(公告)日：2008-05-13
申请号：US10448264
申请日：2003-05-28
Applicant: Xiaojian (David) Zhao , Jeffrey D. Randall , Bijit Kundu , Jessica Kesty , Steve R. Gullans , Eugene Y. Chan , Martin Fuchs
Inventor： Xiaojian (David) Zhao , Jeffrey D. Randall , Bijit Kundu , Jessica Kesty , Steve R. Gullans , Eugene Y. Chan , Martin Fuchs
CPC classification number: C12Q1/6818 , C12Q1/6827 , C12Q1/6834 , C12Q1/6841 , C12Q1/6858 , C12Q2565/601 , C12Q2521/301 , C12Q2563/107 , C12Q2565/619 , C12Q2565/629 , C12Q2535/125 , C12Q2565/101
Abstract: The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.
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公开(公告)号：US07282330B2
公开(公告)日：2007-10-16
申请号：US10773084
申请日：2004-02-05
Applicant: Xiaojian (David) Zhao , Jeffrey D. Randall , Bijit Kundu , Jessica Kesty , Steven R. Gullans , Eugene Y. Chan , Martin Fuchs , Jenny E. Rooke
Inventor： Xiaojian (David) Zhao , Jeffrey D. Randall , Bijit Kundu , Jessica Kesty , Steven R. Gullans , Eugene Y. Chan , Martin Fuchs , Jenny E. Rooke
CPC classification number: C12Q1/6827 , B82Y5/00 , B82Y10/00 , C07H21/02 , C07H21/04 , C12Q1/6818 , C12Q1/6825 , C12Q1/6834 , C12Q2565/101 , C12Q2565/601 , C12Q2521/301 , C12Q2563/107 , C12Q2565/619 , C12Q2565/629 , C12Q2535/125 , C12Q2537/143
Abstract: The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.
Abstract translation: 本发明涉及用于分析和表征单一聚合物如核酸分子的方法。 在优选的实施方案中，使用单分子检测和分析系统分析单分子。
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公开(公告)号：US08222047B2
公开(公告)日：2012-07-17
申请号：US12236486
申请日：2008-09-23
Applicant: David C. Duffy , Evan Ferrell , Jeffrey D. Randall , David M. Rissin , David R. Walt
Inventor： David C. Duffy , Evan Ferrell , Jeffrey D. Randall , David M. Rissin , David R. Walt
IPC: G01N33/543
CPC classification number: G01N33/54313 , C12Q1/6825 , G01N33/54326 , G01N33/54386
Abstract: The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles to form a plurality of complexes, releasing at least a portion of some of the plurality of complexes, determining at least a portion of the plurality of complexes released, and determining a measure of the concentration of the analyte molecules or particles in a fluid sample.
Abstract translation: 本发明涉及用于检测流体样品中的分析物分子或颗粒的系统和方法，并且在某些情况下，确定流体样品中分子或颗粒的浓度的量度。 本发明的方法可以包括固定多个分析物分子或颗粒以形成多个复合物，释放所述多个复合物中的至少一部分，确定所述多个复合物的至少一部分被释放，并且确定 测量流体样品中分析物分子或颗粒的浓度。
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