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26 条记录 (耗时 0.04 秒)

    High resolution linear analysis of polymers
    4.
    发明授权
    High resolution linear analysis of polymers 失效
    聚合物的高分辨率线性分析

    公开(公告)号：US08423294B2

    公开(公告)日：2013-04-16

    申请号：US10762207

    申请日：2004-01-21

    申请人： Mark Nadel ,  Eugene Y. Chan ,  Martin Fuchs ,  Rudolf Gilmanshin

    发明人： Mark Nadel ,  Eugene Y. Chan ,  Martin Fuchs ,  Rudolf Gilmanshin

    IPC分类号： G01N33/50

    CPC分类号： B82Y5/00 ,  B82Y10/00 ,  C12Q1/6869 ,  C12Q2565/629 ,  C12Q2565/102 ,  C12Q2563/107

    摘要： The invention provides methods and systems for improved spatial resolution of signal detection, particularly as applied to the analysis of polymers such as biological polymers. Some of the methods and systems comprise differentially tagging polymers in order to increase resolution. Some of the methods and systems comprise techniques for improving the precision of separation distance measurements, without necessarily requiring improvements in the known detection resolution of prior art systems.

    摘要翻译： 本发明提供用于改善信号检测的空间分辨率的方法和系统，特别是应用于聚合物如生物聚合物的分析。 一些方法和系统包括差异化标记聚合物以提高分辨率。 一些方法和系统包括用于提高分离距离测量的精度的技术，而不一定需要改进现有技术系统的已知检测分辨率。

    Multicoded analytical nanostrips
    5.
    发明授权
    Multicoded analytical nanostrips 有权
    多编分析纳米带

    公开(公告)号：US09568425B2

    公开(公告)日：2017-02-14

    申请号：US13361914

    申请日：2012-01-30

    申请人： Eugene Y. Chan ,  Moon Z. Chan

    发明人： Eugene Y. Chan ,  Moon Z. Chan

    IPC分类号： B82Y15/00 ,  G01N21/64 ,  G01N33/58 ,  G01N33/543 ,  B01L3/00 ,  G01N21/21

    CPC分类号： G01N21/6428 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2200/0663 ,  B82Y15/00 ,  G01N21/21 ,  G01N33/54313 ,  G01N33/54346 ,  G01N33/582 ,  G01N33/587 ,  G01N2021/6441

    摘要： Analytical nanostrips for clinical analysis are improved by using multifunctional coding (“multicoding”) to allow simultaneous identification of the particular assay, the value of the assayed analyte, and a calibration of the analyte. The multicoding layout on the nanostrip minimizes the number of zones that are required for a given assay. Moreover, the nanostrip can be scanned in real time during flow of the nanostrip through a detection beam. This both simplifies the assay and allows for alternative means of coding.

    摘要翻译： 通过使用多功能编码（“多编码”）来改进用于临床分析的分析纳米带，以允许特定测定的同时鉴定，测定的分析物的值和分析物的校准。 纳米线上的多编码布局使给定测定所需的区域数量最小化。 此外，纳米线可以在纳米片通过检测光束的过程中实时扫描。 这两者都简化了测定，并允许替代的编码方式。

    Microfluidic passive mixing chip
    7.
    发明授权
    Microfluidic passive mixing chip 有权
    微流控无源混频芯片

    公开(公告)号：US09194780B2

    公开(公告)日：2015-11-24

    申请号：US13374157

    申请日：2011-12-14

    申请人： Eugene Y. Chan ,  Moon Z Chan

    发明人： Eugene Y. Chan ,  Moon Z Chan

    IPC分类号： G01N1/38 ,  B01F5/00 ,  B01F5/06 ,  B01F13/00 ,  B01F13/10

    CPC分类号： G01N1/38 ,  B01F5/0071 ,  B01F5/0647 ,  B01F13/0059 ,  B01F13/0093 ,  B01F13/1027 ,  Y10T436/25

    摘要： An improved device and method for passive mixing of fluids is described, and the use of the device in clinical diagnostic procedures. The mixer provides thorough mixing of a sample of blood or other fluid with an assay material, such as a diluent or a component of an assay system, in a closed system with a low and limited pressure drop. Sample size is small, typically 5 to 300 microliters. Mixing is accomplished by a combination of rotational vortex mixing due to a fluid stream coming tangent to a drain, and either or both of a second vortex mixer of opposite handedness, and a Dean mixer. Combinations of these techniques reliably provide complete mixing at low pressure drop. In a preferred usage, the microfluidic system can run a diluent continuously and inject samples at intervals, to facilitate automatic data processing of optical or other signatures of the well-mixed stream.

    摘要翻译： 描述了用于流体被动混合的改进的装置和方法，以及该装置在临床诊断程序中的使用。 混合器在具有低和有限压降的封闭系统中提供血液或其它流体样品与测定材料（例如测定系统的稀释剂或组分）的充分混合。 样品尺寸小，通常为5至300微升。 混合通过由于与排水管相切的流体流的旋转涡流混合以及具有相反方向性的第二涡旋混合器中的任一者或两者与Dean混合器组合而实现。 这些技术的组合可靠地在低压降下提供完全混合。 在优选的用途中，微流体系统可连续运行稀释剂并间隔地注入样品，以便于对混合良好的流的光学或其它特征进行自动数据处理。

    Capillary Manipulation of Clinical Samples
    8.
    发明申请
    Capillary Manipulation of Clinical Samples 审中-公开
    临床样品的毛细管理

    公开(公告)号：US20140165711A1

    公开(公告)日：2014-06-19

    申请号：US13694575

    申请日：2012-12-13

    申请人： Julia Z. Sharpe ,  Eugene Y. Chan

    发明人： Julia Z. Sharpe ,  Eugene Y. Chan

    IPC分类号： G01N1/10

    CPC分类号： B01L3/502715 ,  A61B10/0051 ,  A61B10/007 ,  B01L3/502723 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2300/0838 ,  G01N1/02 ,  G01N2001/002

    摘要： A system for collection and delivery of sub-milliliter liquid samples is described that provides a dramatic simplification for the measurement of clinical values. The system produces high dilutions of capillary size samples, such as bodily fluids or blood, by a factor of 1000 or more. Multiple assays can be conducted on a sample of 0.1 cc or less. A small lancet can create a drop of blood on a fingertip or other location, which can be collected into a self-priming capillary blood collector. The sample is then loaded into a consumable loader. Then a fluid, such as saline, is flowed into the consumable loader, and passes through the capillary collector, washing out the fluid. Downstream, the blood in the capillary is reliably diluted by mixing with appropriate reagents to allow analysis of selected blood properties. One or more individual bubbles can be inserted into the stream during loading. The capillary loading system can be used for one or several assays on a single blood sample. It can be very compact and lightweight and is suitable for use in remote environments, such as outer space, in which it is difficult to access diagnostic assays.

    摘要翻译： 描述了用于收集和递送亚毫升液体样品的系统，其为测量临床值提供了显着的简化。 该系统产生毛细管尺寸样品（例如体液或血液）的高稀释倍数为1000或更高。 可以对0.1cc或更少的样品进行多次测定。 小刺血针可以在指尖或其他位置产生一滴血液，可以将其收集到自吸毛细管血液收集器中。 然后将样品装入消耗装载机。 然后，诸如盐水的流体流入消耗装载器，并且通过毛细收集器，洗涤流体。 在下游，通过与适当的试剂混合可靠地稀释毛细血管中的血液，以便分析选定的血液性质。 一个或多个单独的气泡可以在装载过程中插入流中。 毛细管装载系统可用于单次血液样品上的一次或多次测定。 它可以非常紧凑和轻便，适用于远程环境，如外部空间，难以进行诊断测定。

    Optically characterizing polymers
    9.
    发明授权
    Optically characterizing polymers 有权
    光学表征聚合物

    公开(公告)号：US06790671B1

    公开(公告)日：2004-09-14

    申请号：US09373822

    申请日：1999-08-13

    申请人： Robert H. Austin ,  Jonas O. Tegenfeldt ,  Eugene Y. Chan

    发明人： Robert H. Austin ,  Jonas O. Tegenfeldt ,  Eugene Y. Chan

    IPC分类号： C12Q168

    CPC分类号： B82Y20/00 ,  G01N21/6408 ,  G01N2021/6441 ,  Y10S435/808 ,  Y10T436/143333 ,  Y10T436/25375

    摘要： The invention relates to new systems, methods and products for analyzing polymers and in particular new systems, methods and products useful for obtaining sequence information from polymers. The invention has numerous advantages over prior art systems and methods used to obtain sequence-related information. Using the methods of the invention the entire human genome could be analyzed several orders of magnitude faster than could be accomplished using conventional technology. In addition to obtaining sequencing information for the entire genome, the systems, methods and products of the invention can be used to create comprehensive and multiple expression maps for developmental and disease processes. The ability to analyze an individual's genome and to generate multiple expression maps will greatly enhance the ability to determine the genetic basis of any phenotypic trait or disease process.

    摘要翻译： 本发明涉及用于分析聚合物的新系统，方法和产品，特别是可用于从聚合物获得序列信息的新系统，方法和产品。 本发明与用于获得序列相关信息的现有技术系统和方法相比具有许多优点。 使用本发明的方法，可以将整个人类基因组分析比使用常规技术可以实现的几个数量级。 除了获得整个基因组的测序信息之外，本发明的系统，方法和产品可用于为发育和疾病过程创建综合和多重表达图。 分析个体基因组和产生多个表达图谱的能力将大大提高确定任何表型性状或疾病过程的遗传基础的能力。