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1.发明授权公开(公告)号：US08399229B2
公开(公告)日：2013-03-19
申请号：US12950130
申请日：2010-11-19
IPC分类号： B03C1/035
CPC分类号： B03C1/288 , B01L3/502761 , B01L2300/0861 , B01L2400/043 , B03C1/01 , B03C1/032 , B03C1/033 , B03C2201/18 , B03C2201/26 , B82Y25/00 , C07K1/22 , C07K1/24
摘要： Magnetic array platforms such as nano or micro-wire networks that produce trapping, manipulation, and transport of micro- or nano-scale particles such as non-biological entities such as magnetic particles and cells, viruses, DNA, proteins, and other biological entities having magnetic particles labeled or tethered thereto are provided. Methods of manipulating, transporting, and sorting micro- or nano-scale particles are described.
摘要翻译： 诸如纳米或微线网络的磁阵列平台，其产生微尺度或纳米尺度颗粒如磁性颗粒和细胞，病毒，DNA，蛋白质和其他生物实体的非生物实体的捕获，操纵和传输 提供标记或束缚的磁性颗粒。 描述了操作，运输和分选微尺度或纳米尺度颗粒的方法。
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公开(公告)号：US20130315796A1
公开(公告)日：2013-11-28
申请号：US13758695
申请日：2011-02-17
申请人： Jeffrey J. Chalmers , Maciej Zborowski , Thomas J. Ward , George Keller , Adam Landis , Michael Ward , Lee Robert Moore
发明人： Jeffrey J. Chalmers , Maciej Zborowski , Thomas J. Ward , George Keller , Adam Landis , Michael Ward , Lee Robert Moore
IPC分类号： G01N33/487
CPC分类号： G01N33/487 , C12M47/02 , C12M47/04 , C12N1/02 , C12N13/00
摘要： A disposable kit for use in directing fluid through a biological cell separator device (10). The kit generally includes a separator tube (22), a buffer fluid container (34), cell sample container (32), separated cell container (60), and flushing fluid container (62), as well as various conduits (36, 38, 42, 50, 50a, 50b) for connecting the containers (32, 34, 60, 62) and separator tube (22) in fluid communication together. A cell separator system is provided including a separator tube (22), magnet (20), pump (120) and a motorized drive unit (96). The motorized drive unit (96) is operatively connected to the magnet (20) to allow the magnet (20) to be moved a sufficient distance away from the separator tube (22) so as to allow cells adhered to the inside surface thereof to be flushed out of the tube (22).
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3.发明申请公开(公告)号：US20110294185A1
公开(公告)日：2011-12-01
申请号：US13147689
申请日：2010-02-08
CPC分类号： C12N13/00 , G01N33/54326 , G01N33/54366 , G01N33/56966 , G01N33/6854 , Y10T436/11
摘要： A magnetic platform is provided and includes a patterned array of discrete magnetic elements positioned on a substrate, a plurality of first electromagnets for creating a first magnetic field substantially in the plane of the substrate, an electromagnetic coil for creating a second magnetic field substantially perpendicular to the plane of the substrate, and a control device for controlling the application of the magnetic fields. Processes for manipulating, transporting, separating and sorting micro- or nano-scale particles and biomolecules are also described.
摘要翻译： 提供磁性平台，并且包括位于基板上的分立磁性元件的图案化阵列，用于产生基本上在基板平面中的第一磁场的多个第一电磁体，用于产生基本垂直于基板的第二磁场的电磁线圈 基板的平面以及用于控制磁场的应用的控制装置。 还描述了操作，运输，分离和分选微米级或纳米级粒子和生物分子的方法。
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4.发明申请公开(公告)号：US20140199747A1
公开(公告)日：2014-07-17
申请号：US14211731
申请日：2014-03-14
IPC分类号： C12N13/00 , G01N33/543
CPC分类号： C12N13/00 , G01N33/54326 , G01N33/54366 , G01N33/56966 , G01N33/6854 , Y10T436/11
摘要： A magnetic platform is provided and includes a patterned array of discrete magnetic elements positioned on a substrate, a plurality of first electromagnets for creating a first magnetic field substantially in the plane of the substrate, an electromagnetic coil for creating a second magnetic field substantially perpendicular to the plane of the substrate, and a control device for controlling the application of the magnetic fields. Processes for manipulating, transporting, separating and sorting micro- or nano-scale particles and biomolecules are also described.
摘要翻译： 提供磁性平台，并且包括位于基板上的分立磁性元件的图案化阵列，用于产生基本上在基板平面中的第一磁场的多个第一电磁体，用于产生基本垂直于基板的第二磁场的电磁线圈 基板的平面以及用于控制磁场的应用的控制装置。 还描述了操作，运输，分离和分选微米级或纳米级粒子和生物分子的方法。
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5.发明授权公开(公告)号：US08691557B2
公开(公告)日：2014-04-08
申请号：US13147689
申请日：2010-02-08
IPC分类号： C12M1/36
CPC分类号： C12N13/00 , G01N33/54326 , G01N33/54366 , G01N33/56966 , G01N33/6854 , Y10T436/11
摘要： A magnetic platform is provided and includes a patterned array of discrete magnetic elements positioned on a substrate, a plurality of first electromagnets for creating a first magnetic field substantially in the plane of the substrate, an electromagnetic coil for creating a second magnetic field substantially perpendicular to the plane of the substrate, and a control device for controlling the application of the magnetic fields. Processes for manipulating, transporting, separating and sorting micro- or nano-scale particles and biomolecules are also described.
摘要翻译： 提供磁性平台，并且包括位于基板上的分立磁性元件的图案化阵列，用于产生基本上在基板平面中的第一磁场的多个第一电磁体，用于产生基本垂直于基板的第二磁场的电磁线圈 基板的平面以及用于控制磁场的应用的控制装置。 还描述了操作，运输，分离和分选微米级或纳米级粒子和生物分子的方法。
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公开(公告)号：US20100261272A1
公开(公告)日：2010-10-14
申请号：US12438681
申请日：2007-08-27
申请人： Jeffrey J. Chalmers , James F. Rathman , Weiwei Hu
发明人： Jeffrey J. Chalmers , James F. Rathman , Weiwei Hu
CPC分类号： C12N5/0018 , C12N2500/50
摘要： Compositions and methods for reducing gas-cell surface interface damage include a protective composition having at least sugar moiety where the sugar moiety provides a hydrophilic component to the protective composition.
摘要翻译： 用于减少气体细胞表面界面损伤的组合物和方法包括至少具有糖部分的保护性组合物，其中糖部分为保护性组合物提供亲水性组分。
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公开(公告)号：US20100093052A1
公开(公告)日：2010-04-15
申请号：US12514618
申请日：2007-11-14
申请人： Jeffrey J. Chalmers , Oscar R. Lara-Velasco , Xiaodong Tong , Maciej Zborowski , Lee R. Moore , Sherif S. Farag
发明人： Jeffrey J. Chalmers , Oscar R. Lara-Velasco , Xiaodong Tong , Maciej Zborowski , Lee R. Moore , Sherif S. Farag
CPC分类号： B03C1/288 , B03C2201/18 , B03C2201/26
摘要： Systems and methods are provided separating a first group of cells from a mixture of at least first and second groups of cells in a suspending fluid. The system includes an annular flow channel and at least one magnetic element positioned around the exterior of the annular flow channel as to provide a radially symmetric magnetic field around at least a portion of the annular flow channel. The at least one magnetic element is configured to provide a gradually increasing magnetic field along the axis of flow as to limit the maximum magnetic gradient within the annular flow channel. A pump is operatively connected to a terminal end of the annular flow channel to force the suspending fluid through the annular channel.
摘要翻译： 提供了将系统和方法从悬浮液中的至少第一组和第二组细胞的混合物中分离出第一组细胞。 该系统包括环形流动通道和围绕环形流动通道的外部定位的至少一个磁性元件，以便围绕环形流动通道的至少一部分提供径向对称的磁场。 至少一个磁性元件构造成沿流动轴线提供逐渐增加的磁场，以限制环形流动通道内的最大磁梯度。 泵可操作地连接到环形流动通道的终端以迫使悬浮液通过环形通道。
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8.发明授权公开(公告)号：US08906691B2
公开(公告)日：2014-12-09
申请号：US14211731
申请日：2014-03-14
IPC分类号： G01N33/68 , G01N33/569 , C12N13/00 , G01N33/543
CPC分类号： C12N13/00 , G01N33/54326 , G01N33/54366 , G01N33/56966 , G01N33/6854 , Y10T436/11
摘要： A magnetic platform is provided and includes a patterned array of discrete magnetic elements positioned on a substrate, a plurality of first electromagnets for creating a first magnetic field substantially in the plane of the substrate, an electromagnetic coil for creating a second magnetic field substantially perpendicular to the plane of the substrate, and a control device for controlling the application of the magnetic fields. Processes for manipulating, transporting, separating and sorting micro-or nano-scale particles and biomolecules are also described.
摘要翻译： 提供磁性平台，并且包括位于基板上的分立磁性元件的图案化阵列，用于产生基本上在基板平面中的第一磁场的多个第一电磁体，用于产生基本垂直于基板的第二磁场的电磁线圈 基板的平面以及用于控制磁场的应用的控制装置。 还描述了操作，运输，分离和分选微尺度或纳米级颗粒和生物分子的方法。
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公开(公告)号：US08440800B2
公开(公告)日：2013-05-14
申请号：US12438681
申请日：2007-08-27
申请人： Jeffrey J. Chalmers , James F. Rathman , Weiwei Hu
发明人： Jeffrey J. Chalmers , James F. Rathman , Weiwei Hu
CPC分类号： C12N5/0018 , C12N2500/50
摘要： Compositions and methods for reducing gas-cell surface interface damage include a protective composition having at least sugar moiety where the sugar moiety provides a hydrophilic component to the protective composition.
摘要翻译： 用于减少气体细胞表面界面损伤的组合物和方法包括至少具有糖部分的保护性组合物，其中糖部分为保护性组合物提供亲水性组分。
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10.发明申请公开(公告)号：US20110124077A1
公开(公告)日：2011-05-26
申请号：US12950130
申请日：2010-11-19
CPC分类号： B03C1/288 , B01L3/502761 , B01L2300/0861 , B01L2400/043 , B03C1/01 , B03C1/032 , B03C1/033 , B03C2201/18 , B03C2201/26 , B82Y25/00 , C07K1/22 , C07K1/24
摘要： Magnetic array platforms such as nano or micro-wire networks that produce trapping, manipulation, and transport of micro- or nano-scale particles such as non-biological entities such as magnetic particles and cells, viruses, DNA, proteins, and other biological entities having magnetic particles labeled or tethered thereto are provided. Methods of manipulating, transporting, and sorting micro- or nano-scale particles are described.
摘要翻译： 诸如纳米或微线网络的磁阵列平台，其产生微尺度或纳米尺度颗粒如磁性颗粒和细胞，病毒，DNA，蛋白质和其他生物实体的非生物实体的捕获，操纵和传输 提供标记或束缚的磁性颗粒。 描述了操作，运输和分选微尺度或纳米尺度颗粒的方法。
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