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公开(公告)号：US20120128642A1
公开(公告)日：2012-05-24
申请号：US13386263
申请日：2010-07-23
CPC分类号： G01N33/6881 , C12N5/0627 , G01N2800/20
摘要： Methods for identifying trichogenic dermal cells, including dermal papilla cells and dermal sheath cells, capable of inducing hair follicle formation when injected into skin are provided. Biomarkers have been discovered that can be used to detect, identify, and distinguish trichogenic dermal cells, i.e., that are able to induce hair follicle formation, from non-trichogenic skin cells. Populations of enriched trichogenic dermal cells can be produced by selecting for and enriching for dermal cells that the disclosed biomarkers. These enriched trichogenic dermal can be used for inducing hair follicle formation.
摘要翻译： 提供了当注射到皮肤中时能够诱导毛囊形成的毛发真皮细胞（包括真皮乳头细胞和皮肤鞘细胞）的方法。 已经发现生物标志物可用于从非致毛皮肤细胞中检测，鉴定和区分毛发真皮细胞，即能够诱导毛囊形成的细胞。 可以通过选择和富集所公开的生物标志物的真皮细胞来产生富集的毛发真皮细胞的群体。 这些丰富的毛发真皮可用于诱导毛囊形成。
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2.发明授权Hair follicle precursor production by co-culturing mammalian dermal papilla cells and keratinocytes 有权通过共培养哺乳动物真皮乳头细胞和角质形成细胞产生毛囊前体公开(公告)号：US08980628B2
公开(公告)日：2015-03-17
申请号：US12293402
申请日：2007-03-15
IPC分类号： C12N5/02 , A61L27/38 , C12N5/077 , C12N5/071 , C12N5/0775
CPC分类号： A61L27/3886 , A61L27/3813 , A61L2430/18 , C12N5/0627 , C12N5/0628 , C12N5/0656 , C12N5/0666 , C12N2501/415 , C12N2502/02 , C12N2502/091 , C12N2502/092 , C12N2502/094 , C12N2502/1323
摘要： This invention relates to methods of producing hair folliclesin vitro, compositions for producing hair follicles in vitro, in vitro produced hair follicles, methods of providing an in vitro produced hair shaft at an interfollicular or intrafollicular site, methods of treating hair loss by providing an in vitro produced hair shaft at an interfollicular or intrafollicular site and assays for studying the effect of test agents on hair biology. The invention also provides the similar methods and products which are, or use, immature follicles (“defined herein as proto-hairs”). The invention provides a method for in vitro production of a hair follicle or a proto-hair comprising co-culturing dermal papilla cells with keratinocytes, and optionally with melanocytes.
摘要翻译： 本发明涉及体外生产毛囊的方法，用于在体外产生毛囊的组合物，体外产生的毛囊，在滤泡或滤泡内部位提供体外产生的毛干的方法，通过提供在 在滤泡或滤泡内部位产生体外产生的毛干，以及用于研究试验剂对毛发生物学效果的测定。 本发明还提供了类似的方法和产品，其是或使用未成熟卵泡（“本文定义为原毛”）。 本发明提供了用于体外生产毛囊或原毛的方法，其包括用角质形成细胞和任选地与黑素细胞共培养真皮乳头细胞。
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公开(公告)号：US20120128632A1
公开(公告)日：2012-05-24
申请号：US13386456
申请日：2010-07-22
IPC分类号： A61K35/36 , A61M5/00 , A61P17/14 , G01N33/567 , C12N5/02
CPC分类号： G01N33/56966 , C12N5/0627
摘要： Methods for identifying trichogenic dermal cells, including dermal papilla cells and dermal sheath cells, capable of inducing hair follicle formation when injected into skin are provided. It has been discovered that EGF latrophilin and seven transmembrane domain-containing protein 1 (ELTD1). Transmembrane Protein 108 (TMEM1 08), Hyaluronan and proteoglycan link protein 1 (HAPLN1) are biomarkers that can be used to detect, identify, and distinguish trichogenic dermal cells, i.e., that are able to induce hair follicle formation, from other skin cells. Populations of skin cells enriched with trichogenic dermal cells can be produced by selecting for and enriching for dermal cells that express ELTD1, TMEM1 08, HAPLN1, or a combination thereof.
摘要翻译： 提供了当注射到皮肤中时能够诱导毛囊形成的毛发真皮细胞（包括真皮乳头细胞和皮肤鞘细胞）的方法。 已经发现EGF latrophilin和7个跨膜结构域蛋白1（ELTD1）。 透明质酸蛋白108（TMEM1.08），透明质酸和蛋白多糖连接蛋白1（HAPLN1）是可用于检测，鉴定和区分来自其它皮肤细胞的能够诱导毛囊形成的致毛细胞真皮细胞的生物标志物。 可以通过选择和富集表达ELTD1，TMEM1 08，HAPLN1或其组合的真皮细胞来产生富含毛发真皮细胞的皮肤细胞群体。
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公开(公告)号：US20090198336A1
公开(公告)日：2009-08-06
申请号：US12293402
申请日：2007-03-15
CPC分类号： A61L27/3886 , A61L27/3813 , A61L2430/18 , C12N5/0627 , C12N5/0628 , C12N5/0656 , C12N5/0666 , C12N2501/415 , C12N2502/02 , C12N2502/091 , C12N2502/092 , C12N2502/094 , C12N2502/1323
摘要： This invention relates to methods of producing hair folliclesin vitro, compositions for producing hair follicles in vitro, in vitro produced hair follicles, methods of providing an in vitro produced hair shaft at an interfollicular or intrafollicular site, methods of treating hair loss by providing an in vitro produced hair shaft at an interfollicular or intrafollicular site and assays for studying the effect of test agents on hair biology. The invention also provides the similar methods and products which are, or use, immature follicles (“defined herein as proto-hairs”). The invention provides a method for in vitro production of a hair follicle or a proto-hair comprising co-culturing dermal papilla cells with keratinocytes, and optionally with melanocytes.
摘要翻译： 本发明涉及体外生产毛囊的方法，用于在体外产生毛囊的组合物，体外产生的毛囊，在滤泡或滤泡内部位提供体外产生的毛干的方法，通过提供在 在滤泡或滤泡内部位产生体外产生的毛干，以及用于研究试验剂对毛发生物学效果的测定。 本发明还提供了类似的方法和产品，其是或使用未成熟卵泡（“本文定义为原毛”）。 本发明提供了用于体外生产毛囊或原毛的方法，其包括用角质形成细胞和任选地与黑素细胞共培养真皮乳头细胞。
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