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    HAIR FOLLICLE NEOGENESIS
    2.
    发明申请
    HAIR FOLLICLE NEOGENESIS 审中-公开
    头发发光

    公开(公告)号：US20130209427A1

    公开(公告)日：2013-08-15

    申请号：US13704431

    申请日：2011-06-17

    申请人： Rajesh Thangapazham ,  Thomas N. Darling ,  Shaowei Li

    发明人： Rajesh Thangapazham ,  Thomas N. Darling ,  Shaowei Li

    IPC分类号： A61L27/38 ,  A61L27/60

    CPC分类号： A61L27/3886 ,  A61F2/105 ,  A61K35/36 ,  A61L27/24 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/60 ,  A61L2430/18 ,  C12N5/0627 ,  C12N5/0698 ,  C12N2501/04 ,  C12N2501/998 ,  C12N2502/092 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2502/30 ,  C12N2510/00 ,  C12N2533/78

    摘要： This invention provides a skin substitute comprising epithelial cells and modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells, and methods for using the same. This invention also provides a method for transplanting cells capable of inducing hair follicles, comprising subdermally or intradermally delivering to a patient modified mesenchymal cells, wherein the modified mesenchymal cells have decreased TSC1/TSC2 function, increased mTORCI function, and/or decreased mTORC2 function compared to wild type mesenchymal cells.

    摘要翻译： 本发明提供一种皮肤替代物，其包含上皮细胞和修饰的间充质细胞，其中所述修饰的间充质细胞与野生型间充质细胞相比具有降低的TSC1 / TSC2功能，增加的mTORCI功能和/或降低的mTORC2功能及其使用方法。 本发明还提供了一种用于移植能够诱导毛囊的细胞的方法，包括皮下或皮内递送至患者修饰的间充质细胞，其中所述修饰的间充质细胞具有降低的TSC1 / TSC2功能，增加的mTORCI功能和/或降低的mTORC2功能 到野生型间充质细胞。

    CELL CO-CULTURE FOR HAIR FOLLICLE PRODUCTION
    3.
    发明申请
    CELL CO-CULTURE FOR HAIR FOLLICLE PRODUCTION 有权
    细胞共培养用于头发生产

    公开(公告)号：US20090198336A1

    公开(公告)日：2009-08-06

    申请号：US12293402

    申请日：2007-03-15

    申请人： Jizeng Qiao ,  Jeffrey Keeler Teumer ,  Erica Jean Philips

    发明人： Jizeng Qiao ,  Jeffrey Keeler Teumer ,  Erica Jean Philips

    IPC分类号： A61F2/10 ,  C12N5/08 ,  C12Q1/02

    CPC分类号： A61L27/3886 ,  A61L27/3813 ,  A61L2430/18 ,  C12N5/0627 ,  C12N5/0628 ,  C12N5/0656 ,  C12N5/0666 ,  C12N2501/415 ,  C12N2502/02 ,  C12N2502/091 ,  C12N2502/092 ,  C12N2502/094 ,  C12N2502/1323

    摘要： This invention relates to methods of producing hair folliclesin vitro, compositions for producing hair follicles in vitro, in vitro produced hair follicles, methods of providing an in vitro produced hair shaft at an interfollicular or intrafollicular site, methods of treating hair loss by providing an in vitro produced hair shaft at an interfollicular or intrafollicular site and assays for studying the effect of test agents on hair biology. The invention also provides the similar methods and products which are, or use, immature follicles (“defined herein as proto-hairs”). The invention provides a method for in vitro production of a hair follicle or a proto-hair comprising co-culturing dermal papilla cells with keratinocytes, and optionally with melanocytes.

    摘要翻译： 本发明涉及体外生产毛囊的方法，用于在体外产生毛囊的组合物，体外产生的毛囊，在滤泡或滤泡内部位提供体外产生的毛干的方法，通过提供在 在滤泡或滤泡内部位产生体外产生的毛干，以及用于研究试验剂对毛发生物学效果的测定。 本发明还提供了类似的方法和产品，其是或使用未成熟卵泡（“本文定义为原毛”）。 本发明提供了用于体外生产毛囊或原毛的方法，其包括用角质形成细胞和任选地与黑素细胞共培养真皮乳头细胞。

    MICRO ORGAN COMPRISING MESENCHYMAL AND EPITHELIAL CELLS
    4.
    发明申请
    MICRO ORGAN COMPRISING MESENCHYMAL AND EPITHELIAL CELLS 审中-公开
    包含MESENCHYMAL和上皮细胞的MICRO有机体

    公开(公告)号：US20170073646A1

    公开(公告)日：2017-03-16

    申请号：US15358399

    申请日：2016-11-22

    申请人： University of Durham

    发明人： Aihua Guo ,  Colin Albert Buchanan Jahoda

    IPC分类号： C12N5/071 ,  A61K35/36 ,  G01N33/50

    CPC分类号： C12N5/0698 ,  A61K35/36 ,  C12N2502/092 ,  C12N2502/094 ,  C12N2502/1323 ,  C12N2503/06 ,  C12N2513/00 ,  G01N33/5082

    摘要： The invention provides a micro-organ composite which comprises a core group of cells and an outer layer of cells, wherein the cells of the core group are mesenchymal cells and the cells of the outer layer are epithelial cells or wherein the cells of the core group are epithelial cells and the cells of the outer layer are mesenchymal cells, and wherein the core group of cells is at least partially encapsulated by the outer layer of cells.

    摘要翻译： 本发明提供了一种微细器官复合物，其包含核心组和细胞外层，其中核心组的细胞是间充质细胞，外层细胞是上皮细胞，或其中核心组的细胞 是上皮细胞，外层的细胞是间充质细胞，并且其中核心细胞群由细胞的外层至少部分地包封。

    Method for the manufacture of microtissues for inducing the growth of a hair follicle
    5.
    发明授权
    Method for the manufacture of microtissues for inducing the growth of a hair follicle 有权
    用于制造用于诱导毛囊生长的微量组织的方法

    公开(公告)号：US08492112B2

    公开(公告)日：2013-07-23

    申请号：US13008669

    申请日：2011-01-18

    申请人： Sung-Jan Lin ,  Chih-Chieh Chan ,  Chien-Mei Yen

    发明人： Sung-Jan Lin ,  Chih-Chieh Chan ,  Chien-Mei Yen

    IPC分类号： C12Q1/02 ,  C12N5/00

    CPC分类号： C12N5/0698 ,  C12N2502/092 ,  C12N2502/094 ,  C12N2533/30 ,  G01N33/5088

    摘要： Disclosed is a method for the manufacture of microtissues, comprising the steps of: providing a biomaterial substrate; simultaneously seeding a plurality of dermal papilla (DP) cells and keratinocytes on the substrate surface with a predetermined ratio and cellular density; co-culturing for a predetermined period; and carrying the keratinocytes to the substrate surface by the dermal papilla cells, aggregating and finally form a plurality of keratinocyte-dermal papilla cell microtissues, wherein the dermal papilla cells are located in a center of the microtissue and the keratinocytes are sorted to a surface of the microtissue, and the keratinocytes are adult keratinocytes. The method can help to simply and economize the procedures for production of folliculoid microtissues with high-throughput. Once microtissues are transplanted to skin of subject, hair follicles can be regenerated.

    摘要翻译： 公开了一种制造微组织的方法，包括以下步骤：提供生物材料基材; 同时以预定比例和细胞密度在基底表面上接种多个真皮乳头（DP）细胞和角质形成细胞; 共同培养一段时间; 并通过真皮乳头细胞将角质形成细胞携带到底物表面，聚集并最终形成多个角质形成细胞真皮乳头细胞微组织，其中真皮乳头细胞位于微组织的中心，角质形成细胞被分选到 微组织和角质细胞是成体角质形成细胞。 该方法可以简化和节省生产具有高通量的卵泡微生物的程序。 一旦将微量组织移植到受试者的皮肤上，可以再生毛囊。

    Native-state histoculturing method for skin
    7.
    发明授权
    Native-state histoculturing method for skin 失效
    皮肤的原生态组织培养方法

    公开(公告)号：US5849579A

    公开(公告)日：1998-12-15

    申请号：US642322

    申请日：1996-05-03

    申请人： Lingna Li

    发明人： Lingna Li

    IPC分类号： C12N5/071 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50 ,  C12N5/00

    CPC分类号： C12N5/0629 ,  C12N5/0627 ,  G01N33/5014 ,  C12N2502/092 ,  C12N2503/00

    摘要： Methods and compositions for a native-state histoculturing system for skin are disclosed. Skin samples are placed on an extracellular support matrix immersed in a medium whereby the internal surface of the skin is adjacent to the matrix and the external surface is exposed above the surface of the medium and the skin maintained in the medium under skin culturing conditions. An extracellular support matrix comprising a collagen-containing gel and homopolysaccharide sponge or a combination matrix of a top layer of a collagen-containing gel and a bottom layer of a homopolysaccharide sponge is also disclosed. Skin toxicity, hair growth, anti-aging and anti-wrinkling assays utilizing the histoculturing system of the present invention are also disclosed.

    摘要翻译： 公开了用于皮肤的天然状态组织培养系统的方法和组合物。 将皮肤样品放置在浸在培养基中的细胞外支持基质上，由此皮肤的内表面与基质相邻，并且外表面暴露在培养基表面之上，皮肤在皮肤培养条件下保持在培养基中。 还公开了包含含胶原蛋白的凝胶和均聚多糖海绵的细胞外支持基质或含有胶原的凝胶的顶层和均聚糖海绵的底层的组合基质。 还公开了利用本发明的组织培养系统的皮肤毒性，毛发生长，抗衰老和抗皱纹测定。