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公开(公告)号：US08012694B2
公开(公告)日：2011-09-06
申请号：US11521007
申请日：2006-09-14
IPC分类号： A61K38/29 , C07K16/06 , C07K16/26 , G01N33/53 , G01N33/566 , G01N33/577
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/34 , G01N2333/635
摘要： Antibodies for a variant of intact parathyroid hormone (PTH) or its fragments which have at position 17 the amino acid serine which is phosphorylated [p(17) PTH] and methods of producing the same. The invention further includes various immunoassay methods which use the described antibody alone or in combination with other antibodies to determine the circulating levels of p(17) intact PTH (1-84) or fragments thereof in biological fluids. Such antibodies and immunoassays can be used in conjunction with other antibodies to detect all biologically active forms of hPTH present in biological fluids.
摘要翻译： 在17位具有磷酸化的氨基酸丝氨酸[p（17）PTH）的完整甲状旁腺激素（PTH）或其片段的变体的抗体及其制备方法。 本发明还包括各种免疫测定方法，其单独使用所述抗体或与其它抗体组合，以确定生物流体中p（17）完整PTH（1-84）或其片段的循环水平。 这样的抗体和免疫测定可与其它抗体结合使用以检测存在于生物流体中的所有生物活性形式的hPTH。
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2.发明授权Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 有权用于产生对生物活性完整甲状旁腺激素（PTH）1-84具有选择性结合特异性的抗体的抗体和肽抗原公开(公告)号：US07670805B2
公开(公告)日：2010-03-02
申请号：US12286620
申请日：2008-10-01
IPC分类号： G01N33/531 , G01N33/532 , G01N33/533 , G01N33/534 , G01N33/535 , A61K38/10 , A61K38/22 , C07K16/06 , C07K16/26
CPC分类号： C07K16/26 , A61K39/00 , C07K14/635
摘要： Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the same. Such antigens, antibodies and methods producing the same according to the present invention are useful in determining bioactive intact PTH levels in serum, plasma, and/or cell culture media. Such antibodies further possess a high degree of species cross-reactivity, but substantially mitigated cross-reactivity to non-whole PTH peptide fragments and little to no recognition of the first amino acid residue of PTH.
摘要翻译： 对应于甲状旁腺激素（PTH）的氨基酸残基2-12,1-2,2-15和1-15的肽抗原，对这种肽抗原具有亲和性的抗体及其制备方法。 根据本发明的这样的抗原，抗体及其制备方法可用于测定血清，血浆和/或细胞培养基中生物活性的完整PTH水平。 这样的抗体进一步具有高度的物种交叉反应性，但是基本上减轻了与非全部PTH肽片段的交叉反应性，并且几乎没有认识到PTH的第一个氨基酸残基。
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3.发明申请ANTIBODIES AND PEPTIDE ANTIGENS FOR PRODUCING ANTIBODIES HAVING A SELECTIVE BINDING SPECIFICITY TO BIOACTIVE INTACT PARATHYROID HORMONE (PTH) 1-84 审中-公开抗生素和肽抗生素，用于生产具有选择性结合特异性的生物活性直接杀菌激素（PTH）1-84的抗体公开(公告)号：US20100186100A1
公开(公告)日：2010-07-22
申请号：US12709103
申请日：2010-02-19
IPC分类号： C12P21/00
CPC分类号： C07K16/26 , A61K39/00 , C07K14/635
摘要： Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the same. Such antigens, antibodies and methods producing the same according to the present invention are useful in determining bioactive intact PTH levels in serum, plasma, and/or cell culture media. Such antibodies further possess a high degree of species cross-reactivity, but substantially mitigated cross-reactivity to non-whole PTH peptide fragments and little to no recognition of the first amino acid residue of PTH.
摘要翻译： 对应于甲状旁腺激素（PTH）的氨基酸残基2-12,1-2,2-15和1-15的肽抗原，对这种肽抗原具有亲和性的抗体及其制备方法。 根据本发明的这样的抗原，抗体及其制备方法可用于测定血清，血浆和/或细胞培养基中生物活性的完整PTH水平。 这样的抗体进一步具有高度的物种交叉反应性，但是基本上减轻了与非全部PTH肽片段的交叉反应性，并且几乎没有认识到PTH的第一个氨基酸残基。
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公开(公告)号：US20090094704A1
公开(公告)日：2009-04-09
申请号：US12286620
申请日：2008-10-01
IPC分类号： A01K67/027
CPC分类号： C07K16/26 , A61K39/00 , C07K14/635
摘要： Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the same. Such antigens, antibodies and methods producing the same according to the present invention are useful in determining bioactive intact PTH levels in serum, plasma, and/or cell culture media. Such antibodies further possess a high degree of species cross-reactivity, but substantially mitigated cross-reactivity to non-whole PTH peptide fragments and little to no recognition of the first amino acid residue of PTH.
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公开(公告)号：US20100261199A1
公开(公告)日：2010-10-14
申请号：US11521007
申请日：2006-09-14
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/34 , G01N2333/635
摘要： Antibodies for a variant of intact parathyroid hormone (PTH) or its fragments which have at position 17 the amino acid serine which is phosphorylated [p(17) PTH] and methods of producing the same. The invention further includes various immunoassay methods which use the described antibody alone or in combination with other antibodies to determine the circulating levels of p(17) intact PTH (1-84) or fragments thereof in biological fluids. Such antibodies and immunoassays can be used in conjunction with other antibodies to detect all biologically active forms of hPTH present in biological fluids.
摘要翻译： 在17位具有磷酸化的氨基酸丝氨酸[p（17）PTH）的完整甲状旁腺激素（PTH）或其片段的变体的抗体及其制备方法。 本发明还包括各种免疫测定方法，其单独使用所述抗体或与其它抗体组合，以确定生物流体中p（17）完整PTH（1-84）或其片段的循环水平。 这样的抗体和免疫测定可与其它抗体结合使用以检测存在于生物流体中的所有生物活性形式的hPTH。
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6.发明授权Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 有权用于产生对生物活性完整甲状旁腺激素（PTH）1-84具有选择性结合特异性的抗体的抗体和肽抗原公开(公告)号：US07226749B2
公开(公告)日：2007-06-05
申请号：US10998927
申请日：2004-11-29
IPC分类号： C07K14/435 , C07K14/635 , C07K16/18 , C07K16/26 , A61K39/00
CPC分类号： C07K14/635 , A61K39/00 , C07K16/26 , C07K2317/34
摘要： Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the same. Such antigens, antibodies and methods producing the same according to the present invention are useful in determining bioactive intact PTH levels in serum, plasma, and/or cell culture media. Such antibodies further possess a high degree of species cross-reactivity, but substantially mitigated cross-reactivity to non-whole PTH peptide fragments and little to no recognition of the first amino acid residue of PTH.
摘要翻译： 对应于甲状旁腺激素（PTH）的氨基酸残基2-12,1-2,2-15和1-15的肽抗原，对这种肽抗原具有亲和性的抗体及其制备方法。 根据本发明的这样的抗原，抗体及其制备方法可用于测定血清，血浆和/或细胞培养基中生物活性的完整PTH水平。 这样的抗体进一步具有高度的物种交叉反应性，但是基本上减轻了与非全部PTH肽片段的交叉反应性，并且几乎没有认识到PTH的第一个氨基酸残基。
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7.发明授权Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 有权用于产生对生物活性完整甲状旁腺激素（PTH）1-84具有选择性结合特异性的抗体的抗体和肽抗原公开(公告)号：US06838264B2
公开(公告)日：2005-01-04
申请号：US09730174
申请日：2000-12-05
CPC分类号： C07K16/26 , A61K39/00 , C07K14/635
摘要： Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the same. Such antigens, antibodies and methods producing the same according to the present invention are useful in determining bioactive intact PTH levels in serum, plasma, and/or cell culture media. Such antibodies further possess a high degree of species cross-reactivity, but substantially mitigated cross-reactivity to non-whole PTH peptide fragments and little to no recognition of the first amino acid residue of PTH.
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