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公开(公告)号：US20090094704A1
公开(公告)日：2009-04-09
申请号：US12286620
申请日：2008-10-01
IPC分类号： A01K67/027
CPC分类号： C07K16/26 , A61K39/00 , C07K14/635
摘要： Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the same. Such antigens, antibodies and methods producing the same according to the present invention are useful in determining bioactive intact PTH levels in serum, plasma, and/or cell culture media. Such antibodies further possess a high degree of species cross-reactivity, but substantially mitigated cross-reactivity to non-whole PTH peptide fragments and little to no recognition of the first amino acid residue of PTH.
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公开(公告)号：US08012694B2
公开(公告)日：2011-09-06
申请号：US11521007
申请日：2006-09-14
IPC分类号： A61K38/29 , C07K16/06 , C07K16/26 , G01N33/53 , G01N33/566 , G01N33/577
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/34 , G01N2333/635
摘要： Antibodies for a variant of intact parathyroid hormone (PTH) or its fragments which have at position 17 the amino acid serine which is phosphorylated [p(17) PTH] and methods of producing the same. The invention further includes various immunoassay methods which use the described antibody alone or in combination with other antibodies to determine the circulating levels of p(17) intact PTH (1-84) or fragments thereof in biological fluids. Such antibodies and immunoassays can be used in conjunction with other antibodies to detect all biologically active forms of hPTH present in biological fluids.
摘要翻译： 在17位具有磷酸化的氨基酸丝氨酸[p（17）PTH）的完整甲状旁腺激素（PTH）或其片段的变体的抗体及其制备方法。 本发明还包括各种免疫测定方法，其单独使用所述抗体或与其它抗体组合，以确定生物流体中p（17）完整PTH（1-84）或其片段的循环水平。 这样的抗体和免疫测定可与其它抗体结合使用以检测存在于生物流体中的所有生物活性形式的hPTH。
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3.发明授权Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 有权用于产生对生物活性完整甲状旁腺激素（PTH）1-84具有选择性结合特异性的抗体的抗体和肽抗原公开(公告)号：US07670805B2
公开(公告)日：2010-03-02
申请号：US12286620
申请日：2008-10-01
IPC分类号： G01N33/531 , G01N33/532 , G01N33/533 , G01N33/534 , G01N33/535 , A61K38/10 , A61K38/22 , C07K16/06 , C07K16/26
CPC分类号： C07K16/26 , A61K39/00 , C07K14/635
摘要： Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the same. Such antigens, antibodies and methods producing the same according to the present invention are useful in determining bioactive intact PTH levels in serum, plasma, and/or cell culture media. Such antibodies further possess a high degree of species cross-reactivity, but substantially mitigated cross-reactivity to non-whole PTH peptide fragments and little to no recognition of the first amino acid residue of PTH.
摘要翻译： 对应于甲状旁腺激素（PTH）的氨基酸残基2-12,1-2,2-15和1-15的肽抗原，对这种肽抗原具有亲和性的抗体及其制备方法。 根据本发明的这样的抗原，抗体及其制备方法可用于测定血清，血浆和/或细胞培养基中生物活性的完整PTH水平。 这样的抗体进一步具有高度的物种交叉反应性，但是基本上减轻了与非全部PTH肽片段的交叉反应性，并且几乎没有认识到PTH的第一个氨基酸残基。
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公开(公告)号：US20100261199A1
公开(公告)日：2010-10-14
申请号：US11521007
申请日：2006-09-14
CPC分类号： G01N33/74 , C07K16/26 , C07K2317/34 , G01N2333/635
摘要： Antibodies for a variant of intact parathyroid hormone (PTH) or its fragments which have at position 17 the amino acid serine which is phosphorylated [p(17) PTH] and methods of producing the same. The invention further includes various immunoassay methods which use the described antibody alone or in combination with other antibodies to determine the circulating levels of p(17) intact PTH (1-84) or fragments thereof in biological fluids. Such antibodies and immunoassays can be used in conjunction with other antibodies to detect all biologically active forms of hPTH present in biological fluids.
摘要翻译： 在17位具有磷酸化的氨基酸丝氨酸[p（17）PTH）的完整甲状旁腺激素（PTH）或其片段的变体的抗体及其制备方法。 本发明还包括各种免疫测定方法，其单独使用所述抗体或与其它抗体组合，以确定生物流体中p（17）完整PTH（1-84）或其片段的循环水平。 这样的抗体和免疫测定可与其它抗体结合使用以检测存在于生物流体中的所有生物活性形式的hPTH。
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5.发明授权Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 有权用于产生对生物活性完整甲状旁腺激素（PTH）1-84具有选择性结合特异性的抗体的抗体和肽抗原公开(公告)号：US07226749B2
公开(公告)日：2007-06-05
申请号：US10998927
申请日：2004-11-29
IPC分类号： C07K14/435 , C07K14/635 , C07K16/18 , C07K16/26 , A61K39/00
CPC分类号： C07K14/635 , A61K39/00 , C07K16/26 , C07K2317/34
摘要： Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the same. Such antigens, antibodies and methods producing the same according to the present invention are useful in determining bioactive intact PTH levels in serum, plasma, and/or cell culture media. Such antibodies further possess a high degree of species cross-reactivity, but substantially mitigated cross-reactivity to non-whole PTH peptide fragments and little to no recognition of the first amino acid residue of PTH.
摘要翻译： 对应于甲状旁腺激素（PTH）的氨基酸残基2-12,1-2,2-15和1-15的肽抗原，对这种肽抗原具有亲和性的抗体及其制备方法。 根据本发明的这样的抗原，抗体及其制备方法可用于测定血清，血浆和/或细胞培养基中生物活性的完整PTH水平。 这样的抗体进一步具有高度的物种交叉反应性，但是基本上减轻了与非全部PTH肽片段的交叉反应性，并且几乎没有认识到PTH的第一个氨基酸残基。
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6.发明授权Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84 有权用于产生对生物活性完整甲状旁腺激素（PTH）1-84具有选择性结合特异性的抗体的抗体和肽抗原公开(公告)号：US06838264B2
公开(公告)日：2005-01-04
申请号：US09730174
申请日：2000-12-05
CPC分类号： C07K16/26 , A61K39/00 , C07K14/635
摘要： Peptide antigens corresponding to amino acid residues 2-12, 1-12, 2-15 and 1-15 of parathyroid hormone (PTH), antibodies having an affinity to such peptide antigens and methods of producing the same. Such antigens, antibodies and methods producing the same according to the present invention are useful in determining bioactive intact PTH levels in serum, plasma, and/or cell culture media. Such antibodies further possess a high degree of species cross-reactivity, but substantially mitigated cross-reactivity to non-whole PTH peptide fragments and little to no recognition of the first amino acid residue of PTH.
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7.发明授权Immunoassays, assay methods, antibodies and method of creating antibodies for detecting FGF-23 有权免疫测定，测定方法，抗体和产生用于检测FGF-23的抗体的方法公开(公告)号：US07094551B2
公开(公告)日：2006-08-22
申请号：US10245141
申请日：2002-09-17
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/74 , C07K16/22 , G01N2333/50 , Y10S436/815
摘要： Immunoassays, assay methods, antibodies and methods of producing antibodies for the detection of fibroblast growth factor-23 (FGF-23). The immunoassay and assay method preferably comprise a non-competitive, sandwich-type assay utilizing a first bound antibody having affinity to a first site of the FGF-23 molecule, and a second, labeled antibody having an affinity for a second site present upon the FGF-23 molecule. The antibodies and methods of generating the same include administering antigenic peptide fragments of the FGF-23 molecule, monitoring the antibody titre produced thereby, extracting and selecting antibodies from the antisera having a specificity for the desired antigenic region of FGF-23, and purifying same. The antibodies may be incorporated into the immunoassay of the present invention or utilized for a variety of assay-type purposes for the detection of FGF-23.
摘要翻译： 免疫测定，测定方法，抗体和产生用于检测成纤维细胞生长因子-23（FGF-23）的抗体的方法。 免疫测定和测定方法优选包含利用对FGF-23分子的第一位点具有亲和力的第一结合抗体的非竞争性夹心型测定法，和对第二位点具有亲和力的第二标记抗体 FGF-23分子。 抗体及其产生方法包括施用FGF-23分子的抗原肽片段，监测由此产生的抗体滴度，从具有对FGF-23的所需抗原区域的特异性的抗血清中提取和选择抗体，并纯化其 。 可以将抗体掺入本发明的免疫测定中或用于检测FGF-23的各种测定型目的。
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8.发明授权Method and apparatus for performing multiple, simultaneous in vitro diagnostic tests using a solid phase system 失效使用固相系统进行多次同时体外诊断测试的方法和装置
公开(公告)号：US4378344A
公开(公告)日：1983-03-29
申请号：US80106
申请日：1979-09-28
CPC分类号： G01N33/54366 , Y10S435/973 , Y10S436/81
摘要： A method for performing multiple, simultaneous in vitro diagnostic tests is provided. The method utilizes a solid phase device comprising a receptacle and an insert. The receptacle has one or more fixed components immobilized on its inner surface. The insert has one or more fixed components--different from those immobilized on the receptacle--immobilized on its surface which is in contact with a fluid sample when inserted therein. The test is performed by placing a fluid sample, having two or more mobile components reactive with the fixed components, into the receptacle and in contact with the insert for a period of time and measuring the changes which are a function of the concentration of the mobile components.
摘要翻译： 提供了一种执行多个同时体外诊断测试的方法。 该方法利用包括插座和插入件的固相装置。 容器具有固定在其内表面上的一个或多个固定部件。 插入物具有一个或多个固定的组件 - 不同于固定在容器上的固定组件 - 固定在其表面上，当其插入时与流体样品接触。 通过将具有与固定部件反应的两个或多个可移动部件的流体样品放置在插座中并与插入件接触一段时间并测量作为移动体的浓度的变化的变化来进行测试 组件。
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