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    EVALUATING ASSAYS WHICH OPTICAL INHOMOGENEITIES
    4.
    发明申请
    EVALUATING ASSAYS WHICH OPTICAL INHOMOGENEITIES 审中-公开
    评估光学不均匀性的测定

    公开(公告)号：US20140051187A1

    公开(公告)日：2014-02-20

    申请号：US14113964

    申请日：2012-04-23

    申请人： Toon Hendrik Evers ,  Derk Jan Wilfred Klunder ,  Jeroen Hans Nieuwenhuis ,  Joannes Baptist Adianus Dionisius Van Zon

    发明人： Toon Hendrik Evers ,  Derk Jan Wilfred Klunder ,  Jeroen Hans Nieuwenhuis ,  Joannes Baptist Adianus Dionisius Van Zon

    IPC分类号： G01N21/00

    摘要： The invention relates to a method and a sensor device (100) for evaluating an assay with a sample. During the assay, optical measurements are made at a sensing surface (112), and at least one “homogeneity-image” of the sensing surface (112) is generated. From this image, an “homogeneity-indicator” is determined for at least one region of interest, and the optical measurements are then evaluated in dependence on said indicator. The homogeneity-indicator may for example be a binary value which indicates if an inhomogeneity was detected or not. If an inhomogeneity was detected, all optical measurements may be rejected, only measurements for the involved region of interest may be rejected, or measurements for a selected sub-area of the involved region of interest(ROI) may be rejected.

    摘要翻译： 本发明涉及用于评价样品的测定方法和传感器装置（100）。 在测定期间，在感测表面（112）处进行光学测量，并且产生感测表面（112）的至少一个“均匀性图像”。 从该图像中，对于至少一个感兴趣的区域确定“均匀度指标”，然后根据所述指标来评估光学测量。 均匀度指示符可以例如是二进制值，其指示是否检测到不均匀性。 如果检测到不均匀性，则所有光学测量可能被拒绝，只有感兴趣区域的测量可能被拒绝，或者所涉及的感兴趣区域（ROI）的选定子区域的测量可能被拒绝。

    METHOD OF MEASURING MOLECULES IN A FLUID USING LABEL PARTICLES
    6.
    发明申请
    METHOD OF MEASURING MOLECULES IN A FLUID USING LABEL PARTICLES 审中-公开
    使用标签颗粒测量流体中分子的方法

    公开(公告)号：US20100273269A1

    公开(公告)日：2010-10-28

    申请号：US12746180

    申请日：2008-11-28

    申请人： Petrus Johannes Wilhelmus Van Lankvelt ,  Jeroen Hans Nieuwenhuis

    发明人： Petrus Johannes Wilhelmus Van Lankvelt ,  Jeroen Hans Nieuwenhuis

    IPC分类号： G01N27/00 ,  G01N21/75

    CPC分类号： G01N33/54333 ,  G01N21/552 ,  G01N27/745

    摘要： The present invention provides a method of measuring the concentration of molecules in a sample fluid or analyte. Said method comprises the step of mixing the fluid with label particles within a cartridge, wherein the label particles are adapted to capture said molecules and to bind to a sensor surface of said cartridge. Then, the label particles are sedimented towards the sensor surface and the amount of label particles close to the sensor surface is measured. Subsequently, the label particles, which are not bound to the surface, are removed in a “washing” step and finally the amount of label particles close to the sensor surface is measured again.

    摘要翻译： 本发明提供了测量样品流体或分析物中分子浓度的方法。 所述方法包括将流体与盒内的标签颗粒混合的步骤，其中标签颗粒适于捕获所述分子并结合到所述盒的传感器表面。 然后，标签颗粒向传感器表面沉降，并且测量靠近传感器表面的标签颗粒的量。 随后，在“洗涤”步骤中除去未结合表面的标签颗粒，最后再次测量靠近传感器表面的标签颗粒的量。

    MAGNETIC SENSOR DEVICE, METHOD OF OPERATING SUCH A DEVICE AND SAMPLE
    10.
    发明申请
    MAGNETIC SENSOR DEVICE, METHOD OF OPERATING SUCH A DEVICE AND SAMPLE 有权
    磁传感器装置，操作这种装置和样品的方法

    公开(公告)号：US20120107961A1

    公开(公告)日：2012-05-03

    申请号：US13381115

    申请日：2010-06-24

    申请人： Wendy Uyen Dittmer ,  Femke Karina De Theije ,  Albert Hendrik Jan Immink ,  Jeroen Hans Nieuwenhuis ,  Petrus Johannes Wilhelmus Van Lankvelt

    发明人： Wendy Uyen Dittmer ,  Femke Karina De Theije ,  Albert Hendrik Jan Immink ,  Jeroen Hans Nieuwenhuis ,  Petrus Johannes Wilhelmus Van Lankvelt

    IPC分类号： G01N33/566 ,  G01N30/00

    CPC分类号： G01N33/54326 ,  G01N21/552 ,  G01N27/745 ,  G01N33/54366 ,  G01N33/54386

    摘要： A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40′). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14′) from the detection of the further detectable label (40′) in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14′) falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.

    摘要翻译： 公开了一种用于检测样品中目标分子（20）的存在的传感器装置（1）。 所述传感器装置包括测量传感器（2），所述测量传感器（2）包括用于与包含所述目标分子（20）和可检测标记（40）的第一另外部分形成结合对的第一部分（16）和包括 用于与包含另外可检测标记物（40'）的第二另外部分形成另外的结合对的第二部分（50）。 所述传感器装置适于从与所述第一部分（16）结合的所述第一另外部分中的所述可检测标记（40）的检测产生第一检测信号（14），并且从所述第一检测信号（14'）产生来自所述第一检测信号 在第二另外部分结合到第二部分（50）上的另外可检测标记物（40'）的检测，其中至少在传感器装置的操作期间预期第二另外的部分以预定量存在，使得值 当第二另外部分与第二部分的结合反应按预期进行时，第二检测信号（14'）落入预期信号值窗口内。 还公开了一种包括这种传感器装置的装置，操作传感器装置和装置的方法以及与传感器装置一起使用的样本。