公开(公告)号：US07378498B2

公开(公告)日：2008-05-27

申请号：US11008889

申请日：2004-12-10

申请人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

发明人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

IPC分类号： C07K14/435 ,  C07H21/04

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00

摘要： A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.

摘要翻译： 提供了一种用于鉴定调节与荷马相关并由细胞表面或细胞内受体介导的细胞因子反应的化合物的方法。 还提供了一种鉴定调节与荷马相关的受体活化钙动员的化合物的方法。 提供了一种基于荷马蛋白结合结构域的晶体结构坐标来鉴定抑制荷马蛋白活性的化合物的方法。 还提供了一种鉴定影响细胞表面受体形成簇的化合物的方法。 还提供了编码荷马蛋白以及荷马蛋白和荷马相互作用蛋白的核酸。

公开(公告)号：US06720175B1

公开(公告)日：2004-04-13

申请号：US09377285

申请日：1999-08-18

申请人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

发明人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

IPC分类号： C07H2104

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00

摘要： A method is provided for identifying a compound that modulates a cellular response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.

摘要翻译： 提供了一种用于鉴定调节与荷马相关并由细胞表面或细胞内受体介导的细胞应答的化合物的方法。 还提供了一种鉴定调节与荷马相关的受体活化钙动员的化合物的方法。 提供了一种基于荷马蛋白结合结构域的晶体结构坐标来鉴定抑制荷马蛋白活性的化合物的方法。 还提供了一种鉴定影响细胞表面受体形成簇的化合物的方法。 还提供了编码荷马蛋白以及荷马蛋白和荷马相互作用蛋白的核酸。

公开(公告)号：US06864083B2

公开(公告)日：2005-03-08

申请号：US10192381

申请日：2002-07-09

申请人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

发明人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N1/21 ,  C12N7/01 ,  C07H21/04 ,  C12N1/20 ,  C12N5/00 ,  C12N15/00

CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00

摘要： A method is provided for identifying a compound that modulates a cellualr response associate with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.

摘要翻译： 提供了一种鉴定调节与荷马相关并由细胞表面或细胞内受体介导的纤维素反应的化合物的方法。 还提供了一种鉴定调节与荷马相关的受体活化钙动员的化合物的方法。 提供了一种基于荷马蛋白结合结构域的晶体结构坐标来鉴定抑制荷马蛋白活性的化合物的方法。 还提供了一种鉴定影响细胞表面受体形成簇的化合物的方法。 还提供了编码荷马蛋白以及荷马蛋白和荷马相互作用蛋白的核酸。