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    Synaptic activation protein compositions and method
    2.
    发明授权
    Synaptic activation protein compositions and method 失效
    突触激活蛋白的组成和方法

    公开(公告)号：US06294355B1

    公开(公告)日：2001-09-25

    申请号：US09042428

    申请日：1998-03-13

    申请人： Paul F. Worley ,  Paul R. Brakeman

    发明人： Paul F. Worley ,  Paul R. Brakeman

    IPC分类号： C12N1512

    CPC分类号： C07K14/47 ,  C07K2319/00 ,  G01N33/566 ,  G01N2333/70571

    摘要： Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.

    摘要翻译： 公开了用于突触激活结合蛋白质的核苷酸编码序列和多肽序列，其特征在于在大鼠海马神经元活性后在中枢神经系统中诱导。 通过以下方式鉴定此类蛋白质：（i）核苷酸或蛋白质序列水平与特异性定义的大鼠，人或小鼠编码序列或蛋白质的实质同源性，（ii）结合并影响CNS中效应蛋白活性的能力，例如 代谢型谷氨酸受体，（iii）对特定结合序列的结合特异性，和（iv）在PDZ样结构域序列中的存在。 本发明的核苷酸和多肽可用于筛选和诊断测定。

    Synaptic activation protein compositions and method
    3.
    发明授权
    Synaptic activation protein compositions and method 有权
    突触激活蛋白的组成和方法

    公开(公告)号：US07399830B2

    公开(公告)日：2008-07-15

    申请号：US10866256

    申请日：2004-06-10

    申请人： Paul F. Worley ,  Paul R. Brakeman

    发明人： Paul F. Worley ,  Paul R. Brakeman

    IPC分类号： C07K14/435

    CPC分类号： C07K14/47 ,  C07K2319/00 ,  G01N33/566 ,  G01N2333/70571

    摘要： Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.

    摘要翻译： 公开了用于突触激活结合蛋白的核苷酸编码序列和多肽序列，其特征在于在大鼠海马神经元活性后在中枢神经系统中诱导。 通过以下方式鉴定此类蛋白质：（i）核苷酸或蛋白质序列水平与特异性定义的大鼠，人或小鼠编码序列或蛋白质的实质同源性，（ii）结合并影响CNS中效应蛋白活性的能力，例如 代谢型谷氨酸受体，（iii）对特定结合序列的结合特异性，和（iv）在PDZ样结构域序列中的存在。 本发明的核苷酸和多肽可用于筛选和诊断测定。

    Synaptic activation protein compositions and method
    4.
    发明授权
    Synaptic activation protein compositions and method 有权
    突触激活蛋白的组成和方法

    公开(公告)号：US06780600B2

    公开(公告)日：2004-08-24

    申请号：US09910706

    申请日：2001-07-20

    申请人： Paul F. Worley ,  Paul R. Brakeman

    发明人： Paul F. Worley ,  Paul R. Brakeman

    IPC分类号： G01N3353

    CPC分类号： C07K14/47 ,  C07K2319/00 ,  G01N33/566 ,  G01N2333/70571

    摘要： Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.

    摘要翻译： 公开了用于突触激活结合蛋白质的核苷酸编码序列和多肽序列，其特征在于在大鼠海马神经元活性后在中枢神经系统中诱导。 通过以下方式鉴定此类蛋白质：（i）核苷酸或蛋白质序列水平与特异性定义的大鼠，人或小鼠编码序列或蛋白质的实质同源性，（ii）结合并影响CNS中效应蛋白活性的能力，例如 代谢型谷氨酸受体，（iii）对特定结合序列的结合特异性，和（iv）在PDZ样结构域序列中的存在。 本发明的核苷酸和多肽可用于筛选和诊断测定。

    Protein encoded by a nucleic acid
    5.
    发明授权
    Protein encoded by a nucleic acid 失效
    由核酸编码的蛋白质

    公开(公告)号：US07378498B2

    公开(公告)日：2008-05-27

    申请号：US11008889

    申请日：2004-12-10

    申请人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

    发明人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

    IPC分类号： C07K14/435 ,  C07H21/04

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00

    摘要： A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.

    摘要翻译： 提供了一种用于鉴定调节与荷马相关并由细胞表面或细胞内受体介导的细胞因子反应的化合物的方法。 还提供了一种鉴定调节与荷马相关的受体活化钙动员的化合物的方法。 提供了一种基于荷马蛋白结合结构域的晶体结构坐标来鉴定抑制荷马蛋白活性的化合物的方法。 还提供了一种鉴定影响细胞表面受体形成簇的化合物的方法。 还提供了编码荷马蛋白以及荷马蛋白和荷马相互作用蛋白的核酸。

    Nucleic acid molecule encoding homer 1B protein
    6.
    发明授权
    Nucleic acid molecule encoding homer 1B protein 有权
    核酸分子编码融合蛋白1B蛋白

    公开(公告)号：US06720175B1

    公开(公告)日：2004-04-13

    申请号：US09377285

    申请日：1999-08-18

    申请人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

    发明人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

    IPC分类号： C07H2104

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00

    摘要： A method is provided for identifying a compound that modulates a cellular response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.

    摘要翻译： 提供了一种用于鉴定调节与荷马相关并由细胞表面或细胞内受体介导的细胞应答的化合物的方法。 还提供了一种鉴定调节与荷马相关的受体活化钙动员的化合物的方法。 提供了一种基于荷马蛋白结合结构域的晶体结构坐标来鉴定抑制荷马蛋白活性的化合物的方法。 还提供了一种鉴定影响细胞表面受体形成簇的化合物的方法。 还提供了编码荷马蛋白以及荷马蛋白和荷马相互作用蛋白的核酸。