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    Protein encoded by a nucleic acid
    2.
    发明授权
    Protein encoded by a nucleic acid 失效
    由核酸编码的蛋白质

    公开(公告)号：US07378498B2

    公开(公告)日：2008-05-27

    申请号：US11008889

    申请日：2004-12-10

    申请人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

    发明人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

    IPC分类号： C07K14/435 ,  C07H21/04

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00

    摘要： A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.

    摘要翻译： 提供了一种用于鉴定调节与荷马相关并由细胞表面或细胞内受体介导的细胞因子反应的化合物的方法。 还提供了一种鉴定调节与荷马相关的受体活化钙动员的化合物的方法。 提供了一种基于荷马蛋白结合结构域的晶体结构坐标来鉴定抑制荷马蛋白活性的化合物的方法。 还提供了一种鉴定影响细胞表面受体形成簇的化合物的方法。 还提供了编码荷马蛋白以及荷马蛋白和荷马相互作用蛋白的核酸。

    Nucleic acid molecule encoding homer 1B protein
    3.
    发明授权
    Nucleic acid molecule encoding homer 1B protein 有权
    核酸分子编码融合蛋白1B蛋白

    公开(公告)号：US06720175B1

    公开(公告)日：2004-04-13

    申请号：US09377285

    申请日：1999-08-18

    申请人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

    发明人： Paul F. Worley ,  Jian Cheng Tu ,  Bo Xiao ,  Daniel Leahy ,  Jutta Beneken ,  Anthony A. Lanahan ,  Paul R. Brakeman

    IPC分类号： C07H2104

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00

    摘要： A method is provided for identifying a compound that modulates a cellular response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.

    摘要翻译： 提供了一种用于鉴定调节与荷马相关并由细胞表面或细胞内受体介导的细胞应答的化合物的方法。 还提供了一种鉴定调节与荷马相关的受体活化钙动员的化合物的方法。 提供了一种基于荷马蛋白结合结构域的晶体结构坐标来鉴定抑制荷马蛋白活性的化合物的方法。 还提供了一种鉴定影响细胞表面受体形成簇的化合物的方法。 还提供了编码荷马蛋白以及荷马蛋白和荷马相互作用蛋白的核酸。

    Synaptic activation protein compositions and method
    4.
    发明授权
    Synaptic activation protein compositions and method 失效
    突触激活蛋白的组成和方法

    公开(公告)号：US06294355B1

    公开(公告)日：2001-09-25

    申请号：US09042428

    申请日：1998-03-13

    申请人： Paul F. Worley ,  Paul R. Brakeman

    发明人： Paul F. Worley ,  Paul R. Brakeman

    IPC分类号： C12N1512

    CPC分类号： C07K14/47 ,  C07K2319/00 ,  G01N33/566 ,  G01N2333/70571

    摘要： Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.

    摘要翻译： 公开了用于突触激活结合蛋白质的核苷酸编码序列和多肽序列，其特征在于在大鼠海马神经元活性后在中枢神经系统中诱导。 通过以下方式鉴定此类蛋白质：（i）核苷酸或蛋白质序列水平与特异性定义的大鼠，人或小鼠编码序列或蛋白质的实质同源性，（ii）结合并影响CNS中效应蛋白活性的能力，例如 代谢型谷氨酸受体，（iii）对特定结合序列的结合特异性，和（iv）在PDZ样结构域序列中的存在。 本发明的核苷酸和多肽可用于筛选和诊断测定。

    Synaptic activation protein compositions and method
    5.
    发明授权
    Synaptic activation protein compositions and method 有权
    突触激活蛋白的组成和方法

    公开(公告)号：US07399830B2

    公开(公告)日：2008-07-15

    申请号：US10866256

    申请日：2004-06-10

    申请人： Paul F. Worley ,  Paul R. Brakeman

    发明人： Paul F. Worley ,  Paul R. Brakeman

    IPC分类号： C07K14/435

    CPC分类号： C07K14/47 ,  C07K2319/00 ,  G01N33/566 ,  G01N2333/70571

    摘要： Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.

    摘要翻译： 公开了用于突触激活结合蛋白的核苷酸编码序列和多肽序列，其特征在于在大鼠海马神经元活性后在中枢神经系统中诱导。 通过以下方式鉴定此类蛋白质：（i）核苷酸或蛋白质序列水平与特异性定义的大鼠，人或小鼠编码序列或蛋白质的实质同源性，（ii）结合并影响CNS中效应蛋白活性的能力，例如 代谢型谷氨酸受体，（iii）对特定结合序列的结合特异性，和（iv）在PDZ样结构域序列中的存在。 本发明的核苷酸和多肽可用于筛选和诊断测定。

    Synaptic activation protein compositions and method
    6.
    发明授权
    Synaptic activation protein compositions and method 有权
    突触激活蛋白的组成和方法

    公开(公告)号：US06780600B2

    公开(公告)日：2004-08-24

    申请号：US09910706

    申请日：2001-07-20

    申请人： Paul F. Worley ,  Paul R. Brakeman

    发明人： Paul F. Worley ,  Paul R. Brakeman

    IPC分类号： G01N3353

    CPC分类号： C07K14/47 ,  C07K2319/00 ,  G01N33/566 ,  G01N2333/70571

    摘要： Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.

    摘要翻译： 公开了用于突触激活结合蛋白质的核苷酸编码序列和多肽序列，其特征在于在大鼠海马神经元活性后在中枢神经系统中诱导。 通过以下方式鉴定此类蛋白质：（i）核苷酸或蛋白质序列水平与特异性定义的大鼠，人或小鼠编码序列或蛋白质的实质同源性，（ii）结合并影响CNS中效应蛋白活性的能力，例如 代谢型谷氨酸受体，（iii）对特定结合序列的结合特异性，和（iv）在PDZ样结构域序列中的存在。 本发明的核苷酸和多肽可用于筛选和诊断测定。

    Method of screening for agents that modulate a homer signaling pathway
    7.
    发明授权
    Method of screening for agents that modulate a homer signaling pathway 失效
    筛选调节信号通路的药剂的方法

    公开(公告)号：US07442513B2

    公开(公告)日：2008-10-28

    申请号：US10518941

    申请日：2003-06-18

    申请人： Paul F. Worley

    发明人： Paul F. Worley

    IPC分类号： G01N33/53

    CPC分类号： G01N33/573 ,  A61K38/00 ,  C07K16/18 ,  C07K16/286 ,  C12Q1/533 ,  G01N33/6872 ,  G01N33/6896 ,  G01N2333/99 ,  G01N2500/02

    摘要： The invention features a method of identifying, evaluating and screening for compounds or agents for the treatment of disorders involving the Homer signaling pathway in the modulation of immunosupression and neuroprotection. The method includes evaluating the ability of agents to modulate Homer protein activity, Homer protein/immunophilin-peptidylproline cis-trans isomerase interaction, and/or Homer protein/proline-type Homer ligand consensus sequence interaction to identify agents for such treatment. The invention also discloses treatment modalities involving agents identified by such methods.

    摘要翻译： 本发明的特征在于在调节免疫抑制和神经保护中鉴定，评估和筛选用于治疗涉及荷马信号通路的病症的化合物或药剂的方法。 该方法包括评估试剂调节荷马蛋白活性，荷马蛋白/免疫亲和肽 - 肽基脯氨酸顺反异构酶相互作用和/或荷马蛋白/脯氨酸型荷马配体共有序列相互作用的能力，以鉴定用于此类治疗的药剂。 本发明还公开了涉及通过这些方法鉴定的试剂的治疗方式。

    MOLECULES INVOLVED IN SYNAPTOGENESIS AND USES THEREFOR
    9.
    发明申请
    MOLECULES INVOLVED IN SYNAPTOGENESIS AND USES THEREFOR 审中-公开
    参与同义反应的分子及其用途

    公开(公告)号：US20090123940A1

    公开(公告)日：2009-05-14

    申请号：US12249850

    申请日：2008-10-10

    申请人： Paul F. Worley ,  Desheng Xu ,  Richard William Cho ,  Radhika Chinthamani Reddy

    发明人： Paul F. Worley ,  Desheng Xu ,  Richard William Cho ,  Radhika Chinthamani Reddy

    IPC分类号： G01N33/53 ,  C07K2/00 ,  C07H21/00 ,  C07K16/28

    CPC分类号： G01N33/9406 ,  C07K14/70571 ,  C07K16/28 ,  C07K2317/77 ,  G01N33/5041 ,  G01N33/5058 ,  G01N33/6893 ,  G01N2800/28

    摘要： The present invention is based on the discovery that neuronal pentraxins play a role in the clustering and internalization of AMPA receptors, synaptogenesis, and metabotropic glutamate receptor-mediated long term depression (LTD) of a synapse. Accordingly, there are provided methods of identifying compounds that that modulate mGluR-mediated AMPA receptor internalization and LTD. Further provided are cleavage products of a member of the neuronal pentraxin family, neuronal pentraxin receptor (NPR). Also provided are isolated peptides comprising the Narp association regions 1 and 2 (NAR1 and NAR2, respectively) and the Narp binding motif (NBM) of AMPA receptors. Finally, there are provided antibodies that block binding of neuronal pentraxins to AMPA receptors, in particular, antibodies that bind NAR1, or NAR2, or NBM.

    摘要翻译： 本发明基于这样的发现：神经元五聚体在AMPA受体的聚集和内化中发挥作用，突触发生和代谢型谷氨酸受体介导的突触的长期抑制（LTD）。 因此，提供了鉴定调节mGluR介导的AMPA受体内化和LTD的化合物的方法。 还提供了神经元五聚体家族的成员的切割产物，神经元五肽受体（NPR）。 还提供了包含Narp缔合区1和2（分别为NAR1和NAR2）和AMPA受体的Narp结合基序（NBM）的分离的肽。 最后，提供阻断神经元五聚体与AMPA受体结合的抗体，特别是结合NAR1或NAR2或NBM的抗体。