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    Controlled release polyacrylic acid granules and a process for preparing the same
    2.
    发明授权
    Controlled release polyacrylic acid granules and a process for preparing the same 有权
    控释聚丙烯酸颗粒及其制备方法

    公开(公告)号：US06762267B2

    公开(公告)日：2004-07-13

    申请号：US10403721

    申请日：2003-03-31

    申请人： Daniel James Adams ,  David William Weaver ,  William R. Wilber ,  Jian-Hwa Guo ,  Edward S. Greenberg

    发明人： Daniel James Adams ,  David William Weaver ,  William R. Wilber ,  Jian-Hwa Guo ,  Edward S. Greenberg

    IPC分类号： C08F22046

    CPC分类号： C08J3/12 ,  A61K9/2027 ,  B29B9/00 ,  B29K2033/00 ,  C08J3/16 ,  C08J2333/02

    摘要： The present invention pertains to a method for forming polyacrylic acid granules and granules formed therefrom wherein the granules are flowable, have an increased bulk density relative to the as polymerized polyacrylic acids, and a low amount of dust which is generally characterized herein as particles which pass through a 325 mesh screen. The granules formed by the method of the present invention can be used to prepare controlled release tablets, especially controlled release pharmaceutical tablets. The controlled release properties of the tablets formed from granules prepared according to the present invention are unexpectedly better than tablets prepared from granules formed by other known granulation methods.

    摘要翻译： 本发明涉及形成由其形成的聚丙烯酸颗粒和颗粒的方法，其中颗粒是可流动的，相对于作为聚合的聚丙烯酸而言具有增加的堆积密度，并且少量的粉尘通常在本文中被表征为通过 通过325目筛网。 通过本发明的方法形成的颗粒可用于制备控释片剂，特别是控释片剂。 由根据本发明制备的颗粒形成的片剂的控制释放性能出乎意料地优于由通过其它已知的造粒方法形成的颗粒制备的片剂。

    Sustained release polymer blend for pharmaceutical applications
    3.
    发明授权
    Sustained release polymer blend for pharmaceutical applications 失效
    用于制药应用的持续释放聚合物共混物

    公开(公告)号：US06358525B1

    公开(公告)日：2002-03-19

    申请号：US09343425

    申请日：1999-06-30

    申请人： Jian Hwa Guo ,  George William Skinner

    发明人： Jian Hwa Guo ,  George William Skinner

    IPC分类号： A61K920

    CPC分类号： A61K9/205 ,  A61K9/2027 ,  A61K9/2054 ,  Y10S514/937 ,  Y10S514/944

    摘要： A pharmaceutical composition has a blend of at least first and second components and a medicament in a sufficient amount to be therapeutic where the first component is hydroxypropylcellulose (HPC) and the second component is at least one other polymer selected from the group consisting of methylcellulose (MC), ethylhydroxyethylcellulose (EHEC), hydroxyethylmethylcellulose (HEMC), hydrophobically modified hydroxyethylcellulose (HMHEC), hydrophobically modified ethylhydroxyethylcellulose (HMEHEC), carboxymethylhydroxyethylcellulose (CMHEC), carboxymethyl hydrophobically modified hydroxyethylcellulose (CMHMHEC), guar, pectin, carrageenan, agar, algin, gellan gum, acacia, starch and modified starches, co-polymers of carboxyvinyl monomers, co-polymers of acrylate or methacrylate monomers, mono- and co-polymers of oxyethylene and oxypropylene and mixtures thereof and a medicament in a sufficient amount to be therapeutic, with the proviso that low-substituted hydroxypropylcellulose (L-HPC) is excluded from said first and second components. The medicament can be a variety of drugs or nutritional supplements. The pharmaceutical composition releases the medicament for a prolonged or sustained period of time and can be formulated into many dosage forms.

    摘要翻译： 药物组合物具有至少第一组分和第二组分的混合物和足够量的药物，其中第一组分是羟丙基纤维素（HPC），第二组分是至少一种选自甲基纤维素（ 羟乙基纤维素（EHEC），羟乙基甲基纤维素（HEMC），疏水改性的羟乙基纤维素（HMHEC），疏水改性的乙基羟乙基纤维素（HMEHEC），羧甲基羟乙基纤维素（CMHEC），羧甲基疏水改性的羟乙基纤维素（CMHMHEC），瓜尔胶，果胶，角叉菜胶，琼脂， 结晶胶，阿拉伯树胶，淀粉和改性淀粉，羧乙烯基单体的共聚物，丙烯酸酯或甲基丙烯酸酯单体的共聚物，氧化乙烯和氧化丙烯的单聚合物和共聚物及其混合物，以及足够量的治疗剂， 条件是低取代的羟丙基纤维素（L-HPC）是 排除在所述第一和第二组分之外。 药物可以是各种药物或营养补充剂。 药物组合物释放药物持续长时间并且可以配制成许多剂型。

    Hydrogels containing substances
    8.
    发明授权
    Hydrogels containing substances 失效
    含有物质的水凝胶

    公开(公告)号：US06723781B1

    公开(公告)日：2004-04-20

    申请号：US09650926

    申请日：2000-08-29

    申请人： Dean M. Frate ,  Jian-Hwa Guo

    发明人： Dean M. Frate ,  Jian-Hwa Guo

    IPC分类号： C08L3302

    CPC分类号： A61K9/7023 ,  Y10S524/916

    摘要： A blend of one or more crosslinked polymers or copolymers prepared from an olefinically unsaturated polymerizable carboxylic or anhydride monomer and at least one high molecular weight essentially linear polymer prepared from an olefinically unsaturated polymerizable carboxylic acid monomer. The blend is neutralized to typically a low pH, and generally contains a noncovalent, e.g. ionic, crosslinking agent, and a cure rate modifier. The hydrogel blend is capable of containing a large amount of water, has good tack, good adhesion, and can be utilized as an application vehicle having a backing thereon as well as containing various substances such as personal care compounds, pharmaceuticals, active ingredients, and the like. Conversely, the hydrogel blend can be dried and subsequently wetted without substantial loss of properties.

    摘要翻译： 由烯属不饱和可聚合的羧酸或酸酐单体制备的一种或多种交联聚合物或共聚物的共混物和由烯属不饱和可聚合羧酸单体制备的至少一种高分子量基本上线性的聚合物。 共混物被中和至通常的低pH值，并且通常含有非共价键。 离子交联剂和固化速率改性剂。 水凝胶共混物能够含有大量的水，具有良好的粘着性，良好的粘合性，并且可以用作其上具有背衬的应用载体，并且可以含有各种物质，例如个人护理化合物，药物，活性成分和 类似。 相反地​​，水凝胶共混物可以被干燥并随后润湿而没有显着的性能损失。

    Directly compressed solid dosage articles
    9.
    发明授权
    Directly compressed solid dosage articles 失效
    直接压缩固体剂量物品

    公开(公告)号：US06623756B1

    公开(公告)日：2003-09-23

    申请号：US09559687

    申请日：2000-04-27

    申请人： William R. Wilber ,  Jian-Hwa Guo ,  Edward S. Greenberg

    发明人： William R. Wilber ,  Jian-Hwa Guo ,  Edward S. Greenberg

    IPC分类号： A61K920

    CPC分类号： A61K9/2095 ,  A61K9/2027

    摘要： Solid dosage articles such as pharmaceutical tablets for the controlled release of a desired compound such as an active ingredient are directly compressed from a flowable, compressible mixture of the active ingredient, a slightly cross-linked rheology modifying polymer or copolymer, and one or more excipients. The rheology modifying polymer or copolymer is a granulated powder of suitable particle size and is generally made from one or more unsaturated (di)carboxylic acids, half ester thereof, and other optional monomers.

    摘要翻译： 用于控制释放所需化合物如活性成分的固体剂量制品直接从活性成分，轻微交联的流变改性聚合物或共聚物和一种或多种赋形剂的可流动的可压缩混合物中压制 。 流变改性聚合物或共聚物是合适粒度的造粒粉末，通常由一种或多种不饱和（二）羧酸，其半酯和其它任选的单体制成。