摘要:
The present invention relates to a sustained-release drug composition consisting essentially of microparticles of a peptide as the active substance and a biocompatible water-soluble polymer, in particular peptide as meianocortin receptor ligand. The present invention relates also to an injection formulation comprising the sustained-release drug composition suspended in an injection medium.
摘要:
The present invention relates to pharmaceutical compositions for the controlled and sustained release of active substance comprising a biodegradable polymer or copolymer. Furthermore, the invention relates to pharmaceutical compositions for the controlled and sustained release of at least one active substance such as peptides or hormones and analogues thereof and the manufacturing process of such pharmaceutical compositions.
摘要:
The present invention relates to pharmaceutical compositions for the controlled and sustained release of active substance comprising a biodegradable polymer or copolymer. Furthermore, the invention relates to pharmaceutical compositions for the controlled and sustained release of at least one active substance such as peptides or hormones and analogs thereof and the manufacturing process of such pharmaceutical compositions.
摘要:
The present invention relates to a sustained-release drug composition consisting essentially of microparticles of a peptide as the active substance and a biocompatible water-soluble polymer, in particular peptide as meianocortin receptor ligand. The present invention relates also to an injection formulation comprising the sustained-release drug composition suspended in an injection medium.
摘要:
The present invention relates to a solid pharmaceutical composition including the active principle 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate. The present invention also relates to polymorphs of the 6-oxo-6,7,8,9,10,11-hexahydrocyclohepta[c]chromen-3-yl sulfamate compound.
摘要:
The present invention relates to pharmaceutical compositions. More particularly, the invention relates to formulations of growth hormone (GH) and insulin-like growth factor (IGF-1) combination compositions which provide stable pharmaceutical compositions without aggregation formation at a desirable pH, and to processes of preparation thereof.
摘要:
The invention concerns a method for the mechanochemical treatment of a material characterised in that to improve said material surface properties by mechanochemical anchoring, such as in particular its adhesive capacity during subsequent assembling, or to improve its use properties by producing composite structure surface coatings, consisting in projecting on said material particles with laminated structure consisting of a core and a coating comprising at least a polymer and optionally a chemical agent, in conditions such that said particles and/or fragments resulting from their fracturing are embedded and/or penetrate into said material. The invention is applicable in dentistry, the biomedical field, motor industry, avionics, printing industries, agro-industry, mechanical industries.
摘要:
The invention concerns a method for preparing microcapsules containing an active substance coated with a substantially polar polymer film, characterized in that it consists in the following steps: suspending an active substance insoluble in a substantially polar polymer solution in an organic solvent, said substantially polar polymer being insoluble in liquid or supercritical CO2, said organic solvent being soluble in liquid or supercritical CO2; contacting the suspension with liquid or supercritical CO2 so as to extract the solvent from the polymer in a controlled manner and ensure the coacervation of the polymer; substantially extracting the solvent by means of supercritical CO2 and draining off the CO2/solvent mixture; recuperating the microcapsules in the form of dry powder. The invention also concerns microcapsules containing an active substance coated with a substantially polar polymer selected among the group consisting of polysaccharides, cellulose derivatives, acrylic, methacrylic polymers or derivatives of esters of vinyl, polyesters, polyamides, polyanhydrides, polyorthoesters and polyphosphazenes, characterized in that the polymer film has low surface energy and is free from organic solvent and in that the microcapsules are obtainable by said method.
摘要:
The invention concerns nanocapsules, in particular with an average size less than 50 nm, consisting of an essentially lipid core liquid or semiliquid at room temperature, coated with an essentially lipid film solid at room temperature having a thickness of 2-10 nm. The invention also concerns a method for preparing same which consists in producing a reverse phase of an aqueous emulsion brought about by several temperature raising and lowering cycles. Said lipid nanocapsules are particularly designed for producing a medicine.
摘要:
The present invention relates to a water-redispersible powder based on film-forming polymers which are substantially water-insoluble and which are prepared by aqueous emulsion polymerization of monomers containing ethylenic unsaturation and with a “core/shell” structure comprising a hydrophobic core based on a polymer exhibiting a Tg (glass transition temperature) of between −30 and 25° C., preferably between −10 and 20° C., and a shell, the shell being bonded to the core by covalent bonds resulting from the reaction of an agent for grafting the shell onto the ethylenic unsaturations remaining in the core, characterized in that the shell is prepared by emulsion polymerization, on the core particles, of a mixture of monomers comprising at least one monomer chosen from styrene and a C1-C12 alkyl acrylate or methacrylate, at least one monomer carrying a saccharide group and exhibiting at least one ethylenic unsaturation, and at least one grafting agent.