公开(公告)号：US20240083079A1

公开(公告)日：2024-03-14

申请号：US18513097

申请日：2023-11-17

申请人： General Dynamics Ordnance and Tactical Systems - Canada, Inc.

发明人： Etienne Comtois ,  Charles Dubois ,  Pierre-Yves Paradis

IPC分类号： B29C45/00 ,  F42B33/00

CPC分类号： B29C45/0001 ,  F42B33/001 ,  B29K2067/043

摘要： Small-, medium-, and large-caliber combustible cartridge cases and propellant combustible containers that are manufactured using reactive injection molding of azido polymers. An injection process for a single propellant combustible charge including the steps of: providing a quantity of azido bearing polymer; providing a quantity of curing agent; optionally providing a quantity of chemical blowing agent; optionally providing a quantity of fibers; optionally providing a quantity of additives and catalysts; and providing a mold defining a male cavity, a female cavity, and an injection port. The injection process further includes mixing together the azido bearing polymer, the curing agent, the optional chemical blowing agent, the optional fibers, the optional additives and catalysts, and injecting the resulting mixture into the mold.

公开(公告)号：US20180304553A1

公开(公告)日：2018-10-25

申请号：US15650436

申请日：2017-07-14

申请人： RION CO., LTD.

发明人： Ki Woong Park ,  Ku Chan Chung ,  Jung Keun Hyun ,  Jong Wan Kim

IPC分类号： B29C67/20 ,  A61F2/04 ,  A61F2/00 ,  A61L27/56 ,  A61L27/18

CPC分类号： B29C67/202 ,  A61F2/0077 ,  A61F2/04 ,  A61F2002/0081 ,  A61F2240/001 ,  A61L27/18 ,  A61L27/56 ,  A61L2430/32 ,  B29K2067/043 ,  B29K2067/046 ,  B29K2105/0073 ,  B29K2105/0085 ,  B29L2031/7532

摘要： The present disclosure relates to an apparatus for manufacturing a nerve conduit, more particularly to an apparatus for manufacturing a porous nerve conduit using glass fibers whereby microchannels are formed using the space between the glass fibers and the defective rate and location-dependent variation of each nerve conduit can be minimized through uniform decompression during the manufacture. The nerve conduit manufactured according to the present disclosure can be manufactured to have various diameters and lengths to be applicable to in vitro and in vivo researches on nerves.

公开(公告)号：US20180078680A1

公开(公告)日：2018-03-22

申请号：US15560142

申请日：2015-12-10

申请人： COSMED PHARMACEUTICAL CO., LTD.

发明人： Ying-shu Quan ,  Ying-zhe Li ,  Mio Saito ,  Shouta Kitaoka ,  Fumio Kamiyama

IPC分类号： A61L31/06 ,  A61M37/00 ,  A61L31/16 ,  B29C45/00

CPC分类号： A61L31/06 ,  A61K9/0021 ,  A61L31/16 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0053 ,  B29C45/0001 ,  B29K2067/043 ,  B29K2905/00 ,  B29L2031/7544

摘要： Provided are a microneedle with excellent performance and a method for manufacturing the microneedle.A microneedle array in which a polyglycolic acid is used as a material, crystallinity of the polyglycolic acid is 21% or more and axial contraction rate of tips is 99% or more, and a manufacturing method in which a polyglycolic acid are injection-molded at a cylinder temperature of 230-280° C., a metal mold temperature of 60-130° C., and an injection pressure of 1000-1500 KPa so as to manufacture a microneedle array in which crystallinity of the polyglycolic acid is 21% or more and an axial contraction rate of tips is 99% or more.

公开(公告)号：US20170114480A1

公开(公告)日：2017-04-27

申请号：US14921103

申请日：2015-10-23

申请人： Suman Khatiwada

发明人： Suman Khatiwada

IPC分类号： D03D15/00 ,  E21B17/00 ,  E21B33/12 ,  B29C43/00

CPC分类号： D03D15/0011 ,  B29C43/003 ,  B29K2029/04 ,  B29K2067/043 ,  B29K2067/046 ,  B29K2995/0062 ,  D10B2401/12 ,  E21B33/12

摘要： In one embodiment, a method to form a downhole element is disclosed, including weaving a continuous glass filament and a continuous degradable thermoplastic filament to form a commingled glass fiber. In another embodiment, a commingled glass fiber is disclosed, including a continuous glass filament, and a continuous degradable thermoplastic filament interwoven with the continuous glass filament. In another embodiment, a downhole element is disclosed, including a commingled glass fiber. The commingled glass fiber includes a continuous glass filament, and a continuous degradable thermoplastic filament interwoven with the continuous glass filament.

公开(公告)号：US20160289374A1

公开(公告)日：2016-10-06

申请号：US15079079

申请日：2016-03-24

申请人： Kureha Corporation

发明人： MIZUKI SAITO ,  FUMINORI KOBAYASHI

IPC分类号： C08G63/08 ,  B29C35/08 ,  B29C45/00

CPC分类号： B29C35/0866 ,  B29C35/0805 ,  B29C45/0001 ,  B29C71/0009 ,  B29C71/02 ,  B29C2035/085 ,  B29C2035/0877 ,  B29K2067/043 ,  C08G63/06

摘要： Problem:To provide a molded article that has a thickness and that contains polyglycolic acid having high hydrolyzability without using a hydrolysis auxiliary agent.Resolution means:The polyglycolic acid having a content of low molecular weight substance of less than 1% by weight; and a molded article thereof having a thickness of 2 mm or greater, the time at which immersion of the molded article in water at 66° C. is started to the time at which the polyglycolic acid decomposed by the water starts to elute being 1 hour or longer but 30 hours or shorter, and a rate of embrittlement, at which embrittlement proceeds due to the elution of the polyglycolic acid, being 0.025 mm/h or greater.

摘要翻译： 具有小于1重量％的低分子量物质含量的聚乙醇酸; 其厚度为2mm以上的成形品开始于水分解为66℃的时间，水分解的聚乙醇酸开始洗脱1小时 或更长但30小时或更短，并且由于聚乙醇酸洗脱导致的脆化进行的脆化速率为0.025mm / h或更大。

公开(公告)号：US20160287796A1

公开(公告)日：2016-10-06

申请号：US14928701

申请日：2015-10-30

申请人： XEND MEDICAL SYSTEMS, LLC

发明人： Randall J. Olson ,  Owen D. Brimhall ,  Jeremy Hammer ,  Andrew G. Raguskus

IPC分类号： A61M5/31 ,  A61M5/32

CPC分类号： A61M5/31 ,  A61M5/32 ,  A61M5/3202 ,  A61M5/329 ,  A61M2005/3117 ,  A61M2005/3118 ,  A61M2005/312 ,  A61M2207/00 ,  B29C35/02 ,  B29C70/682 ,  B29C70/745 ,  B29C70/88 ,  B29K2067/043 ,  B29K2067/046 ,  B29K2995/006 ,  B29L2031/7544

摘要： A needle hypodermic system and method for reducing the incidence of infections due to administering fluids by injection or for reducing the risk of surface contamination of an aspirated sample of blood or other bodily tissue in humans or animals is provided. The hypodermic needle system may include a needle with a plug or film disposed over or within its hollow bore to substantially prevent bacteria, fungi and/or other organisms/contaminants, which may be present on the exterior surface to be penetrated, from adhering to the inner surfaces of the needle's channel or become trapped in the needle bore. A second stylet or needle may be deployed to pierce or push aside the plug.

摘要翻译： 提供了一种针皮肤系统和方法，用于减少由注射给予流体引起的感染的发生率或降低人或动物中抽吸的血液或其他身体组织的样品的表面污染的风险。 皮下注射针系统可以包括具有设置在其中空孔内或其中空孔内的塞子或膜的针，以基本上防止可能存在于要穿透的外表面上的细菌，真菌和/或其他生物/污染物粘附到 针通道的内表面或被困在针孔中。 可以部署第二个探针或针，以刺穿或推开插头。

公开(公告)号：US20160287527A1

公开(公告)日：2016-10-06

申请号：US15177687

申请日：2016-06-09

申请人： DePuy Synthes Products, Inc.

发明人： David Armbruster ,  James Dwyer ,  Jeffrey Chomyn ,  Sean Kerr

IPC分类号： A61K9/70 ,  B29C39/26 ,  C08J5/18 ,  B29C39/38 ,  A61K31/085 ,  A61K31/7036 ,  B29C39/24 ,  B29C39/02

CPC分类号： A61K9/7007 ,  A61B17/70 ,  A61B17/80 ,  A61B17/8028 ,  A61B2017/00004 ,  A61B2017/00526 ,  A61B2017/561 ,  A61F2/0063 ,  A61F2/0077 ,  A61F2/02 ,  A61F2/28 ,  A61F2/2846 ,  A61F2/30907 ,  A61F2002/30062 ,  A61F2002/30064 ,  A61F2002/30067 ,  A61F2002/30069 ,  A61F2002/30919 ,  A61F2013/00221 ,  A61F2013/00357 ,  A61F2210/0004 ,  A61F2250/0031 ,  A61F2250/0067 ,  A61K9/0024 ,  A61K31/085 ,  A61K31/7036 ,  A61L27/18 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/604 ,  A61M31/002 ,  B29C39/003 ,  B29C39/026 ,  B29C39/24 ,  B29C39/26 ,  B29C39/38 ,  B29C41/02 ,  B29D7/01 ,  B29K2067/04 ,  B29K2067/043 ,  B29K2067/046 ,  B29K2105/0002 ,  B29K2105/0035 ,  B29K2105/0073 ,  B29K2995/006 ,  B29L2007/008 ,  B29L2031/753 ,  C08J5/18 ,  C08J2367/04 ,  C08J2369/00 ,  C08L67/04 ,  C08L69/005 ,  Y10S525/937 ,  Y10T428/24182 ,  Y10T428/24281 ,  Y10T428/24479 ,  Y10T428/25 ,  Y10T428/26

摘要： A flexible body comprises a polymer film having a first surface and an opposing second surface. The polymer film has a plurality of apertures extending from the first surface to the second surface and a plurality of raised lips protruding from the first surface such that each of the plurality of apertures is surrounded by one of the plurality of raised lips. A method of producing a polymer film comprises placing a polymer solution into a one sided mold having a plurality of protrusions extending from a bottom of the mold wherein the polymer solution is characterized by a viscosity that inhibits the unaided flow of the polymer throughout the mold; urging the polymer solution around each of the plurality of protrusions; and solidifying the polymer solution.

摘要翻译： 柔性体包括具有第一表面和相对的第二表面的聚合物膜。 聚合物膜具有从第一表面延伸到第二表面的多个孔，以及从第一表面突出的多个凸起的唇部，使得多个孔中的每一个被多个凸起的唇中的一个包围。 制备聚合物膜的方法包括将聚合物溶液放置在具有从模具底部延伸的多个突起的单面模具中，其中聚合物溶液的特征在于抑制聚合物在整个模具中的无支撑流动的粘度; 在所述多个突起中的每一个周围施加聚合物溶液; 并固化聚合物溶液。

公开(公告)号：US09314549B2

公开(公告)日：2016-04-19

申请号：US14260442

申请日：2014-04-24

申请人： University of South Carolina

发明人： Esmaiel Jabbari

IPC分类号： A61F2/28 ,  A61L27/22 ,  A61L27/54 ,  A61K9/00 ,  A61L27/58 ,  A61L27/12 ,  A61L27/50 ,  A61L27/56

CPC分类号： A61L27/12 ,  A61F2/28 ,  A61K9/0024 ,  A61L27/18 ,  A61L27/227 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2400/12 ,  A61L2430/02 ,  B29C47/0004 ,  B29C47/0054 ,  B29C47/0076 ,  B29C51/004 ,  B29C51/02 ,  B29C65/02 ,  B29K2067/043 ,  B29K2067/046 ,  B29K2105/0073 ,  B29K2105/0088 ,  B29K2105/256 ,  B29K2995/0056 ,  B29L2031/7532 ,  D01D5/003 ,  D01D5/0076 ,  D10B2331/041 ,  D10B2401/00 ,  D10B2509/00

摘要： Bone tissue biomimetic materials, biomimetic constructs that can be formed with the materials, and methods for forming the materials and constructs are described. The bone tissue biomimetic materials include electrospun nanofibers formed of polymers that are conjugated with peptides that include acidic amino acid residues. The materials can incorporate high levels of mineralization so as to provide mechanical strength and promote osteogenesis and/or osteoconductivity on/in the bone tissue biomimetic materials. The materials and constructs can be utilized in forming tissue engineered structures for in vitro and in vivo use. Macroscopic bone tissue biomimetic scaffolds formed from the materials can be seeded with osteogenic cells and utilized to develop bone graft materials that can exhibit strength and osteoconductivity similar to the native bone and that exhibit uniform distribution of nutrients in the scaffolds.

摘要翻译： 描述了可以用材料形成的骨组织仿生材料，仿生构造物，以及形成材料和构建体的方法。 骨组织仿生材料包括由与包含酸性氨基酸残基的肽缀合的聚合物形成的电纺纳米纤维。 这些材料可以包含高水平的矿化，以便提供机械强度并促进骨组织仿生材料上的成骨和/或骨传导性。 材料和构建体可用于形成用于体外和体内使用的组织工程结构。 从材料形成的宏观骨组织仿生支架可以用成骨细胞接种，并用于开发骨移植材料，其可以表现出类似于天然骨的强度和骨传导性，并且在支架中显示出均匀的营养分布。

公开(公告)号：US20150290858A1

公开(公告)日：2015-10-15

申请号：US14442745

申请日：2013-12-10

申请人： Kureha Corporation

发明人： Masayuki Okura ,  Hiroyuki Sato

IPC分类号： B29C47/00 ,  C08K3/00 ,  C08K5/00 ,  E21B33/12 ,  C08G63/06

CPC分类号： B29C48/0011 ,  B29C48/022 ,  B29C48/03 ,  B29K2023/0658 ,  B29K2035/00 ,  B29K2067/043 ,  B29L2031/26 ,  C08G63/06 ,  C08K3/013 ,  C08K5/0008 ,  C08K5/0041 ,  E21B33/1208

摘要： Provided are: a polyglycolic acid (PGA) solidification- and extrusion-molded article that is formed from a resin material containing PGA, the PGA having a weight average molecular weight of 100,000 to 300,000 and a melt viscosity (temperature: 270° C.; shearing speed: 120 sec−1) of 100 to 2,000 Pa·s, and that has a tensile strength at a temperature of 150° C. of 20 to 200 MPa; a downhole tool or component thereof for drilling and completion of petroleum recovery formed by machining the solidification- and extrusion-molded article; an isolation plug provided with the component; an isolation plug mandrel; and a method for manufacturing the PGA solidification- and extrusion-molded article and a method for manufacturing the downhole tool or component thereof that comprise the steps of: supplying the resin material to an extruder (preferably from a fixed-quantity feeder); and after solidification- and extrusion-molding, pressurizing the solidification- and extrusion-molded article, and drawing the same while applying back pressure thereto in a direction of a forming die to suppress the expansion of the solidified and extruded matter.

摘要翻译： 提供：由含有PGA的树脂材料形成的聚乙醇酸（PGA）固化和挤出成型制品，重均分子量为100,000〜300,000，熔融粘度（温度：270℃）的PGA。 剪切速度：120秒-1）为100〜2000Pa·s，在150℃的温度下的拉伸强度为20〜200MPa; 用于钻孔和完成通过机械加工固化和挤出成型制品形成的石油回收的井下工具或其部件; 设置有所述部件的隔离塞; 隔离塞心轴; 以及制造PGA固化和挤出成型制品的方法及其制造方法，包括以下步骤：将树脂材料供给到挤出机（优选为固定量的进料器）中; 在固化和挤出成型之后，对固化和挤出成型制品进行加压，并在成形模具的方向上对其进行拉压，同时对成形模具的方向施加背压，以抑制固化和挤出物质的膨胀。

公开(公告)号：US09067362B2

公开(公告)日：2015-06-30

申请号：US11932051

申请日：2007-10-31

申请人： Peter M. Bonutti ,  Matthew J. Cremens ,  Kevin Ruholl

发明人： Peter M. Bonutti ,  Matthew J. Cremens ,  Kevin Ruholl

IPC分类号： A61B17/04 ,  B29C65/08 ,  B29C65/00 ,  B29C65/50 ,  A61B17/06 ,  B29C65/48

CPC分类号： B29C65/08 ,  A61B17/0487 ,  A61B2017/0445 ,  A61B2017/0454 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0488 ,  A61B2017/0619 ,  B29C65/4815 ,  B29C65/5071 ,  B29C65/5085 ,  B29C66/1122 ,  B29C66/526 ,  B29C66/5261 ,  B29C66/69 ,  B29C66/71 ,  B29C66/7379 ,  B29C66/73791 ,  B29C66/81423 ,  B29C66/83221 ,  B29C66/83241 ,  B29C66/861 ,  B29C66/8614 ,  B29C66/951 ,  B29C66/9513 ,  B29C66/9517 ,  B29K2067/043 ,  B29K2077/00 ,  B29K2067/006 ,  B29K2067/003 ,  B29K2059/00

摘要： A suture and a suture retainer are positioned relative to body tissue. Ultrasonic vibratory energy is utilized to heat the suture retainer and effect a bonding of portions of the suture retainer to each other and/or to the suture. Portions of the body tissue may be pressed into linear apposition with each other and held in place by cooperation between the suture and the suture retainer. The suture retainer may include one or more portions between which the suture extends. The suture retainer may include sections which have surface areas which are bonded together. If desired, the suture may be wrapped around one of the sections of the suture retainer. The suture retainer may be formed with a recess in which the suture is received. If desired, the suture retainer may be omitted and the sections of the suture bonded to each other.

摘要翻译： 缝合线和缝合线保持器相对于身体组织定位。 使用超声波振动能量来加热缝合线保持器并且实现缝合线保持器的部分彼此和/或缝合线的结合。 身体组织的部分可以彼此压制成线性组合，并且通过缝合线和缝线保持器之间的协作保持在适当位置。 缝合线保持器可以包括缝合线延伸在其之间的一个或多个部分。 缝合线保持器可以包括具有结合在一起的表面区域的部分。 如果需要，缝合线可以缠绕在缝合线保持器的一个部分上。 缝合线保持器可以形成有其中接收缝合线的凹部。 如果需要，可以省略缝合线保持器并且将缝合线的部分彼此粘结。