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    Fibroblast growth factor-13
    1.
    发明授权
    Fibroblast growth factor-13 失效
    成纤维细胞生长因子-13

    公开(公告)号：US06403557B1

    公开(公告)日：2002-06-11

    申请号：US08976315

    申请日：1997-11-21

    申请人： John M. Greene ,  Joachim R. Gruber ,  Craig A. Rosen

    发明人： John M. Greene ,  Joachim R. Gruber ,  Craig A. Rosen

    IPC分类号： A61K3818

    CPC分类号： C07K14/50 ,  A01K67/027 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026 ,  Y10S530/866

    摘要： The present invention relates to a novel FGF-13 protein which is a member of the fibroblast growth factor (FGF) family. In particular, isolated nucleic acid molecules are provided encoding the human FGF-13 protein. FGF-13 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of FGF-13 activity. Also provided are diagnostic methods for detecting FGF-13-related disorders and therapeutic methods for treating FGF-13-related disorders. Disclosed is a method of prolonging dopaminergic neuron survival.

    摘要翻译： 本发明涉及作为成纤维细胞生长因子（FGF）家族成员的新型FGF-13蛋白。 特别地，提供编码人FGF-13蛋白的分离的核酸分子。 还提供FGF-13多肽，载体，宿主细胞以及用于制备其的重组方法。 本发明还涉及用于鉴定FGF-13活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测FGF-13相关病症的诊断方法和用于治疗FGF-13相关疾病的治疗方法。 公开了延长多巴胺能神经元存活的方法。

    Fibroblast growth factor 13
    2.
    发明授权
    Fibroblast growth factor 13 失效
    成纤维细胞生长因子13

    公开(公告)号：US06368822B1

    公开(公告)日：2002-04-09

    申请号：US09036985

    申请日：1998-03-09

    申请人： John M. Greene ,  Joachim R. Gruber ,  Craig A. Rosen

    发明人： John M. Greene ,  Joachim R. Gruber ,  Craig A. Rosen

    IPC分类号： C12P2106

    CPC分类号： C07K14/50 ,  A61K38/00

    摘要： Disclosed is a human Fibroblast growth factor-13 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage associated with stroke and due to neuronal disorders and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate angiogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    摘要翻译： 公开了人成纤维细胞生长因子-13多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 还公开了利用这种多肽促进伤口愈合的方法，例如作为烧伤和溃疡的结果，以防止与中风相关的神经元损伤以及由于神经元紊乱并促进神经元生长，并且防止皮肤老化和脱发，以刺激 血管生成，早期胚胎中胚层诱导和肢体再生。 还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖，高血管疾病和上皮细胞增殖的治疗剂的用途。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

    Fibroblast growth factor-13
    3.
    发明授权
    Fibroblast growth factor-13 有权
    成纤维细胞生长因子-13

    公开(公告)号：US07208584B2

    公开(公告)日：2007-04-24

    申请号：US10123481

    申请日：2002-04-17

    申请人： John M. Greene ,  Joachim R. Gruber ,  Craig A. Rosen

    发明人： John M. Greene ,  Joachim R. Gruber ,  Craig A. Rosen

    IPC分类号： C07K16/22 ,  C07K14/50

    CPC分类号： C07K14/50 ,  A01K67/027 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N2799/026 ,  Y10S530/866

    摘要： The present invention relates to a novel FGF-13 protein which is a member of the fibroblast growth factor (FGF) family. In particular, isolated nucleic acid molecules are provided encoding the human FGF-13 protein. FGF-13 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of FGF-13 activity. Also provided are diagnostic methods for detecting FGF-13-related disorders and therapeutic methods for treating FGF-13-related disorders. Disclosed is a method of prolonging dopaminergic neuron survival.

    摘要翻译： 本发明涉及作为成纤维细胞生长因子（FGF）家族成员的新型FGF-13蛋白。 特别地，提供编码人FGF-13蛋白的分离的核酸分子。 还提供FGF-13多肽，载体，宿主细胞以及用于制备其的重组方法。 本发明还涉及用于鉴定FGF-13活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测FGF-13相关病症的诊断方法和用于治疗FGF-13相关疾病的治疗方法。 公开了延长多巴胺能神经元存活的方法。

    Fibroblast growth factor 13
    4.
    发明授权
    Fibroblast growth factor 13 失效
    成纤维细胞生长因子13

    公开(公告)号：US5728546A

    公开(公告)日：1998-03-17

    申请号：US462965

    申请日：1995-06-05

    申请人： John M. Greene ,  Joachim R. Gruber ,  Craig A. Rosen

    发明人： John M. Greene ,  Joachim R. Gruber ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  C07K14/50 ,  C12N15/19 ,  C12N15/12

    CPC分类号： C07K14/50 ,  A61K38/00

    摘要： Disclosed is a human Fibroblast growth factor-13 polypeptide and DNA(RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for promoting wound healing for example as a result of burns and ulcers, to prevent neuronal damage associated with stroke and due to neuronal disorders and promote neuronal growth, and to prevent skin aging and hair loss, to stimulate anglogenesis, mesodermal induction in early embryos and limb regeneration. Antagonists against such polypeptides and their use as a therapeutic to prevent abnormal cellular proliferation, hyper-vascular diseases and epithelial lens cell proliferation are also disclosed. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    摘要翻译： 公开了人成纤维细胞生长因子-13多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法。 还公开了利用这种多肽促进伤口愈合的方法，例如作为烧伤和溃疡的结果，以防止与中风相关的神经元损伤以及由于神经元紊乱并促进神经元生长，并且防止皮肤老化和脱发，以刺激 早期胚胎中的血管生成，中胚层诱导和肢体再生。 还公开了抗这些多肽的拮抗剂及其作为预防异常细胞增殖，高血管疾病和上皮细胞增殖的治疗剂的用途。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

    Human tissue inhibitor of metalloproteinase-4
    7.
    发明授权
    Human tissue inhibitor of metalloproteinase-4 失效
    人体组织金属蛋白酶抑制剂-4

    公开(公告)号：US06391853B1

    公开(公告)日：2002-05-21

    申请号：US09262087

    申请日：1999-03-04

    申请人： John M. Greene ,  Craig A. Rosen

    发明人： John M. Greene ,  Craig A. Rosen

    IPC分类号： A61K3857

    CPC分类号： C07K14/8146 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    摘要： A human tissue inhibitor of metalloproteinases-4 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques. Also disclosed are methods for utilizing such polypeptide for the treatment of diseases, including arthritis and cancer. Antagonists against such polypeptides and their use as a therapeutic to resorb scar tissue are also disclosed. Diagnostic assays for detecting levels of human TIMP-4 protein and mutations in human TIMP-4 nucleic acid sequence are also disclosed.

    摘要翻译： 金属蛋白酶-4多肽的人体组织抑制剂和编码这种多肽的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽治疗包括关节炎和癌症在内的疾病的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗疤痕组织再吸收的用途。 还公开了用于检测人类TIMP-4蛋白水平和人TIMP-4核酸序列突变的诊断测定法。

    Human geranylgeranyl pyrophosphate synthethase
    8.
    发明授权
    Human geranylgeranyl pyrophosphate synthethase 失效
    人类香叶基香叶基焦磷酸合成酶

    公开(公告)号：US5786193A

    公开(公告)日：1998-07-28

    申请号：US469665

    申请日：1995-06-06

    申请人： John M. Greene ,  Ewen F. Kirkness ,  Craig A. Rosen

    发明人： John M. Greene ,  Ewen F. Kirkness ,  Craig A. Rosen

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N9/10 ,  C12N15/54 ,  C12N15/63 ,  C12N15/79

    CPC分类号： C12N9/1085 ,  C12Y205/01029 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

    摘要： A human geranylgeranyl pyrophosphate synthetase polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for controlling morphology of cells. Antagonist against such polypeptides and their use as a therapeutic to treat cancer is also disclosed. Diagnostic assays are also disclosed which detect the presence of a mutated form of hGGPS and over-expression of the hGGPS protein.

    摘要翻译： 公开了人类香叶基香叶基焦磷酸合成酶多肽和编码这种多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了利用这种多肽来控制细胞形态的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗癌症治疗剂的用途。 还公开了诊断测定法，其检测突变形式的hGGPS的存在和hGGPS蛋白的过表达。