公开(公告)号：US06916786B2

公开(公告)日：2005-07-12

申请号：US10075446

申请日：2002-02-15

申请人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

发明人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/00 ,  C07K14/50 ,  C12N5/02 ,  C12N15/18 ,  A61K38/18 ,  C12N1/20 ,  C12N5/10

CPC分类号： C07H21/00 ,  A61K38/00 ,  A61K48/00 ,  C07K14/50 ,  C12N2799/026 ,  Y10S514/925

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

公开(公告)号：US6077692A

公开(公告)日：2000-06-20

申请号：US23082

申请日：1998-02-13

申请人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

发明人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/00 ,  C07K14/50 ,  C12N5/02 ,  C12N15/18 ,  A61K38/18 ,  C12N15/63

CPC分类号： C07H21/00 ,  C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026 ,  Y10S514/925

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

公开(公告)号：US07232667B2

公开(公告)日：2007-06-19

申请号：US10733311

申请日：2003-12-12

申请人： Steven M. Ruben ,  Joachim R. Gruber ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Pablo Jimenez

发明人： Steven M. Ruben ,  Joachim R. Gruber ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Pablo Jimenez

IPC分类号： C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C07K14/50

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

公开(公告)号：US06903072B2

公开(公告)日：2005-06-07

申请号：US09345373

申请日：1999-07-01

申请人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

发明人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/00 ,  C07K14/50 ,  C12N5/02 ,  C12N15/18 ,  A61K38/18 ,  C12N1/21

CPC分类号： C07H21/00 ,  A61K38/00 ,  A61K48/00 ,  C07K14/50 ,  C12N2799/026 ,  Y10S514/925

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

公开(公告)号：US06693077B1

公开(公告)日：2004-02-17

申请号：US09610651

申请日：2000-06-30

申请人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian NI ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

发明人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian NI ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

IPC分类号： A61K3818

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

公开(公告)号：US07364865B2

公开(公告)日：2008-04-29

申请号：US11381977

申请日：2006-05-05

申请人： Reiner L. Gentz ,  Brent L. Kreider ,  Jun Zhang ,  Michael Antonaccio ,  Donna Mendrick ,  Pablo Jimenez ,  Vikram Patel ,  Craig A. Rosen ,  Mark D. Adams ,  Haodong Li ,  Steven M. Ruben

发明人： Reiner L. Gentz ,  Brent L. Kreider ,  Jun Zhang ,  Michael Antonaccio ,  Donna Mendrick ,  Pablo Jimenez ,  Vikram Patel ,  Craig A. Rosen ,  Mark D. Adams ,  Haodong Li ,  Steven M. Ruben

IPC分类号： C12N5/10 ,  C12N5/12 ,  G01N33/53 ,  C07K16/24

CPC分类号： G01N33/6863 ,  A61K38/00 ,  A61K48/00 ,  C07K1/113 ,  C07K1/36 ,  C07K14/50 ,  C07K14/521 ,  C07K14/523 ,  C07K16/24 ,  C07K2319/00 ,  C12N15/72 ,  C12N2799/026 ,  G01N2333/52

摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1(CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

摘要翻译： 公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKbeta8或ckb-8））的分离的核酸分子的治疗组合物和方法。 人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子β1（CKbeta1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4）以及MPIF-1 ，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。

公开(公告)号：US07851596B2

公开(公告)日：2010-12-14

申请号：US12111079

申请日：2008-04-28

申请人： Reiner L. Gentz ,  Brent L. Kreider ,  Jun Zhang ,  Michael Antonaccio ,  Donna Mendrick ,  Pablo Jimenez ,  Vikram Patel ,  Craig A. Rosen ,  Mark D. Adams ,  Haodong Li ,  Steven M. Ruben

发明人： Reiner L. Gentz ,  Brent L. Kreider ,  Jun Zhang ,  Michael Antonaccio ,  Donna Mendrick ,  Pablo Jimenez ,  Vikram Patel ,  Craig A. Rosen ,  Mark D. Adams ,  Haodong Li ,  Steven M. Ruben

IPC分类号： C07K14/52

CPC分类号： G01N33/6863 ,  A61K38/00 ,  A61K48/00 ,  C07K1/113 ,  C07K1/36 ,  C07K14/50 ,  C07K14/521 ,  C07K14/523 ,  C07K16/24 ,  C07K2319/00 ,  C12N15/72 ,  C12N2799/026 ,  G01N2333/52

摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

摘要翻译： 公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子8（CK＆bgr; 8或ckb-8））的分离的核酸分子的治疗组合物和方法; 人类单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子1（CK＆bgr; 1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4） 作为MPIF-1，M-CIF和/或MIP-4多肽本身，载体，宿主细胞和用于制备它们的重组方法也是如此。

公开(公告)号：US07041460B2

公开(公告)日：2006-05-09

申请号：US10626530

申请日：2003-07-25

申请人： Reiner L. Gentz ,  Brent L. Kreider ,  Jun Zhang ,  Michael Antonaccio ,  Donna Mendrick ,  Pablo Jimenez ,  Vikram Patel ,  Craig A. Rosen ,  Mark D. Adams ,  Haodong Li ,  Steven M. Ruben

发明人： Reiner L. Gentz ,  Brent L. Kreider ,  Jun Zhang ,  Michael Antonaccio ,  Donna Mendrick ,  Pablo Jimenez ,  Vikram Patel ,  Craig A. Rosen ,  Mark D. Adams ,  Haodong Li ,  Steven M. Ruben

IPC分类号： C07K16/24 ,  C12N5/12 ,  G01N33/53

CPC分类号： G01N33/6863 ,  A61K38/00 ,  A61K48/00 ,  C07K1/113 ,  C07K1/36 ,  C07K14/50 ,  C07K14/521 ,  C07K14/523 ,  C07K16/24 ,  C07K2319/00 ,  C12N15/72 ,  C12N2799/026 ,  G01N2333/52

摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

摘要翻译： 公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKbeta8或ckb-8））的分离的核酸分子的治疗组合物和方法。 人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子β1（CKbeta1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4）以及MPIF-1 ，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。

公开(公告)号：US20080274109A1

公开(公告)日：2008-11-06

申请号：US12111079

申请日：2008-04-28

申请人： Reiner L. Gentz ,  Brent L. Kreider ,  Jun Zhang ,  Michael Antonaccio ,  Donna Mendrick ,  Pablo Jimenez ,  Vikram Patel ,  Craig A. Rosen ,  Mark D. Adams ,  Haodong Li ,  Steven M. Ruben

发明人： Reiner L. Gentz ,  Brent L. Kreider ,  Jun Zhang ,  Michael Antonaccio ,  Donna Mendrick ,  Pablo Jimenez ,  Vikram Patel ,  Craig A. Rosen ,  Mark D. Adams ,  Haodong Li ,  Steven M. Ruben

IPC分类号： A61K39/395 ,  C07H21/04 ,  C12Q1/68 ,  C07K14/00 ,  G01N33/53 ,  A61P43/00 ,  A61K38/00 ,  C12Q1/00 ,  C07K16/18

CPC分类号： G01N33/6863 ,  A61K38/00 ,  A61K48/00 ,  C07K1/113 ,  C07K1/36 ,  C07K14/50 ,  C07K14/521 ,  C07K14/523 ,  C07K16/24 ,  C07K2319/00 ,  C12N15/72 ,  C12N2799/026 ,  G01N2333/52

摘要： There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human myeloid progenitor inhibitory factor-1 (MPIF-1) polypeptide (previously termed MIP-3 and chemokine β8 (CKβ8 or ckb-8)); a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-γ and chemokine β1 (CKβ1 or ckb-1)), and a macrophage inhibitory protein-4 (MIP-4), as well as MPIF-1, M-CIF and/or MIP-4 polypeptides themselves, as are vectors, host cells and recombinant methods for producing the same.

摘要翻译： 公开了使用编码人骨髓祖细胞抑制因子-1（MPIF-1）多肽（以前称为MIP-3和趋化因子β8（CKbeta8或ckb-8））的分离的核酸分子的治疗组合物和方法。 人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ和趋化因子β1（CKbeta1或ckb-1））和巨噬细胞抑制蛋白-4（MIP-4）以及MPIF-1 ，M-CIF和/或MIP-4多肽本身，以及用于产生它们的载体，宿主细胞和重组方法。

公开(公告)号：US06811773B1

公开(公告)日：2004-11-02

申请号：US09571013

申请日：2000-05-15

申请人： Reiner L. Gentz ,  Brent L. Kreider ,  Jun Zhang ,  Michael Antonaccio ,  Donna Mendrick ,  Pablo Jimenez ,  Vikram Patel ,  Craig A. Rosen ,  Mark D. Adams ,  Haodong Li ,  Steven M. Ruben

发明人： Reiner L. Gentz ,  Brent L. Kreider ,  Jun Zhang ,  Michael Antonaccio ,  Donna Mendrick ,  Pablo Jimenez ,  Vikram Patel ,  Craig A. Rosen ,  Mark D. Adams ,  Haodong Li ,  Steven M. Ruben

IPC分类号： A61K3819

CPC分类号： G01N33/6863 ,  A61K38/00 ,  A61K48/00 ,  C07K1/113 ,  C07K1/36 ,  C07K14/50 ,  C07K14/521 ,  C07K14/523 ,  C07K16/24 ,  C07K2319/00 ,  C12N15/72 ,  C12N2799/026 ,  G01N2333/52

摘要： There are disclosed therapeutic compositions and methods using a human monocyte-colony inhibitory factor (M-CIF) polypeptide (previously termed MIP1-&ggr; chemokine &bgr;1(CK&bgr;1 or ckb-1)), as well as ioslated nucleic acid molecules encoding M-CIF, and vectors, host cells and recombinant methods for producing the same.

摘要翻译： 公开了使用人单核细胞集落抑制因子（M-CIF）多肽（以前称为MIP1-γ趋化因子β1（CKbeta1或ckb-1））的治疗组合物和方法，以及编码M-CIF的分离的核酸分子， 和载体，宿主细胞和用于制备其的重组方法。