公开(公告)号：US07232667B2

公开(公告)日：2007-06-19

申请号：US10733311

申请日：2003-12-12

申请人： Steven M. Ruben ,  Joachim R. Gruber ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Pablo Jimenez

发明人： Steven M. Ruben ,  Joachim R. Gruber ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Patrick J. Dillon ,  Reiner L. Gentz ,  Pablo Jimenez

IPC分类号： C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12N15/63 ,  C07K14/50

CPC分类号： C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

公开(公告)号：US06916786B2

公开(公告)日：2005-07-12

申请号：US10075446

申请日：2002-02-15

申请人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

发明人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/00 ,  C07K14/50 ,  C12N5/02 ,  C12N15/18 ,  A61K38/18 ,  C12N1/20 ,  C12N5/10

CPC分类号： C07H21/00 ,  A61K38/00 ,  A61K48/00 ,  C07K14/50 ,  C12N2799/026 ,  Y10S514/925

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

公开(公告)号：US6077692A

公开(公告)日：2000-06-20

申请号：US23082

申请日：1998-02-13

申请人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

发明人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/00 ,  C07K14/50 ,  C12N5/02 ,  C12N15/18 ,  A61K38/18 ,  C12N15/63

CPC分类号： C07H21/00 ,  C07K14/50 ,  A61K38/00 ,  A61K48/00 ,  C12N2799/026 ,  Y10S514/925

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

公开(公告)号：US06903072B2

公开(公告)日：2005-06-07

申请号：US09345373

申请日：1999-07-01

申请人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

发明人： Steven M. Ruben ,  Pablo Jimenez ,  D. Roxanne Duan ,  Mark A. Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul A. Moore ,  Timothy A. Coleman ,  Joachim R. Gruber ,  Patrick J. Dillon ,  Reiner L. Gentz

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/00 ,  C07K14/50 ,  C12N5/02 ,  C12N15/18 ,  A61K38/18 ,  C12N1/21

CPC分类号： C07H21/00 ,  A61K38/00 ,  A61K48/00 ,  C07K14/50 ,  C12N2799/026 ,  Y10S514/925

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

公开(公告)号：US20120122762A1

公开(公告)日：2012-05-17

申请号：US13359199

申请日：2012-01-26

申请人： Steven M. Ruben ,  Craig A. Rosen ,  Daniel R. Soppet ,  Kenneth C. Carter ,  Daniel P. Bednarik ,  Gregory A. Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul E. Young ,  John M. Greene ,  Ann M. Ferrie ,  D. Roxanne Duan ,  Jing-Shan Hu ,  Kimberly A. Florence ,  Henrik S. Olsen ,  Carrie L. Fischer ,  Reinhard Ebner ,  Laurie A. Brewer ,  Paul A. Moore ,  Yanggu Shi ,  David W. LaFleur ,  Yi Li ,  Zhizhen Zeng ,  Hla Kyaw

发明人： Steven M. Ruben ,  Craig A. Rosen ,  Daniel R. Soppet ,  Kenneth C. Carter ,  Daniel P. Bednarik ,  Gregory A. Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul E. Young ,  John M. Greene ,  Ann M. Ferrie ,  D. Roxanne Duan ,  Jing-Shan Hu ,  Kimberly A. Florence ,  Henrik S. Olsen ,  Carrie L. Fischer ,  Reinhard Ebner ,  Laurie A. Brewer ,  Paul A. Moore ,  Yanggu Shi ,  David W. LaFleur ,  Yi Li ,  Zhizhen Zeng ,  Hla Kyaw

IPC分类号： A61K38/17 ,  C12N15/63 ,  C07K14/435 ,  C07K16/18 ,  G01N33/53 ,  C12Q1/68 ,  C12P21/00 ,  G01N33/68 ,  C12N15/85 ,  C12N15/70 ,  C12N1/21 ,  C12N5/10 ,  A61P7/00 ,  A61P35/00 ,  A61P13/12 ,  A61P9/00 ,  A61P11/00 ,  A61P17/02 ,  A61P25/00 ,  A61P5/00 ,  A61P15/00 ,  A61P31/00 ,  A61P1/00 ,  C12N15/12

CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47 ,  G01N33/566 ,  G01N2800/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20090011983A1

公开(公告)日：2009-01-08

申请号：US11745580

申请日：2007-05-08

申请人： Steven M. Ruben ,  Craig A. Rosen ,  Daniel R. Soppet ,  Kenneth C. Carter ,  Daniel P. Bednarik ,  Gregory A. Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul E. Young ,  John M. Greene ,  Ann M. Ferrie ,  D. Roxanne Duan ,  Jing-Shan Hu ,  Kimberly A. Florence ,  Henrik S. Olsen ,  Carrie L. Fischer ,  Reinhard Ebner ,  Laurie A. Brewer ,  Paul A. Moore ,  Yanggu Shi ,  David W. LaFleur ,  Yi Li ,  Zhizhen Zeng ,  Hla Kyaw

发明人： Steven M. Ruben ,  Craig A. Rosen ,  Daniel R. Soppet ,  Kenneth C. Carter ,  Daniel P. Bednarik ,  Gregory A. Endress ,  Guo-Liang Yu ,  Jian Ni ,  Ping Feng ,  Paul E. Young ,  John M. Greene ,  Ann M. Ferrie ,  D. Roxanne Duan ,  Jing-Shan Hu ,  Kimberly A. Florence ,  Henrik S. Olsen ,  Carrie L. Fischer ,  Reinhard Ebner ,  Laurie A. Brewer ,  Paul A. Moore ,  Yanggu Shi ,  David W. LaFleur ,  Yi Li ,  Zhizhen Zeng ,  Hla Kyaw

IPC分类号： A61K38/00 ,  C12N15/11 ,  C12N15/00 ,  C12N15/63 ,  C12N5/06 ,  C12Q1/00 ,  A61P43/00 ,  G01N33/566 ,  C12Q1/68 ,  C07K14/00 ,  C07K16/18 ,  C12P21/04

CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K14/47 ,  G01N33/566 ,  G01N2800/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US20050037966A1

公开(公告)日：2005-02-17

申请号：US10901210

申请日：2004-07-29

申请人： Steven Ruben ,  Pablo Jimenez ,  Roxanne Duan ,  Mark Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul Moore ,  Timothy Coleman ,  Joachim Gruber ,  Patrick Dillon ,  Reiner Gentz

发明人： Steven Ruben ,  Pablo Jimenez ,  Roxanne Duan ,  Mark Rampy ,  Donna Mendrick ,  Jun Zhang ,  Jian Ni ,  Paul Moore ,  Timothy Coleman ,  Joachim Gruber ,  Patrick Dillon ,  Reiner Gentz

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/50 ,  C12N5/08 ,  A61K38/18 ,  C07K14/475

CPC分类号： C07K14/50 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

公开(公告)号：US20090005301A1

公开(公告)日：2009-01-01

申请号：US11759448

申请日：2007-06-07

申请人： Jian Ni ,  Reinhard Ebner ,  David W. LaFleur ,  Paul A. Moore ,  Henrik S. Olsen ,  Craig A. Rosen ,  Steven M. Ruben ,  Daniel R. Soppet ,  Paul E. Young ,  Yanggu Shi ,  Kimberly A. Florence ,  Ying-Fei Wei ,  Charles Florence ,  Jing-Shan Hu ,  Yi Li ,  Hla Kyaw ,  Carrie L. Fischer ,  Ann M. Ferrie ,  Ping Fan ,  Ping Feng ,  Gregory A. Endress ,  Patrick J. Dillon ,  Kenneth C. Carter ,  Laurie A. Brewer ,  Guo-Liang Yu ,  Zhizhen Zeng ,  John M. Greene

发明人： Jian Ni ,  Reinhard Ebner ,  David W. LaFleur ,  Paul A. Moore ,  Henrik S. Olsen ,  Craig A. Rosen ,  Steven M. Ruben ,  Daniel R. Soppet ,  Paul E. Young ,  Yanggu Shi ,  Kimberly A. Florence ,  Ying-Fei Wei ,  Charles Florence ,  Jing-Shan Hu ,  Yi Li ,  Hla Kyaw ,  Carrie L. Fischer ,  Ann M. Ferrie ,  Ping Fan ,  Ping Feng ,  Gregory A. Endress ,  Patrick J. Dillon ,  Kenneth C. Carter ,  Laurie A. Brewer ,  Guo-Liang Yu ,  Zhizhen Zeng ,  John M. Greene

IPC分类号： C07K14/47 ,  C12N15/12 ,  C12N15/85 ,  C07K16/18 ,  C12Q1/68 ,  A61K38/14 ,  A61K31/7088 ,  G01N33/68 ,  C12P21/02 ,  C12N15/00 ,  C12N5/10

CPC分类号： C07K14/47 ,  A61K48/00

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

公开(公告)号：US06525174B1

公开(公告)日：2003-02-25

申请号：US09205258

申请日：1998-12-04

申请人： Paul Young ,  John M. Greene ,  Ann M. Ferrie ,  Steven M. Ruben ,  Craig A. Rosen ,  Jing-Shan Hu ,  Henrik S. Olsen ,  Reinhard Ebner ,  Laurie A. Brewer ,  Paul A. Moore ,  Yanggu Shi ,  Charles Florence ,  Kimberly Florence ,  David W. Lafleur ,  Jian Ni ,  Ping Fan ,  Ying-Fei Wei ,  Carrie L. Fischer ,  Daniel R. Soppet ,  Yi Li ,  Zhizhen Zeng ,  Hla Kyaw ,  Guo-Liang Yu ,  Ping Feng ,  Patrick J. Dillon ,  Gregory A. Endress ,  Kenneth C. Carter

发明人： Paul Young ,  John M. Greene ,  Ann M. Ferrie ,  Steven M. Ruben ,  Craig A. Rosen ,  Jing-Shan Hu ,  Henrik S. Olsen ,  Reinhard Ebner ,  Laurie A. Brewer ,  Paul A. Moore ,  Yanggu Shi ,  Charles Florence ,  Kimberly Florence ,  David W. Lafleur ,  Jian Ni ,  Ping Fan ,  Ying-Fei Wei ,  Carrie L. Fischer ,  Daniel R. Soppet ,  Yi Li ,  Zhizhen Zeng ,  Hla Kyaw ,  Guo-Liang Yu ,  Ping Feng ,  Patrick J. Dillon ,  Gregory A. Endress ,  Kenneth C. Carter

IPC分类号： C07K1447

CPC分类号： G01N33/68 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/4718 ,  C07K2319/00 ,  C07K2319/02 ,  C12N15/11 ,  C12N2799/026

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US20080171016A1

公开(公告)日：2008-07-17

申请号：US12046107

申请日：2008-03-11

申请人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

发明人： Guo-Liang Yu ,  Jian Ni ,  Reiner L. Gentz ,  Patrick J. Dillon

IPC分类号： A61K38/20 ,  C07K16/00 ,  A61K39/395 ,  A61K38/21 ,  C07K14/00 ,  A61P35/04 ,  A61P29/00

CPC分类号： C07K14/4747 ,  A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C07K14/70578 ,  C07K16/2878 ,  C07K2317/21 ,  C12N2799/026

摘要： The present invention relates to novel Death Domain Containing Receptor (DR3 and DR3-V1) proteins that are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR3 and DR3-V1 proteins. DR3 and DR3-V1 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are antibodies and fragments thereof that bind to polypeptides of the invention. The invention further relates to screening methods for identifying agonists and antagonists of DR3 and DR3-V1 activity.

摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新型死亡域含有受体（DR3和DR3-V1）蛋白。 特别地，提供编码人DR3和DR3-V1蛋白的分离的核酸分子。 还提供DR3和DR3-V1多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 还提供了结合本发明多肽的抗体及其片段。 本发明还涉及用于鉴定DR3和DR3-V1活性的激动剂和拮抗剂的筛选方法。