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公开(公告)号：US06287816B1
公开(公告)日：2001-09-11
申请号：US08254353
申请日：1994-06-06
IPC分类号： C12P2100
CPC分类号： C07K14/51 , A61K38/1875 , A61K38/30 , A61L27/227 , C07K2319/02 , Y10S530/84 , Y10S930/12 , A61K2300/00
摘要： Purified bone morphogenetic protein-9 (BMP-9) proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
摘要翻译： 公开了纯化的骨形态发生蛋白-9（BMP-9）蛋白及其生产方法。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号：US07091007B2
公开(公告)日：2006-08-15
申请号：US10600645
申请日：2003-06-23
摘要： Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding the BMP receptor proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to the BMP receptor proteins.
摘要翻译： 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质，以及编码BMP受体蛋白质的DNA分子和使用受体蛋白质的方法。 还公开了截短的BMP受体蛋白质和作为BMP受体蛋白质的配体的分子。
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公开(公告)号：US06610513B2
公开(公告)日：2003-08-26
申请号：US09874628
申请日：2001-06-05
IPC分类号： C12P2106
摘要： Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding these proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to these BMP receptor proteins.
摘要翻译： 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质，以及编码这些蛋白质的DNA分子和使用受体蛋白质的方法。 进一步公开的是截短的BMP受体蛋白质和作为这些BMP受体蛋白质的配体的分子。
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公开(公告)号：US06340668B1
公开(公告)日：2002-01-22
申请号：US09414234
申请日：1999-10-07
IPC分类号： A61K3818
CPC分类号： A61K38/1875 , C07K14/51 , C07K14/575 , C07K2319/00 , C12N5/0619 , C12N2501/155 , Y10S930/12
摘要： Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the proteins may be useful for the induction and/or maintenance of bone, cartilage and/or other connective tissue, and/or neuronal tissue.
摘要翻译： 公开了纯化的BMP-11蛋白质及其生产方法。 还公开了编码BMP-11蛋白的重组DNA分子。 蛋白质可用于调节促卵泡激素，例如用于避孕。 此外，蛋白质可用于诱导和/或维持骨，软骨和/或其它结缔组织和/或神经元组织。
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公开(公告)号：US06291206B1
公开(公告)日：2001-09-18
申请号：US08123934
申请日：1993-09-17
IPC分类号： C12P2106
摘要： Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding said proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to said BMP receptor proteins.
摘要翻译： 公开了新的丝氨酸/苏氨酸受体蛋白质和BMP受体蛋白质，以及编码所述蛋白质的DNA分子和使用受体蛋白质的方法。 还公开了截短的BMP受体蛋白质和作为所述BMP受体蛋白质的配体的分子。
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6.发明授权Use of TGF beta superfamily antagonists and neurotrophins to make neurons from embryonic stem cells 有权使用TGFβ超家族拮抗剂和神经营养因子从胚胎干细胞中制备神经元公开(公告)号：US08153428B2
公开(公告)日：2012-04-10
申请号：US12500998
申请日：2009-07-10
CPC分类号： C12N5/0606 , A61K35/12 , C12N15/1034 , C12N15/1072 , C12N15/1096 , C12N2500/14 , C12N2500/30 , C12N2500/38 , C12N2500/44 , C12N2500/62 , C12N2501/105 , C12N2501/13 , C12N2501/155 , C12N2501/385 , C12N2501/39 , C12N2501/999 , C12N2502/13 , C12N2502/99 , C12N2503/02 , C12N2510/00 , C12N2510/04 , C12N2533/90
摘要： This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies according to established techniques, differentiation is effected directly in monolayer culture on a suitable solid surface. The cells are either plated directly onto a differentiation-promoting surface, or grown initially on the solid surface in the absence of feeder cells and then exchanged into a medium that assists in the differentiation process. The solid surface and the culture medium can be chosen to direct differentiation down a particular pathway, generating a cell population that is remarkably uniform. The methodology is well adapted to bulk production of committed precursor and terminally differentiated cells for use in drug screening or regenerative medicine.
摘要翻译： 本发明提供了一种用于从多能细胞例如人胚胎干细胞有效产生分化细胞的系统。 不是根据确定的技术使细胞形成胚状体，而是在合适的固体表面的单层培养物中直接进行分化。 将细胞直接铺板到分化促进表面上，或者在不存在饲养细胞的情况下最初在固体表面上生长，然后交换到有助于分化过程的培养基中。 可以选择固体表面和培养基以指导特定途径的分化，产生非常均匀的细胞群体。 该方法适用于大量生产用于药物筛选或再生医学的定型前体和终末分化细胞。
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7.发明申请USE OF TGF BETA SUPERFAMILY ANTAGONISTS AND NEUROTROPHINS TO MAKE NEURONS FROM EMBRYONIC STEM CELLS 有权使用TGFβA超级拮抗剂和神经营养剂从胚胎干细胞中产生神经元公开(公告)号：US20090305405A1
公开(公告)日：2009-12-10
申请号：US12500998
申请日：2009-07-10
CPC分类号： C12N5/0606 , A61K35/12 , C12N15/1034 , C12N15/1072 , C12N15/1096 , C12N2500/14 , C12N2500/30 , C12N2500/38 , C12N2500/44 , C12N2500/62 , C12N2501/105 , C12N2501/13 , C12N2501/155 , C12N2501/385 , C12N2501/39 , C12N2501/999 , C12N2502/13 , C12N2502/99 , C12N2503/02 , C12N2510/00 , C12N2510/04 , C12N2533/90
摘要： This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies according to established techniques, differentiation is effected directly in monolayer culture on a suitable solid surface. The cells are either plated directly onto a differentiation-promoting surface, or grown initially on the solid surface in the absence of feeder cells and then exchanged into a medium that assists in the differentiation process. The solid surface and the culture medium can be chosen to direct differentiation down a particular pathway, generating a cell population that is remarkably uniform. The methodology is well adapted to bulk production of committed precursor and terminally differentiated cells for use in drug screening or regenerative medicine.
摘要翻译： 本发明提供了一种用于从多能细胞例如人胚胎干细胞有效产生分化细胞的系统。 不是根据确定的技术使细胞形成胚状体，而是在合适的固体表面的单层培养物中直接进行分化。 将细胞直接铺板到分化促进表面上，或者在不存在饲养细胞的情况下最初在固体表面上生长，然后交换到有助于分化过程的培养基中。 可以选择固体表面和培养基以指导特定途径的分化，产生非常均匀的细胞群体。 该方法适用于大量生产用于药物筛选或再生医学的定型前体和终末分化细胞。
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公开(公告)号：US09790466B2
公开(公告)日：2017-10-17
申请号：US13561296
申请日：2012-07-30
IPC分类号： C12N5/10 , C12N5/0793 , C12R1/91 , C12N5/077 , C12Q1/02 , C12P21/02 , C12N5/02 , A61K35/12 , C12N15/09 , C12N5/073 , C12N5/0735 , C12N5/079 , C12N15/10 , C12N5/07
CPC分类号： C12N5/0606 , A61K35/12 , C12N15/1034 , C12N15/1072 , C12N15/1096 , C12N2500/14 , C12N2500/30 , C12N2500/38 , C12N2500/44 , C12N2500/62 , C12N2501/105 , C12N2501/13 , C12N2501/155 , C12N2501/385 , C12N2501/39 , C12N2501/999 , C12N2502/13 , C12N2502/99 , C12N2503/02 , C12N2510/00 , C12N2510/04 , C12N2533/90
摘要： This invention provides a system for efficiently producing differentiated cells from pluripotent cells, such as human embryonic stem cells. Rather than permitting the cells to form embryoid bodies according to established techniques, differentiation is effected directly in monolayer culture on a suitable solid surface. The cells are either plated directly onto a differentiation-promoting surface, or grown initially on the solid surface in the absence of feeder cells and then exchanged into a medium that assists in the differentiation process. The solid surface and the culture medium can be chosen to direct differentiation down a particular pathway, generating a cell population that is remarkably uniform. The methodology is well adapted to bulk production of committed precursor and terminally differentiated cells for use in drug screening or regenerative medicine.
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公开(公告)号：US20130274215A1
公开(公告)日：2013-10-17
申请号：US13639644
申请日：2011-04-06
IPC分类号： A61K31/47 , A61K31/428 , A61K31/277 , A61K31/4709 , A61K31/551 , A61K31/502 , A61K31/706 , A61K31/194 , A61K31/4375 , A61K31/337 , A61K31/165 , A61K31/444 , A61K31/429 , A61K31/58 , A61K31/7048 , A61K31/4985
CPC分类号： A61K31/47 , A61K31/00 , A61K31/165 , A61K31/194 , A61K31/277 , A61K31/337 , A61K31/428 , A61K31/429 , A61K31/4375 , A61K31/444 , A61K31/4709 , A61K31/4985 , A61K31/502 , A61K31/551 , A61K31/58 , A61K31/7048 , A61K31/706
摘要： The present invention provides methods for the prevention, treatment and/or amelioration of fibrosis or fibrotic conditions. The present invention further provides small molecule inhibitors of Wnt- and TGF-p-mediated β-catenin signaling to prevent, treat and/or ameliorate fibrosis or fibrotic conditions. Kits comprising small molecule inhibitors of Wnt- and TGF-p-mediated β-catenin signaling and methods of identifying small molecule inhibitors of Wnt- and TGF-p-mediated β-catenin signaling are also provided.
摘要翻译： 本发明提供了预防，治疗和/或改善纤维化或纤维化病症的方法。 本发明进一步提供Wnt-和TGF-p介导的β-连环蛋白信号传导的小分子抑制剂以预防，治疗和/或改善纤维化或纤维化病症。 还提供了包含Wnt-和TGF-p介导的β-连环蛋白信号的小分子抑制剂的试剂盒以及鉴定Wnt-和TGF-β-介导的β-连环蛋白信号传导的小分子抑制剂的方法。
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10.发明授权Use of cyclic AMP and ascorbic acid to produce dopaminergic neurons from embryonic stem cells 有权使用环AMP和抗坏血酸从胚胎干细胞产生多巴胺能神经元公开(公告)号：US07763463B2
公开(公告)日：2010-07-27
申请号：US11009504
申请日：2004-12-10
CPC分类号： C12N5/0606 , A61K35/12 , C12N5/0618 , C12N5/0619 , C12N5/0622 , C12N5/0623 , C12N15/1034 , C12N15/1096 , C12N2501/01 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/135 , C12N2501/155 , C12N2502/13 , C12N2502/99 , C12N2503/02 , C12N2506/02 , C12N2510/00 , C12N2510/04 , C12Q1/6881 , Y02A50/471
摘要： This disclosure provides improved methods for obtaining populations of dopaminergic neurons from pluripotent stem cells. The process involves taking a population of neural precursor cells derived from a line of human embryonic stem cells, and culturing the cells in a medium that contains a neurotrophin, either cyclic adenosine monophosphate (cAMP) or a compound that elevates intracellular cAMP levels, and optionally an antioxidant such as ascorbic acid. Cell populations have been obtained that contain a high proportion of cells staining for tyrosine hydroxylase, which is a feature of dopaminergic neurons. The neural progenitors and terminally differentiated neurons of this invention can be generated in large quantities for use in drug screening and the treatment of clinically important neurological disorders, such as Parkinson's disease.
摘要翻译： 本公开提供了从多能干细胞获得多巴胺能神经元群体的改进方法。 该方法包括摄取来自人类胚胎干细胞系的神经前体细胞群，并在含有神经营养因子的培养基（环腺苷一磷酸（cAMP）或提高细胞内cAMP水平的化合物）中培养细胞，以及任选地 抗氧化剂如抗坏血酸。 已经获得了含有高比例染色酪氨酸羟化酶的细胞的细胞群，其是多巴胺能神经元的特征。 本发明的神经祖细胞和终末分化的神经元可以大量产生，用于药物筛选和治疗临床上重要的神经障碍，例如帕金森病。
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