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公开(公告)号：US06207813B1
公开(公告)日：2001-03-27
申请号：US09189157
申请日：1998-11-09
IPC分类号： C07H2104
CPC分类号： C12N15/85 , A61K38/00 , A61L24/043 , A61L27/227 , C07K14/51 , Y10S530/84 , C08L89/00
摘要： Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译： 公开了纯化的BMP-6蛋白质及其生产方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号：US06613744B2
公开(公告)日：2003-09-02
申请号：US09816299
申请日：2001-03-23
IPC分类号： A61K3818
CPC分类号： C12N15/85 , A61K38/00 , A61L24/043 , A61L27/227 , C07K14/51 , Y10S530/84 , C08L89/00
摘要： Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
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公开(公告)号：US5849880A
公开(公告)日：1998-12-15
申请号：US469936
申请日：1995-06-06
IPC分类号： A61K38/00 , A61L24/04 , A61L27/22 , C07K14/51 , C12N15/85 , C07K14/46 , A61K38/18 , C07H21/04 , C12P21/00
CPC分类号： C12N15/85 , A61L24/043 , A61L27/227 , C07K14/51 , A61K38/00 , Y10S530/84
摘要： Purified bone morphogenetic protein (BMP)-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译： 公开了纯化的骨形态发生蛋白（BMP）-6蛋白及其生产方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号：US5459047A
公开(公告)日：1995-10-17
申请号：US251069
申请日：1994-05-27
IPC分类号： A61K38/00 , A61L24/04 , A61L27/22 , C07K14/51 , C12N15/85 , C12P21/02 , A01N37/18 , C07H15/12 , C07K1/00 , C12N1/21 , C12N5/00 , C12N7/00 , C12N15/00
CPC分类号： C12N15/85 , A61L24/043 , A61L27/227 , C07K14/51 , A61K38/00 , Y10S530/84
摘要： Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
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公开(公告)号：US5187076A
公开(公告)日：1993-02-16
申请号：US490033
申请日：1990-03-07
CPC分类号： C12N15/85 , A61L24/043 , A61L27/227 , C07K14/51 , A61K38/00
摘要： Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
摘要翻译： 公开了纯化的BMP-6蛋白质及其生产方法。 蛋白质可用于治疗骨和/或软骨缺损以及伤口愈合和相关组织修复。
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公开(公告)号：US6027919A
公开(公告)日：2000-02-22
申请号：US333576
申请日：1994-11-02
申请人： Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人： Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61K38/27 , A61L27/22 , A61L27/36 , A61P1/02 , A61P5/00 , A61P19/04 , A61P43/00 , C07H21/04 , C07K14/51 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12R1/19 , C12R1/91 , C07K14/475
CPC分类号： A61L27/227 , A61L27/38 , C07K14/51 , A61K38/00 , C07K2319/02
摘要： The present invention relates to a novel family of purified proteins, and compositions containing such proteins, which compositions are useful for the induction of tendon/ligament-like tissue formation, wound healing and ligament and other tissue repair. The present invention further relates to DNA molecules, vectors and host cells useful for production of such proteins.
摘要翻译： 本发明涉及一种纯化蛋白质的新家族，以及含有这些蛋白质的组合物，该组合物可用于诱导腱/类韧带组织形成，伤口愈合和韧带以及其它组织修复。 本发明还涉及可用于生产这种蛋白质的DNA分子，载体和宿主细胞。
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公开(公告)号：US06284872B1
公开(公告)日：2001-09-04
申请号：US08808324
申请日：1997-02-28
申请人： Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人： Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
IPC分类号： C07K1451
CPC分类号： C07K14/51 , A61K38/1875 , A61L27/227 , A61L27/386 , A61L27/54 , C07K2319/02
摘要： Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
摘要翻译： 公开了具有肌腱/类韧带组织诱导活性的蛋白质组成。 该组合物可用于治疗腱炎和腱或韧带缺陷以及相关组织修复。
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公开(公告)号：US6034061A
公开(公告)日：2000-03-07
申请号：US750222
申请日：1996-12-04
IPC分类号： C12N15/09 , A61K9/00 , A61K38/00 , A61K38/18 , A61K38/22 , A61K38/30 , A61L27/22 , A61P1/02 , A61P1/16 , A61P19/02 , A61P43/00 , C07K14/51 , C12N15/12 , C12P21/02 , C12R1/91
CPC分类号： C07K14/51 , A61K38/1875 , A61K38/30 , A61L27/227 , C07K2319/02 , Y10S530/84 , Y10S930/12
摘要： Purified Bone Morphogenetic Protein (BMP)-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair, and in hepatic growth and function.
摘要翻译： 公开了纯化骨形态发生蛋白（BMP）-9蛋白及其制备方法。 蛋白质可用于治疗骨和软骨缺损以及伤口愈合和相关组织修复以及肝脏生长和功能。
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公开(公告)号：US07365052B2
公开(公告)日：2008-04-29
申请号：US11154826
申请日：2005-06-17
申请人： Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人： Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
CPC分类号： C07K14/51 , A61K38/1875 , A61L27/227 , A61L27/386 , A61L27/54 , C07K2319/02
摘要： Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
摘要翻译： 公开了具有肌腱/类韧带组织诱导活性的蛋白质组成。 该组合物可用于治疗腱炎和腱或韧带缺陷以及相关组织修复。
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公开(公告)号：US06984623B2
公开(公告)日：2006-01-10
申请号：US10779635
申请日：2004-02-18
申请人： Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
发明人： Anthony J. Celeste , John M. Wozney , Vicki A. Rosen , Neil M. Wolfman , Gerald H. Thomsen , Douglas A. Melton
CPC分类号： C07K14/51 , A61K38/1875 , A61L27/227 , A61L27/386 , A61L27/54 , C07K2319/02
摘要： Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
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