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公开(公告)号：US06991901B2
公开(公告)日：2006-01-31
申请号：US10044564
申请日：2002-01-11
IPC分类号： C12Q1/68 , C12N15/63 , A61K31/711 , C07H21/04
CPC分类号： C07K16/18 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US06964849B2
公开(公告)日：2005-11-15
申请号：US10099322
申请日：2002-03-15
IPC分类号： A61K38/00 , A61K47/48 , C07K14/47 , C07K14/705 , C07K16/18 , C12N9/36 , C12Q1/68 , A61K31/711 , C07H21/04 , C12N15/63
CPC分类号： C12N9/2462 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , G01N33/6893
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US20060084054A1
公开(公告)日：2006-04-20
申请号：US10455772
申请日：2003-06-04
申请人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
发明人： John Alsobrook , David Anderson , Jason Baumgartner , Constance Berghs , Ferenc Boldog , Catherine Burgess , Stacie Casman , Elina Catterton , Mohanraj Dhanabal , Shlomit Edinger , Karen Ellerman , Seth Ettenberg , Esha Gangolli , Valerie Gerlach , Linda Gorman , William Grosse , Erik Gunther , Xiaojia Guo , Vladimir Gusev , John Herrmann , Weizhen Ji , Ramesh Kekuda , Nikolai Khramtsov , William LaRochelle , Li Li , Hongping Liang , Kenneth Low , John MacDougall , Timothy Maclachlan , Uriel Malyankar , Kelly McQueeney , Amanda Mezick , Charles Miller , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , John Peyman , Xiaozhong Qian , Luca Rastelli , Daniel Rieger , Mark Rothenberg , Suresh Shenoy , Richard Shimkets , Glennda Smithson , Kimberly Spytek , David Stone , Sujatha Sukumaran , Edward Szekeres , Corine Vernet , Edward Voss , Adam Wolenc , Mei Zhong , Haihong Zhong
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。 公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：US20060013813A1
公开(公告)日：2006-01-19
申请号：US11054281
申请日：2005-02-08
申请人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Frenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook , Denise Lepley , Daniel Rieger , Catherine Burgess , Sholmit Edinger , Edward Voss , Charles Miller
发明人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Frenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook , Denise Lepley , Daniel Rieger , Catherine Burgess , Sholmit Edinger , Edward Voss , Charles Miller
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , A61K39/395 , C07K14/705 , C07K16/18
CPC分类号： C12N9/2462 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , G01N33/6893
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US07141549B2
公开(公告)日：2006-11-28
申请号：US11054281
申请日：2005-02-08
申请人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Ferenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook, II , Denise Lepley , Daniel Rieger , Catherine Burgess , Shlomit Edinger , Edward Voss , Charles Miller
发明人： Peter Mezes , Luca Rastelli , John Herrmann , John MacDougall , Haihong Zhong , Stacie Casman , Ferenc Boldog , Richard Shimkets , Linda Gorman , Andrew Eisen , Steven Spaderna , Corine Vernet , Constance Berghs , Kimberly Spytek , Vincent DiPippo , Bryan Zerhusen , John Peyman , Karen Ellerman , David Stone , William Grosse , John Alsobrook, II , Denise Lepley , Daniel Rieger , Catherine Burgess , Shlomit Edinger , Edward Voss , Charles Miller
CPC分类号： C12N9/2462 , A61K38/00 , A61K47/6829 , A61K47/6851 , A61K47/6869 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K16/18 , G01N33/6893
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US07034132B2
公开(公告)日：2006-04-25
申请号：US10162335
申请日：2002-06-03
申请人： David W. Anderson , Jason C. Baumgartner , Ferenc L. Boldog , Stacie J. Casman , Shlomit R. Edinger , Esha A. Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John R. MacDougall , Uriel M. Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol E. A. Pena , Luca Rastelli , Richard A. Shimkets , David J. Stone , Kimberly A. Spytek , Corine A. M. Vernet , Edward Z. Voss , Bryan D. Zerhusen
发明人： David W. Anderson , Jason C. Baumgartner , Ferenc L. Boldog , Stacie J. Casman , Shlomit R. Edinger , Esha A. Gangolli , Valerie Gerlach , Linda Gorman , Xiaojia Guo , Tord Hjalt , Ramesh Kekuda , Li Li , John R. MacDougall , Uriel M. Malyankar , Isabelle Millet , Muralidhara Padigaru , Meera Patturajan , Carol E. A. Pena , Luca Rastelli , Richard A. Shimkets , David J. Stone , Kimberly A. Spytek , Corine A. M. Vernet , Edward Z. Voss , Bryan D. Zerhusen
摘要： Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US07109000B2
公开(公告)日：2006-09-19
申请号：US10087684
申请日：2002-03-01
申请人： Shlomit R. Edinger , John R. MacDougall , Isabelle Millet , Karen Ellerman , David J. Stone , Valerie Gerlach , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , Catherine E. Burgess , Stacie J. Casman , Kimberly A. Spytek , Ferenc L. Boldog , Li Li , Muralidhara Padigaru , Vishnu Mishra , Meera Patturajan , Suresh G. Shenoy , Luca Rastelli , Velizar T. Tchernev , Corine A. M. Vernet , Bryan D. Zerhusen , Uriel M. Malyankar , Xiaojia Guo , Charles E. Miller , Esha A. Gangolli
发明人： Shlomit R. Edinger , John R. MacDougall , Isabelle Millet , Karen Ellerman , David J. Stone , Valerie Gerlach , William M. Grosse , John P. Alsobrook, II , Denise M. Lepley , Daniel K. Rieger , Catherine E. Burgess , Stacie J. Casman , Kimberly A. Spytek , Ferenc L. Boldog , Li Li , Muralidhara Padigaru , Vishnu Mishra , Meera Patturajan , Suresh G. Shenoy , Luca Rastelli , Velizar T. Tchernev , Corine A. M. Vernet , Bryan D. Zerhusen , Uriel M. Malyankar , Xiaojia Guo , Charles E. Miller , Esha A. Gangolli
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/705
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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8.发明申请DIFFERENTIALLY EXPRESSED GENES INVOLVED IN ANGIOGENESIS, THE POLYPEPTIDES ENCODED THEREBY, AND METHODS OF USING THE SAME 审中-公开与生物降解有关的差异表达基因，编码的多肽及其使用方法公开(公告)号：US20080241835A1
公开(公告)日：2008-10-02
申请号：US11927609
申请日：2007-10-29
申请人： Fuad Mehraban , Mary Gerritsen , Luca Rastelli
发明人： Fuad Mehraban , Mary Gerritsen , Luca Rastelli
CPC分类号： C07K14/47 , A61K48/00 , C12N2799/026 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention is directed to nucleic acid sequences and the polypeptides encoded thereby that are differentially expressed in angiogenesis. Also provided are methods for stimulating or inhibiting angiogenesis in mammals, including humans. Pharmaceutical compositions based on polypeptides, agonists, or antagonists thereto are also provided. Additionally, the invention also provides methods for diagnosing and treating angiogenic disorders including, but not limited to, wound healing and cancer.
摘要翻译： 本发明涉及在血管发生中差异表达的核酸序列和由其编码的多肽。 还提供了用于刺激或抑制哺乳动物（包括人）中血管生成的方法。 还提供了基于多肽，激动剂或其拮抗剂的药物组合物。 另外，本发明还提供诊断和治疗血管生成障碍的方法，包括但不限于伤口愈合和癌症。
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公开(公告)号：US20080166724A1
公开(公告)日：2008-07-10
申请号：US11932133
申请日：2007-10-31
申请人： Hans-Peter Gerber , Luca Rastelli
发明人： Hans-Peter Gerber , Luca Rastelli
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/574
摘要： The present invention provides methods for modulating angiogenesis and/or apoptosis comprising modulating the activity of at least one VEGF-modulated gene polypeptide. The invention also provides pharmaceutical compositions for modulating angiogenesis and apoptosis for the prevention or treatment of diseases associated with VEGF-modulated genes expression. The invention also provides diagnostic assays that use VEGF-modulated gene polynucleotides that hybridize with naturally occurring sequences encoding VEGF-modulated genes and antibodies that specifically bind to the protein.The invention also provides novel human and mouse arginine-rich proteins (ARPs) and nucleotide sequences. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequence encoding ARPs and for a method for producing the protein.
摘要翻译： 本发明提供调节血管生成和/或凋亡的方法，包括调节至少一种VEGF调节的基因多肽的活性。 本发明还提供用于调节血管发生和凋亡以用于预防或治疗与VEGF调节的基因表达相关的疾病的药物组合物。 本发明还提供使用VEGF调节的基因多核苷酸的诊断测定法，其与编码VEGF调节的基因的天然存在的序列和与蛋白质特异性结合的抗体杂交。 本发明还提供新的人和小鼠富含精氨酸的蛋白质（ARP）和核苷酸序列。 本发明提供了基因工程表达载体和宿主细胞，其包含编码ARP的核酸序列和用于产生蛋白质的方法。
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10.发明申请公开(公告)号：US20050250178A1
公开(公告)日：2005-11-10
申请号：US10614599
申请日：2003-07-07
申请人： David Andrew , David Lewin , Diane Pennica , Luca Rastelli , Bruce Tallion
发明人： David Andrew , David Lewin , Diane Pennica , Luca Rastelli , Bruce Tallion
摘要： The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FCTRX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as to other uses.
摘要翻译： 本发明提供了称为FCTRX多肽的新型多肽，以及编码FCTRX多肽的多核苷酸和免疫特异性结合FCTRX或FCTRX多肽，多核苷酸或抗体的衍生物，变体，突变体或片段的抗体。 本发明还提供了FCTRX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。
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