公开(公告)号：US20060003465A1

公开(公告)日：2006-01-05

申请号：US11160617

申请日：2005-06-30

申请人： Tatyana Zhukov ,  Sergei Ostapenko ,  Rebecca Sutphen ,  Johnathan Lancaster ,  Thomas Sellers ,  Jin Zhang

发明人： Tatyana Zhukov ,  Sergei Ostapenko ,  Rebecca Sutphen ,  Johnathan Lancaster ,  Thomas Sellers ,  Jin Zhang

IPC分类号： G01N33/551

CPC分类号： B82Y15/00 ,  B82Y5/00 ,  B82Y10/00 ,  G01N33/57423 ,  G01N33/57449 ,  G01N33/588

摘要： Luminescent semiconductor quantum dots (QDs) conjugated with biomolecules to serve as sensitive probes for early detection of the cancer cells, specifically for ovarian cancer and lung cancer, which represents the most lethal malignancies. The luminescence characterization of the bin-conjugated QDs with cancer specific antigens using linkage molecules. Photo-enhancement is measured at various laser density power, temperatures and laser wavelengths.

摘要翻译： 与生物分子结合的发光半导体量子点（QDs）用作早期检测癌细胞的敏感探针，特别是代表最致命的恶性肿瘤的卵巢癌和肺癌。 使用连锁分子的具有癌症特异性抗原的bin结合的QD的发光表征。 在各种激光密度功率，温度和激光波长下测量光增强。

公开(公告)号：US09063143B2

公开(公告)日：2015-06-23

申请号：US12975970

申请日：2010-12-22

申请人： Johnathan Lancaster ,  Douglas C. Marchion ,  Dung-Tsa Chen

发明人： Johnathan Lancaster ,  Douglas C. Marchion ,  Dung-Tsa Chen

IPC分类号： G01N33/53 ,  G01N33/574

CPC分类号： G01N33/57449 ,  G01N33/57484 ,  G01N2800/52

摘要： The phosphorylation status of the BAD protein is a determinant of ovarian cancer cell responsiveness to platinum chemotherapy. Indirect manipulation of BAD phosphorylation status influences cisplatin sensitivity. BAD phosphorylation represents a biomarker that predicts platinum sensitivity and is a therapeutic target to increase platinum sensitivity. The methods employ phospho-specific antibody against a particular amino acid residue or site. Phospho-specific protein characterization methods include immunohistochemical (IHC), flow cytometric, immunofluorescent, capture-and-detection, or reversed phase assay.

摘要翻译： BAD蛋白的磷酸化状态是卵巢癌细胞对铂化疗反应的决定因素。 间接操作BAD磷酸化状态影响顺铂敏感性。 BAD磷酸化代表了预测铂敏感性的生物标志物，并且是增加铂敏感性的治疗靶标。 该方法使用针对特定氨基酸残基或位点的磷酸特异性抗体。 磷酸特异性蛋白质表征方法包括免疫组织化学（IHC），流式细胞术，免疫荧光，捕获和检测或反相测定。

公开(公告)号：US07655479B2

公开(公告)日：2010-02-02

申请号：US11160617

申请日：2005-06-30

申请人： Tatyana A. Zhukov ,  Sergei Ostapenko ,  Rebecca Sutphen ,  Johnathan Lancaster ,  Thomas A. Sellers ,  Jin Z. Zhang

发明人： Tatyana A. Zhukov ,  Sergei Ostapenko ,  Rebecca Sutphen ,  Johnathan Lancaster ,  Thomas A. Sellers ,  Jin Z. Zhang

IPC分类号： G01N33/551 ,  G01N33/553

CPC分类号： B82Y15/00 ,  B82Y5/00 ,  B82Y10/00 ,  G01N33/57423 ,  G01N33/57449 ,  G01N33/588

摘要： Luminescent semiconductor quantum dots (QDs) conjugated with biomolecules to serve as sensitive probes for early detection of the cancer cells, specifically for ovarian cancer and lung cancer, which represents the most lethal malignancies. The luminescence characterization of the bin-conjugated QDs with cancer specific antigens using linkage molecules. Photo-enhancement is measured at various laser density power, temperatures and laser wavelengths.

摘要翻译： 与生物分子结合的发光半导体量子点（QDs）用作早期检测癌细胞的敏感探针，特别是代表最致命的恶性肿瘤的卵巢癌和肺癌。 使用连锁分子的具有癌症特异性抗原的bin结合的QD的发光表征。 在各种激光密度功率，温度和激光波长下测量光增强。

公开(公告)号：US20070172844A1

公开(公告)日：2007-07-26

申请号：US11541165

申请日：2006-09-28

申请人： Johnathan Lancaster ,  Joseph Nevins

发明人： Johnathan Lancaster ,  Joseph Nevins

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G16B25/00 ,  G16H50/50 ,  Y02A90/26

摘要： The invention provides for compositions and methods for predicting an individual's responsitivity to cancer treatments and methods of treating cancer. In certain embodiments, the invention provides compositions and methods for predicting an individual's responsitivity to chemotherapeutics, including platinum-based chemotherapeutics, to treat cancers such as ovarian cancer. Furthermore, the invention provides for compositions and methods for predicting an individual's responsivity to salvage therapeutic agents. By predicting if an individual will or will not respond to platinum-based chemotherapeutics, a physician can reduce side effects and toxicity by administering a particular additional salvage therapeutic agent. This type of personalized medical treatment for ovarian cancer allows for more efficient treatment of individuals suffering from ovarian cancer. The invention also provides reagents, such as DNA microarrays, software and computer systems useful for personalizing cancer treatments, and provides methods of conducting a diagnostic business for personalizing cancer treatments.

摘要翻译： 本发明提供了用于预测个体对癌症治疗的反应性的组合物和方法以及治疗癌症的方法。 在某些实施方案中，本发明提供用于预测个体对化学治疗剂（包括基于铂的化学治疗剂）对治疗癌症如卵巢癌的反应性的组合物和方法。 此外，本发明提供了用于预测个体对救助治疗剂的反应性的组合物和方法。 通过预测个体是否会对铂类化疗药物反应，医师可以通过施用特定的补救治疗剂来减少副作用和毒性。 卵巢癌的这种个性化治疗方式可以更有效地治疗患有卵巢癌的个体。 本发明还提供了诸如DNA微阵列之类的试剂，用于个性化癌症治疗的软件和计算机系统，并且提供了用于个性化癌症治疗的诊断业务的方法。