公开(公告)号：US20060003465A1

公开(公告)日：2006-01-05

申请号：US11160617

申请日：2005-06-30

申请人： Tatyana Zhukov ,  Sergei Ostapenko ,  Rebecca Sutphen ,  Johnathan Lancaster ,  Thomas Sellers ,  Jin Zhang

发明人： Tatyana Zhukov ,  Sergei Ostapenko ,  Rebecca Sutphen ,  Johnathan Lancaster ,  Thomas Sellers ,  Jin Zhang

IPC分类号： G01N33/551

CPC分类号： B82Y15/00 ,  B82Y5/00 ,  B82Y10/00 ,  G01N33/57423 ,  G01N33/57449 ,  G01N33/588

摘要： Luminescent semiconductor quantum dots (QDs) conjugated with biomolecules to serve as sensitive probes for early detection of the cancer cells, specifically for ovarian cancer and lung cancer, which represents the most lethal malignancies. The luminescence characterization of the bin-conjugated QDs with cancer specific antigens using linkage molecules. Photo-enhancement is measured at various laser density power, temperatures and laser wavelengths.

摘要翻译： 与生物分子结合的发光半导体量子点（QDs）用作早期检测癌细胞的敏感探针，特别是代表最致命的恶性肿瘤的卵巢癌和肺癌。 使用连锁分子的具有癌症特异性抗原的bin结合的QD的发光表征。 在各种激光密度功率，温度和激光波长下测量光增强。

公开(公告)号：US20080166706A1

公开(公告)日：2008-07-10

申请号：US11396098

申请日：2006-03-30

申请人： Jin Zhang ,  Adam Schwartzberg ,  Thaddeus Norman ,  Tammy Y. Oshiro ,  Christian D. Grant ,  Rebecca Sutphen ,  Leo Seballos ,  Yi Zhang ,  Claire Gu

发明人： Jin Zhang ,  Adam Schwartzberg ,  Thaddeus Norman ,  Tammy Y. Oshiro ,  Christian D. Grant ,  Rebecca Sutphen ,  Leo Seballos ,  Yi Zhang ,  Claire Gu

IPC分类号： C12Q1/68 ,  C12M1/34 ,  G01N33/551

CPC分类号： G01N33/54346 ,  G01N21/658 ,  G01N33/54313 ,  G01N33/553 ,  G01N33/585 ,  G01N33/587 ,  G01N33/6854

摘要： The invention is drawn to novel gold nanoparticles that are used in a dual optical method for sensitive and selective detection of antigens. The gold nanoparticle aggregates are synthesized from gold hydrochloride and sulfur salts in an aqueous solution. The aggregates can be selectively sized using a spectral notch filter that results in an improved product with versatile uses. The gold nanoparticles can also be used in improved optical communications devices.

摘要翻译： 本发明涉及用于双光学方法中用于敏感和选择性检测抗原的新型金纳米颗粒。 金纳米颗粒聚集体由金盐酸盐和硫盐在水溶液中合成。 聚集体可以使用频谱陷波滤波器选择性地定尺寸，其产生具有通用用途的改进的产品。 金纳米颗粒也可用于改进的光通信设备中。

公开(公告)号：US20120142119A1

公开(公告)日：2012-06-07

申请号：US13199563

申请日：2011-09-03

申请人： Jin Zhang ,  Adam Schwartzberg ,  Thaddeus Norman ,  Tammy Y. Oshiro ,  Christian D. Grant ,  Rebecca Sutphen ,  Leo Seballos ,  Yi Zhang ,  Claire Gu

发明人： Jin Zhang ,  Adam Schwartzberg ,  Thaddeus Norman ,  Tammy Y. Oshiro ,  Christian D. Grant ,  Rebecca Sutphen ,  Leo Seballos ,  Yi Zhang ,  Claire Gu

IPC分类号： G01N21/65 ,  B82Y15/00

CPC分类号： G01N33/54346 ,  G01N21/658 ,  G01N33/54313 ,  G01N33/553 ,  G01N33/585 ,  G01N33/587 ,  G01N33/6854

摘要： The invention is drawn to a method of using nanoparticle aggregates to form sensors and optical filters. Properly sized (60 and 200 nm) nanoparticle aggregates with cores having a sulfur-oxygen molecular species and a shell with a surface in contact with the core are obtained. Those nanoparticle aggregates have a first resonance profile to wavelengths between 350 nm and 1075 nm. A modified resonance profile for those nanoparticle aggregates is determined. The nanoparticle aggregates are then selectively sized by irradiating them with electromagnetic energy at sufficient intensity and spectral content to modify the first resonance profile towards the modified resonance profile. The resulting nanoparticle aggregates can be used as sensors or optical filters at a selected wavelength.

摘要翻译： 本发明涉及使用纳米颗粒聚集体形成传感器和滤光器的方法。 获得具有硫 - 氧分子种类的芯和具有与芯接触的表面的壳的适当尺寸（60和200nm）纳米颗粒聚集体。 那些纳米颗粒聚集体具有在350nm和1075nm之间的波长的第一共振分布。 确定这些纳米颗粒聚集体的改性共振谱。 然后通过以足够的强度和光谱含量的电磁能照射纳米颗粒聚集体来选择性地调整纳米颗粒聚集体，以改变朝向修饰的共振分布的第一共振分布。 所得到的纳米颗粒聚集体可以用作选定波长的传感器或光学滤光器。

公开(公告)号：US20160153977A1

公开(公告)日：2016-06-02

申请号：US15018761

申请日：2016-02-08

申请人： Jin Zhang ,  Adam Scheartzberg ,  Thaddeus Norman ,  Tammy Oshiro ,  Christian D. Grant ,  Rebecca Sutphen ,  Leo Seballos ,  Yi Zhang

发明人： Jin Zhang ,  Adam Scheartzberg ,  Thaddeus Norman ,  Tammy Oshiro ,  Christian D. Grant ,  Rebecca Sutphen ,  Leo Seballos ,  Yi Zhang

IPC分类号： G01N33/543 ,  G01N21/65 ,  G01N33/58 ,  G01N33/553 ,  G01N33/68

CPC分类号： G01N33/54346 ,  G01N21/658 ,  G01N33/54313 ,  G01N33/553 ,  G01N33/585 ,  G01N33/587 ,  G01N33/6854

摘要： The invention is drawn to a method of using nanoparticle aggregates to form sensors and optical filters. Properly sized (60 and 200 nm) nanoparticle aggregates with cores having a sulfur-oxygen molecular species and a shell with a surface in contact with the core are obtained. Those nanoparticle aggregates have a first resonance profile to wavelengths between 350 nm and 1075 nm. A modified resonance profile for those nanoparticle aggregates is determined. The nanoparticle aggregates are then selectively sized by irradiating them with electromagnetic energy at sufficient intensity and spectral content to modify the first resonance profile towards the modified resonance profile. The resulting nanoparticle aggregates can be used as sensors or optical filters at a selected wavelength.

摘要翻译： 本发明涉及使用纳米颗粒聚集体形成传感器和滤光器的方法。 获得具有硫 - 氧分子种类的芯和具有与芯接触的表面的壳的适当尺寸（60和200nm）纳米颗粒聚集体。 那些纳米颗粒聚集体具有在350nm和1075nm之间的波长的第一共振分布。 确定这些纳米颗粒聚集体的改性共振谱。 然后通过以足够的强度和光谱含量的电磁能照射纳米颗粒聚集体来选择性地调整纳米颗粒聚集体，以改变朝向修饰的共振分布的第一共振分布。 所得到的纳米颗粒聚集体可以用作选定波长的传感器或光学滤光器。

公开(公告)号：US09297801B2

公开(公告)日：2016-03-29

申请号：US13199563

申请日：2011-09-03

申请人： Jin Zhang ,  Adam Schwartzberg ,  Thaddeus Norman ,  Tammy Y. Oshiro ,  Christian D. Grant ,  Rebecca Sutphen ,  Leo Seballos ,  Yi Zhang ,  Claire Gu

发明人： Jin Zhang ,  Adam Schwartzberg ,  Thaddeus Norman ,  Tammy Y. Oshiro ,  Christian D. Grant ,  Rebecca Sutphen ,  Leo Seballos ,  Yi Zhang ,  Claire Gu

IPC分类号： G01N33/553 ,  G01N33/543 ,  G01N33/58

CPC分类号： G01N33/54346 ,  G01N21/658 ,  G01N33/54313 ,  G01N33/553 ,  G01N33/585 ,  G01N33/587 ,  G01N33/6854

摘要： The invention is drawn to a method of using nanoparticle aggregates to form sensors and optical filters. Properly sized (60 and 200 nm) nanoparticle aggregates with cores having a sulfur-oxygen molecular species and a shell with a surface in contact with the core are obtained. Those nanoparticle aggregates have a first resonance profile to wavelengths between 350 nm and 1075 nm. A modified resonance profile for those nanoparticle aggregates is determined. The nanoparticle aggregates are then selectively sized by irradiating them with electromagnetic energy at sufficient intensity and spectral content to modify the first resonance profile towards the modified resonance profile. The resulting nanoparticle aggregates can be used as sensors or optical filters at a selected wavelength.

摘要翻译： 本发明涉及使用纳米颗粒聚集体形成传感器和滤光器的方法。 获得具有硫 - 氧分子种类的芯和具有与芯接触的表面的壳的适当尺寸（60和200nm）纳米颗粒聚集体。 那些纳米颗粒聚集体具有在350nm和1075nm之间的波长的第一共振分布。 确定这些纳米颗粒聚集体的改性共振谱。 然后通过以足够的强度和光谱含量的电磁能照射纳米颗粒聚集体来选择性地调整纳米颗粒聚集体，以改变朝向修饰的共振分布的第一共振分布。 所得到的纳米颗粒聚集体可以用作选定波长的传感器或光学滤光器。

公开(公告)号：US20240124610A1

公开(公告)日：2024-04-18

申请号：US18318232

申请日：2023-05-16

申请人： Nicole Maher ,  Christopher Maher ,  Andrew Nickless ,  Jin Zhang ,  Amy Ly ,  Jace Webster

发明人： Nicole Maher ,  Christopher Maher ,  Andrew Nickless ,  Jin Zhang ,  Amy Ly ,  Jace Webster

IPC分类号： C07K16/32 ,  A61K31/506 ,  A61P35/00 ,  C12Q1/6886

CPC分类号： C07K16/32 ,  A61K31/506 ,  A61P35/00 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

摘要： The present disclosure provides methods for treating a subject having a HER2 non-amplified (HER2-negative) cancer or low HER2 expressing (HER2-low) cancer, comprising detecting expression of a BCAR4 gene fusion in a biological sample from the subject. If expression of the BCAR4 gene fusion is detected, a HER2-targeted cancer treatment is administered to the subject; if expression of the BCAR4 gene fusion is not detected, a cancer treatment that is not HER2-targeted is administered to the subject. Methods of predicting response to a HER2-targeted cancer treatment and detecting BCAR4 or BCAR4 gene fusion activation are also provided.

公开(公告)号：US20240044907A1

公开(公告)日：2024-02-08

申请号：US17988832

申请日：2022-11-17

申请人： JIN ZHANG

发明人： Jin Zhang ,  Xianbin Wang

IPC分类号： G01N33/66

CPC分类号： G01N33/66

摘要： The present disclosure discloses a non-invasive wireless glucose level monitoring device. The device is fitted into a contact lens and can analyze glucose levels in tear fluid. The results of the analysis can be continuously transmitted to a nearby receiver and uploaded to a computer, mobile device or server.

公开(公告)号：US11215355B2

公开(公告)日：2022-01-04

申请号：US16607872

申请日：2018-03-30

申请人： Jin Zhang

发明人： Jin Zhang

IPC分类号： F22B3/06 ,  F24V40/00

摘要： The present invention discloses an air energy boiler and belongs to the technical field of energy conversion. A crankshaft of the boiler is fixed at the output end of a rotating unit. The crankshaft is provided with at least one bulge. A driving piston of each conversion assembly is arranged in an air cavity in a reciprocating motion. The driving piston divides the air cavity into a first cavity and a second cavity. A wrist pin is arranged in the second cavity, and the wrist pin is fixed and connected with the driving piston. Both ends of a piston rod is rotatably connected with the wrist pin and the corresponding bulge respectively. The first cavity is provided with an air intake. Multiple heating pipes are in communication with the first cavity at one end and stretch into the boiler body at the other end. The boiler body is sealed and stores water, and the boiler body is provided with a steam outlet, wherein the steam outlet of the boiler body is connected to various terminals through the use of pipelines. Since air is used as the heat source, no conditional limitations exist for installation, and it is safe to use and saves energy and electricity.

公开(公告)号：US11150349B2

公开(公告)日：2021-10-19

申请号：US16104129

申请日：2018-08-16

申请人： Wei Chen ,  Shan Zhong ,  Jin Zhang ,  Zhonghua Zhu ,  Lei Wu

发明人： Wei Chen ,  Shan Zhong ,  Jin Zhang ,  Zhonghua Zhu ,  Lei Wu

IPC分类号： G01S17/00 ,  G01S17/36 ,  G01S17/58 ,  G01S7/4911 ,  G01S7/4912

摘要： The present disclosure relates to a FMCW Light Detection and Ranging system, a wave train of carrier frequency is modulated in narrow-band sequence, an delay interferometer with in-phase and quadrature outputs extracts the phase of this frequency modulation, and a coherent receiver with in-phase and quadrature outputs detects the phase of reflected light from a remote object, the ratio between two phases determines the distance of the remote object.

公开(公告)号：US20210015659A1

公开(公告)日：2021-01-21

申请号：US16602473

申请日：2019-10-15

申请人： Kam Cham Lau ,  Jin Zhang

发明人： Kam Cham Lau ,  Jin Zhang

IPC分类号： A61F7/00 ,  A61F9/04

摘要： The therapeutic eye mask includes a multi-layer composite main body having a heater plate and a plurality of vibrators mounted therein. The heater plate is located over the wear's eyes when the mask is worn. The vibrators are located in upper locations relative to the heater plate. The heater plate and the vibrators are operated by a pulse control circuit and a timer which are operative by an electrical controller connected to an electrical supply with a USB connector. A space cloth plate and a plurality of magnet disks are provided in the main body. The electrical controller has a first switch operative to connect the eye mask to the electrical supply and a second switch is operative to facilitate the user in choosing selective massage motions to provide effective therapeutic operation.