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    Method of Biomolecule Immobilization On Polymers Using Click-Type Chemistry
    2.
    发明申请
    Method of Biomolecule Immobilization On Polymers Using Click-Type Chemistry 有权
    使用点击式化学的聚合物上生物分子固定的方法

    公开(公告)号：US20090297609A1

    公开(公告)日：2009-12-03

    申请号：US11988207

    申请日：2006-07-06

    Applicant: Molly S. Shoichet ,  Yumin Yuan ,  Meng Shi ,  Jordan Wosnick

    Inventor： Molly S. Shoichet ,  Yumin Yuan ,  Meng Shi ,  Jordan Wosnick

    IPC: A61K9/14 ,  A61K39/395 ,  A61K35/12 ,  A61K35/76 ,  A61K38/43 ,  A61K38/00 ,  A61K31/7088 ,  C08F18/24 ,  C08F24/00 ,  C08F116/02 ,  C08F20/58 ,  C07C43/00

    CPC classification number: C08G63/912 ,  A61K47/48907 ,  A61K47/6935 ,  C08G63/64 ,  C08G64/0241 ,  C08G64/42

    Abstract: The present invention provides a method for the covalent immobilization of biomolecules on polymers for delivery of the biomolecules, which has the advantage of being simple, highly efficient, environmentally friendly and free of side products relative to traditional immobilization techniques. The invention provides a modified micro/nanoparticle system, which uses a functionalized polymer formed into micro or nanoparticles to bind a molecule to the particles using uses facile chemistry, the Diels-Alder cycloaddition between a diene and a dienophile with the polymer being functionalized with one of them and the molecule with the other, or the Huisgen 1,3-dipolar cycloaddition between a terminal alkyne and an azide to bind the molecule to the particle. The molecules and/or other therapeutic agents may be encapsulated within the polymer particles for intravenous therapeutic delivery. The invention also provides a novel synthetic biodegradable polymer, a furan/alkyne-functionalized poly(trimethylene carbonate) (PTMC)-based polymer, whose composition can be designed to meet the defined physical and chemical property requirements. In one example, the particle system self-aggregates from functionalized PTMC-based copolymers containing poly(ethylene glycol) (PEG) segments. The composition of the copolymers can be designed to meet various particle system requirements, including size, thermodynamic stability, surface PEG density, drug encapsulation capacity and biomolecule immobilization capacity.

    Abstract translation: 本发明提供了生物分子共价固定在聚合物上用于递送生物分子的方法，其具有相对于传统固定技术简单，高效，环保且无副产物的优点。 本发明提供了一种修饰的微/纳米颗粒体系，其使用形成微米或纳米颗粒的官能化聚合物使用易于使用的化学方法将分子与颗粒结合，二烯与亲双烯体之间的Diels-Alder环加成与聚合物被一个官能化 的分子和另一个分子，或者在末端炔烃和叠氮化物之间的Huisgen 1,3-偶极环加成以将分子结合到颗粒。 分子和/或其它治疗剂可以包封在聚合物颗粒内用于静脉内治疗递送。 本发明还提供了一种新型的合成可生物降解聚合物，呋喃/炔官能化的聚（碳酸亚丙基酯）（PTMC）（PTMC））聚合物，其组合物可以被设计成满足规定的物理和化学性质要求。 在一个实例中，颗粒系统自聚集于含有聚（乙二醇）（PEG）链段的官能化的基于PTMC的共聚物。 共聚物的组成可以设计成满足各种颗粒系统的要求，包括尺寸，热力学稳定性，表面PEG密度，药物包封能力和生物分子固定能力。

    Method of biomolecule immobilization on polymers using click-type chemistry
    6.
    发明授权
    Method of biomolecule immobilization on polymers using click-type chemistry 有权
    使用点击式化学的聚合物上生物分子固定的方法

    公开(公告)号：US09290617B2

    公开(公告)日：2016-03-22

    申请号：US11988207

    申请日：2006-07-06

    Applicant: Molly S. Shoichet ,  Yumin Yuan ,  Meng Shi ,  Jordan Wosnick

    Inventor： Molly S. Shoichet ,  Yumin Yuan ,  Meng Shi ,  Jordan Wosnick

    IPC: A61K47/00 ,  C08G64/00 ,  C08G63/91 ,  C08G63/64 ,  C08G64/02 ,  C08G64/42 ,  A61K47/48

    CPC classification number: C08G63/912 ,  A61K47/48907 ,  A61K47/6935 ,  C08G63/64 ,  C08G64/0241 ,  C08G64/42

    Abstract: The present invention provides a method for the covalent immobilization of biomolecules on polymers for delivery of the biomolecules, which has the advantage of being simple, highly efficient, environmentally friendly and free of side products relative to traditional immobilization techniques. The invention provides a modified micro/nanoparticle system, which uses a functionalized polymer formed into micro or nanoparticles to bind a molecule to the particles using uses facile chemistry, the Diels-Alder cycloaddition between a diene and a dienophile with the polymer being functionalized with one of them and the molecule with the other, or the Huisgen 1,3-dipolar cycloaddition between a terminal alkyne and an azide to bind the molecule to the particle. The molecules and/or other therapeutic agents may be encapsulated within the polymer particles for intravenous therapeutic delivery. The invention also provides a novel synthetic biodegradable polymer, a furan/alkyne-functionalized poly(trimethylene carbonate) (PTMC)-based polymer, whose composition can be designed to meet the defined physical and chemical property requirements. In one example, the particle system self-aggregates from functionalized PTMC-based copolymers containing poly(ethylene glycol) (PEG) segments. The composition of the copolymers can be designed to meet various particle system requirements, including size, thermodynamic stability, surface PEG density, drug encapsulation capacity and biomolecule immobilization capacity.

    Abstract translation: 本发明提供了生物分子共价固定在聚合物上用于递送生物分子的方法，其具有相对于传统固定技术简单，高效，环保且无副产物的优点。 本发明提供了一种修饰的微/纳米颗粒体系，其使用形成微米或纳米颗粒的官能化聚合物，以使用易于使用的化学，二烯和亲二烯体之间的Diels-Alder环加成，聚合物被一个官能化 的分子和另一个分子，或者在末端炔烃和叠氮化物之间的Huisgen 1,3-偶极环加成以将分子结合到颗粒。 分子和/或其它治疗剂可以包封在聚合物颗粒内用于静脉内治疗递送。 本发明还提供了一种新型的合成可生物降解聚合物，呋喃/炔官能化的聚（碳酸亚丙基酯）（PTMC）（PTMC））聚合物，其组合物可以被设计成满足规定的物理和化学性质要求。 在一个实例中，颗粒系统自聚集于含有聚（乙二醇）（PEG）链段的官能化的基于PTMC的共聚物。 共聚物的组成可以设计成满足各种颗粒系统的要求，包括尺寸，热力学稳定性，表面PEG密度，药物包封能力和生物分子固定能力。

    Chemically patterned hydrogels, manufacture and use thereof
    7.
    发明授权
    Chemically patterned hydrogels, manufacture and use thereof 失效
    化学图案化水凝胶，其制造和使用

    公开(公告)号：US08629197B2

    公开(公告)日：2014-01-14

    申请号：US12082002

    申请日：2008-04-07

    Applicant: Molly Shoichet ,  Jordan Wosnick ,  Ryan Wylie

    Inventor： Molly Shoichet ,  Jordan Wosnick ,  Ryan Wylie

    IPC: C08F2/46 ,  C08J3/28 ,  G01N33/52 ,  C07D407/00

    CPC classification number: C07D311/16 ,  C08J3/28 ,  C08K5/205 ,  C08K5/3725 ,  Y02P20/55

    Abstract: A chemically patterned modified hydrogel formed from a modified hydrogel is provided. The hydrogel is conjugated with a multiphoton photocleavable molecule. The molecule has a multiphoton-labile protective group and a protected group. The protective group is cleavable upon multiphoton excitation to deprotect the protected group, without substantial polymerization of the hydrogel. The chemically patterned modified hydrogel is formed by exposing the modified hydrogel to multiphoton excitation to deprotect a portion of the protected groups.

    Abstract translation: 提供由改性水凝胶形成的化学图案化的改性水凝胶。 水凝胶与多光子可透光分子结合。 该分子具有多光子不稳定保护基团和受保护基团。 保护基团可以在多光子激发下切割，以使保护基团脱保护，而不会使水凝胶基本上聚合。 化学图案化的改性水凝胶通过将改性水凝胶暴露于多光子激发以使一部分受保护基团脱保护而形成。

    METHODS FOR APPLYING FLUORESCENT ULTRAVIOLET CURABLE VARNISHES
    8.
    发明申请
    METHODS FOR APPLYING FLUORESCENT ULTRAVIOLET CURABLE VARNISHES 审中-公开
    用于应用荧光超紫外线固化变性的方法

    公开(公告)号：US20090104373A1

    公开(公告)日：2009-04-23

    申请号：US11877319

    申请日：2007-10-23

    Applicant: Daryl W. VANBESIEN ,  Gabriel IFTIME ,  Gordon SISLER ,  Kurt I. HALFYARD ,  Jordan WOSNICK ,  T. Brian MCANENEY

    Inventor： Daryl W. VANBESIEN ,  Gabriel IFTIME ,  Gordon SISLER ,  Kurt I. HALFYARD ,  Jordan WOSNICK ,  T. Brian MCANENEY

    IPC: C08J7/18

    CPC classification number: B41M7/02 ,  B41M7/0045 ,  B41M7/0081 ,  G03G8/00

    Abstract: Disclosed is methods for applying a radiation curable fluorescent varnish to a document and authenticating the document via the radiation curable fluorescent varnish. The ultraviolet radiation curable fluorescent varnish comprising at least one curable monomer or oligomer, at least one photoinitiator, and at least one fluorescent material, wherein upon exposure to activating radiation, the fluorescent material fluoresces to cause a visible change in the appearance of the ultraviolet radiation curable fluorescent varnish. The methods include determining a location of printed portions of an image on a substrate and digitally printing the ultraviolet radiation curable fluorescent varnish onto the substrate in image registration only upon one or more portions of the determined printed portions on the substrate.

    Abstract translation: 公开了将可辐射固化的荧光漆施用于文件并通过可辐射固化的荧光漆进行认证的方法。 包含至少一种可固化单体或低聚物，至少一种光引发剂和至少一种荧光材料的紫外线辐射固化荧光漆，其中当暴露于活化辐射时，荧光材料发荧光，引起紫外线辐射的外观的可见变化 可固化荧光漆。 所述方法包括：在基板上确定图像的印刷部分的位置，并且仅在所确定的印刷部分的一个或多个部分上以图像配准将紫外线辐射固化荧光清漆数字打印到基板上。

    Chemically patterned hydrogels, manufacture and use thereof
    9.
    发明申请
    Chemically patterned hydrogels, manufacture and use thereof 失效
    化学图案化水凝胶，其制造和使用

    公开(公告)号：US20080286360A1

    公开(公告)日：2008-11-20

    申请号：US12082002

    申请日：2008-04-07

    Applicant: Molly Shoichet ,  Jordan Wosnick ,  Ryan Wylie

    Inventor： Molly Shoichet ,  Jordan Wosnick ,  Ryan Wylie

    IPC: A61K9/00 ,  A61K38/43 ,  A61K38/02 ,  A61K38/39 ,  A61K35/12 ,  A61K35/18 ,  C07D311/06

    CPC classification number: C07D311/16 ,  C08J3/28 ,  C08K5/205 ,  C08K5/3725 ,  Y02P20/55

    Abstract: A chemically patterned modified hydrogel formed from a modified hydrogel is provided. The hydrogel is conjugated with a multiphoton photocleavable molecule. The molecule has a multiphoton-labile protective group and a protected group. The protective group is cleavable upon multiphoton excitation to deprotect the protected group, without substantial polymerization of the hydrogel. The chemically patterned modified hydrogel is formed by exposing the modified hydrogel to multiphoton excitation to deprotect a portion of the protected groups.

    Abstract translation: 提供由改性水凝胶形成的化学图案化的改性水凝胶。 水凝胶与多光子可透光分子结合。 该分子具有多光子不稳定保护基团和受保护基团。 保护基团可以在多光子激发下切割，以使保护基团脱保护，而不会使水凝胶基本上聚合。 化学图案化的改性水凝胶通过将改性水凝胶暴露于多光子激发以使一部分受保护基团脱保护而形成。

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