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    Method of Biomolecule Immobilization On Polymers Using Click-Type Chemistry
    1.
    发明申请
    Method of Biomolecule Immobilization On Polymers Using Click-Type Chemistry 有权
    使用点击式化学的聚合物上生物分子固定的方法

    公开(公告)号：US20090297609A1

    公开(公告)日：2009-12-03

    申请号：US11988207

    申请日：2006-07-06

    Applicant: Molly S. Shoichet ,  Yumin Yuan ,  Meng Shi ,  Jordan Wosnick

    Inventor： Molly S. Shoichet ,  Yumin Yuan ,  Meng Shi ,  Jordan Wosnick

    IPC: A61K9/14 ,  A61K39/395 ,  A61K35/12 ,  A61K35/76 ,  A61K38/43 ,  A61K38/00 ,  A61K31/7088 ,  C08F18/24 ,  C08F24/00 ,  C08F116/02 ,  C08F20/58 ,  C07C43/00

    CPC classification number: C08G63/912 ,  A61K47/48907 ,  A61K47/6935 ,  C08G63/64 ,  C08G64/0241 ,  C08G64/42

    Abstract: The present invention provides a method for the covalent immobilization of biomolecules on polymers for delivery of the biomolecules, which has the advantage of being simple, highly efficient, environmentally friendly and free of side products relative to traditional immobilization techniques. The invention provides a modified micro/nanoparticle system, which uses a functionalized polymer formed into micro or nanoparticles to bind a molecule to the particles using uses facile chemistry, the Diels-Alder cycloaddition between a diene and a dienophile with the polymer being functionalized with one of them and the molecule with the other, or the Huisgen 1,3-dipolar cycloaddition between a terminal alkyne and an azide to bind the molecule to the particle. The molecules and/or other therapeutic agents may be encapsulated within the polymer particles for intravenous therapeutic delivery. The invention also provides a novel synthetic biodegradable polymer, a furan/alkyne-functionalized poly(trimethylene carbonate) (PTMC)-based polymer, whose composition can be designed to meet the defined physical and chemical property requirements. In one example, the particle system self-aggregates from functionalized PTMC-based copolymers containing poly(ethylene glycol) (PEG) segments. The composition of the copolymers can be designed to meet various particle system requirements, including size, thermodynamic stability, surface PEG density, drug encapsulation capacity and biomolecule immobilization capacity.

    Abstract translation: 本发明提供了生物分子共价固定在聚合物上用于递送生物分子的方法，其具有相对于传统固定技术简单，高效，环保且无副产物的优点。 本发明提供了一种修饰的微/纳米颗粒体系，其使用形成微米或纳米颗粒的官能化聚合物使用易于使用的化学方法将分子与颗粒结合，二烯与亲双烯体之间的Diels-Alder环加成与聚合物被一个官能化 的分子和另一个分子，或者在末端炔烃和叠氮化物之间的Huisgen 1,3-偶极环加成以将分子结合到颗粒。 分子和/或其它治疗剂可以包封在聚合物颗粒内用于静脉内治疗递送。 本发明还提供了一种新型的合成可生物降解聚合物，呋喃/炔官能化的聚（碳酸亚丙基酯）（PTMC）（PTMC））聚合物，其组合物可以被设计成满足规定的物理和化学性质要求。 在一个实例中，颗粒系统自聚集于含有聚（乙二醇）（PEG）链段的官能化的基于PTMC的共聚物。 共聚物的组成可以设计成满足各种颗粒系统的要求，包括尺寸，热力学稳定性，表面PEG密度，药物包封能力和生物分子固定能力。

    Open-ring copolymer, hydrogenated open-ring copolymer, process for production of both, and compositions
    4.
    发明申请
    Open-ring copolymer, hydrogenated open-ring copolymer, process for production of both, and compositions 有权
    开环共聚物，氢化开环共聚物，二者的生产方法和组合物

    公开(公告)号：US20040152843A1

    公开(公告)日：2004-08-05

    申请号：US10480002

    申请日：2004-03-09

    Inventor： Kazunori Taguchi ,  Yasuo Tsunogae ,  Hitomi Takeuchi ,  Yasuhiro Wakisaka ,  Kei Sakamoto

    IPC: C08F004/06 ,  C08F010/00 ,  C08F116/02

    CPC classification number: C08G61/06

    Abstract: A ring-opened metathesis copolymer and its hydrogenated product having a desired monomer unit ratio and a high molecular weight and having hydroxyl groups or hydroxycarbonyl groups can be obtained by conducting a ring-opening metathesis copolymerization of a norbornene-type monomer having hydroxyl groups or hydroxycarbonyl groups with an unsubstituted norbornene-type monomer having at least three rings in the presence of a catalyst predominantly comprised of an organic ruthenium compound having coordinated therewith a neutral electron-donating ligand, and, if desired, hydrogenating the resulting copolymer. The thus-obtained ring-opened metathesis copolymer and its hydrogenation product are characterized by having a low water absorption, good adhesion to metal and other materials, good compatibility with a curing agent and other compounds, and high heat resistance, and exhibiting reduced signal retardation and signal noise.

    Abstract translation: 通过进行具有羟基或羟基羰基的降冰片烯型单体的开环易位共聚，可以获得具有所需单体单元比和高分子量并具有羟基或羟基羰基的开环复分解共聚物及其氢化产物 具有至少三个环的未取代的降冰片烯型单体的基团在主要由与其配位有中性给电子配体的有机钌化合物组成的催化剂的存在下进行，并且如果需要，氢化所得共聚物。 由此获得的开环复分解共聚物及其氢化产物的特征在于具有低吸水性，对金属和其他材料的良好粘附性，与固化剂和其它化合物的良好相容性，以及高耐热性，并且表现出降低的信号延迟 和信号噪声。

    Preparation of polymer and resist composition
    8.
    发明申请
    Preparation of polymer and resist composition 审中-公开
    聚合物和抗蚀剂组合物的制备

    公开(公告)号：US20040260031A1

    公开(公告)日：2004-12-23

    申请号：US10868931

    申请日：2004-06-17

    Inventor： Takanobu Takeda ,  Osamu Watanabe ,  Jun Hatakeyama ,  Wataru Kasaki

    IPC: C08F016/02 ,  C08F116/02 ,  C08F216/02

    CPC classification number: G03F7/0392 ,  C08F12/22 ,  C08F12/24 ,  C08F212/14 ,  C09D125/18

    Abstract: A polymer comprising hydroxystyrene units and tert-alkoxycarbonylstyrene units is prepared by polymerizing an acetal group-blocked hydroxystyrene monomer and a tert-alkoxycarbonylstyrene monomer to form a preliminary polymer, and subjecting the preliminary polymer to selective deblocking reaction of acetal groups in the presence of an acid catalyst. The polymer thus produced has a narrower molecular weight distribution. A resist composition comprising the polymer as a base resin has advantages including a dissolution contrast of resist film, high resolution, exposure latitude, process flexibility, good pattern profile after exposure, and minimized line edge roughness.

    Abstract translation: 包含羟基苯乙烯单元和叔烷氧基羰基苯乙烯单元的聚合物是通过聚合缩醛基封端的羟基苯乙烯单体和叔烷氧基羰基苯乙烯单体以形成预聚合物制备的，并且在预聚物的存在下使预聚物进行缩醛基的选择性解封反应 酸催化剂。 由此制备的聚合物具有更窄的分子量分布。 包含聚合物作为基础树脂的抗蚀剂组合物具有抗蚀剂膜的溶解对比度，高分辨率，曝光宽容度，工艺柔韧性，曝光后的良好图案轮廓和最小化线边缘粗糙度的优点。

    Chelated polyhydroxstyrene for removing metal ions from aqueous and nonaqueous systems
    9.
    发明授权
    Chelated polyhydroxstyrene for removing metal ions from aqueous and nonaqueous systems 失效
    用于从水和非水系统中去除金属离子的螯合多羟基苯乙烯

    公开(公告)号：US6028120A

    公开(公告)日：2000-02-22

    申请号：US991033

    申请日：1997-12-15

    Applicant: M. Dalil Rahman ,  John Saukaitis ,  Robert E. Potvin ,  Mohammad Khadim

    Inventor： M. Dalil Rahman ,  John Saukaitis ,  Robert E. Potvin ,  Mohammad Khadim

    IPC: C08F8/28 ,  C08F8/30 ,  C08F116/02

    CPC classification number: C08F8/30

    Abstract: A process for producing a deionizing resin, which comprises reacting an organic compound having at least one reactive hydroxy group and at least one active chelating site with an organic polymer matrix having at least one reactive --OH or --NH.sub.2 group, and thereby producing a chelated.sub.-- polymer complex, as shown in FIG. II or FIG. IV: ##STR1## Washing the polymer complex with water, followed by washing with a mineral acid solution and then again washing with water and thereby reducing the level of sodium, iron and chromium ions in the polymer complex to less than 100 ppb each.

    Abstract translation: 一种用于生产去离子树脂的方法，其包括将具有至少一个反应性羟基的有机化合物和至少一个活性螯合位点与具有至少一个反应性-OH或-NH 2基团的有机聚合物基质反应，从而产生螯合的 - 聚合物复合物，如图1所示。 II或图 IV：用水洗涤聚合物配合物，然后用无机酸溶液洗涤，然后再次用水洗涤，从而降低聚合物络合物中的钠，铁和铬离子的水平，每个低于100ppb。

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