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    Method for measuring the activity of proteases
    1.
    发明授权
    Method for measuring the activity of proteases 失效
    测定蛋白酶活性的方法

    公开(公告)号：US08759019B2

    公开(公告)日：2014-06-24

    申请号：US12667960

    申请日：2008-07-07

    Applicant: Hans Werner Hofer ,  Hans Jorg Meier

    Inventor： Hans Werner Hofer ,  Hans Jorg Meier

    IPC: C12Q1/37

    CPC classification number: C12Q1/37 ,  G01N2333/96413

    Abstract: A method for determining the activity of proteases is provided. Fluorogenic substrates from which the fluorogen 7-amino-4-trifluoromethylcoumarin is eliminated proved to be particularly advantageous for the activity measurement. These substrates make it possible for measurement in microtiter plates with a fluorescence reader and thus for the fluorimetric determination of such enzyme activities in blood serum.

    Abstract translation: 提供了一种确定蛋白酶活性的方法。 消除氟7-氨基-4-三氟甲基香豆素的荧光底物证明对于活性测量是特别有利的。 这些底物使得可以用荧光读数器在微量滴定板中进行测量，并因此用于荧光测定血清中的这些酶活性。

    COMPRESSED AIR SUPPLY SYSTEM AND CONTROL METHOD
    3.
    发明申请
    COMPRESSED AIR SUPPLY SYSTEM AND CONTROL METHOD 有权
    压缩空气供应系统和控制方法

    公开(公告)号：US20130192681A1

    公开(公告)日：2013-08-01

    申请号：US13754214

    申请日：2013-01-30

    Applicant: Jorg MEIER

    Inventor： Jorg MEIER

    IPC: F17D1/02

    CPC classification number: F17D1/02 ,  B60G17/0523 ,  B60G17/0565 ,  B60G2500/2021 ,  B60G2500/204 ,  B60G2500/2044 ,  Y10T137/0324 ,  Y10T137/7761 ,  Y10T137/87249 ,  Y10T137/87917

    Abstract: A compressed air supply assembly for operating a pneumatic assembly includes a compressed air supply; a compressed air connection to the pneumatic assembly; a purge connection to the environment; a pneumatic main line between the compressed air supply and the compressed air connection comprising an air dryer; a purge line between the compressed air connection and the purge connection; and a solenoid valve arrangement with a control valve to control a purge valve. The control valve is connected to a control valve connection in a pneumatic control line connected to a pressure control connection of the purge valve; and the purge valve is connected to a purge valve connection in the purge line. A pressure-maintaining device is connected to the pneumatic control line and maintains control pressure at the pressure control connection when the purge valve connection is open, independently of pressure in the purge line and/or the main line.

    Abstract translation: 用于操作气动组件的压缩空气供应组件包括压缩空气供应; 与气动组件的压缩空气连接; 与环境的清除连接; 压缩空气供应和压缩空气连接之间的气动主线包括空气干燥器; 压缩空气连接和净化连接之间的净化管线; 以及具有控制阀以控制排气阀的电磁阀装置。 控制阀连接到与净化阀的压力控制连接相连接的气动控制线路中的控制阀连接; 并且净化阀连接到净化管线中的清洗阀连接。 压力保持装置连接到气动控制管线，并且当清洗阀连接打开时，与吹扫管线和/或主管线中的压力无关，保持压力控制连接处的控制压力。

    Transporting mechanism having a link chain and clamps
    5.
    发明申请
    Transporting mechanism having a link chain and clamps 失效
    具有连杆链和夹具的输送机构

    公开(公告)号：US20060283690A1

    公开(公告)日：2006-12-21

    申请号：US11510410

    申请日：2006-08-25

    Applicant: Jorg Meier ,  Jean-Claude Oppliger

    Inventor： Jorg Meier ,  Jean-Claude Oppliger

    IPC: B65G47/86

    CPC classification number: B65H29/003 ,  B65H29/04 ,  B65H2405/552 ,  B65H2405/5521

    Abstract: A transporting mechanism includes a link chain and clamps which are attached to a chain link of the link chain and which are capable of gripping at least one printed product. At least two clamps are attached to each chain link of the link chain, wherein the clamps in the link chain are spaced apart from one another by equal spacings.

    Abstract translation: 传送机构包括连接链和夹具，其连接到链节链的链节上并且能够夹持至少一个印刷品。 至少两个夹具连接到链节的每个链节上，其中链节链中的夹具彼此间隔开等间距。

    Apparatus for stapling sequential printed sheets positioned straddled one above the other
    6.
    发明授权
    Apparatus for stapling sequential printed sheets positioned straddled one above the other 失效
    用于装订顺序印刷的片材的装置，其被定位在另一个之上

    公开(公告)号：US5570832A

    公开(公告)日：1996-11-05

    申请号：US258834

    申请日：1994-06-13

    Applicant: Jorg Meier

    Inventor： Jorg Meier

    IPC: B42B4/00 ,  B42B4/02 ,  B42B9/04 ,  B42C19/04 ,  B65H5/32 ,  B27F7/17

    CPC classification number: B42B4/02

    Abstract: An apparatus for stapling printed sheets includes a conveying apparatus having a plurality of sequentially spaced, saddle-shaped supports. The printed sheets straddle the sequentially spaced supports. A shaping body is rotatingly disposed on a first axis, and receives and conveys a wire segment. A stapling head holder is rotatingly driven about a second axis parallel to the first axis. At least one stapling head is radially displaceably seated in a guide arrangement on the stapling head holder. The stapling head has a bending apparatus having an end with an opening forming a guide. The opening is penetrated by the shaping body for receiving the wire segment from the shaping body, and shaping the wire segment into a staple. The stapling head further has a driver that forces the staple through the printed sheets positioned on the supports. The driver and the staple are guided by the guide formed by the opening of the bending apparatus.

    Abstract translation: 用于装订打印纸的装置包括具有多个顺序间隔的鞍形支撑件的输送装置。 打印的纸张跨顺序间隔的支撑。 成形体旋转地设置在第一轴上，并且接收并传送线段。 装订头架围绕平行于第一轴线的第二轴旋转地驱动。 至少一个装订头可径向移动地安置在钉装置头上的引导装置中。 装订头具有弯曲装置，其具有形成导向件的开口的端部。 开口由成型体穿过，用于从成形体接收线段，并将线段成形为钉。 装订头还具有驱动器，该驱动器迫使订书钉穿过位于支撑件上的打印片材。 驱动器和订书钉由通过弯曲装置的开口形成的引导件引导。

    Method of collecting and subsequently stitching folded sheet-like printed products and arrangement for carrying out the method
    7.
    发明授权
    Method of collecting and subsequently stitching folded sheet-like printed products and arrangement for carrying out the method 失效
    收集和随后缝合折叠的片状印刷品的方法以及进行该方法的装置

    公开(公告)号：US5417410A

    公开(公告)日：1995-05-23

    申请号：US48459

    申请日：1993-04-14

    Applicant: Jorg Meier

    Inventor： Jorg Meier

    IPC: B42B4/02 ,  B27F7/17 ,  B42B4/00 ,  B42C1/12 ,  B65H37/04 ,  B31B1/68

    CPC classification number: B42C1/12 ,  B42B4/00 ,  B65H2405/352

    Abstract: A method and an arrangement for collecting and subsequently stitching folded sheet-like printed products. The method includes regularly feeding printed products to a conveying track. The arrangement has a plurality of supports for placing the printed products thereon, wherein the supports extend transversely of the conveying direction and are spaced apart in conveying direction. At least one feeder station is provided for the supports. A stitching apparatus is arranged in front of the end of the conveyor track. The conveyor track is driven by a bending means which engages the supports.

    Abstract translation: 用于收集和随后缝合折叠的片状印刷产品的方法和装置。 该方法包括将印刷产品定期地输送到输送轨道。 该装置具有用于将印刷产品放置在其上的多个支撑件，其中支撑件沿输送方向横向延伸并且沿传送方向间隔开。 为支撑件提供至少一个给料站。 在输送机履带的端部前方装有缝合装置。 输送机轨道由与支撑件接合的弯曲装置驱动。

    Measuring The Activity Of Proteases
    9.
    发明申请
    Measuring The Activity Of Proteases 失效
    测量蛋白酶的活性

    公开(公告)号：US20100267054A1

    公开(公告)日：2010-10-21

    申请号：US12667960

    申请日：2008-07-07

    Applicant: Hans Werner Hofer ,  Hans Jorg Meier

    Inventor： Hans Werner Hofer ,  Hans Jorg Meier

    IPC: G01N33/573 ,  C12M1/34

    CPC classification number: C12Q1/37 ,  G01N2333/96413

    Abstract: A method and apparatuses for determining the total content of proteases by means of measuring their enzyme activity after previous deinhibition is disclosed. In biological samples, lysosomal proteases are completely (e.g. in blood serum) or partly (e.g. in tissue homogenates) inhibited. A method proposed for the deinhibition entails immersing a solid support material (e.g. nylon or nitrocellulose) as plastic strip to which is linked, covalently or by adsorption, an inhibitor-binding substance which binds the inhibitor corresponding to the protease more strongly than the protease in the sample for measurement. After the deinhibition has taken place, the plastic strip is removed from the liquid sample for measurement, and the sample for measurement is passed on for measurement of the enzyme activity. Fluorogenic substrates from which the fluorogen 7-amino-4-trifluoromethylcoumarin is eliminated proved to be particularly advantageous for the activity measurement. These substrates make it possible for the sensitivity on measurement in microtitre plates with a fluorescence reader to be at least 10 times higher compared with conventional AMC substrates in blood serum, and thus for the fluorimetric determination of such enzyme activities in blood serum to be efficient with this measuring arrangement which is widely used in clinical laboratories.

    Abstract translation: 公开了一种通过测量其在先前禁忌后的酶活性来测定蛋白酶的总含量的方法和装置。 在生物样品中，溶酶体蛋白酶是完全的（例如在血清中）或部分（例如在组织匀浆中）被抑制。 提出用于去绝抑制的方法需要将固体支持材料（例如尼龙或硝化纤维素）作为塑料条浸渍，其通过共价或通过吸附连接抑制剂结合物质，其将对应于蛋白酶的抑制剂与蛋白酶相比更强 用于测量的样品。 脱胶后，从液体样品中取出塑料条，进行测定，测定酶活性。 消除氟7-氨基-4-三氟甲基香豆素的荧光底物证明对于活性测量是特别有利的。 这些底物使得在荧光阅读器的微量滴定板中的测量灵敏度与血清中的常规AMC底物相比至少高10倍，因此用于血液中这种酶活性的荧光测定是有效的 该测量装置广泛应用于临床实验室。

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