公开(公告)号：US20190194315A1

公开(公告)日：2019-06-27

申请号：US15737042

申请日：2016-06-17

Applicant: Tinya ABRAMS ,  Steven Bruce COHEN ,  Joseph Anthony D'Alessio ,  Jason Damiano ,  Clemens Durr ,  Bernhard Hubert GEIERSTANGER ,  Qi-Ying HU ,  Thomas HUBER ,  Hidetomo IMASE ,  Yunho JIN ,  Daniel MENEZES ,  Kathy MILLER ,  Morvarid MOHSENI ,  Weijia OU ,  Katherine RENDAHL ,  Tetsuo UNO ,  Yongqin WAN ,  Xing WANG

Inventor： Tinya ABRAMS ,  Steven Bruce COHEN ,  Joseph Anthony D'Alessio ,  Jason Damiano ,  Clemens Durr ,  Bernhard Hubert GEIERSTANGER ,  Qi-Ying HU ,  Thomas HUBER ,  Hidetomo IMASE ,  Yunho JIN ,  Daniel MENEZES ,  Kathy MILLER ,  Morvarid MOHSENI ,  Weijia OU ,  Katherine RENDAHL ,  Tetsuo UNO ,  Yongqin WAN ,  Xing WANG

IPC: C07K16/28 ,  A61K47/65 ,  A61K47/68 ,  A61P35/00 ,  A61K38/07

CPC classification number: C07K16/28 ,  A61K38/07 ,  A61K45/06 ,  A61K47/65 ,  A61K47/6803 ,  A61K47/6849 ,  A61K49/0058 ,  A61K51/10 ,  A61K2039/505 ,  A61P35/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments, particularly antibody drug conjugates comprising anti-P-cadherin antibodies conjugated to auristatin analogs. The invention also relates to methods of treating cancer using the antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

公开(公告)号：US20240252668A1

公开(公告)日：2024-08-01

申请号：US18286664

申请日：2022-04-15

Applicant: Anne-Sophie BLUEMMEL ,  Kathrin BUNTIN ,  Joseph Anthony D'ALESSIO ,  Liqiong FAN ,  Boris FESSLER ,  Doris GABRIEL ,  Dominik HAINZL ,  Keith HOFFMASTER ,  Shwetha IYER ,  Eshita KHERA ,  Eusebio Manchado ROBLES ,  Pierre MAUDENS ,  Dominik PISTORIUS ,  Roee RAMOT ,  Vincent ROMANET ,  Kuno WUERSCH ,  Padmaja YERRAMILLI-RAO ,  Novartis AG

Inventor： Liqiong Fan ,  Dominik Hainzl ,  Roee Ramot ,  Shwetha Iyer ,  Joseph Anthony D'Alessio ,  Kuno Wuersch ,  Dominik Pistorius ,  Eusebio Manchado Robles ,  Kathrin Buntin ,  Doris Gabriel ,  Boris Fessler ,  Pierre Maudens ,  Vincent Romanet ,  Anne-Sophie Bluemmel ,  Keith Hoffmaster ,  Eshita Khera ,  Padmaja Yerramilli-Rao

IPC: A61K47/68 ,  A61P35/00 ,  C07K11/02 ,  C07K14/47 ,  C07K16/28 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/18 ,  C12N15/52 ,  C12P21/02 ,  C12R1/01 ,  G01N33/574

CPC classification number: A61K47/6849 ,  A61K47/6811 ,  A61K47/6865 ,  A61P35/00 ,  C07K11/02 ,  C07K14/4722 ,  C07K16/28 ,  C12N9/0006 ,  C12N9/0073 ,  C12N9/18 ,  C12N9/93 ,  C12N15/52 ,  C12P21/02 ,  C12Y301/01001 ,  G01N33/57492 ,  C12R2001/01

Abstract: This application discloses microorganisms and methods of producing GNAQ/GNA11 inhibitors and methods of making antibody drug conjugates of anti-PMEL17 antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The disclosure also relates to formulations comprising antibody drug conjugates of anti-PMEL 17 antibodies or antigen binding fragments conjugated to a GNAQ/GNA1 inhibitor and methods of treating or preventing cancer using the formulations.