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公开(公告)号：US08633024B2
公开(公告)日：2014-01-21
申请号：US12039701
申请日：2008-02-28
CPC分类号： C12N5/0608 , A61K35/12 , C12N5/0018 , C12N5/0603 , C12N5/0606 , C12N5/0676 , C12N5/0679 , C12N15/1086 , C12N2500/90 , C12N2501/115 , C12N2501/119 , C12N2501/155 , C12N2501/16 , C12N2501/385 , C12N2501/415 , C12N2502/02 , C12N2502/13 , C12N2503/00 , C12N2506/02 , C12N2510/00 , C12Q1/6881 , C12Q2600/158
摘要： Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of endoderm cells, such as PDX1-positive foregut endoderm cells and PDX1-negative definitive endoderm cells, are also disclosed.
摘要翻译： 本文公开了包含PDX1阳性内胚层细胞的细胞培养物及其制备方法。 本文还公开了包含基本上纯化的PDX1阳性内胚层细胞的细胞群，以及从其它细胞类型富集，分离和纯化PDX1阳性内胚层细胞的方法。 还公开了能够促进内胚层细胞分化的分化因子如PDX1阳性前肠内胚层细胞和PDX1阴性定形内胚层细胞的方法。
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公开(公告)号：US08586357B2
公开(公告)日：2013-11-19
申请号：US12093590
申请日：2006-11-13
CPC分类号： A61K35/407 , A61K35/38 , C12N5/0603 , C12N5/0617 , C12N5/0672 , C12N5/068 , C12N2501/16 , C12N2501/415
摘要： Disclosed herein are reagent-cell complexes comprising one or more definitive endoderm cells. Also described herein are compositions for detecting definitive endoderm. Method of enriching, isolating and/or purifying definitive endoderm cells are also disclosed.
摘要翻译： 本文公开了包含一种或多种确定性内胚层细胞的试剂 - 细胞复合物。 本文还描述了用于检测确定性内胚层的组合物。 还公开了富集，分离和/或纯化定形内胚层细胞的方法。
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公开(公告)号：US20100272695A1
公开(公告)日：2010-10-28
申请号：US12765714
申请日：2010-04-22
申请人： Alan Agulnick , Kevin Allen D'Amour
发明人： Alan Agulnick , Kevin Allen D'Amour
CPC分类号： C12N5/0676 , C12N5/0678 , C12N2500/25 , C12N2501/11 , C12N2501/117 , C12N2501/15 , C12N2501/16 , C12N2501/385 , C12N2501/41 , C12N2501/70 , C12N2501/727 , C12N2506/45
摘要： Methods and cell culture compositions, in particular, pancreatic cell culture methods and compositions, derived from dedifferentiated human reprogrammed pluripotent stem cells, such as, induced pluripotent stem (iPS) cells.
摘要翻译： 方法和细胞培养组合物，特别是衍生自去分化的人重编程多能干细胞（如诱导多能干细胞（iPS））细胞的胰细胞培养方法和组合物。
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公开(公告)号：US20090298178A1
公开(公告)日：2009-12-03
申请号：US12132437
申请日：2008-06-03
申请人： Kevin Allen D'Amour
发明人： Kevin Allen D'Amour
IPC分类号： C12N5/06
CPC分类号： C12N5/0676 , C12N2501/115 , C12N2501/117 , C12N2501/15 , C12N2501/16 , C12N2501/19 , C12N2501/385 , C12N2501/41 , C12N2501/415 , C12N2501/70 , C12N2506/02
摘要： Disclosed herein are methods for generating endoderm lineage type cells derived from human pluripotent cells, such as human embryonic stem cells, by using various agents including, but not limited to, GDF8, GDF11 and GSK-3beta inhibitors. Also disclosed herein are endoderm lineage cell populations or compositions, such as populations or compositions comprising definitive endoderm and/or other definitive endoderm-derived cell types.
摘要翻译： 本文公开了通过使用各种试剂（包括但不限于GDF8，GDF11和GSK-3β抑制剂）来产生源自人多能细胞如人胚胎干细胞的内胚层谱系型细胞的方法。 本文还公开了内胚层谱系细胞群体或组合物，例如包含定形内胚层和/或其它确定性内胚层衍生细胞类型的种群或组合物。
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公开(公告)号：US08623645B2
公开(公告)日：2014-01-07
申请号：US12414482
申请日：2009-03-30
CPC分类号： C12N5/0606 , C12N5/0603 , C12N5/068 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/415 , C12N2502/13 , C12N2506/02
摘要： Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.
摘要翻译： 本文公开了包含定形内胚层细胞的细胞培养物及其制备方法。 本文还公开了包含基本上纯化的定形内胚层细胞的细胞群，以及用于从其它细胞类型富集，分离和纯化定形内胚层细胞的方法。
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公开(公告)号：US20090253202A1
公开(公告)日：2009-10-08
申请号：US12414482
申请日：2009-03-30
IPC分类号： C12N5/08
CPC分类号： C12N5/0606 , C12N5/0603 , C12N5/068 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/415 , C12N2502/13 , C12N2506/02
摘要： Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.
摘要翻译： 本文公开了包含定形内胚层细胞的细胞培养物及其制备方法。 本文还公开了包含基本上纯化的定形内胚层细胞的细胞群，以及用于从其它细胞类型富集，分离和纯化定形内胚层细胞的方法。
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公开(公告)号：US07541185B2
公开(公告)日：2009-06-02
申请号：US11165305
申请日：2005-06-23
CPC分类号： C12N5/0606 , A61K35/12 , C12N5/0018 , C12N5/0603 , C12N5/0676 , C12N5/0679 , C12N15/1086 , C12N2500/90 , C12N2501/115 , C12N2501/119 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/385 , C12N2501/415 , C12N2502/02 , C12N2502/13 , C12N2503/00 , C12N2506/02 , C12N2510/00 , C12Q1/6881 , C12Q2600/158 , G01N33/5023 , G01N33/5073 , G01N33/56966
摘要： Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which are capable of forming tissues and/or organs that are derived from the gut tube.
摘要翻译： 本文公开了鉴定一种或多种分化因子的方法，所述分化因子可用于将包含定形内胚层细胞的细胞群中的细胞分化成能够形成源自肠管的组织和/或器官的细胞。
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公开(公告)号：US09732318B2
公开(公告)日：2017-08-15
申请号：US13190390
申请日：2011-07-25
IPC分类号： C12N5/071 , C12N5/00 , C12N5/073 , C12N5/0735
CPC分类号： C12N5/0606 , C12N5/0603 , C12N2500/90 , C12N2501/115 , C12N2501/155 , C12N2501/16 , C12N2506/02
摘要： This disclosure relates to compositions comprising human preprimitive streak cells and/or human mesendoderm cells as well as methods for their production. Additionally, disclosed herein are methods of identifying factors useful in the further differentiation of preprimitive streak and mesendoderm cell types.
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公开(公告)号：US20170183623A9
公开(公告)日：2017-06-29
申请号：US13190390
申请日：2011-07-25
IPC分类号： C12N5/071
CPC分类号： C12N5/0606 , C12N5/0603 , C12N2500/90 , C12N2501/115 , C12N2501/155 , C12N2501/16 , C12N2506/02
摘要： This disclosure relates to compositions comprising human preprimitive streak cells and/or human mesendoderm cells as well as methods for their production. Additionally, disclosed herein are methods of identifying factors useful in the further differentiation of preprimitive streak and mesendoderm cell types.
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10.发明申请公开(公告)号：US20120276624A1
公开(公告)日：2012-11-01
申请号：US13544870
申请日：2012-07-09
IPC分类号： C12N5/071 , C12N5/0735
CPC分类号： C12N5/0606 , A61K35/12 , C12N5/0018 , C12N5/0603 , C12N5/0676 , C12N5/0679 , C12N15/1086 , C12N2500/90 , C12N2501/115 , C12N2501/119 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/385 , C12N2501/415 , C12N2502/02 , C12N2502/13 , C12N2503/00 , C12N2506/02 , C12N2510/00 , C12Q1/6881 , C12Q2600/158 , G01N33/5023 , G01N33/5073 , G01N33/56966
摘要： Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which are capable of forming tissues and/or organs that are derived from the gut tube.
摘要翻译： 本文公开了鉴定一种或多种分化因子的方法，所述分化因子可用于将包含定形内胚层细胞的细胞群中的细胞分化成能够形成源自肠管的组织和/或器官的细胞。
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