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公开(公告)号：US08623645B2
公开(公告)日：2014-01-07
申请号：US12414482
申请日：2009-03-30
CPC分类号： C12N5/0606 , C12N5/0603 , C12N5/068 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/415 , C12N2502/13 , C12N2506/02
摘要： Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.
摘要翻译： 本文公开了包含定形内胚层细胞的细胞培养物及其制备方法。 本文还公开了包含基本上纯化的定形内胚层细胞的细胞群，以及用于从其它细胞类型富集，分离和纯化定形内胚层细胞的方法。
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公开(公告)号：US08425928B2
公开(公告)日：2013-04-23
申请号：US13188706
申请日：2011-07-22
申请人： Laura Martinson , Chad Green , Evert Kroon , Alan Agulnick , Olivia Kelly , Emmanuel E. Baetge
发明人： Laura Martinson , Chad Green , Evert Kroon , Alan Agulnick , Olivia Kelly , Emmanuel E. Baetge
CPC分类号： A61L27/3804 , A01N1/0221 , A61F2/022 , A61K35/39 , A61K38/28 , A61K2035/126 , A61L27/14 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/62 , A61L2300/64 , A61M5/00 , A61M31/00 , A61M31/002 , A61M2202/07 , A61M2205/04 , C12N5/0676 , C12N5/0678 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/16 , C12N2501/19 , C12N2501/385 , C12N2501/41 , C12N2501/415 , C12N2506/02
摘要： The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
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公开(公告)号：US20090253202A1
公开(公告)日：2009-10-08
申请号：US12414482
申请日：2009-03-30
IPC分类号： C12N5/08
CPC分类号： C12N5/0606 , C12N5/0603 , C12N5/068 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/415 , C12N2502/13 , C12N2506/02
摘要： Disclosed herein are cell cultures comprising definitive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified definitive endoderm cells as well as methods for enriching, isolating and purifying definitive endoderm cells from other cell types.
摘要翻译： 本文公开了包含定形内胚层细胞的细胞培养物及其制备方法。 本文还公开了包含基本上纯化的定形内胚层细胞的细胞群，以及用于从其它细胞类型富集，分离和纯化定形内胚层细胞的方法。
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公开(公告)号：US07541185B2
公开(公告)日：2009-06-02
申请号：US11165305
申请日：2005-06-23
CPC分类号： C12N5/0606 , A61K35/12 , C12N5/0018 , C12N5/0603 , C12N5/0676 , C12N5/0679 , C12N15/1086 , C12N2500/90 , C12N2501/115 , C12N2501/119 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/385 , C12N2501/415 , C12N2502/02 , C12N2502/13 , C12N2503/00 , C12N2506/02 , C12N2510/00 , C12Q1/6881 , C12Q2600/158 , G01N33/5023 , G01N33/5073 , G01N33/56966
摘要： Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which are capable of forming tissues and/or organs that are derived from the gut tube.
摘要翻译： 本文公开了鉴定一种或多种分化因子的方法，所述分化因子可用于将包含定形内胚层细胞的细胞群中的细胞分化成能够形成源自肠管的组织和/或器官的细胞。
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公开(公告)号：US08633024B2
公开(公告)日：2014-01-21
申请号：US12039701
申请日：2008-02-28
CPC分类号： C12N5/0608 , A61K35/12 , C12N5/0018 , C12N5/0603 , C12N5/0606 , C12N5/0676 , C12N5/0679 , C12N15/1086 , C12N2500/90 , C12N2501/115 , C12N2501/119 , C12N2501/155 , C12N2501/16 , C12N2501/385 , C12N2501/415 , C12N2502/02 , C12N2502/13 , C12N2503/00 , C12N2506/02 , C12N2510/00 , C12Q1/6881 , C12Q2600/158
摘要： Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of endoderm cells, such as PDX1-positive foregut endoderm cells and PDX1-negative definitive endoderm cells, are also disclosed.
摘要翻译： 本文公开了包含PDX1阳性内胚层细胞的细胞培养物及其制备方法。 本文还公开了包含基本上纯化的PDX1阳性内胚层细胞的细胞群，以及从其它细胞类型富集，分离和纯化PDX1阳性内胚层细胞的方法。 还公开了能够促进内胚层细胞分化的分化因子如PDX1阳性前肠内胚层细胞和PDX1阴性定形内胚层细胞的方法。
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6.发明授权Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production 有权内分泌前体细胞，表达胰腺激素的细胞和生产方法公开(公告)号：US08129182B2
公开(公告)日：2012-03-06
申请号：US11681687
申请日：2007-03-02
申请人： Kevin A. D'Amour , Anne Bang , Emmanuel E. Baetge
发明人： Kevin A. D'Amour , Anne Bang , Emmanuel E. Baetge
CPC分类号： C12N5/0676 , A61K35/39 , C12N5/0678 , C12N2500/38 , C12N2501/10 , C12N2501/105 , C12N2501/115 , C12N2501/119 , C12N2501/12 , C12N2501/15 , C12N2501/16 , C12N2501/33 , C12N2501/335 , C12N2501/385 , C12N2501/41 , C12N2501/415 , C12N2501/42 , C12N2501/58 , C12N2501/734 , C12N2501/999 , C12N2506/02
摘要： Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.
摘要翻译： 本文公开了内分泌前体细胞，未成熟的表达胰腺激素的细胞和成熟的胰腺激素表达细胞的细胞培养物和富集的细胞群。 本文还公开了产生这种细胞培养物和细胞群体的方法。
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7.发明申请ENDOCRINE PRECURSOR CELLS, PANCREATIC HORMONE-EXPRESSING CELLS AND METHODS OF PRODUCTION 有权内切蛋白前体细胞，胰蛋白激素表达细胞和生产方法公开(公告)号：US20120034692A1
公开(公告)日：2012-02-09
申请号：US13275274
申请日：2011-10-17
申请人： Kevin A. D'Amour , Anne Bang , Emmanuel E. Baetge
发明人： Kevin A. D'Amour , Anne Bang , Emmanuel E. Baetge
IPC分类号： C12N5/071
CPC分类号： C12N5/0676 , A61K35/39 , C12N5/0678 , C12N2500/38 , C12N2501/10 , C12N2501/105 , C12N2501/115 , C12N2501/119 , C12N2501/12 , C12N2501/15 , C12N2501/16 , C12N2501/33 , C12N2501/335 , C12N2501/385 , C12N2501/41 , C12N2501/415 , C12N2501/42 , C12N2501/58 , C12N2501/734 , C12N2501/999 , C12N2506/02
摘要： Disclosed herein are cell cultures and enriched cell populations of endocrine precursor cells, immature pancreatic hormone-expressing cells and mature pancreatic hormone-expressing cells. Also disclosed herein are methods of producing such cell cultures and cell populations.
摘要翻译： 本文公开了内分泌前体细胞，未成熟的表达胰腺激素的细胞和成熟的胰腺激素表达细胞的细胞培养物和富集的细胞群。 本文还公开了产生这种细胞培养物和细胞群体的方法。
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8.发明申请公开(公告)号：US20100124564A1
公开(公告)日：2010-05-20
申请号：US12618659
申请日：2009-11-13
申请人： Laura Martinson , Chad Green , Evert Kroon , Alan Agulnick , Olivia Kelly , Emmanuel E. Baetge
发明人： Laura Martinson , Chad Green , Evert Kroon , Alan Agulnick , Olivia Kelly , Emmanuel E. Baetge
CPC分类号： A61L27/3804 , A01N1/0221 , A61F2/022 , A61K35/39 , A61K38/28 , A61K2035/126 , A61L27/14 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/252 , A61L2300/62 , A61L2300/64 , A61M5/00 , A61M31/00 , A61M31/002 , A61M2202/07 , A61M2205/04 , C12N5/0676 , C12N5/0678 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/16 , C12N2501/19 , C12N2501/385 , C12N2501/41 , C12N2501/415 , C12N2506/02
摘要： The present invention relates to methods for encapsulating pancreatic progenitors in a biocompatible semi-permeable encapsulating device. The present invention also relates to production of human insulin in a mammal in response to glucose stimulation.
摘要翻译： 本发明涉及将胰腺祖细胞包封在生物相容的半渗透包封装置中的方法。 本发明还涉及响应于葡萄糖刺激而在哺乳动物中生产人胰岛素。
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公开(公告)号：US08647873B2
公开(公告)日：2014-02-11
申请号：US11587735
申请日：2005-04-26
CPC分类号： C12N5/0603 , C12N5/0606 , C12N2501/115 , C12N2501/119 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/385 , C12N2501/415 , C12N2502/13 , C12N2506/02
摘要： Disclosed herein are cell cultures comprising PDX1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified PDX1-positive endoderm cells as well as methods for enriching, isolating and purifying PDX1-positive endoderm cells from other cell types. Methods of identifying differentiation factors capable of promoting the differentiation of endoderm cells, such as PDX1-positive foregut endoderm cells and PDX1-negative definitive endoderm cells, are also disclosed.
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公开(公告)号：US20110294211A1
公开(公告)日：2011-12-01
申请号：US13196381
申请日：2011-08-02
申请人： Kevin D'Amour , Emmanuel E. Baetge
发明人： Kevin D'Amour , Emmanuel E. Baetge
IPC分类号： C12N5/071
CPC分类号： C12N5/0672 , C12N5/067 , C12N2501/115 , C12N2501/119 , C12N2501/155 , C12N2506/02
摘要： Disclosed herein are methods for producing liver precursor cells as well as hepatocyte cells form pluripotent and/or multipotent cells. Also disclosed herein are methods of enriching isolating and/or purifying liver precursor cells and/or hepatocyte cells. Further disclosed are compositions comprising cell cultures and cell populations that are enriched for liver precursor cells or hepatocyte cells.
摘要翻译： 本文公开了用于产生肝前体细胞以及形成多潜能细胞和/或多能细胞的肝细胞细胞的方法。 本文还公开了富集分离和/或纯化肝前体细胞和/或肝细胞细胞的方法。 还公开了包含富含肝前体细胞或肝细胞细胞的细胞培养物和细胞群的组合物。
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