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    Polyisoprenylated benzophenones and their isomers as inhibitors of histone acetyltransferases and uses thereof
    1.
    发明授权
    Polyisoprenylated benzophenones and their isomers as inhibitors of histone acetyltransferases and uses thereof 失效
    聚异戊二烯基化二苯甲酮及其异构体作为组蛋白乙酰转移酶的抑制剂及其用途

    公开(公告)号：US07402706B2

    公开(公告)日：2008-07-22

    申请号：US10579219

    申请日：2004-11-04

    Applicant: Kundu Tapas Kumar ,  Karanam Balasubramanyam ,  Kempegowda Mantelingu ,  Altaf Mohammad ,  Venkatesh Swaminathan ,  A. Varier Radhika

    Inventor： Kundu Tapas Kumar ,  Karanam Balasubramanyam ,  Kempegowda Mantelingu ,  Altaf Mohammad ,  Venkatesh Swaminathan ,  A. Varier Radhika

    IPC: C07C49/00 ,  A61K31/12

    CPC classification number: C07C49/747 ,  C07C45/78 ,  C07C49/697 ,  C07C49/753 ,  C07C2602/24

    Abstract: In this patent we describe the purification of prenylated benzophenones from the fruit rinds of Garcinia species and its evaluation as an inhibitor for Histone acetyltransferases p300 and PCAF. We have found that prenylated benzophenones are potent HAT inhibitors of p300 (IC50-1 μM) and pCAF (IC50-15 μM). The inhibitors significantly repress the p300 HAT dependent transcriptional activation from in vitro assembled chromatin template but had no effect on transcription from DNA. These results suggest that the compounds could be specific to HATs. Thus these compounds should be useful as biological switching molecule for evaluating the role of p300 and PCAF in cellular functions and may be useful as new chemical entities for the development of anticancer drugs.

    Abstract translation: 在本专利中，我们描述了来自藤黄果实果皮的去甲基化二苯甲酮的纯化及其作为组蛋白乙酰转移酶p300和PCAF的抑制剂的评估。 我们已经发现，异戊二烯基化的二苯甲酮是p300（IC50μM-1μM）和pCAF（IC50-15μM）的有效HAT抑制剂。 抑制剂从体外组装的染色质模板显着抑制p300HAT依赖性转录激活，但对DNA的转录没有影响。 这些结果表明这些化合物可能是特异性的HATs。 因此，这些化合物应用作生物转换分子，用于评估p300和PCAF在细胞功能中的作用，可用作抗癌药物开发的新化学实体。

    Polyisoprenylated Benzophenones and Their Isomers as Inhibitors of Histone Acetyltransferases and Uses thereof
    2.
    发明申请
    Polyisoprenylated Benzophenones and Their Isomers as Inhibitors of Histone Acetyltransferases and Uses thereof 失效
    多异戊二烯基化二苯甲酮及其异构体作为组蛋白乙酰转移酶的抑制剂及其用途

    公开(公告)号：US20070254961A1

    公开(公告)日：2007-11-01

    申请号：US10579219

    申请日：2004-11-04

    Applicant: Kundu Tapas Kumar ,  Karanam Balasubramanyam ,  Kempegowda Mantelingu ,  Altaf Mohammad ,  Venkatesh Swaminathan ,  A. Radhika

    Inventor： Kundu Tapas Kumar ,  Karanam Balasubramanyam ,  Kempegowda Mantelingu ,  Altaf Mohammad ,  Venkatesh Swaminathan ,  A. Radhika

    IPC: A61K31/12 ,  C07C49/00

    CPC classification number: C07C49/747 ,  C07C45/78 ,  C07C49/697 ,  C07C49/753 ,  C07C2602/24

    Abstract: In this patent we describe the purification of prenylated benzophenones from the fruit rinds of Garcinia species and its evaluation as an inhibitor for Histone acetyltransferases p300 and PCAF. We have found that prenylated benzophenones are potent HAT inhibitors of p300 (IC50-1 μM) and pCAF (IC50-15 μM). The inhibitors significantly repress the p300 HAT dependent transcriptional activation from in vitro assembled chromatin template but had no effect on transcription from DNA. These results suggest that the compounds could be specific to HATs. Thus these compounds should be useful as biological switching molecule for evaluating the role of p300 and PCAF in cellular functions and may be useful as new chemical entities for the development of anticancer drugs.

    Abstract translation: 在本专利中，我们描述了来自藤黄果实果皮的去甲基化二苯甲酮的纯化及其作为组蛋白乙酰转移酶p300和PCAF的抑制剂的评估。 我们已经发现，异戊二烯基化的二苯甲酮是p300（IC50μM-1μM）和pCAF（IC50-15μM）的有效HAT抑制剂。 抑制剂从体外组装的染色质模板显着抑制p300HAT依赖性转录激活，但对DNA的转录没有影响。 这些结果表明这些化合物可能是特异性的HATs。 因此，这些化合物应用作生物转换分子，用于评估p300和PCAF在细胞功能中的作用，可用作抗癌药物开发的新化学实体。

    Soluble double metal salt of group IA and IIA of hydroxycitric acid, process of preparing the same and its use in beverages and other food products without effecting their flavor and properties
    3.
    发明授权
    Soluble double metal salt of group IA and IIA of hydroxycitric acid, process of preparing the same and its use in beverages and other food products without effecting their flavor and properties 有权

    公开(公告)号：US06395296B1

    公开(公告)日：2002-05-28

    申请号：US09637085

    申请日：2000-08-11

    Applicant: Karanam Balasubramanyam ,  Bhaskaran Chandrasekhar ,  Candadai Seshadri Ramadoss ,  Pillarisetti Venkata Subba Rao

    Inventor： Karanam Balasubramanyam ,  Bhaskaran Chandrasekhar ,  Candadai Seshadri Ramadoss ,  Pillarisetti Venkata Subba Rao

    IPC: C07C59265

    CPC classification number: C07C59/285 ,  C07C51/412

    Abstract: The present invention is directed to a new soluble double metal salt of group IA and IIA of (−) hydroxycitric acid of general formula I: where X is IA group metal: Li or Na or K or Rb or Cs or Fr where Y is IIA group metal: Be or Mg or Ca or Sr or Ba or Ra where the concentration of X in the salt varies from 1.5-51.0%, the concentration of Y in the salts varies from 2.0-50.9%, the concentration of HCA in the salt varies from 31.0-93.0% depending on the nature of X and Y. This invention more particularly relates to new soluble double metal salt of group IA and IIA of (−) hydroxycitric acid of general formula II. This invention also includes a process of preparing the soluble double metal salt of group IA and IIA of (−) hydroxycitric acid of general formula I comprising: preparing (−) hydroxycitric acid liquid concentrate/solid lactone of hyroxycitric acid from Garcinia extract, neutralizing the free (−) hydroxycitric acid present in the said (−) hydroxycitric acid liquid concentrate/solid lactone (−) hydroxycitric acid with group IA metal hydroxides, displacing partially the group IA metal ions in the above salt solutions by adding group IIA metal chlorides to form soluble double metal salt of group IA and IIA of (−) hydroxycitric acid, precipitating the said double metal salt of group IA & IIA of (−) hydroxycitric acid by adding aqueous polar solvent to get soluble IIA metal salt of (−) hydroxycitric acid or obtaining the soluble double metal salt as powder by spray drying prior to the solvent addition or spray drying water solubilized solvent precipitated material. The instant invention also discloses the use of the said soluble double metal salt of group IA and IIA of (−) hydroxycitric acid of formula I and particularly formula II in beverages and other food products and its use in beverages and other food products.

    Ion beam exposure of (g-Ge.sub.x -Se.sub.1-x) inorganic resists
    4.
    发明授权
    Ion beam exposure of (g-Ge.sub.x -Se.sub.1-x) inorganic resists 失效
    （g-Gex-Se1-x）无机抗蚀剂的离子束曝光

    公开(公告)号：US4405710A

    公开(公告)日：1983-09-20

    申请号：US276115

    申请日：1981-06-22

    Applicant: Karanam Balasubramanyam ,  Arthur L. Ruoff

    Inventor： Karanam Balasubramanyam ,  Arthur L. Ruoff

    IPC: G03F7/004 ,  G03F7/20 ,  G03C5/00

    CPC classification number: G03F7/20 ,  G03F7/0043 ,  Y10S430/136 ,  Y10S438/945 ,  Y10S438/949

    Abstract: This invention relates to thin (g-Ge.sub.x -Se.sub.1--x) positive ionresists and thin (g-Ge.sub.x -Se.sub.1--x) with absorbed or chemically bonded silver as a negative ionresist, which when exposed to H.sup.+ ion beams and subsequently developed, for example by alkaline solutions, have a useful differential dissolution rate, when comparing exposed and unexposed areas, with excellent resolution. The ionresist materials and processes of the invention are useful, for example, in forming solid-state electronic articles.

    Abstract translation: 本发明涉及具有吸收或化学键合的银作为负离子电阻的薄（g-Gex-Se1-x）正离子沉积剂和薄（g-Gex-Se1-x），当暴露于H +离子束并随后显影时， 例如通过碱性溶液，当比较曝光和未曝光区域时，具有很好的分辨率，具有优异的分辨率。 本发明的离子电阻材料和方法可用于例如形成固态电子制品。

    Soluble double metal salt of group IA and IIA of (-) hydroxycitric acid, process of preparing the same and its use in beverages and other food products without effecting their flavor and properties
    7.
    发明授权
    Soluble double metal salt of group IA and IIA of (-) hydroxycitric acid, process of preparing the same and its use in beverages and other food products without effecting their flavor and properties 失效

    公开(公告)号：US6160172A

    公开(公告)日：2000-12-12

    申请号：US59354

    申请日：1998-04-14

    Applicant: Karanam Balasubramanyam ,  Bhaskaran Chandrasekhar ,  Candadai Seshadri Ramadoss ,  Pillarisetti Venkata Subba Rao

    Inventor： Karanam Balasubramanyam ,  Bhaskaran Chandrasekhar ,  Candadai Seshadri Ramadoss ,  Pillarisetti Venkata Subba Rao

    IPC: C07C51/41 ,  C07C59/285 ,  C07C59/265

    CPC classification number: C07C59/285 ,  C07C51/412

    Abstract: The present invention is directed to a new soluble double metal salt of group IA and IIA of (-) hydroxycitric acid of general formula I:where X is IA group metal: Li or Na or K or Rb or Cs or Frwhere Y is IIA group metal: Be or Mg or Ca or Sr or Ba or Rawhere the concentration of X in the salt varies from 1.5-51.0%,the concentration of Y in the salts varies from 2.0-50.9%,the concentration of HCA in the salt varies from 31.0-93.0% depending on the nature of X and Y.This invention more particularly relates to new soluble double metal salt of group IA and IIA of (-) hydroxycitric acid of general formula II.This invention also includes a process of preparing the soluble double metal salt of group IA and IIA of (-) hydroxycitric acid of general formula I comprising: preparing (-) hydroxycitric acid liquid concentrate/solid lactone of hyroxycitric acid from Garcinia extract, neutralizing the free (-) hydroxycitric acid present in the said (-) hydroxycitric acid liquid concentrate/solid lactone (-) hydroxycitric acid with group IA metal hydroxides, displacing partially the group IA metal ions in the above salt solutions by adding group IIA metal chlorides to form soluble double metal salt of group IA and IIA of (-) hydroxycitric acid, precipitating the said double metal salt of group IA & IIA of (-) hydroxycitric acid by adding aqueous polar solvent to get soluble IIA metal salt of (-) hydroxycitric acid or obtaining the soluble double metal salt as powder by spray drying prior to the solvent addition or spray drying water solubilised solvent precipitated material.The instant invention also discloses the use of the said soluble double metal salt of group IA and IIA of (-) hydroxycitric acid of formula I and particularly formula II in beverages and other food products and its use in beverages and other food products.

    METHOD FOR FORMING AN ELECTRONIC DEVICE
    10.
    发明申请
    METHOD FOR FORMING AN ELECTRONIC DEVICE 失效
    形成电子设备的方法

    公开(公告)号：US20050095831A1

    公开(公告)日：2005-05-05

    申请号：US10701191

    申请日：2003-11-04

    Applicant: Karanam Balasubramanyam ,  Serge Biesemans ,  Byeongju Park

    Inventor： Karanam Balasubramanyam ,  Serge Biesemans ,  Byeongju Park

    IPC: H01L21/28 ,  H01L21/336 ,  H01L21/8238 ,  H01L29/49

    CPC classification number: H01L29/6656 ,  H01L21/28035 ,  H01L29/4925

    Abstract: Under the present invention, a layer of amorphous silicon is formed over a layer of gate dielectric. Over the layer of amorphous silicon, a gate cap dielectric is formed. The layer of amorphous silicon is then confined by at least one spacer, which is deposited under a low temperature process. Once the at least one spacer is in place, the amorphous silicon is exposed to a temperature sufficiently high to convert the amorphous silicon to polysilicon. By waiting until the amorphous silicon is confined within the at least one spacer before converting it to polysilicon, the variation in gate length is reduced

    Abstract translation: 在本发明的范围内，在栅绝缘层上形成非晶硅层。 在非晶硅层上形成栅极电介质。 然后将非晶硅层限制在至少一个在低温工艺下沉积的间隔物。 一旦至少一个间隔物就位，则非晶硅暴露于足够高的温度以将非晶硅转化为多晶硅。 通过等待直到非晶硅在将其转换成多晶硅之前被限制在至少一个间隔物内，则栅极长度的变化减小

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