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1.发明授权Methods of screening for pharmacologically active compounds for the treatment of tumour diseases 失效筛选用于治疗肿瘤疾病的药理活性化合物的方法公开(公告)号：US06383733B1
公开(公告)日：2002-05-07
申请号：US09155716
申请日：1999-02-16
申请人： Hartmut Beug , Martin Oft , Ernst Reichmann , Karl-Heinz Heider
发明人： Hartmut Beug , Martin Oft , Ernst Reichmann , Karl-Heinz Heider
IPC分类号： C12Q100
CPC分类号： A61K39/3955 , A61K38/179
摘要： Pharmaceutical compositions containing as active compound a substance which inhibits the activity of TGF&bgr; on tumour cells of epithelial origin, for the treatment of epithelial, invasive tumour diseases which are characterized by a reversible transition of the cells from an epithelial, non-invasive state into a fibroblastoid, invasive state. The pharmaceutical composition contains a TGF&bgr; inhibitor, preferably combined with an Ras inhibitor. Process for screening substances for the treatment of epithelial, invasive tumour diseases.
摘要翻译： 含有作为活性化合物的药物组合物，其抑制TGFbeta在上皮起源的肿瘤细胞上的活性，用于治疗上皮，浸润性肿瘤疾病，其特征在于细胞从上皮，非侵入状态向 成纤维细胞，侵袭状态。 药物组合物含有TGFbeta抑制剂，优选与Ras抑制剂组合。 筛选用于治疗上皮，侵袭性肿瘤疾病的物质的方法。
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公开(公告)号：US6010865A
公开(公告)日：2000-01-04
申请号：US564225
申请日：1996-06-03
申请人： Helmut Ponta , Karl-Heinz Heider , Peter Herrlich , Steven T. Pals , Peter Dall
发明人： Helmut Ponta , Karl-Heinz Heider , Peter Herrlich , Steven T. Pals , Peter Dall
IPC分类号： G01N33/53 , C07K14/705 , C07K16/28 , C12N15/09 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N33/574 , G01N33/577 , G01N33/68 , G01J33/53 , C07H21/02 , C07K16/00
CPC分类号： G01N33/57446 , C07K14/70585 , C07K16/2884 , C12Q1/6886 , G01N33/566 , G01N33/57411 , G01N33/57415 , G01N33/57419 , G01N33/57484 , G01N33/68 , C07K2317/34 , C12Q2600/112 , C12Q2600/118 , G01N2333/705 , G01N2333/70585
摘要： The invention relates to a process for diagnosing and analysing tumours which is based on detecting the expression of certain variant exons of the CD44-gene. Detection may be carried out at the protein or nucleic acid level. In a preferred embodiment the expression is detected in biopsy material using exon-specific antibodies. Thus, for example, v6-expression is a suitable prognostic parameter for breast cancer, the expression of a transitional epitope which is coded by exons v7 and v8 serves to diagnose cervical cancer.
摘要翻译： PCT No.PCT / EP94 / 01952 371日期：1996年6月3日 102（e）1996年6月3日PCT 1994年6月15日PCT公布。 公开号WO95 / 00851 日期1995年1月5日本发明涉及一种基于检测CD44-基因的某些变体外显子的表达的诊断和分析肿瘤的方法。 检测可以在蛋白质或核酸水平进行。 在优选的实施方案中，使用外显子特异性抗体在活检材料中检测表达。 因此，例如，v6-表达是乳腺癌的合适预后参数，由外显子v7和v8编码的过渡表位的表达用于诊断子宫颈癌。
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公开(公告)号：US20140010808A1
公开(公告)日：2014-01-09
申请号：US13974226
申请日：2013-08-23
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , A01K67/0275 , A01K2207/15 , A01K2217/072 , A01K2227/105 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/2896 , C07K16/3061 , C07K2317/24 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： Chimeric and humanized anti-CD37 antibodies and pharmaceutical compositions containing them are useful for the treatment of B cell malignancies and autoimmune and inflammatory diseases that involve B cells in their pathology.
摘要翻译： 嵌合和人源化抗CD37抗体和含有它们的药物组合物可用于治疗涉及B细胞病理学的B细胞恶性肿瘤和自身免疫性和炎性疾病。
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公开(公告)号：US20130287797A1
公开(公告)日：2013-10-31
申请号：US13870487
申请日：2013-04-25
申请人： Karl-Heinz HEIDER , Petra BLUM
发明人： Karl-Heinz HEIDER , Petra BLUM
IPC分类号： A61K39/395 , A61K31/4184
CPC分类号： A61K39/39558 , A61K31/4184 , A61K39/3955 , A61K2039/505 , A61K2039/545 , A61K2039/55 , C07K16/2896 , C07K2317/24 , A61K2300/00
摘要： The present invention relates to immunotherapies that are based on depletion of CD37-positive cells such as B-cells. The present invention provides methods for reduction of CD37-positive cells such as B-cells in an individual/patient using a combination of CD37 antibody/antibodies and bendamustine. The combination of CD37 antibodies and bendamustine is shown to have a synergistic effect. The application further provides materials and methods for treatment of diseases involving aberrant B-cell activity.
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5.发明授权Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them 有权对成纤维细胞活化蛋白和含有它们的免疫缀合物的抗体分子公开(公告)号：US08568727B2
公开(公告)日：2013-10-29
申请号：US12159070
申请日：2006-12-22
IPC分类号： A61K39/395 , C07K1/107 , C07K16/00
CPC分类号： C07K16/40 , A61K47/6803 , A61K47/6849 , A61K47/6871 , C07K2317/24 , C07K2317/33 , C07K2317/92
摘要： Anti-FAP-antibodies and immunoconjugates, pharmaceutical compositions containing such conjugates, and their use in cancer therapy.
摘要翻译： 抗FAP抗体和免疫偶联物，含有这些缀合物的药物组合物及其在癌症治疗中的应用。
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6.发明授权Antibodies to interleukin-like epithelial-mesenchymal transition inducer (ILEI) 有权白细胞介素样上皮间质转化诱导因子（ILEI）公开(公告)号：US07745585B2
公开(公告)日：2010-06-29
申请号：US10570448
申请日：2004-09-02
申请人： Andreas Zophel , Horst Johann Ahorn , Birgit Jung , Renate Konopitzky , Karl-Heinz Heider , Norbert Kraut , Peter Seither , Thomas Waerner , Hartmut Beug , Martin Jechlinger , Ido M. Tamir , Andreas Weith , Stefan Gruenert
发明人： Andreas Zophel , Horst Johann Ahorn , Birgit Jung , Renate Konopitzky , Karl-Heinz Heider , Norbert Kraut , Peter Seither , Thomas Waerner , Hartmut Beug , Martin Jechlinger , Ido M. Tamir , Andreas Weith , Stefan Gruenert
IPC分类号： C12P21/08 , C07K16/00 , A61K39/395 , A61K39/00
CPC分类号： C12N15/1136 , A61K38/00 , C07K14/52
摘要： The functional characterization of ILEI to be a novel cytokine involved in epithelial/mesenchymal transition and the identification of biologically active ILEI provides the basis for generating ILEI inhibitors, in particular anti-ILEI antibodies, that are useful in the therapy of cancer, fibrosis and COPD.
摘要翻译： ILEI作为参与上皮/间充质转化的新细胞因子的功能表征和生物活性ILEI的鉴定提供了产生ILEI抑制剂，特别是抗ILEI抗体的基础，其可用于治疗癌症，纤维化和COPD 。
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7.发明申请Antibody Molecules Specific for Fibroblast Activation Protein and Immunoconjugates Containing Them 有权成纤维细胞活化蛋白和含有免疫偶联物的抗体分子公开(公告)号：US20090304718A1
公开(公告)日：2009-12-10
申请号：US12159070
申请日：2006-12-22
IPC分类号： A61K39/395 , C07K16/00 , C07K1/107 , A61P35/00 , A61P37/00
CPC分类号： C07K16/40 , A61K47/6803 , A61K47/6849 , A61K47/6871 , C07K2317/24 , C07K2317/33 , C07K2317/92
摘要： Anti-FAP-antibodies and immunoconjugates, pharmaceutical compositions containing such conjugates, and their use in cancer therapy.
摘要翻译： 抗FAP抗体和免疫偶联物，含有这些缀合物的药物组合物及其在癌症治疗中的应用。
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公开(公告)号：US07417127B2
公开(公告)日：2008-08-26
申请号：US11136538
申请日：2005-05-25
申请人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John J. Miglietta , Augustinus Antonius Maria Silvester Van Dongen
发明人： Gunther Adolf , Elinborg Ostermann , Erik Patzelt , Marlies Sproll , Karl-Heinz Heider , John J. Miglietta , Augustinus Antonius Maria Silvester Van Dongen
IPC分类号： C12P21/08
CPC分类号： C07K16/2884 , A61K2039/505 , C07K2319/00 , C12N2799/021
摘要： The present invention belongs to the field of oncology. The invention relates to antibodies with specified sequence which are specific for an epitope which is coded by the variant exon v6 of the CD44 gene and to derivatives of said antibody. The invention also provides nucleic acid molecules encoding said antibody proteins. The invention furthermore pertains to methods for producing said antibody proteins. The invention also provides pharmaceutical compositions comprising said antibody proteins. The invention furthermore is concerned with the use in the manufacture of a medicament for the treatment of cancer.
摘要翻译： 本发明属于肿瘤学领域。 本发明涉及具有特定序列的抗体，其对于由CD44基因的变体外显子v6编码的表位和所述抗体的衍生物是特异性的。 本发明还提供编码所述抗体蛋白质的核酸分子。 本发明还涉及生产所述抗体蛋白质的方法。 本发明还提供包含所述抗体蛋白质的药物组合物。 本发明还涉及在制备用于治疗癌症的药物中的用途。
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公开(公告)号：US07361347B2
公开(公告)日：2008-04-22
申请号：US11173969
申请日：2005-07-01
IPC分类号： A61K39/395
CPC分类号： A61K47/6849 , A61K47/6803
摘要： The invention relates to novel conjugates of CD44 antibodies with cytotoxic compounds, pharmaceutical compositions comprising such compounds, and their use in tumor therapy.
摘要翻译： 本发明涉及CD44抗体与细胞毒性化合物的新型缀合物，包含这些化合物的药物组合物及其在肿瘤治疗中的用途。
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公开(公告)号：US20050271672A1
公开(公告)日：2005-12-08
申请号：US11173969
申请日：2005-07-01
IPC分类号： A61K47/48 , A61K39/395 , C07K16/46
CPC分类号： A61K47/6849 , A61K47/6803
摘要： The invention relates to novel conjugates of CD44 antibodies with cytotoxic compounds, pharmaceutical compositions comprising such compounds, and their use in tumor therapy.
摘要翻译： 本发明涉及CD44抗体与细胞毒性化合物的新型缀合物，包含这些化合物的药物组合物及其在肿瘤治疗中的用途。
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