公开(公告)号：US06855761B2

公开(公告)日：2005-02-15

申请号：US09553948

申请日：2000-04-21

申请人： Kazuaki Muranaka ,  Teruhiko Tsuda

发明人： Kazuaki Muranaka ,  Teruhiko Tsuda

IPC分类号： C08F2/22 ,  C08F265/04 ,  C08F265/06 ,  C08L33/08 ,  C08L33/10

CPC分类号： C08F265/06 ,  C08F265/04

摘要： Monodisperse particles having a particle diameter in the range of about from 1 to 1,000 μm; a process for easily producing the particles; a column for liquid chromatography which is packed with the particles; and a method of liquid chromatography which comprises using the column. The monodisperse particles are obtained by adding an aqueous emulsion containing a polymerizable monomer to monodisperse polymer seed particles comprising a poly((meth)acrylic ester) containing at least one kind of groups selected from the group consisting of straight-chain alkyl groups having 6 or more carbon atoms, alicyclic alkyl groups having 6 or more carbon atoms, phenyl groups, benzyl groups and halogenated alkyl groups having 3 or more carbon atoms to thereby swell the seed particles and then polymerizing the polymerizable monomer.

摘要翻译： 粒径在1〜1000μm左右的单分散粒子; 用于容易地生成颗粒的方法; 用于填充颗粒的液相色谱柱; 以及包括使用该柱的液相色谱法。 通过将含有可聚合单体的水性乳液加入到包含聚（（甲基）丙烯酸酯）的单分散聚合物种子颗粒中而获得单分散颗粒，所述聚合物种子颗粒含有至少一种选自下列的基团：直链烷基，其具有6或 具有6个或更多个碳原子的脂环族烷基，苯基，苄基和具有3个或更多个碳原子的卤代烷基，从而使种子颗粒溶胀，然后聚合可聚合单体。

公开(公告)号：US06689820B2

公开(公告)日：2004-02-10

申请号：US10051193

申请日：2002-01-22

申请人： Kazuaki Muranaka ,  Teruhiko Tsuda

发明人： Kazuaki Muranaka ,  Teruhiko Tsuda

IPC分类号： C08J520

CPC分类号： B01J41/20 ,  B01J41/13 ,  C08F8/32 ,  C08J5/20

摘要： An anion exchanger comprised of a fine particle having a cured polyethyleneimine surface layer formed on the fine particle surface. The cured polyethyleneimine surface layer is formed by the steps of: (1) dispersing a fine particle having a functional group capable of reacting with polyethyleneimine on the fine particle surface, in an aqueous solution of a crosslinking agent capable of crosslinking polyethyleneimine to prepare an aqueous dispersion of the fine particle; and then, (2) adding the polyethyleneimine and a catalyst for crosslinking the polyethyleneimine in the aqueous dispersion of the fine particle, and carrying a reaction of bonding the polyethyleneimine to the functional group on the fine particle surface and a reaction of crosslinking the polyethyleneimine with the crossslinking agent. The anion exchanger is used as a packing for chromatography.

摘要翻译： 一种阴离子交换剂，其由在微粒表面上形成的具有固化的聚乙烯亚胺表面层的细颗粒组成。 固化的聚乙烯亚胺表面层通过以下步骤形成：（1）将能够与聚乙烯亚胺反应的官能团的微粒分散在细颗粒表面上，在能够交联聚乙烯亚胺的交联剂的水溶液中， 微粒分散; 然后，（2）在该微粒子的水分散液中加入聚乙烯亚胺和交联聚乙烯亚胺的催化剂，并且将聚乙烯亚胺与微粒表面的官能团结合的反应和使聚乙烯亚胺与 交联剂。 阴离子交换剂用作色谱填料。

公开(公告)号：US06624205B2

公开(公告)日：2003-09-23

申请号：US10055921

申请日：2002-01-28

申请人： Kazuaki Muranaka

发明人： Kazuaki Muranaka

IPC分类号： C08J520

CPC分类号： B01J39/20 ,  B01J39/26

摘要： A cation exchanger comprised of a fine particle having bound to the surface thereof a polymer having a cation exchanging property, wherein said polymer is selected from (i) polymers prepared by polymerization of an unsaturated carboxylic acid and partially crosslinked with a polymer having a functional group capable of reacting with a carboxylic acid, and (ii) an acrylic acid-maleic acid copolymer. The cation exchanger is produced by the steps of: dispersing fine particles in a solution containing (i) a combination of a polymer prepared by polymerization of an unsaturated carboxylic acid, with a polymer having a functional group capable of reacting with a carboxylic acid, or (ii) an acrylic acid-maleic acid copolymer, to prepare a dispersion of fine particles; removing a liquid medium from the particle dispersion to separate a solid content; and then, heating the solid content in a dried state. The cation exchanger is useful as a packing for chromatography.

公开(公告)号：US20060084765A1

公开(公告)日：2006-04-20

申请号：US11247157

申请日：2005-10-12

申请人： Kazuaki Muranaka ,  Maho Yamanaka ,  Kosuke Araki

发明人： Kazuaki Muranaka ,  Maho Yamanaka ,  Kosuke Araki

IPC分类号： C08F20/56

CPC分类号： B01J39/26 ,  B01J20/261 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/285 ,  B01J41/20 ,  B01J43/00 ,  B01J2220/54 ,  C08F8/00 ,  C08F220/58

摘要： Crosslinked (meth)acrylamide particles in the form of substantially spherical fine particles having particle sizes of from 1 to 1000 μm made of a polymer of a N-alkoxymethyl(meth)acrylamide and a polyfunctional unsaturated monomer copolymerizable with the N-alkoxymethyl(meth)acrylamide, wherein the structural units derived from the N-alkoxymethyl(meth)acrylamide are crosslinked by a crosslink having a structure represented by the formula 1 (wherein X is hydrogen or a methyl group, and each of R8 and R9 is another structural unit derived from the N-alkoxymethyl(meth)acrylamide and bonded to the nitrogen atom in another structural unit derived from the N-alkoxymethyl(meth)acrylamide monomer via a methylene group).

摘要翻译： 交联的（甲基）丙烯酰胺颗粒，其形式为粒径为1-1000μm的基本上为球形的细颗粒，其由N-烷氧基甲基（甲基）丙烯酰胺的聚合物和可与N-烷氧基甲基（甲基）丙烯酸烷基酯共聚的多官能不饱和单体制成， 丙烯酰胺，其中衍生自N-甲氧基甲基（甲基）丙烯酰胺的结构单元通过具有由式1表示的结构的交联（其中X是氢或甲基，并且R SUB 8 >和R 9是来自N-烷氧基甲基（甲基）丙烯酰胺的另一结构单元，并且通过亚甲基与N-烷氧基甲基（甲基）丙烯酰胺单体衍生的另一结构单元中的氮原子键合 ）。

公开(公告)号：US07659348B2

公开(公告)日：2010-02-09

申请号：US11247157

申请日：2005-10-12

申请人： Kazuaki Muranaka ,  Maho Yamanaka ,  Kosuke Araki

发明人： Kazuaki Muranaka ,  Maho Yamanaka ,  Kosuke Araki

IPC分类号： C08F20/56 ,  C08C19/22 ,  G01N30/02 ,  B01D15/34

CPC分类号： B01J39/26 ,  B01J20/261 ,  B01J20/267 ,  B01J20/28004 ,  B01J20/285 ,  B01J41/20 ,  B01J43/00 ,  B01J2220/54 ,  C08F8/00 ,  C08F220/58

摘要： Crosslinked (meth)acrylamide particles in the form of substantially spherical fine particles having particle sizes of from 1 to 1000 μm made of a polymer of a N-alkoxymethyl(meth)acrylamide and a polyfunctional unsaturated monomer copolymerizable with the N-alkoxymethyl(meth)acrylamide, wherein the structural units derived from the N-alkoxymethyl(meth)acrylamide are crosslinked by a crosslink having a structure represented by the formula 1 (wherein X is hydrogen or a methyl group, and each of R8 and R9 is another structural unit derived from the N-alkoxymethyl(meth)acrylamide and bonded to the nitrogen atom in another structural unit derived from the N-alkoxymethyl(meth)acrylamide monomer via a methylene group).

摘要翻译： 交联的（甲基）丙烯酰胺颗粒，其形式为粒径为1-1000μm的基本上为球形的细颗粒，其由N-烷氧基甲基（甲基）丙烯酰胺和可与N-烷氧基甲基（甲基）丙烯酸烷基酯共聚的多官能不饱和单体制成， 丙烯酰胺，其中衍生自N-甲氧基甲基（甲基）丙烯酰胺的结构单元通过具有式1表示的结构的交联（其中X是氢或甲基，并且R 8和R 9各自是衍生自 由N-烷氧基甲基（甲基）丙烯酰胺和通过亚甲基与N-烷氧基甲基（甲基）丙烯酰胺单体衍生的另一结构单元中的氮原子结合）。