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    L-nucleic acid derivatives and process for the synthesis thereof
    3.
    发明授权
    L-nucleic acid derivatives and process for the synthesis thereof 有权
    L-核酸衍生物及其合成方法

    公开(公告)号：US07125983B2

    公开(公告)日：2006-10-24

    申请号：US10433004

    申请日：2001-11-29

    申请人： Hajime Iizuka ,  Kazuhiko Togashi ,  Tsuneji Suzuki

    发明人： Hajime Iizuka ,  Kazuhiko Togashi ,  Tsuneji Suzuki

    IPC分类号： C07H19/06 ,  C07H19/09

    CPC分类号： C07D498/04 ,  C07D498/14 ,  C07H9/06 ,  C07H19/06 ,  C07H19/073 ,  C07H19/09

    摘要： A novel method has been found to produce 2,2′-anhydro-1-(β-L-arabinofuranosyl)thymine as a novel useful intermediate compound. A novel method has been further found to produce thymidine from 2,2′-anhydro-1-(β-L-arabinofuranosyl)thymine. A novel method has been further found to L-2′-deoxyribose derivatives as a useful synthetic intermediate through L-2,2′-anhydro-5,6-dihydrocyclouridine derivative. According to these methods, synthesis of various L-nucleic acid derivatives, synthesis of which has been difficult till now.

    摘要翻译： 已经发现一种新的方法生产2,2'-脱水-1-（β-L-阿拉伯呋喃糖基）胸腺嘧啶作为新的有用的中间体化合物。 已经进一步发现一种从2,2'-脱水-1-（β-L-阿拉伯呋喃糖基）胸腺嘧啶产生胸苷的新方法。 通过L-2,2'-脱水-5,6-二氢环尿苷衍生物，进一步发现L-2'-脱氧核糖衍生物作为有用的合成中间体的新方法。 根据这些方法，合成各种L-核酸衍生物，其合成迄今难以实现。

    Process for production 2-deoxyaldose compound
    7.
    发明申请
    Process for production 2-deoxyaldose compound 审中-公开
    生产2-脱氧葡萄糖复合物的方法

    公开(公告)号：US20060069289A1

    公开(公告)日：2006-03-30

    申请号：US10537299

    申请日：2003-12-24

    申请人： Hideki Umetani ,  Hironori Komatsu ,  Tomoyuki Ando ,  Kazuhiko Togashi

    发明人： Hideki Umetani ,  Hironori Komatsu ,  Tomoyuki Ando ,  Kazuhiko Togashi

    IPC分类号： C07C45/51

    CPC分类号： C07D307/33 ,  C07H1/00 ,  C07H3/02

    摘要： A method for preparing 2-deoxyaldoses on an industrial scale in which the yield or the volumetric efficiency is excellent and the operation is simple, as compared to the conventionally known preparation method. In one aspect, a compound represented by a defined formula, such as 2-keto-3-deoxygluconic acid or the like, is reduced by the catalytic hydrogenation method using a metal, such as palladium or the like, or a compound such as 2-keto-3-deoxygluconic acid or the like is reduced by using a hydride reducing agent in a solvent of not more than 30 weight times the amount of the above compound, for synthesizing 2-keto-3-deoxyaldonic acid. The 2-keto-deoxyaldonic acid is decarboxylated to obtain 2-deoxyaldoses.

    摘要翻译： 与常规已知的制备方法相比，制备工业规模的2-脱氧葡萄糖的方法，其中产率或体积效率优异，操作简单。 在一个方面，通过使用金属如钯等的催化氢化方法或诸如2-酮-3-脱氧葡萄糖酸等化合物的方式，将由定义的式表示的化合物如2-酮-3-脱氧葡萄糖酸等还原， 通过在不超过上述化合物的30重量倍的溶剂的溶剂中使用氢化物​​还原剂来还原2-酮-3-脱氧果糖酸等，以合成2-酮-3-脱氧醛酸。 将2-酮 - 脱氧醛酸脱羧，得到2-脱氧葡萄糖。