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公开(公告)号：US5260214A
公开(公告)日：1993-11-09
申请号：US860019
申请日：1992-03-30
申请人： Kazutoh Takesako , Katsushige Ikai , Kazuo Shimanaka , Junko Yamamoto , Fumiyo Haruna , Teruya Nakamura , Hideyo Yamaguchi , Katsuhisa Uchida
发明人： Kazutoh Takesako , Katsushige Ikai , Kazuo Shimanaka , Junko Yamamoto , Fumiyo Haruna , Teruya Nakamura , Hideyo Yamaguchi , Katsuhisa Uchida
CPC分类号： C12R1/645 , C07K11/02 , A61K38/00 , Y10S435/911
摘要： An antibiotic R106 represented by the general formula I): ##STR1## wherein: R is methyl or ethyl;X.sub.1 is MePhe, .beta.-HOMePhe or Phe;X.sub.2 is allo-Ile, Val or Leu;X.sub.3 is MeVal or Val;X.sub.4 is .beta.-HOMeVal, .gamma.-HOMeVal, MeVal, Val, N,.beta.-MeAsp, .beta.-HOMePhe, MePhe, MeDH.sub.2,3 Val or MeDH.sub.3,4 Valis produced by a process which comprises culturing a strain of the genus Aureobasidium that is capable of producing the said antibiotic R106 and collecting the said antibiotic from the fermentation broth. The antibiotic R106 compounds are useful in the treatment of fungal infection.
摘要翻译： 由通式I）表示的抗生素R106：其中：R是甲基或乙基; X1是MePhe，β-HOMePhe或Phe; X2是异亮氨酸，Val或Leu; X3是MeVal或Val; X4是β-HOMeVal，γ-HOMeVal，MeVal，Val，N，β-MeAsp，β-HOMePhe，MePhe，MeDH2,3Val或MeDH3,4Val是通过包括培养能够产生的Aureobasidium属的菌株 生产所述抗生素R106并从发酵液中收集所述抗生素。 抗生素R106化合物可用于治疗真菌感染。
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公开(公告)号：US5057493A
公开(公告)日：1991-10-15
申请号：US379629
申请日：1989-07-13
申请人： Kazutoh Takesako , Katsushige Ikai , Kazuo Shimanaka , Junko Yamamoto , Fumiyo Haruna , Teruya Nakamura , Hideyo Yamaguchi , Katsuhisa Uchida
发明人： Kazutoh Takesako , Katsushige Ikai , Kazuo Shimanaka , Junko Yamamoto , Fumiyo Haruna , Teruya Nakamura , Hideyo Yamaguchi , Katsuhisa Uchida
摘要： An antibiotic R106 represented by the general formula (I): ##STR1## wherein: R is methyl or ethyl;X.sub.1 is MePhe, .beta.-HOMePhe or Phe;X.sub.2 is allo-Ile, Val or Leu;X.sub.3 is MeVal or Val;X.sub.4 is .beta.-HOMeVal, .gamma.-HOMeVal, MeVal, Val, N,.beta.-MeAsp, .beta.-HOMePhe, MePhe, MeDH.sub.2,3 Val or MeDH.sub.3,4 Valis produced by a process which comprises culturing a strain of the genus Aureobasidium that is capable of producing the said antibiotic R106 and collecting the said antibiotic from the fermentation broth. The antibiotic R106 compounds are useful in the treatment of fungal infection.
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公开(公告)号：US5200505A
公开(公告)日：1993-04-06
申请号：US643948
申请日：1991-01-22
申请人： Kazutoh Takesako , Katsushige Ikai , Kazuo Shimanaka , Junko Yamamoto , Fumiyo Haruna , Teruya Nakamura , Hideyo Yamaguchi , Katsuhisa Uchida
发明人： Kazutoh Takesako , Katsushige Ikai , Kazuo Shimanaka , Junko Yamamoto , Fumiyo Haruna , Teruya Nakamura , Hideyo Yamaguchi , Katsuhisa Uchida
IPC分类号： C12N1/14 , A61K38/00 , A61P31/04 , C07K1/20 , C07K7/06 , C07K11/02 , C07K14/195 , C07K14/37 , C07K14/41 , C12P21/02 , C12R1/645
CPC分类号： C07K11/02
摘要： There are provided R106 compounds represented by the following general formula (I): ##STR1## wherein: A.sub.1 is Phe, o-FPhe, m-FPhe, or Tyr;A.sub.2 is MePhe, o-FMePhe, m-FMePhe, MeTyr, Sar, MeSery, or .beta.-oxoMePhe;A.sub.3 is Pro, 4Hyp, or SPro;A.sub.4 is allo-Ile or Nle;A.sub.5 is Leu or Nva;A.sub.6 is .beta.-HOMeVal or Sar;excluding those wherein A.sub.1 is Phe and A.sub.2 is MePhe and A.sub.3 is Pro and A.sub.4 is allo-Ile and A.sub.5 is Leu and A.sub.6 is .beta.-HOMeVal (SEQ ID No. 4), which are useful as therapeutic agents for fungal infection.
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4.发明授权Process for the production of antibiotic R106 by a strain of Aureobasidium pullulans 失效抗生素R106的制备方法，由抗生素短杆菌（Aureobasidium pullulans）生产
公开(公告)号：US5158876A
公开(公告)日：1992-10-27
申请号：US657811
申请日：1991-02-02
申请人： Kazutoh Takesako , Katsushige Ikai , Kazuo Shimanaka , Junko Yamamoto , Fumiyo Haruna , Teruya Nakamura , Hideyo Yamaguchi , Katsuhisa Uchida
发明人： Kazutoh Takesako , Katsushige Ikai , Kazuo Shimanaka , Junko Yamamoto , Fumiyo Haruna , Teruya Nakamura , Hideyo Yamaguchi , Katsuhisa Uchida
摘要： An antibiotic R106 represented by the general formula (I): ##STR1## wherein: R is methyl or ethyl;X.sub.1 is MePhe, .beta.-HOMePhe or Phe;X.sub.2 is allo-Ile, Val or Leu;X.sub.3 is MeVal or Val;X.sub.4 is .beta.-HOMeVal, .gamma.HOMeVal, MeVal, Val, N,.beta.-MeAsp, .beta.-HOMePhe, MePhe, MeDH.sub.2,3 Val or MeDH.sub.3,4 Valis produced by a process which comprises culturing a strain of the genus Aureobasidium that is capable of producing the said antibiotic R106 and collecting the said antibiotic from the fermentation broth. The antibiotic R106 compounds are useful in the treatment of fungal infection.
摘要翻译： 由通式（I）表示的抗生素R106：其中：R是甲基或乙基; X1是MePhe，β-HOMePhe或Phe; X2是异亮氨酸，Val或Leu; X3是MeVal或Val; X4是β-HOMeVal，γHOMeVal，MeVal，Val，N，β-MeAsp，β-HOMePhe，MePhe，MeDH2,3Val或MeDH3,4Val是通过包括培养能够产生的Aureobasidium属的菌株 产生所述抗生素R106并从发酵液中收集所述抗生素。 抗生素R106化合物可用于治疗真菌感染。
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公开(公告)号：US06337410B2
公开(公告)日：2002-01-08
申请号：US09731041
申请日：2000-12-07
IPC分类号： C07D31500
CPC分类号： C07D313/00 , C12P17/08
摘要： The present invention has its object to provide a noble antifungal substance which is use of as clinical medicine in the therapy of fungal infectious diseases. The present invention is related to an antibiotic TKR459 having the following chemical formula (1) or its pharmacologically acceptable salt.
摘要翻译： 本发明的目的是提供一种在真菌感染性疾病的治疗中用作临床药物的贵重抗真菌物质。本发明涉及具有以下化学式（1）或其药理学上可接受的盐的抗生素TKR459。
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公开(公告)号：US4703128A
公开(公告)日：1987-10-27
申请号：US885818
申请日：1986-07-18
IPC分类号： C07D493/08 , A61K31/357 , A61K31/365 , A61P31/04 , A61P31/10 , C07D313/00 , C07D315/00 , C07D321/00 , C07H19/01 , C07D325/00
CPC分类号： C07D315/00 , C07H19/01
摘要： The feature of the present invention is a process for preparing compounds represented by general formula (Ia) described below: ##STR1## wherein X.sub.1, X.sub.2, X.sub.3, R.sub.1, R.sub.2, R.sub.3 and R.sub.7 are as defined in formula (I) and R.sub.10 represents a lower alkyl group, or acid salts thereof, which process is characterized by using the guanidylfungins (II) as raw materials, reacting these guanidylfungins with alcohols (III) in the presence of an acid catalyst, and then hydrolyzing the malonic acid monoester (IV).
摘要翻译： 本发明的特征是制备下述通式（Ia）表示的化合物的方法：其中X 1，X 2，X 3，R 1，R 2，R 3和R 7如式（I）中所定义， R10表示低级烷基或其酸式盐，该方法的特征在于使用胍基生物素（II）作为原料，在酸催化剂存在下使这些胍基生物素与醇（III）反应，然后水解丙二酸 单酯（IV）。
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公开(公告)号：US20080069829A1
公开(公告)日：2008-03-20
申请号：US11116371
申请日：2005-04-28
申请人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译： 从马拉色氏菌属真菌的基本上纯的，分离的抗原性蛋白质，其特征在于所述抗原蛋白质具有与过敏原患者的IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。 根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。 此外，可以提供用于马拉色氏菌过敏原的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。
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公开(公告)号：US06911208B2
公开(公告)日：2005-06-28
申请号：US10109670
申请日：2002-04-01
申请人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
IPC分类号： A61K38/00 , C07K14/37 , C07K16/14 , C12N15/31 , C12P21/08 , A61K39/35 , A61K39/36 , C12N21/04 , C12N21/06
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergies; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergies, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译： 一种基本上纯的，分离的抗原蛋白，其来源于马拉色氏菌属的真菌，其特征在于所述抗原蛋白具有与过敏患者IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。 根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。 此外，可以提供用于马拉色氏菌过敏症的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。
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公开(公告)号：US06432407B1
公开(公告)日：2002-08-13
申请号：US09091097
申请日：1998-06-12
申请人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人： Kazutoh Takesako , Takashi Okado , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
IPC分类号： A61K3900
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译： 从马拉色氏菌属真菌的基本上纯的，分离的抗原性蛋白质，其特征在于所述抗原蛋白质具有与过敏原患者的IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。 根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。 此外，可以提供用于马拉色氏菌过敏原的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。
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公开(公告)号：US07491405B2
公开(公告)日：2009-02-17
申请号：US11116371
申请日：2005-04-28
申请人： Kazutoh Takesako , Takashi Okada , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
发明人： Kazutoh Takesako , Takashi Okada , Tomoko Yagihara , Masanobu Kuroda , Yoshimi Onishi , Ikunoshin Kato , Kazuo Akiyama , Hiroshi Yasueda , Hideyo Yamaguchi
CPC分类号： A61K39/0002 , A61K38/00 , A61K39/00 , C07K14/37 , C07K16/14 , Y10S530/858
摘要： A substantially pure, isolated, antigenic protein from fungi of the genus Malassezia, characterized in that said antigenic protein has a binding ability to IgE antibodies from patients with allergoses; an antigenic fragment derived from the antigenic protein; and an antibody against the antigenic protein or fragments thereof. According to the present invention, there can be provided an isolated and purified antigenic protein having high purity from Malassezia, antigenic fragments thereof, and a specific antibody against those antigenic protein or fragments thereof. In addition, there can be provided a diagnostic agent, a therapeutic agent, or a prophylactic drug for Malassezia allergoses, wherein the agent includes, as an active ingredient, the antigenic protein or fragments thereof.
摘要翻译： 从马拉色氏菌属真菌的基本上纯的，分离的抗原性蛋白质，其特征在于所述抗原蛋白质具有与过敏原患者的IgE抗体的结合能力; 衍生自抗原蛋白的抗原片段; 和针对抗原蛋白或其片段的抗体。 根据本发明，可以提供从马拉色霉属，其抗原性片段和针对那些抗原性蛋白质或其片段的特异性抗体具有高纯度的分离和纯化的抗原性蛋白质。 此外，可以提供用于马拉色氏菌过敏原的诊断剂，治疗剂或预防药物，其中所述药剂包含抗原蛋白或其片段作为活性成分。
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