公开(公告)号：US20060166335A1

公开(公告)日：2006-07-27

申请号：US11373989

申请日：2006-03-14

申请人： Takeshi Sakai ,  Kumiko Ishizuka ,  Kaoru Kojima ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Takeshi Sakai ,  Kumiko Ishizuka ,  Kaoru Kojima ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： C12P19/04 ,  C12N9/24

CPC分类号： C12Y302/01139 ,  C08B37/00 ,  C08B37/006 ,  C12N9/2402 ,  C12P19/14 ,  C12R1/01 ,  C12Y302/01044

摘要： Three enzymes degrading sulfated glucuronofucan; processes for producing these enzymes; activators for these enzymes; glucuronofucan sulfate and degradation products thereof; and a novel microorganism.

公开(公告)号：US07125984B2

公开(公告)日：2006-10-24

申请号：US10258133

申请日：2001-04-19

申请人： Takeshi Sakai ,  Kumiko Ishizuka ,  Kaoru Kojima ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Takeshi Sakai ,  Kumiko Ishizuka ,  Kaoru Kojima ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： C08B37/00 ,  C12P19/04

CPC分类号： C12Y302/01139 ,  C08B37/00 ,  C08B37/006 ,  C12N9/2402 ,  C12P19/14 ,  C12R1/01 ,  C12Y302/01044

摘要： Three enzymes degrading sulfated glucuronofucan; processes for producing these enzymes; activators for these enzymes; glucuronofucan sulfate and degradation products thereof; and a novel microorganism.

公开(公告)号：US06207652B1

公开(公告)日：2001-03-27

申请号：US09051284

申请日：1998-04-09

申请人： Takeshi Sakai ,  Hideo Kitano ,  Fu-Gong Yu ,  Shinji Nakayama ,  Kaoru Kojima ,  Hitomi Kimura ,  Yoshikuni Nakanishi ,  Kaoru Katayama ,  Takanari Tominaga ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Takeshi Sakai ,  Hideo Kitano ,  Fu-Gong Yu ,  Shinji Nakayama ,  Kaoru Kojima ,  Hitomi Kimura ,  Yoshikuni Nakanishi ,  Kaoru Katayama ,  Takanari Tominaga ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A61K31715

CPC分类号： C12Y302/01078 ,  A61K31/737 ,  C12N9/2494 ,  C12P19/14 ,  C12Y302/01044

摘要： Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.

公开(公告)号：US06593311B2

公开(公告)日：2003-07-15

申请号：US09770504

申请日：2001-01-29

申请人： Takeshi Sakai ,  Hideo Kitano ,  Fu-Gong Yu ,  Shinji Nakayama ,  Kaoru Kojima ,  Hitomi Kimura ,  Yoshikuni Nakanishi ,  Kaoru Katayama ,  Takanari Tominaga ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Takeshi Sakai ,  Hideo Kitano ,  Fu-Gong Yu ,  Shinji Nakayama ,  Kaoru Kojima ,  Hitomi Kimura ,  Yoshikuni Nakanishi ,  Kaoru Katayama ,  Takanari Tominaga ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： A61K31715

CPC分类号： C12Y302/01078 ,  A61K31/737 ,  C12N9/2494 ,  C12P19/14 ,  C12Y302/01044

摘要： Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.

摘要翻译： 含有硫酸化岩藻糖的多糖和/或其降解产物的细胞凋亡诱导剂，抗癌药和抗癌药以及使用含有硫酸化岩藻糖的多糖和/或降解产物诱导细胞凋亡的方法 作为活性成分。 一种可用于生产含硫酸化岩藻糖多糖的降解产物的降解酶。

公开(公告)号：US06927289B2

公开(公告)日：2005-08-09

申请号：US10694352

申请日：2003-10-28

申请人： Takeshi Sakai ,  Hitomi Amarume ,  Takashi Kawai ,  Kaoru Kojima ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Takeshi Sakai ,  Hitomi Amarume ,  Takashi Kawai ,  Kaoru Kojima ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： C08B37/00 ,  C07H5/00

CPC分类号： C08B37/006

摘要： A smaller molecule obtainable by allowing a sulfated fucan-digesting enzyme which digests a novel sulfated polysaccharide derived from an alga belonging to Laminariales to act on a sulfated fucan, and a method for producing the same.

摘要翻译： 通过使来自属于层状藻酸盐的藻类的新型硫酸化多糖消化的硫酸化的岩藻糖消化酶作用于硫酸化的岩藻石上的小分子及其制造方法。

公开(公告)号：US06720419B2

公开(公告)日：2004-04-13

申请号：US10278942

申请日：2002-10-24

申请人： Takeshi Sakai ,  Hitomi Amarume ,  Takashi Kawai ,  Kaoru Kojima ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Takeshi Sakai ,  Hitomi Amarume ,  Takashi Kawai ,  Kaoru Kojima ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： C08B3700

CPC分类号： C08B37/006

摘要： A smaller molecule obtainable by allowing a sulfated fucan-digesting enzyme which digests a novel sulfated polysaccharide derived from an alga belonging to Laminariales to act on a sulfated fucan, and a method for producing the same.

摘要翻译： 通过使来自属于层状藻酸盐的藻类的新型硫酸化多糖消化的硫酸化的岩藻糖消化酶作用于硫酸化的岩藻石上的小分子及其制造方法。

公开(公告)号：US06590097B1

公开(公告)日：2003-07-08

申请号：US09913599

申请日：2001-08-16

申请人： Takeshi Sakai ,  Hitomi Kimura ,  Kaoru Kojima ,  Kaoru Katayama ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

发明人： Takeshi Sakai ,  Hitomi Kimura ,  Kaoru Kojima ,  Kaoru Katayama ,  Kazuo Shimanaka ,  Katsushige Ikai ,  Ikunoshin Kato

IPC分类号： C08B3700

CPC分类号： C08B37/006 ,  C12N9/2402 ,  C12P19/04

摘要： Sulfated fucogalactan or its salt useful as a reagent for sugar chain engineering or an HGF-production inducer; a degraded product or its salt obtained by treating the sulfated fucogalactan with a sulfated fucogalactan digesting enzyme; the sulfated fucogalactan digesting enzyme useful in sugar chain engineering; a process for producing the degraded product by treating sulfated fucogalactan or its salt with the above enzyme; and a process for producing the sulfated fucogalactan digesting enzyme.

摘要翻译： 硫酸化的赖卡半乳糖或其盐可用作糖链工程或HGF生产诱导剂的试剂; 通过用硫酸化的福卡美凝乳消化酶处理硫酸化的核糖乳聚糖获得的降解产物或其盐; 用于糖链工程的硫酸岩藻糖半乳糖消化酶; 通过用上述酶处理硫酸化的赖氨酰半乳糖或其盐来生产降解产物的方法; 以及生产硫酸化的赖卡半乳聚糖消化酶的方法。

公开(公告)号：US20080038289A1

公开(公告)日：2008-02-14

申请号：US11596395

申请日：2005-05-30

申请人： Takashi Kawai ,  Shigetoshi Mizutani ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Takeshi Sakai ,  Kazuo Shimanaka ,  Ikunoshin Kato

发明人： Takashi Kawai ,  Shigetoshi Mizutani ,  Tatsuji Enoki ,  Hiroaki Sagawa ,  Takeshi Sakai ,  Kazuo Shimanaka ,  Ikunoshin Kato

IPC分类号： A61K36/06 ,  A61K31/045 ,  A61P35/00

CPC分类号： A61K36/07 ,  A23L33/105 ,  A61K31/047

摘要： According to the present invention, an antitumor agent, an apoptosis-inducing agent or an angiogenesis-suppressing agent having the effect even via an oral route, containing a compound contained in an inexpensive edible basidiomycete or a composition derived from an edible basidiomycete, and a food having the antitumor activity, the apoptosis-inducing activity or the angiogenesis-suppressing activity containing the compound or the composition can be obtained. Therefore, the present invention is particularly useful, especially in the field of a medicine and a health food.

摘要翻译： 根据本发明，通过口服途径具有效果的抗肿瘤剂，细胞凋亡诱导剂或血管生成抑制剂，其含有廉价的可食用担子菌或含有可食用担子菌的组合物，以及 可以获得具有抗肿瘤活性，含有化合物或组合物的细胞凋亡诱导活性或血管生成抑制活性的食品。 因此，本发明特别有用，特别是在药物和保健食品领域。

公开(公告)号：US5200505A

公开(公告)日：1993-04-06

申请号：US643948

申请日：1991-01-22

申请人： Kazutoh Takesako ,  Katsushige Ikai ,  Kazuo Shimanaka ,  Junko Yamamoto ,  Fumiyo Haruna ,  Teruya Nakamura ,  Hideyo Yamaguchi ,  Katsuhisa Uchida

发明人： Kazutoh Takesako ,  Katsushige Ikai ,  Kazuo Shimanaka ,  Junko Yamamoto ,  Fumiyo Haruna ,  Teruya Nakamura ,  Hideyo Yamaguchi ,  Katsuhisa Uchida

IPC分类号： C12N1/14 ,  A61K38/00 ,  A61P31/04 ,  C07K1/20 ,  C07K7/06 ,  C07K11/02 ,  C07K14/195 ,  C07K14/37 ,  C07K14/41 ,  C12P21/02 ,  C12R1/645

CPC分类号： C07K11/02

摘要： There are provided R106 compounds represented by the following general formula (I): ##STR1## wherein: A.sub.1 is Phe, o-FPhe, m-FPhe, or Tyr;A.sub.2 is MePhe, o-FMePhe, m-FMePhe, MeTyr, Sar, MeSery, or .beta.-oxoMePhe;A.sub.3 is Pro, 4Hyp, or SPro;A.sub.4 is allo-Ile or Nle;A.sub.5 is Leu or Nva;A.sub.6 is .beta.-HOMeVal or Sar;excluding those wherein A.sub.1 is Phe and A.sub.2 is MePhe and A.sub.3 is Pro and A.sub.4 is allo-Ile and A.sub.5 is Leu and A.sub.6 is .beta.-HOMeVal (SEQ ID No. 4), which are useful as therapeutic agents for fungal infection.

公开(公告)号：US5158876A

公开(公告)日：1992-10-27

申请号：US657811

申请日：1991-02-02

申请人： Kazutoh Takesako ,  Katsushige Ikai ,  Kazuo Shimanaka ,  Junko Yamamoto ,  Fumiyo Haruna ,  Teruya Nakamura ,  Hideyo Yamaguchi ,  Katsuhisa Uchida

发明人： Kazutoh Takesako ,  Katsushige Ikai ,  Kazuo Shimanaka ,  Junko Yamamoto ,  Fumiyo Haruna ,  Teruya Nakamura ,  Hideyo Yamaguchi ,  Katsuhisa Uchida

IPC分类号： A61K38/00 ,  C07K11/02 ,  C12P21/04

CPC分类号： C12R1/645 ,  C07K11/02 ,  A61K38/00

摘要： An antibiotic R106 represented by the general formula (I): ##STR1## wherein: R is methyl or ethyl;X.sub.1 is MePhe, .beta.-HOMePhe or Phe;X.sub.2 is allo-Ile, Val or Leu;X.sub.3 is MeVal or Val;X.sub.4 is .beta.-HOMeVal, .gamma.HOMeVal, MeVal, Val, N,.beta.-MeAsp, .beta.-HOMePhe, MePhe, MeDH.sub.2,3 Val or MeDH.sub.3,4 Valis produced by a process which comprises culturing a strain of the genus Aureobasidium that is capable of producing the said antibiotic R106 and collecting the said antibiotic from the fermentation broth. The antibiotic R106 compounds are useful in the treatment of fungal infection.

摘要翻译： 由通式（I）表示的抗生素R106：其中：R是甲基或乙基; X1是MePhe，β-HOMePhe或Phe; X2是异亮氨酸，Val或Leu; X3是MeVal或Val; X4是β-HOMeVal，γHOMeVal，MeVal，Val，N，β-MeAsp，β-HOMePhe，MePhe，MeDH2,3Val或MeDH3,4Val是通过包括培养能够产生的Aureobasidium属的菌株 产生所述抗生素R106并从发酵液中收集所述抗生素。 抗生素R106化合物可用于治疗真菌感染。