公开(公告)号：US5578466A

公开(公告)日：1996-11-26

申请号：US872673

申请日：1992-04-17

Applicant: Toshiya Hayano ,  Setsuko Katoh ,  Nobuhiro Takahashi ,  Masanori Suzuki ,  Keiichi Honma

Inventor： Toshiya Hayano ,  Setsuko Katoh ,  Nobuhiro Takahashi ,  Masanori Suzuki ,  Keiichi Honma

IPC: C07K14/395 ,  C07K14/765 ,  C12N9/90 ,  C12N15/14 ,  C12N15/61 ,  C12N15/81 ,  C12N15/90 ,  C12N1/19 ,  C12N15/62

CPC classification number: C07K14/395 ,  C07K14/765 ,  C12N15/81 ,  C12N15/90 ,  C12N9/90 ,  C07K2319/00 ,  C07K2319/02

Abstract: The present invention is directed to a transformant comprising the following expression units in a co-expressible state:an expression unit containing a gene coding for a receptor protein ERD2 from yeast or analog thereof which is capable of binding to a protein localizing in endoplasmic reticulum and having a signal for staying therein;an expression unit containing a gene coding for said protein localizing in endoplasmic reticulum; andan expression unit containing a foreign gene coding for a polypeptide which is a subject of function of said protein localizing in endoplasmic reticulum, andto a transformant comprising, in a co-expressible state, a fusion gene which is composed of a DNA fragment coding for a human serum albumin prepro-sequence and a foreign gene coding for a useful polypeptide. The present invention is also directed to a process for producing said polypeptide by co-expressing said genes in said transformant such that the polypeptide is predominantly secreted out of the transformant cell. Consequently, the invention has an advantage of improving the productivity of said polypeptide.

Abstract translation: 本发明涉及包含可共表达状态的以下表达单元的转化体：包含编码来自酵母或其类似物的受体蛋白ERD2的基因的表达单元，其能够结合定位在内质网中的蛋白质，以及 具有留在其中的信号; 含有编码所述蛋白质定位在内质网中的基因的表达单元; 以及表达单元，其含有编码作为所述蛋白质在内质网中定位的功能的多肽的外源基因，以及含有共可表达状态的转化体，所述融合基因由编码 用于人血清白蛋白前原序列和编码有用多肽的外源基因。 本发明还涉及通过在所述转化体中共表达所述基因以使多肽主要从转化体细胞中分泌而产生所述多肽的方法。 因此，本发明具有提高所述多肽的生产率的优点。

公开(公告)号：US6156090A

公开(公告)日：2000-12-05

申请号：US164582

申请日：1998-10-01

Applicant: Tominori Ishikawa ,  Yuji Toyama ,  Makoto Yokoyama ,  Yoshihiro Takada ,  Keiichi Honma ,  Osamu Kawasaki ,  Masayosi Inoue ,  Kazunari Sugai ,  Jun Tazawa

Inventor： Tominori Ishikawa ,  Yuji Toyama ,  Makoto Yokoyama ,  Yoshihiro Takada ,  Keiichi Honma ,  Osamu Kawasaki ,  Masayosi Inoue ,  Kazunari Sugai ,  Jun Tazawa

IPC: F04D29/30 ,  F04D29/66 ,  F24F1/00 ,  F24F3/16 ,  B01D35/30 ,  F01D5/22

CPC classification number: F24F3/1603 ,  F04D29/30 ,  F04D29/662 ,  F24F2001/0096

Abstract: An air cleaner includes a housing having an upper wall and side walls, an air filter mounted with respect to the housing, a fan including a vane-wheel having a plurality of vanes, a supporting plate extending substantially between at least two side walls for supporting the fan. An air flow directional member directs an air flow output from the fan. The vane is formed to have a winglike cross-section, and the vane-wheel includes not more than four vanes. The vane-wheel has a base plate and a shroud. Each of the base plate and the shroud is formed to have a reinforcement portion on its circumference. A U-shaped balance weight is attached to a flattened portion formed on the curled portion. The air cleaner of the present invention can reduce noise and vibration and improve efficiency of the fan.

Abstract translation: 空气净化器包括具有上壁和侧壁的壳体，相对于壳体安装的空气过滤器，包括具有多个叶片的叶轮的风扇，基本上在至少两个侧壁之间延伸的支撑板，用于支撑 风扇。 气流定向构件引导从风扇输出的空气流。 叶片形成为具有翼状横截面，并且叶轮包括不超过四个叶片。 叶轮具有底板和护罩。 基板和护罩中的每一个形成为在其圆周上具有加强部分。 U形平衡重附着在形成在卷曲部分上的扁平部分上。 本发明的空气滤清器可以降低噪音和振动，提高风扇的效率。

公开(公告)号：US6019808A

公开(公告)日：2000-02-01

申请号：US97591

申请日：1998-06-16

Applicant: Tominori Ishikawa ,  Yuji Toyama ,  Masayuki Terano ,  Yoshihiro Takada ,  Keiichi Honma

Inventor： Tominori Ishikawa ,  Yuji Toyama ,  Masayuki Terano ,  Yoshihiro Takada ,  Keiichi Honma

IPC: F04D25/08 ,  B01D46/00 ,  B01D46/10 ,  B01D46/42 ,  F04D29/66 ,  F24F7/007 ,  F24F7/06 ,  F24F13/28

CPC classification number: B01D46/10 ,  F24F13/28 ,  B01D2273/30 ,  B01D2279/51 ,  F24F2001/0096

Abstract: An air cleaner of the present invention includes a housing having an upper wall and side walls, a fan, a supporting plate extending between the two side walls for supporting the fan, a first air flow directional member extending between the supporting plate and the upper wall, and a second air flow directional member provided at a horizontal periphery of the housing. The first air flow directional member not only provides reinforcement to the supporting plate and the upper wall, but also directs an air flow output from the fan. The second air flow directional member has a horizontal plate and vertical plates for directing air flow at the horizontal periphery of the housing. The first air flow directional member and the second air flow directional member are adapted to equalize a velocity of an air flow distributed across an air flow output area of the fan unit. The supporting plate and the first air flow directional member are adapted to maintain a predetermined spacing between a predetermined portion of the fan and the first air flow directional member. The air cleaner of the present invention can reduce energy consumption by improving efficient of the fan.

Abstract translation: 本发明的空气滤清器包括具有上壁和侧壁的壳体，风扇，在两个侧壁之间延伸用于支撑风扇的支撑板，在支撑板和上壁之间延伸的第一气流定向件 以及设置在壳体的水平周边处的第二气流定向构件。 第一气流定向构件不仅对支撑板和上壁提供加强，而且还引导从风扇输出的空气流。 第二气流定向构件具有用于在壳体的水平周边处引导气流的水平板和垂直板。 第一气流定向构件和第二气流定向构件适于均衡分配在风扇单元的空气流输出区域上的空气流的速度。 支撑板和第一气流定向构件适于在风扇的预定部分和第一气流定向构件之间保持预定的间隔。 本发明的空气净化器可以通过提高风扇的效率来降低能量消耗。

公开(公告)号：US07472847B2

公开(公告)日：2009-01-06

申请号：US10736544

申请日：2003-12-17

Applicant: Hiroshi Mukai ,  Keiichi Honma ,  Takeshi Honda ,  Tetsuo Kimiya

Inventor： Hiroshi Mukai ,  Keiichi Honma ,  Takeshi Honda ,  Tetsuo Kimiya

IPC: B05B1/08

CPC classification number: B05B1/005 ,  B05B1/08 ,  Y10S239/03 ,  Y10T137/2104 ,  Y10T137/2185

Abstract: For achieving a fluidic device, being able to be made small in sizes, comprising a fluid inflow opening 1, a connector duct 2, and a fluid jet nozzle, wherein the connector duct 2 is constructed with curves, and is further constructed with two (2) pieces of flow passages, being symmetric on both sides. Constructing the connector duct with the curves reduces resistance of fluid within the duct, and further dividing the connector duct into two (2) parts in both side enhances the flows at confluent point in the duct (increase of the flow velocity).

Abstract translation: 为了实现能够制造尺寸较小的流体装置，包括流体流入开口1，连接器管道2和流体喷射喷嘴，其中连接器管道2构成曲线，并且进一步构造为具有两个 2）流动通道，两侧对称。 用曲线构造连接器导管可以降低管道内流体的阻力，并进一步将连接管道分成两侧（2）部分，以增加管道汇流点的流量（增加流速）。