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公开(公告)号：US20100241241A1
公开(公告)日：2010-09-23
申请号：US12729671
申请日：2010-03-23
申请人： Timothy E. McKnight , Anthony Johnson , Kenneth J. Moise, JR. , Milton Nance Ericson , Justin S. Baba , John B. Wilgen , Boyd Mccutchen Evans, III
发明人： Timothy E. McKnight , Anthony Johnson , Kenneth J. Moise, JR. , Milton Nance Ericson , Justin S. Baba , John B. Wilgen , Boyd Mccutchen Evans, III
CPC分类号： A61F2/04 , A61B17/1204 , A61B17/12104 , A61B17/12136 , A61B17/42 , A61B2017/00411 , A61B2017/00876 , A61B2017/1205 , A61M5/16813 , A61M5/172 , A61M27/006 , A61M2205/0283 , A61M2205/04 , A61M2205/3334 , A61M2205/3523 , A61M2205/3569 , A61M2205/3653 , A61M2205/8243 , A61M2210/1032 , A61M2210/1075 , A61M2210/1089 , A61M2210/145
摘要： Valve implant systems positionable within a flow passage, the systems having an inlet, an outlet, and a remotely activatable valve between the inlet and outlet, with the valves being operable to provide intermittent occlusion of the flow path. A remote field is applied to provide thermal or magnetic activation of the valves.
摘要翻译： 阀门植入系统可定位在流动通道内，该系统在入口和出口之间具有入口，出口和可远程激活的阀，其中阀可操作以提供流路的间歇闭塞。 应用远程场来提供阀门的热或磁性激活。
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公开(公告)号：US06911178B2
公开(公告)日：2005-06-28
申请号：US09991121
申请日：2001-11-14
CPC分类号： G01N33/80 , A61K38/00 , C07K14/705 , C07K16/34 , Y10S435/975 , Y10S436/824 , Y10T436/10
摘要： Disclosed are novel protein and peptide compositions comprising soluble and bound forms of immunologically-active blood group antigens including mammalian Rh antigens. In preferred embodiments methods for the isolation and purification of serologically-active human Rh antigens such as D, c, C, E, and e are disclosed. Also disclosed are methods for the adsorption of immunologically-active Rh antigens to solid supports. Diagnostic kits, methods, and devices for the detection of Rh antibodies in clinical and non-clinical samples are also disclosed. Devices, compositions and methods for the isolation, purification and quantitation of anti-Rh antibodies from solution are also provided.
摘要翻译： 公开了包含可溶性和结合形式的免疫活性血型抗原（包括哺乳动物Rh抗原）的新型蛋白质和肽组合物。 在优选实施方案中，公开了用于分离和纯化血清学活性的人Rh抗原如D，c，C，E和e的方法。 还公开了用于将免疫活性Rh抗原吸附到固体支持物上的方法。 还公开了用于检测临床和非临床样品中Rh抗体的诊断试剂盒，方法和装置。 还提供了用于从溶液中分离，纯化和定量抗Rh抗体的装置，组合物和方法。
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公开(公告)号：US06551830B2
公开(公告)日：2003-04-22
申请号：US09789378
申请日：2001-02-20
IPC分类号： G01V3100
CPC分类号： G01N33/80 , A61K38/00 , C07K14/705 , C07K16/34 , Y10S435/975 , Y10S436/824 , Y10T436/10
摘要： Disclosed are novel protein and peptide compositions comprising soluble and bound forms of immunologically-active blood group antigens including mammalian Rh antigens. In preferred embodiments methods for the isolation and purification of serologically-active human Rh antigens such as D, c, C, E, and e are disclosed. Also disclosed are methods for the adsorption of immunologically-active Rh antigens to solid supports. Diagnostic kits, methods, and devices for the detection of Rh antibodies in clinical and non-clinical samples are also disclosed. Devices, compositions and methods for the isolation, purification and quantitation of anti-Rh antibodies from solution are also provided.
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公开(公告)号：US06280958B1
公开(公告)日：2001-08-28
申请号：US09488157
申请日：2000-01-20
IPC分类号： G01N3353
CPC分类号： G01N33/80 , A61K38/00 , C07K14/705 , C07K16/34 , Y10S435/975 , Y10S436/824 , Y10T436/10
摘要： Disclosed are novel protein and peptide compositions comprising soluble and bound forms of immunologically-active blood group antigens including mammalian Rh antigens. In preferred embodiments methods for the isolation and purification of serologically-active human Rh antigens such as D, c, C, E, and e are disclosed. Also disclosed are methods for the adsorption of immunologically-active Rh antigens to solid supports. Diagnostic kits, methods, and devices for the detection of Rh antibodies in clinical and non-clinical samples are also disclosed. Devices, compositions and methods for the isolation, purification and quantitation of anti-Rh antibodies from solution are also provided.
摘要翻译： 公开了包含可溶性和结合形式的免疫活性血型抗原（包括哺乳动物Rh抗原）的新型蛋白质和肽组合物。 在优选实施方案中，公开了用于分离和纯化血清学活性的人Rh抗原如D，c，C，E和e的方法。 还公开了用于将免疫活性Rh抗原吸附到固体支持物上的方法。 还公开了用于在临床和非临床样品中检测Rh抗体的诊断试剂盒，方法和装置。 还提供了用于从溶液中分离，纯化和定量抗Rh抗体的装置，组合物和方法。
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公开(公告)号：US08657883B2
公开(公告)日：2014-02-25
申请号：US12729671
申请日：2010-03-23
申请人： Timothy E. McKnight , Anthony Johnson , Kenneth J. Moise, Jr. , Milton Nance Ericson , Justin S. Baba , John B. Wilgen , Boyd McCutchen Evans, III
发明人： Timothy E. McKnight , Anthony Johnson , Kenneth J. Moise, Jr. , Milton Nance Ericson , Justin S. Baba , John B. Wilgen , Boyd McCutchen Evans, III
CPC分类号： A61F2/04 , A61B17/1204 , A61B17/12104 , A61B17/12136 , A61B17/42 , A61B2017/00411 , A61B2017/00876 , A61B2017/1205 , A61M5/16813 , A61M5/172 , A61M27/006 , A61M2205/0283 , A61M2205/04 , A61M2205/3334 , A61M2205/3523 , A61M2205/3569 , A61M2205/3653 , A61M2205/8243 , A61M2210/1032 , A61M2210/1075 , A61M2210/1089 , A61M2210/145
摘要： Valve implant systems positionable within a flow passage, the systems having an inlet, an outlet, and a remotely activatable valve between the inlet and outlet, with the valves being operable to provide intermittent occlusion of the flow path. A remote field is applied to provide thermal or magnetic activation of the valves.
摘要翻译： 阀门植入系统可定位在流动通道内，该系统在入口和出口之间具有入口，出口和可远程激活的阀，其中阀可操作以提供流路的间歇闭塞。 应用远程场来提供阀门的热或磁性激活。
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公开(公告)号：US06191108B1
公开(公告)日：2001-02-20
申请号：US09164789
申请日：1998-10-01
IPC分类号： A61K3800
CPC分类号： G01N33/80 , A61K38/00 , C07K14/705 , C07K16/34 , Y10S435/975 , Y10S436/824 , Y10T436/10
摘要： Disclosed are novel protein and peptide compositions comprising soluble and bound forms of immunologically-active blood group antigens including mammalian Rh antigens. In preferred embodiments methods for the isolation and purification of serologically-active human Rh antigens such as D, c, C, E, and e are disclosed. Also disclosed are methods for the adsorption of immunologically-active Rh antigens to solid supports. Diagnostic kits, methods, and devices for the detection of Rh antibodies in clinical and non-clinical samples are also disclosed. Devices, compositions and methods for the isolation, purification and quantitation of anti-Rh antibodies from solution are also provided.
摘要翻译： 公开了包含可溶性和结合形式的免疫活性血型抗原（包括哺乳动物Rh抗原）的新型蛋白质和肽组合物。 在优选实施方案中，公开了用于分离和纯化血清学活性的人Rh抗原如D，c，C，E和e的方法。 还公开了用于将免疫活性Rh抗原吸附到固体支持物上的方法。 还公开了用于在临床和非临床样品中检测Rh抗体的诊断试剂盒，方法和装置。 还提供了用于从溶液中分离，纯化和定量抗Rh抗体的装置，组合物和方法。
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公开(公告)号：US5840585A
公开(公告)日：1998-11-24
申请号：US715173
申请日：1996-09-17
CPC分类号： G01N33/80 , C07K14/705 , C07K16/34 , A61K38/00 , Y10S435/975 , Y10S436/824 , Y10T436/10
摘要： Disclosed are novel protein and peptide compositions comprising soluble and bound forms of immunologically-active blood group antigens including mammalian Rh antigens. In preferred embodiments methods for the isolation and purification of serologically-active human Rh antigens such as D, c, C, E, and e are disclosed. Also disclosed are methods for the adsorption of immunologically-active Rh antigens to solid supports. Diagnostic kits, methods, and devices for the detection of Rh antibodies in clinical and non-clinical samples are also disclosed. Devices, compositions and methods for the isolation, purification and quantitation of anti-Rh antibodies from solution are also provided.
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