Inhibition of angiogenesis
    8.
    发明授权
    Inhibition of angiogenesis 失效
    抑制血管发生

    公开(公告)号:US06255353B1

    公开(公告)日:2001-07-03

    申请号:US09267510

    申请日:1999-03-12

    IPC分类号: A61K31255

    摘要: Certain simple chemical agents, referred to herein as nitrone related therapeutics or “NRTs”, when administered to a patient susceptible to neovascularization (angiogenesis), can intervene and inhibit the disease's progress. Methods for therapeutically and prophylactically inhibiting angiogenesis by administering one or more NRTs are disclosed as are pharmaceutical compositions for use in such methods of treating. NRTs useful in these compositions and therapeutic methods are also disclosed.

    摘要翻译: 当被给予对新血管形成(血管生成)敏感的患者时,某些简单的化学试剂(本文称为硝酮相关治疗剂或“NRT”)可以介入并抑制该疾病的进展。 公开了通过施用一种或多种NRT来治疗和预防性地抑制血管生成的方法,用于这些治疗方法的药物组合物。 还公开了可用于这些组合物和治疗方法的NRT。

    Hydrophilic colored contact lens
    10.
    发明授权
    Hydrophilic colored contact lens 失效
    亲水色的隐形眼镜

    公开(公告)号:US4963159A

    公开(公告)日:1990-10-16

    申请号:US377990

    申请日:1989-07-11

    IPC分类号: B41M1/30 G02B1/04 G02B1/10

    CPC分类号: G02B1/10 B41M1/30 G02B1/043

    摘要: There is disclosed a method for making colored hydrophilic contact lenses. A contact lens constructed of hydrophilic polymer that is substantially devoid of the functional groups --COOH, --OH, --NH--R, wherein R is hydrogen or C.sub.1 to C.sub.8 alkyl, --NCO and epoxy is provided. At least a portion of the surface of the lens is coated with a color coat comprising at least one pigment, binding polymer having functional groups selected from at least one of --COOH, --OH, and --NH--R, wherein R is hydrogen or C.sub.1 to C.sub.8 alkyl, and an additional compound having at least two groups per molecule of --NCO. The coated lens is subjected to conditions which cause the color coat to adhere to the lens.

    摘要翻译: 公开了制造有色亲水性隐形眼镜的方法。 提供由亲水性聚合物构成的隐形眼镜,其基本上不含官能团-COOH,-OH,-NH-R,其中R为氢或C1至C8烷基,-NCO和环氧基。 透镜表面的至少一部分涂覆有包含至少一种颜料的着色涂层,具有选自-COOH,-OH和-NH-R中至少一个的官能团的结合聚合物,其中R是氢或 C1至C8烷基,以及每分子-NCO具有至少两个基团的另外的化合物。 涂覆的透镜经受使着色涂层粘附到透镜的条件。