-
公开(公告)号：US10221159B2
公开(公告)日：2019-03-05
申请号：US13467694
申请日：2012-05-09
申请人： Kevin Groves , Bagna Bao
发明人： Kevin Groves , Bagna Bao
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00 , C07D401/06 , C07D209/14 , C07D209/60 , C07D401/14 , C07D417/14 , A61K49/00 , G01N33/58 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/506 , G01N21/64 , C09B23/01 , C09B23/08
摘要： The invention provides agents that target carbonic anhydrase, which can be used as imaging agents or therapeutic agents. The agents can be used to image tumor hypoxia as well as other physiological processes in a subject.
-
公开(公告)号：US09913917B2
公开(公告)日：2018-03-13
申请号：US11645111
申请日：2006-12-22
申请人： Kevin Groves , Milind Rajopadhye
发明人： Kevin Groves , Milind Rajopadhye
CPC分类号： A61K49/1866 , A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K49/0093 , A61K49/1833 , A61K49/186 , B82Y5/00
摘要： The invention relates to highly fluorescent metal oxide nanoparticles to which biomolecules and other compounds can be chemically linked to form biocompatible, stable optical imaging agents for in vitro and in vivo applications. The fluorescent metal oxide nanoparticles may also be used for magnetic resonance imaging (MRI), thus providing a multi modality imaging agent.
-
公开(公告)号：US20090220430A1
公开(公告)日：2009-09-03
申请号：US12355777
申请日：2009-01-17
申请人： Milind Rajopadhye , Kevin Groves , Dorin V. Preda
发明人： Milind Rajopadhye , Kevin Groves , Dorin V. Preda
CPC分类号： A61K49/0032 , A61K47/65 , A61K49/0056 , C07K5/1019 , C07K7/06 , C07K7/64 , C09B23/0008 , C09B23/083 , C09B23/086
摘要： Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
摘要翻译： 提供了用于体内和体外成像的分子内骤冷成像剂家族，其包含至少一种可酶促切割的寡肽和两个荧光团或荧光团和猝灭剂。 当进行蛋白水解切割时，至少一个荧光团是不淬灭的，并且在用适当波长的光激发时变得能够产生荧光信号。 还提供了使用这种成像剂的体内和体外成像方法。
-
公开(公告)号：US20080317676A1
公开(公告)日：2008-12-25
申请号：US12065385
申请日：2006-09-01
申请人： Milind Rajopadhye , Kevin Groves
发明人： Milind Rajopadhye , Kevin Groves
IPC分类号： C07D401/14 , C07D401/02 , C07D413/14 , A61K49/00 , A61K49/04
CPC分类号： G01N33/582 , A61K49/0032 , A61K49/0052 , C09B23/0008 , C09B23/0066 , C09B23/083 , C09B23/086 , G01N33/533
摘要： This invention relates to new fluorescent chemical entities that are designed to attach to biocompatible molecules to form in vivo optical imaging agents.
摘要翻译： 本发明涉及被设计成附着于生物相容性分子以形成体内光学成像剂的新荧光化学实体。
-
公开(公告)号：US20080226562A1
公开(公告)日：2008-09-18
申请号：US11645111
申请日：2006-12-22
申请人： Kevin Groves , Milind Rajopadhye
发明人： Kevin Groves , Milind Rajopadhye
CPC分类号： A61K49/1866 , A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K49/0093 , A61K49/1833 , A61K49/186 , B82Y5/00
摘要： The invention relates to highly fluorescent metal oxide nanoparticles to which biomolecules and other compounds can be chemically linked to form biocompatible, stable optical imaging agents for in vitro and in vivo applications. The fluorescent metal oxide nanoparticles may also be used for magnetic resonance imaging (MRI), thus providing a multi modality imaging agent.
摘要翻译： 本发明涉及高度荧光的金属氧化物纳米颗粒，生物分子和其它化合物可以化学连接以形成用于体外和体内应用的生物相容性，稳定的光学成像剂。 荧光金属氧化物纳米颗粒也可用于磁共振成像（MRI），从而提供多模态成像剂。
-
6.发明授权Biocompatible N, N-disubstituted sulfonamide-containing fluorescent dye labels 有权生物相容性N，N-二取代磺酰胺荧光染料标记公开(公告)号：US09574085B2
公开(公告)日：2017-02-21
申请号：US12065387
申请日：2006-09-01
IPC分类号： A61K49/00 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C09B23/08 , C07D209/14 , C09B23/01 , G01N33/533 , G01N33/537 , G01N33/58
CPC分类号： C09B23/086 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D401/14 , C07D403/06 , C07D403/14 , C09B23/0066 , C09B23/083 , G01N33/533 , G01N33/537 , G01N33/582
摘要： This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译： 本发明涉及新的荧光化学实体，特别是包含生物相容性N，N-二取代磺酰胺荧光染料的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。
-
公开(公告)号：US08620059B2
公开(公告)日：2013-12-31
申请号：US11955731
申请日：2007-12-13
申请人： Conrad Kevin Groves , Chunping Dai
发明人： Conrad Kevin Groves , Chunping Dai
CPC分类号： G06K9/4609 , G06T7/0004 , G06T7/44 , G06T2207/30161
摘要： A system for determining at least one characteristic of wood furnish from an upstream source. The system includes: an inclined panel comprising a transparent window having a top surface for the wood furnish to slide down; a lighting means adjacent the transparent window for lighting the wood furnish visible through a bottom surface of the window; an image capturing means adjacent the transparent window for capturing an image of the wood furnish visible through the bottom surface of the window; and a processing means in communication with the image capturing means for deriving from the captured images the at least one characteristic of the wood furnish.
摘要翻译： 一种用于从上游源确定木材配料的至少一种特性的系统。 该系统包括：倾斜面板，其包括具有用于木材配件向下滑动的顶表面的透明窗口; 靠近透明窗口的照明装置，用于照亮通过窗口的底部表面可见的木材配料; 靠近所述透明窗口的图像捕获装置，用于捕获通过所述窗的底表面可见的木材配料的图像; 以及与图像捕获装置通信的处理装置，用于从捕获的图像中导出木材配料的至少一个特征。
-
8.发明申请Biocompatible N, N-Disubstituted Sulfonamide-Containing Fluorescent Dye Labels 有权生物相容的N，N-二取代的含磺酰胺的荧光染料标签公开(公告)号：US20090130024A1
公开(公告)日：2009-05-21
申请号：US12065387
申请日：2006-09-01
IPC分类号： A61K49/00 , C07D403/12 , C07D401/14 , C07D403/06 , C07D403/14
CPC分类号： C09B23/086 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D401/14 , C07D403/06 , C07D403/14 , C09B23/0066 , C09B23/083 , G01N33/533 , G01N33/537 , G01N33/582
摘要： This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译： 本发明涉及新的荧光化学实体，特别是包含生物相容性N，N-二取代磺酰胺荧光染料的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。
-
公开(公告)号：US20080102036A1
公开(公告)日：2008-05-01
申请号：US10559558
申请日：2004-06-04
CPC分类号： G01N33/54346 , A61K49/0017 , A61K49/0052 , A61K49/0056 , A61K49/0065 , B82Y5/00
摘要： The invention features biocompatible fluorescent nanoparticle and their use in in vivo imaging methods.
摘要翻译： 本发明特征在于生物相容的荧光纳米颗粒及其在体内成像方法中的应用。
-
公开(公告)号：US07947256B2
公开(公告)日：2011-05-24
申请号：US12065385
申请日：2006-09-01
申请人： Milind Rajopadhye , Kevin Groves
发明人： Milind Rajopadhye , Kevin Groves
IPC分类号： A61K49/04
CPC分类号： G01N33/582 , A61K49/0032 , A61K49/0052 , C09B23/0008 , C09B23/0066 , C09B23/083 , C09B23/086 , G01N33/533
摘要： This invention relates to new carbocyanine fluorophores comprising a biomolecule targeting moiety containing 1-6 aromatic moieties, wherein the targeting moiety is designed to attach to biocompatible molecules to form in vivo optical imaging agents.
摘要翻译： 本发明涉及包含含有1-6个芳族部分的生物分子靶向部分的新的碳代花青荧光团，其中靶向部分设计成附着于生物相容性分子以形成体内光学成像剂。
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.034 秒)
