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1.发明授权Biocompatible N, N-disubstituted sulfonamide-containing fluorescent dye labels 有权生物相容性N，N-二取代磺酰胺荧光染料标记公开(公告)号：US09574085B2
公开(公告)日：2017-02-21
申请号：US12065387
申请日：2006-09-01
IPC分类号： A61K49/00 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C09B23/08 , C07D209/14 , C09B23/01 , G01N33/533 , G01N33/537 , G01N33/58
CPC分类号： C09B23/086 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D401/14 , C07D403/06 , C07D403/14 , C09B23/0066 , C09B23/083 , G01N33/533 , G01N33/537 , G01N33/582
摘要： This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译： 本发明涉及新的荧光化学实体，特别是包含生物相容性N，N-二取代磺酰胺荧光染料的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。
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2.发明申请Biocompatible N, N-Disubstituted Sulfonamide-Containing Fluorescent Dye Labels 有权生物相容的N，N-二取代的含磺酰胺的荧光染料标签公开(公告)号：US20090130024A1
公开(公告)日：2009-05-21
申请号：US12065387
申请日：2006-09-01
IPC分类号： A61K49/00 , C07D403/12 , C07D401/14 , C07D403/06 , C07D403/14
CPC分类号： C09B23/086 , A61K49/0032 , A61K49/0052 , C07D209/14 , C07D401/14 , C07D403/06 , C07D403/14 , C09B23/0066 , C09B23/083 , G01N33/533 , G01N33/537 , G01N33/582
摘要： This invention relates to new fluorescent chemical entities, especially fluorescent molecules that comprise biocompatible N,N-disubstituted sulfonamide fluorochromes. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译： 本发明涉及新的荧光化学实体，特别是包含生物相容性N，N-二取代磺酰胺荧光染料的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。
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公开(公告)号：US20120321562A1
公开(公告)日：2012-12-20
申请号：US13450003
申请日：2012-04-18
IPC分类号： C09B23/08 , C12N5/071 , C12N5/09 , C12N5/04 , C12N5/0783 , C12N5/078 , C12N5/07 , A61K49/00 , C12N1/20
CPC分类号： A61K49/0032 , A61K49/0021 , C07D401/06 , C07D401/14 , C07D417/06 , C09B23/0008 , C09B23/083
摘要： This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译： 本发明涉及新的荧光化学实体，包括含有羧基或羰基官能化的吡啶部分的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。
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公开(公告)号：US08173819B2
公开(公告)日：2012-05-08
申请号：US12065391
申请日：2006-09-01
IPC分类号： C07D401/06
CPC分类号： A61K49/0032 , A61K49/0021 , C07D401/06 , C07D401/14 , C07D417/06 , C09B23/0008 , C09B23/083
摘要： This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译： 本发明涉及新的荧光化学实体，包括含有羧基或羰基官能化的吡啶部分的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。
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公开(公告)号：US08455651B2
公开(公告)日：2013-06-04
申请号：US13450003
申请日：2012-04-18
IPC分类号： C07D401/06
CPC分类号： A61K49/0032 , A61K49/0021 , C07D401/06 , C07D401/14 , C07D417/06 , C09B23/0008 , C09B23/083
摘要： This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译： 本发明涉及新的荧光化学实体，包括含有羧基或羰基官能化的吡啶部分的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。
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公开(公告)号：US20080267883A1
公开(公告)日：2008-10-30
申请号：US12065391
申请日：2006-09-01
IPC分类号： C07D401/14 , C07D417/14 , A61K49/04 , A61K49/00
CPC分类号： A61K49/0032 , A61K49/0021 , C07D401/06 , C07D401/14 , C07D417/06 , C09B23/0008 , C09B23/083
摘要： This invention relates to new fluorescent chemical entities, including fluorescent molecules that comprise a carboxyl or carbonyl functionalized pyridine moiety. This invention also relates to the corresponding reactive versions of such molecules. This invention also relates to the corresponding conjugates with moieties such as peptides, proteins, various biomolecules, carbocyclic and heterocyclic compounds, sugars, and their uses thereof.
摘要翻译： 本发明涉及新的荧光化学实体，包括含有羧基或羰基官能化的吡啶部分的荧光分子。 本发明还涉及这种分子的相应的反应性形式。 本发明还涉及与诸如肽，蛋白质，各种生物分子，碳环和杂环化合物，糖等部分的相应缀合物及其用途。
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7.发明申请VIABLE NEAR-INFRARED FLUOROCHROME LABELED CELLS AND METHODS OF MAKING AND USING THE SAME 审中-公开可变的近红外荧光标记细胞及其制备和使用方法公开(公告)号：US20100172841A1
公开(公告)日：2010-07-08
申请号：US12555754
申请日：2009-09-08
CPC分类号： A61B5/0059 , A61B5/411 , A61B5/415 , A61B5/418 , A61B5/4504 , A61B5/4528 , A61K49/0032 , A61K49/0097
摘要： The invention provides viable near-infrared fluorochrome labeled cells and in vivo imaging methods for tracking, locating or determining the quantity of the viable cells once they have been administered to a subject.
摘要翻译： 本发明提供了可行的近红外荧光染料标记细胞和体内成像方法，用于跟踪，定位或确定活细胞一旦施用于受试者的数量。
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公开(公告)号：US08815214B2
公开(公告)日：2014-08-26
申请号：US12355777
申请日：2009-01-17
申请人： Milind Rajopadhye , Kevin Groves , Dorin V. Preda
发明人： Milind Rajopadhye , Kevin Groves , Dorin V. Preda
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K38/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K38/00 , A61K38/04
CPC分类号： A61K49/0032 , A61K47/65 , A61K49/0056 , C07K5/1019 , C07K7/06 , C07K7/64 , C09B23/0008 , C09B23/083 , C09B23/086
摘要： Provided is a family of intramolecularly quenched imaging agents for use in both in vivo and in vitro imaging that contain at least one enzymatically cleavable oligopeptide and two fluorophores or a fluorophore and a quencher. When subjected to proteolytic cleavage, at least one fluorophore is unquenched and becomes capable of producing a fluorescent signal upon excitation with light of an appropriate wavelength. Also provided are in vivo and in vitro imaging methods using such imaging agents.
摘要翻译： 提供了用于体内和体外成像的分子内骤冷成像剂家族，其包含至少一种可酶促切割的寡肽和两个荧光团或荧光团和猝灭剂。 当进行蛋白水解切割时，至少一个荧光团是不淬灭的，并且在用适当波长的光激发时变得能够产生荧光信号。 还提供了使用这种成像剂的体内和体外成像方法。
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公开(公告)号：US07947256B2
公开(公告)日：2011-05-24
申请号：US12065385
申请日：2006-09-01
申请人： Milind Rajopadhye , Kevin Groves
发明人： Milind Rajopadhye , Kevin Groves
IPC分类号： A61K49/04
CPC分类号： G01N33/582 , A61K49/0032 , A61K49/0052 , C09B23/0008 , C09B23/0066 , C09B23/083 , C09B23/086 , G01N33/533
摘要： This invention relates to new carbocyanine fluorophores comprising a biomolecule targeting moiety containing 1-6 aromatic moieties, wherein the targeting moiety is designed to attach to biocompatible molecules to form in vivo optical imaging agents.
摘要翻译： 本发明涉及包含含有1-6个芳族部分的生物分子靶向部分的新的碳代花青荧光团，其中靶向部分设计成附着于生物相容性分子以形成体内光学成像剂。
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公开(公告)号：US09913917B2
公开(公告)日：2018-03-13
申请号：US11645111
申请日：2006-12-22
申请人： Kevin Groves , Milind Rajopadhye
发明人： Kevin Groves , Milind Rajopadhye
CPC分类号： A61K49/1866 , A61K49/0002 , A61K49/0032 , A61K49/0056 , A61K49/0093 , A61K49/1833 , A61K49/186 , B82Y5/00
摘要： The invention relates to highly fluorescent metal oxide nanoparticles to which biomolecules and other compounds can be chemically linked to form biocompatible, stable optical imaging agents for in vitro and in vivo applications. The fluorescent metal oxide nanoparticles may also be used for magnetic resonance imaging (MRI), thus providing a multi modality imaging agent.
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