公开(公告)号：US5142028A

公开(公告)日：1992-08-25

申请号：US377121

申请日：1989-07-10

申请人： Yoshitaka Nagai ,  Hideki Yamamoto ,  Kinji Takada ,  Masayoshi Ito

发明人： Yoshitaka Nagai ,  Hideki Yamamoto ,  Kinji Takada ,  Masayoshi Ito

IPC分类号： G01N33/53 ,  A61K39/395 ,  C07K16/18 ,  C12N5/10 ,  C12N5/18 ,  C12N5/20 ,  C12N15/02 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577

CPC分类号： C07K16/18

摘要： A monoclonal antibody specifically recognizes an epitope or an antigenic determinant represented by the following formula and specifically reacts therewith: ##STR1## The monoclonal antibody can be obtained by cultivating hybridoma cells which can be generated by a method comprising cell-fusing (A) B cells or lymphocytes obtained by immunizing an animal with a substance involving the epitope or the antigenic determinant represented by the foregoing formula and (B) myeloma cells. The monoclonal antibody shows high specificity to ganglioside GQ.sub.1b and ganglioside GT.sub.1a having a specific epitope and thus can detect the epitope in high sensitivity. Therefore, the antibody can be used for the elucidation of sugar chain's roles in cell functions and for studying the development of animals. Moreover, the monoclonal antibody would have various clinical applications.

公开(公告)号：US5224021A

公开(公告)日：1993-06-29

申请号：US601231

申请日：1990-10-19

申请人： Kinji Takada ,  Kazuo Oishi ,  Syozo Yamashita ,  Koji Nishida

发明人： Kinji Takada ,  Kazuo Oishi ,  Syozo Yamashita ,  Koji Nishida

IPC分类号： H01C1/16 ,  H01R12/70 ,  H01R12/71 ,  H01R13/66 ,  H05K1/18 ,  H05K3/34 ,  H05K5/00

CPC分类号： H05K3/3426 ,  H01C1/16 ,  H01R12/7076 ,  H01R12/714 ,  H01L2224/48247 ,  H01L2224/48472 ,  H01L2224/8592 ,  H01L2924/181 ,  H01R13/66 ,  Y02P70/613

摘要： A surface-mount network device which is to be mounted on a mounting substrate is disclosed. This device has an insulating substrate having wirings and passive elements. A plurality of lead terminals sandwich the insulating substrate from an end face of the insulating substrate. Terminal connection conductors are formed on the main surfaces of the insulating substrate and connect the lead terminals and at least one of the wirings and the passive elements. Sealing material cover at least connecting portions between the terminal connection conductors and the lead terminals. End portions of the lead terminals are bent to extend in a direction substantially parallel to the mounting substrate. This device is to be mounted vertically on the mounting substrate through the bent end portions of the lead terminals.

公开(公告)号：US5158886A

公开(公告)日：1992-10-27

申请号：US268895

申请日：1988-11-08

申请人： Atsushi Kawamura ,  Isao Suda ,  Kinji Takada ,  Masayoshi Ito ,  Yoshiyasu Shitori

发明人： Atsushi Kawamura ,  Isao Suda ,  Kinji Takada ,  Masayoshi Ito ,  Yoshiyasu Shitori

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/395 ,  C07K16/18 ,  C07K16/30 ,  C12N5/18 ,  C12N5/20 ,  C12P21/08 ,  C12R1/91 ,  G01N33/574

CPC分类号： C07K16/18 ,  C07K16/30 ,  A61K38/00

摘要： A hybridoma producing a monoclonal antibody specific for free N-acetylneuraminic acid or beta glycoconjugates thereof, is herein disclosed. The hybridoma can be generated by fusing (i) B cells of lymphocytes obtained by immunizing an animal with an N-acetylneuraminic acid or a beta-glycoconjugate thereof, and (ii) myeloma cells.

摘要翻译： 本文公开了产生对游离N-乙酰神经氨酸或其β-糖缀合物特异性的单克隆抗体的杂交瘤。 杂交瘤可以通过将（i）通过用N-乙酰神经氨酸或其β-糖结合物免疫动物获得的淋巴细胞的B细胞和（ii）骨髓瘤细胞融合来产生。

公开(公告)号：US5141864A

公开(公告)日：1992-08-25

申请号：US270205

申请日：1988-11-14

申请人： Yoshitaka Nagai ,  Hideki Yamamoto ,  Kinji Takada ,  ;Masayoshi Ito ,  Yoshiyasu Shitori

发明人： Yoshitaka Nagai ,  Hideki Yamamoto ,  Kinji Takada ,  ;Masayoshi Ito ,  Yoshiyasu Shitori

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K14/005 ,  C07K14/195 ,  C07K14/705 ,  C07K16/00 ,  C07K16/18 ,  C07K16/32 ,  C07K16/44 ,  C12N5/00 ,  C12N5/10 ,  C12N5/20 ,  C12N15/02 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/53 ,  G01N33/574 ,  G01N33/577 ,  G01N33/92

CPC分类号： G01N33/574 ,  G01N33/5743 ,  G01N33/57469 ,  G01N33/92 ,  Y10S424/807 ,  Y10S530/864

摘要： A hybridoma capable of producing a monoclonal antibody specific to a sialic acid containing glycolipid carrying N-acetylneuraminic acid residue having alpha 2.fwdarw.3 linkage is herein disclosed. The hybridoma can be generated by fusing (i) B cells or lymphocytes obtained by immunizing an animal with a sialic acid containing glycolipid carrying N-acetylneuraminic acid residue having alpha 2.fwdarw.3 linkage and (ii) myeloma cells. The monoclonal antibody produced by the hybridoma can be used for purifying gangliosides, for treating patients suffering from melanoma and for diagnosing sera.

公开(公告)号：US4436904A

公开(公告)日：1984-03-13

申请号：US337380

申请日：1982-01-06

申请人： Shigeo Shimizu ,  Hiroyuki Takano ,  Shoji Yoshimura ,  Kinji Takada

发明人： Shigeo Shimizu ,  Hiroyuki Takano ,  Shoji Yoshimura ,  Kinji Takada

IPC分类号： C07D233/38 ,  C07D501/20 ,  C07D501/22 ,  C07D501/34 ,  C07D501/36 ,  C07D501/38 ,  C07D501/56

CPC分类号： C07D233/38

摘要： Novel cephalosporin derivatives are described which have excellent antibiotic activity against pathogenic bacteria belonging to the Pseudomonas, Serratia and Enterobacter. The compounds have general formula ##STR1## in which R is hydrogen, acyloxy, carbamoyloxy, a substituted or unsubstituted pyridinium group or a group -S-Het in which Het represents a substituted or unsubstituted, hetero atom-containing, 5- or 6-membered heterocyclic ring, R' is hydrogen, alkali metal, an organic amine or an ester moiety, R.sub.1 and R.sub.2 are the same or different and are hydrogen or a lower alkyl and B stands for a 1,4-cyclohexadienyl group, a group ##STR2## in which Y is hydrogen, --OH or ##STR3## in which R.sub.5 is an alkyl of 1 to 5 carbon atoms, aryl or alkoxy having 1 to 4 carbon atoms, Z stands for hydrogen or halogen and p is an integer of 1 or 2, a furan group or a thiophene group. Methods of preparation are described.

摘要翻译： 描述了对属于假单胞菌属，沙雷氏菌属和肠杆菌属的病原菌具有优异抗生素活性的新型头孢菌素衍生物。 所述化合物具有通式（I）其中R为氢，酰氧基，氨基甲酰氧基，取代或未取代的吡啶鎓基或-S-Het，其中Het表示取代或未取代的含杂原子的 5或6元杂环，R'是氢，碱金属，有机胺或酯部分，R 1和R 2相同或不同，为氢或低级烷基，B代表1,4- 环己二烯基，其中Y是氢的-OH基团，其中R 5是1到5个碳原子的烷基，R 1代表氢或卤素的芳基或烷氧基， p为1或2的整数，呋喃基或噻吩基。 描述制备方法。