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公开(公告)号:US08856193B2
公开(公告)日:2014-10-07
申请号:US13332151
申请日:2011-12-20
申请人: Klaus Otto Mueller
发明人: Klaus Otto Mueller
CPC分类号: G06F17/30289 , G06F17/30 , G06F17/30442
摘要: At runtime first and second cost functions associated with a request for a merge of a main partition of a table with a delta partition of the table can be calculated. The first and second cost functions can respectively quantify an urgency of the merge relative to availability of system resources required to perform the merge and an urgency of the merge relative to other merges. Determining whether the merge should occur can include comparing the calculated first and second cost functions with calculations of other first and second cost functions for other merge requests of one or more other tables. If the merge should occur, a merge thread can be assigned to execute the merge, and execution of the merge by the merge thread can be commenced if at least one merge token representing system resources usable for merge operations is available.
摘要翻译: 在运行时,可以计算与表的主分区的合并请求与表的增量分区相关联的第一和第二成本函数。 第一和第二成本函数可以分别量化合并相对于执行合并所需的系统资源的可用性的紧急性以及合并相对于其他合并的紧急性。 确定合并是否应发生可以包括将计算的第一和第二成本函数与其他一个或多个其他表的其他合并请求的其他第一和第二成本函数的计算进行比较。 如果合并应发生,则可以分配合并线程来执行合并,并且如果至少有一个代表可用于合并操作的系统资源的合并令牌可用,则合并线程合并的执行可以开始。
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公开(公告)号:US5739142A
公开(公告)日:1998-04-14
申请号:US592660
申请日:1996-01-26
IPC分类号: C07D295/14 , A61K31/155 , A61K31/425 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61P9/00 , A61P9/06 , A61P9/10 , C07C279/22 , C07C315/04 , C07C317/48 , C07D213/74 , C07D233/88 , C07D239/42 , C07D277/20 , C07D277/42 , C07D295/155 , A61K31/505 , C07D277/38
CPC分类号: C07D213/74 , C07C317/48 , C07D239/42 , C07D295/155
摘要: 4-Aminobenzoylguanidines of the formula I ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties and are active as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
摘要翻译: 其中A,R 1,R 2和R 3具有给定的含义的式I的4-氨基苯甲酰基胍,其生理上无反应的盐表现出抗心律失常性质,并且作为细胞Na + / H +反转录酶的抑制剂是有活性的。
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公开(公告)号:US5700839A
公开(公告)日:1997-12-23
申请号:US546570
申请日:1995-10-20
IPC分类号: A61K31/165 , A61K31/155 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , C07C279/18 , C07C315/04 , C07C317/44 , C07C317/46 , C07C317/50 , C07C231/02 , C07C231/12 , C07C235/50
CPC分类号: C07C317/44 , Y10S514/821 , Y10S514/866
摘要: Benzoylguanidines of the formula I ##STR1## wherein R.sup.1 and R.sup.2 have the meanings indicated herein, and their physiologically acceptable salts, show anti-arrhythmic properties and act as inhibitors of the cellular NA.sup.+ /H.sup.+ antiporter.
摘要翻译: 其中R 1和R 2具有本文所示含义的式I的苯甲酰基胍及其生理上可接受的盐显示抗心律失常性质,并且作为细胞NA + / H +反转录酶的抑制剂。
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公开(公告)号:US5696167A
公开(公告)日:1997-12-09
申请号:US593863
申请日:1996-01-30
IPC分类号: C07C279/22 , A61K31/10 , A61K31/155 , A61K31/18 , A61K31/41 , A61K31/425 , A61K31/426 , A61K31/44 , A61P9/06 , A61P9/08 , A61P9/10 , A61P35/00 , A61P43/00 , C07C319/20 , C07C323/65 , C07D213/70 , C07D239/10 , C07D239/38 , C07D249/10 , C07D249/12 , C07D277/16 , C07D521/00
CPC分类号: C07D213/70 , C07C323/65
摘要: 4-Mercaptobenzoylguanidines of the formula I ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.3 have the meanings given, and the physiologically unobjectionable salts thereof exhibit antiarrhythmic properties and are active as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
摘要翻译: 其中A,R 1,R 2和R 3具有给定的含义的式I的4-巯基苯甲酰基胍,其生理上无反应的盐表现出抗心律失常性质,并且作为细胞Na + / H +反转录酶的抑制剂是有活性的。
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公开(公告)号:US5461066A
公开(公告)日:1995-10-24
申请号:US385790
申请日:1995-02-09
申请人: Rolf Gericke , Manfred Baumgarth , Dieter Dorsch , Norbert Beier , Klaus-Otto Minck , Ingeborg Lues
发明人: Rolf Gericke , Manfred Baumgarth , Dieter Dorsch , Norbert Beier , Klaus-Otto Minck , Ingeborg Lues
IPC分类号: A61K31/4427 , A61K31/445 , A61K31/4465 , A61K31/4468 , A61K31/4523 , A61P9/00 , A61P9/06 , A61P9/10 , C07D211/58 , C07D401/04 , C07D401/06 , C07D401/12 , C07D211/98
CPC分类号: C07D401/04 , C07D211/58
摘要: 4-amino-1-piperidylbenzoylguanidines of the formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the given meanings, and also the physiologically compatible salts thereof, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.
摘要翻译: 其中R 1,R 2,R 3和R 4具有给定含义的式I的4-氨基-1-哌啶基苯甲酰基胍以及其生理上相容的盐表现出抗心律失常性质,并且作为细胞Na + / H + 反倾销
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公开(公告)号:US5438063A
公开(公告)日:1995-08-01
申请号:US254834
申请日:1994-06-06
申请人: Mathias Osswald , Werner Mederski , Dieter Dorsch , Pierre Schelling , Norbert Beier , Ingeborg Lues , Klaus-Otto Minck
发明人: Mathias Osswald , Werner Mederski , Dieter Dorsch , Pierre Schelling , Norbert Beier , Ingeborg Lues , Klaus-Otto Minck
IPC分类号: A61K31/435 , A61K31/44 , A61P5/38 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/02 , A61P15/00 , A61P25/00 , A61P27/02 , A61P27/06 , A61P43/00 , C07D233/72 , C07D249/08 , C07D271/06 , C07D285/08 , C07D285/12 , C07D291/04 , C07D471/04
CPC分类号: C07D471/04
摘要: Novel imidazopyridine derivatives of formula I ##STR1## wherein ##STR2## and R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are as defined herein, and their salts, exhibit antagonistic properties toward angiotensin II and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure, and of disorders of the central nervous system.
摘要翻译: 式I的新型咪唑并吡啶衍生物其中其中R IMA,R 1,R 2,R 3,R 4,X和Y如本文所定义,及其盐对血管紧张素II表现出拮抗作用,可用于治疗高血压 ,醛固酮增多症,心功能不全和眼压升高以及中枢神经系统疾病。
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公开(公告)号:US5389642A
公开(公告)日:1995-02-14
申请号:US167369
申请日:1993-12-16
申请人: Dieter Dorsch , Werner Mederski , Mathias Osswald , Pierre Schelling , Norbert Beier , Ingeborg Lues , Klaus-Otto Minck
发明人: Dieter Dorsch , Werner Mederski , Mathias Osswald , Pierre Schelling , Norbert Beier , Ingeborg Lues , Klaus-Otto Minck
IPC分类号: A61K31/435 , A61K31/44 , A61P9/00 , A61P9/12 , A61P27/02 , A61P43/00 , C07D471/04
CPC分类号: C07D471/04
摘要: Novel imidazopyridine derivatives of the formula I ##STR1## in which R is ##STR2## and R.sup.1 to R.sup.4, X and Y are as defined herein, and their salts have antagonistic properties towards angiotensin(II) and can be used for the treatment of hypertension, aldosteronism, cardiac insufficiency and increased intraocular pressure and also disorders of the central nervous system.
摘要翻译: 式I的新型咪唑并吡啶衍生物,其中R是R和R 1至R 4,X和Y如本文所定义,并且其盐对血管紧张素(II)具有拮抗作用,可用于治疗 高血压,醛固酮增多症,心功能不全和眼内压升高以及中枢神经系统疾病。
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公开(公告)号:US5332750A
公开(公告)日:1994-07-26
申请号:US50800
申请日:1993-04-22
IPC分类号: C07D213/64 , C07D213/80 , C07D213/82 , C07D213/85 , C07D401/10 , C07D401/12 , C07D401/14 , A61K31/44 , C07D401/04
CPC分类号: C07D213/64 , C07D213/80 , C07D213/82 , C07D213/85 , C07D401/10 , C07D401/12 , C07D401/14
摘要: New 1,2-dihydro-2-oxopyridines of formula I ##STR1## in which R is the radical ##STR2## and R.sup.1 to R.sup.6 and X are as defined herein,and their salts, have antagonistic properties towards angiotensin II and can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.
摘要翻译: 式I的新1,2-二氢-2-氧代吡啶,其中R是基团,且R 1至R 6和X如本文所定义,并且其盐对血管紧张素II具有拮抗作用,并且可以是 用于治疗高血压,醛固酮增多和心功能不全。
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公开(公告)号:US5328916A
公开(公告)日:1994-07-12
申请号:US694617
申请日:1991-05-02
IPC分类号: A61K38/00 , A61P9/12 , C07D213/63 , C07D213/70 , C07D213/71 , C07K1/113 , C07K5/06 , C07K5/065 , C07K5/078 , C07K14/81 , C07D211/18 , C07D401/12
CPC分类号: C07K5/06078 , C07K5/06139 , A61K38/00
摘要: New heterocyclic compounds of the formulaX--W--CR.sup.1 R.sup.2 --CO--Y--NR.sup.3 --CHR.sup.4 --CR.sup.5 --CH.sub.2 --(CR.sup.6 R.sup.7).sub.r --Z--Het Iin which R.sup.1 to R.sup.7, W, X, Y, Z, r and Het have the meanings defined herein, and the salts thereof, inhibit the activity of human plasma renin.
摘要翻译: 式XW-CR1R2-CO-Y-NR3-CHR4-CR5-CH2-(CR6R7)rZ-HetI的新杂环化合物,其中R 1至R 7,W,X,Y,Z,r和Het具有本文定义的含义 及其盐抑制人血浆肾素的活性。
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公开(公告)号:US5256673A
公开(公告)日:1993-10-26
申请号:US377343
申请日:1989-07-10
IPC分类号: C07D401/06 , C07D401/12 , A61K31/44
CPC分类号: C07D401/06 , C07D401/12
摘要: Indole derivatives of the general formula I ##STR1## wherein Ind is an indol-3-yl radical which is substituted by a hydroxymethyl or COW group and can additionally be monosubstituted or disubstituted by alkyl, O-alkyl, OH, F, Cl or Br,W is H, OH, Oalkyl, NH.sub.2, NHalkyl or N(alkyl).sub.2,A is --(CH.sub.2).sub.n --, CH.sub.2 --S--CH.sub.2 CH.sub.2 --, --CH.sub.2 --SO--CH.sub.2 CH.sub.2 or --CH.sub.2 --SO.sub.2 --CH.sub.2 CH.sub.2,n is 2, 3, 4 or 5,the two radicals Y are each H or together are a C--C bond, one radical Z is Ar,the other radical Z is H andAr is a phenyl group which is unsubstituted or monosubstituted or disubstituted by O-alkyl and/or OH or is substituted by a methylenedioxy group, or Ar is a 2-thienyl or 3-thienyl group,the alkyl groups each having 1-4 C atoms,wherein, however, when n is 2 or 3, the hydroxymethyl or COW group must be in the 4-, 5-, 6- or 7-position of the indol-3-yl radical,and physiologically acceptable acid addition salts thereof exhibit an action on the central nervous system.
摘要翻译: 其中Ind是被羟甲基或COW基团取代的吲哚-3-基,并且可以另外被烷基,O-烷基,OH,F,Cl或Br单取代或二取代的通式I的吲哚衍生物 ,W是H,OH,O烷基,NH2,NH烷基或N(烷基)2,A是 - (CH2)n-,CH2-S-CH2CH2-,-CH2-SO-CH2CH2或-CH2-SO2-CH2CH2,n 2个,3个,4个或5个,两个基团Y各自为H或一起为CC键,一个基团Z为Ar,另一个基团Z为H,Ar为未被取代或被O取代或二取代的苯基 - 烷基和/或OH或被亚甲二氧基取代,或Ar是2-噻吩基或3-噻吩基,所述烷基各自具有1-4个C原子,但是,当n为2或3时, 羟甲基或COW基必须在吲哚-3-基自由基的4-,5-,6-或7-位,其生理上可接受的酸加成盐对中枢神经系统表现出作用。
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