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    Root canal filler and dental tissue regeneration method
    1.
    发明授权
    Root canal filler and dental tissue regeneration method 有权
    根管填充和牙组织再生方法

    公开(公告)号：US08920791B2

    公开(公告)日：2014-12-30

    申请号：US12922097

    申请日：2009-03-12

    申请人： Misako Nakashima ,  Koichiro Iohara

    发明人： Misako Nakashima ,  Koichiro Iohara

    IPC分类号： A61K6/02 ,  A61K35/12 ,  A61L27/38 ,  A61K6/00 ,  A61L27/36

    CPC分类号： A61L27/3834 ,  A61K6/0032 ,  A61L27/3633 ,  A61L27/3865 ,  A61L2400/06 ,  A61L2430/12

    摘要： Provided is a novel and creative dental tissue regeneration method for regenerating dental tissue after pulpectomy or the enlargement and cleaning of an infected root canal. After pulpectomy or the enlargement and cleaning of an infected root canal, a root canal filler (200) having an extracellular matrix (210) containing the cells (220) enriched for dental pulp stem cells, is inserted into the apical side of the root canal of a target tooth (100). The cells including dental pulp stem cells include at least one of the following: dental pulp SP cells, CD31-negative and CD146-negative cells, CD24-positive cells, CD105-positive cells, and CD150-positive cells. For instance, dental pulp SP cells are CD31− and CD146− negative. Even if pulpitis due to deep caries occurs, appropriate dental pulp regeneration and recovery of dental pulp function are possible.

    摘要翻译： 提供了一种新颖创新的牙科组织再生方法，用于在切除术后进行牙齿组织再生或扩大和清洁受感染的根管。 在进行切割或扩大和清洁感染的根管之后，将含有富含牙髓干细胞的细胞（220）的细胞外基质（210）的根管填料（200）插入到根管的顶端 的目标牙齿（100）。 包括牙髓干细胞的细胞包括以下至少一种：牙髓SP细胞，CD31阴性和CD146阴性细胞，CD24阳性细胞，CD105阳性细胞和CD150阳性细胞。 例如，牙髓SP细胞是CD31-和CD146-阴性的。 即使发生由于深度龋齿引起的牙髓炎，也可以适当地进行牙髓再生和恢复牙髓功能。

    ROOT CANAL FILLING MATERIAL CONTAINING MESENCHYMAL STEM CELLS AND METHOD FOR REGENERATING DENTAL TISSUE USING THE SAME
    2.
    发明申请
    ROOT CANAL FILLING MATERIAL CONTAINING MESENCHYMAL STEM CELLS AND METHOD FOR REGENERATING DENTAL TISSUE USING THE SAME 有权
    含有中枢神经干细胞的根冠填充材料及其再生牙周组织的方法

    公开(公告)号：US20140322672A1

    公开(公告)日：2014-10-30

    申请号：US13985111

    申请日：2012-01-31

    申请人： Misako Nakashima ,  Koichiro Iohara

    发明人： Misako Nakashima ,  Koichiro Iohara

    IPC分类号： A61L27/38 ,  A61C5/04 ,  A61C5/02 ,  A61L27/54

    CPC分类号： A61C5/40 ,  A61C5/50 ,  A61K6/0035 ,  A61K6/0041 ,  A61L27/3633 ,  A61L27/3834 ,  A61L27/54 ,  A61L2300/412 ,  A61L2430/12

    摘要： A root canal filling material for a tooth extraction or tooth non-extraction process can be used clinically because of its easy availability and can efficiently enhance dental tissue regeneration; a method for regenerating dental tissue using the filling material is also provided. A root canal filling material 200 including mesenchymal stem cells 220 excluding dental pulp stem cells, which are inserted into the apical side of a root canal subjected to pulp extirpation or to root canal enlargement and cleaning of an infected root canal and including an extracellular matrix 210 is provided, and a method for regenerating dental tissue, through a tooth extracting or tooth non-extracting process, including a step of injecting the root canal filling material into the apical side of a root canal of a non-extracted tooth subjected to pulp extirpation or to root canal enlargement and cleaning of an infected root canal is provided.

    摘要翻译： 用于拔牙或牙齿非提取过程的根管填充材料可以临床使用，因为其容易获得并且可以有效地增强牙齿组织再生; 还提供了使用填充材料再生牙组织的方法。 一根根管填充材料200，其包括不包括牙髓干细胞的间充质干细胞220，其被插入经根髓脱髓鞘根管扩大和清洁感染根管并包括细胞外基质210的根管顶端 以及用于通过拔牙或拔牙过程再生牙科组织的方法，包括将根管填充材料注入经脱髓鞘的非提取牙齿的根管的顶端侧的步骤 或根管扩大和清洁受感染的根管。

    UNEXTRACTED TOOTH ROOT CANAL FILLER AND DENTAL TISSUE REGENERATION METHOD FOR UNEXTRACTED TOOTH
    3.
    发明申请
    UNEXTRACTED TOOTH ROOT CANAL FILLER AND DENTAL TISSUE REGENERATION METHOD FOR UNEXTRACTED TOOTH 审中-公开
    独立牙根牙根填充物和牙科组织再生方法

    公开(公告)号：US20120164604A1

    公开(公告)日：2012-06-28

    申请号：US13395374

    申请日：2010-09-10

    申请人： Misako Nakashima ,  Koichiro Iohara

    发明人： Misako Nakashima ,  Koichiro Iohara

    IPC分类号： A61C5/04 ,  A61K35/32

    CPC分类号： A61K35/28 ,  A61C5/50 ,  A61K35/32 ,  A61K38/193 ,  A61L27/3633 ,  A61L27/3834 ,  A61L27/3865 ,  A61L2430/12 ,  C12N5/0664 ,  A61K2300/00

    摘要： Disclosed is a root canal filler for non-extracted tooth which causes no internal resorption or external resorption in a tooth with complete root formation, shows no odontoclast, and contributes to the regeneration of a dental tissue in which odontoblasts are smoothly aligned on the dentin wall. After pulpectomy or enlargement/cleaning of an infected root canal, a root canal filler for non-extracted tooth, which comprises tooth pulp stem cells and an extracellular matrix, is inserted into the apical side of the root canal of the non-extracted tooth. The tooth pulp stem cells may be, for example, dental pulp CXCR4-positive cells. It is preferred to attach, to the crown side of the root canal, migration factor(s) including at least one factor selected from among a cell migration factor, a cell proliferation factor, a neurotrophic factor and an angiogenic factor.

    摘要翻译： 公开了一种用于非提取牙齿的根管填料，其在完全根部形成的牙齿中不引起内部吸收或外部吸收，不显示牙齿清除物，并且有助于牙齿组织的再生，其中成牙本质细胞在牙本质壁上平滑地排列 。 在对受感染的根管进行切割或扩大/清洁之后，将包含牙髓干细胞和细胞外基质的未提取牙齿的根管填充物插入非提取牙齿根管的顶端。 牙髓干细胞可以是例如牙髓CXCR4阳性细胞。 优选在根管的冠侧附着包括选自细胞迁移因子，细胞增殖因子，神经营养因子和血管生成因子中的至少一种因子的迁移因子。

    ROOT CANAL FILLER AND DENTAL TISSUE REGENERATION METHOD
    4.
    发明申请
    ROOT CANAL FILLER AND DENTAL TISSUE REGENERATION METHOD 有权
    ROOT CANAL FILLER和牙齿组织再生方法

    公开(公告)号：US20110020310A1

    公开(公告)日：2011-01-27

    申请号：US12922097

    申请日：2009-03-12

    申请人： Misako Nakashima ,  Koichiro Iohara

    发明人： Misako Nakashima ,  Koichiro Iohara

    IPC分类号： A61K35/12 ,  A61P1/02

    CPC分类号： A61L27/3834 ,  A61K6/0032 ,  A61L27/3633 ,  A61L27/3865 ,  A61L2400/06 ,  A61L2430/12

    摘要： Provided is a novel and creative dental tissue regeneration method for regenerating dental tissue after pulpectomy or the enlargement and cleaning of an infected root canal. After pulpectomy or the enlargement and cleaning of an infected root canal, a root canal filler (200) having an extracellular matrix (210) containing the cells (220) enriched for dental pulp stem cells, is inserted into the apical side of the root canal of a target tooth (100). The cells including dental pulp stem cells include at least one of the following: dental pulp SP cells, CD31-negative and CD146-negative cells, CD24-positive cells, CD105-positive cells, and CD150-positive cells. For instance, dental pulp SP cells are CD31− and CD146− negative. Even if pulpitis due to deep caries occurs, appropriate dental pulp regeneration and recovery of dental pulp function are possible.

    摘要翻译： 提供了一种新颖创新的牙科组织再生方法，用于在切除术后进行牙齿组织再生或扩大和清洁受感染的根管。 在进行切割或扩大和清洁感染的根管之后，将含有富含牙髓干细胞的细胞（220）的细胞外基质（210）的根管填料（200）插入到根管的顶端 的目标牙齿（100）。 包括牙髓干细胞的细胞包括以下至少一种：牙髓SP细胞，CD31阴性和CD146阴性细胞，CD24阳性细胞，CD105阳性细胞和CD150阳性细胞。 例如，牙髓SP细胞是CD31-和CD146-阴性的。 即使发生由于深度龋齿引起的牙髓炎，也可以适当地进行牙髓再生和恢复牙髓功能。