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    Process for production of a betaine such as carnitine
    2.
    发明授权
    Process for production of a betaine such as carnitine 失效
    生产甜菜碱如肉碱的方法

    公开(公告)号：US08334132B2

    公开(公告)日：2012-12-18

    申请号：US12514000

    申请日：2007-11-09

    申请人： Kosuke Oishi ,  Eiji Sato ,  Hiroyuki Mori ,  Akira Yoshioka

    发明人： Kosuke Oishi ,  Eiji Sato ,  Hiroyuki Mori ,  Akira Yoshioka

    IPC分类号： C12P41/00

    CPC分类号： C07C227/12 ,  C12P13/007 ,  C07C229/22

    摘要： According to the present invention, by using 4-halogeno-3-hydroxybutanamide as a substrate in quaternary amination reaction with trialkylamine which is an important step in betaine (such as carnitine) preparation processes, it becomes possible to reduce the production of crotonic acid derivatives (the major by-product) greatly compared to conventional processes. Consequently, it becomes possible to prepare a betaine, such as carnitine, at a high yield.

    摘要翻译： 根据本发明，通过在作为甜菜碱（例如肉碱）制备方法中的重要步骤的三烷基胺的季胺化反应中使用4-卤代-3-羟基丁酰胺作为底物，可以减少巴豆酸衍生物的生产 （主要副产品）与常规工艺相比大大增加。 因此，可以以高收率制备甜菜碱，如肉毒碱。

    METHOD FOR MANUFACTURING POLYIMIDE METAL LAMINATE
    4.
    发明申请
    METHOD FOR MANUFACTURING POLYIMIDE METAL LAMINATE 有权
    制备聚酰亚胺金属层压板的方法

    公开(公告)号：US20140290853A1

    公开(公告)日：2014-10-02

    申请号：US14238071

    申请日：2012-08-10

    申请人： Shin-ichiro Kohama ,  Nobuharu Hisano ,  Taizou Murakami ,  Kosuke Oishi ,  Hiroaki Yamaguchi

    发明人： Shin-ichiro Kohama ,  Nobuharu Hisano ,  Taizou Murakami ,  Kosuke Oishi ,  Hiroaki Yamaguchi

    IPC分类号： B29C65/00

    CPC分类号： B29C66/742 ,  B32B15/08 ,  B32B15/20 ,  B32B27/08 ,  B32B27/18 ,  B32B27/281 ,  B32B2255/10 ,  B32B2255/26 ,  B32B2264/10 ,  B32B2307/20 ,  B32B2307/306 ,  B32B2307/50 ,  B32B2307/714 ,  B32B2307/734 ,  B32B2457/00 ,  B32B2457/08 ,  B32B2457/14 ,  C08G73/1085

    摘要： A method for manufacturing a polyimide-metal laminate including forming a polyimide film, in which at least surfaces of both sides of the film are formed by thermally fusion-bondable polyimide layers (a), and thermal compression-bonding metal layers on both sides of the polyimide film; in which forming the polyimide film includes reacting a tetracarboxylic dianhydride component with a diamine component containing a diamine compound represented by general formula (1) to give a solution of a polyamic acid (a), forming a self-supporting film from the solution of the polyamic acid (a) and imidizing the self-supporting film by heating at a maximum heating temperature of 440° C. or lower to form the polyimide layer (a); in which R1 represents hydrogen or alkyl or aryl having 1 to 12 carbon atoms; and R2 represents hydrogen or alkyl or aryl having 1 to 12 carbon atoms.

    摘要翻译： 一种制造聚酰亚胺 - 金属层压体的方法，包括形成聚酰亚胺膜，其中至少通过可热熔融粘合的聚酰亚胺层（a）形成膜的两侧表面，并且在两侧形成热压接金属层 聚酰亚胺膜; 其中形成聚酰亚胺膜包括使四羧酸二酐组分与含有由通式（1）表示的二胺化合物的二胺组分反应，得到聚酰胺酸（a）的溶液，从该溶液中形成自支撑膜 聚酰胺酸（a），通过在最高加热温度440℃以下加热而使自支撑膜酰亚胺化以形成聚酰亚胺层（a）; 其中R1表示氢或具有1至12个碳原子的烷基或芳基; 并且R 2表示氢或具有1至12个碳原子的烷基或芳基。

    PROCESS FOR PRODUCTION OF BETAINE
    5.
    发明申请
    PROCESS FOR PRODUCTION OF BETAINE 失效
    生产BETAINE的方法

    公开(公告)号：US20090325246A1

    公开(公告)日：2009-12-31

    申请号：US12514000

    申请日：2007-11-09

    申请人： Kosuke Oishi ,  Eiji Sato ,  Hiroyuki Mori ,  Akira Yoshioka

    发明人： Kosuke Oishi ,  Eiji Sato ,  Hiroyuki Mori ,  Akira Yoshioka

    IPC分类号： C12P13/02 ,  C07C231/12 ,  C07C227/14

    CPC分类号： C07C227/12 ,  C12P13/007 ,  C07C229/22

    摘要： According to the present invention, by using 4-halogeno-3-hydroxybutanamide as a substrate in quaternary amination reaction with trialkylamine which is an important step in betaine (such as carnitine) preparation processes, it becomes possible to reduce the production of crotonic acid derivatives (the major by-product) greatly compared to conventional processes. Consequently, it becomes possible to prepare a betaine, such as carnitine, at a high yield.The present invention also relates to a process for preparing a betaine represented by formula (1) below, comprising a step of quaternary aminating an amide represented by formula (2) below: wherein A1, A2 and A3 individually represent a C1-C20 hydrocarbon group which may have a substituent(s); and X1 is a halogen atom.

    摘要翻译： 根据本发明，通过在作为甜菜碱（例如肉碱）制备方法中的重要步骤的三烷基胺的季胺化反应中使用4-卤代-3-羟基丁酰胺作为底物，可以减少巴豆酸衍生物的生产 （主要副产品）与常规工艺相比大大增加。 因此，可以以高收率制备甜菜碱，如肉毒碱。 本发明还涉及由下式（1）表示的甜菜碱的制备方法，该方法包括下述式（2）表示的酰胺季铵化的步骤：其中A1，A2和A3各自表示C1-C20烃基 其可以具有取代基; X1是卤原子。