公开(公告)号：US20120308816A1

公开(公告)日：2012-12-06

申请号：US13577900

申请日：2011-02-10

申请人： Shin-ichiro Kohama ,  Nobuharu Hisano ,  Hiroaki Yamaguchi ,  Yoshiyuki Oishi ,  Toru Miura ,  Tadahiro Yokozawa ,  Masafumi Kohda ,  Kosuke Oishi

发明人： Shin-ichiro Kohama ,  Nobuharu Hisano ,  Hiroaki Yamaguchi ,  Yoshiyuki Oishi ,  Toru Miura ,  Tadahiro Yokozawa ,  Masafumi Kohda ,  Kosuke Oishi

IPC分类号： B32B27/06 ,  B32B15/08 ,  B29C39/00 ,  B32B7/12

CPC分类号： B32B15/08 ,  B32B7/12 ,  B32B15/088 ,  B32B27/06 ,  B32B27/28 ,  B32B27/34 ,  B32B2379/08 ,  B32B2457/202 ,  C08G73/0273 ,  C08G73/0644 ,  C08G73/1085 ,  C08J5/128 ,  C08J2379/08 ,  C08J2479/08 ,  C09D179/08 ,  H05K1/0346 ,  Y10T428/2848 ,  Y10T428/31678 ,  Y10T428/31681 ,  Y10T428/31721

摘要： Disclosed is a polyimide film having improved adhesiveness to an adhesive and/or adherence to a metal layer. The polyimide film has at least a polyimide layer (b) and a polyimide layer (a) formed contacting the polyimide layer (b), wherein the polyimide layer (a) is a polyimide formed from a tetracarboxylic dianhydride component and a diamine component containing a diamine compound represented by general formula (1): wherein R1 denotes a hydrogen atom, an alkyl group having 1 to 12 carbon atoms or an aryl group, and R2 denotes an alkyl group having 1 to 12 carbon atoms or an aryl group.

摘要翻译： 公开了具有改进的粘合剂粘附性和/或与金属层的粘附性的聚酰亚胺膜。 聚酰亚胺膜至少具有聚酰亚胺层（b）和与聚酰亚胺层（b）接触形成的聚酰亚胺层（a），其中聚酰亚胺层（a）是由四羧酸二酐组分形成的聚酰亚胺和含有 由通式（1）表示的二胺化合物：其中R1表示氢原子，具有1至12个碳原子的烷基或芳基，R2表示具有1至12个碳原子的烷基或芳基。

公开(公告)号：US08916389B2

公开(公告)日：2014-12-23

申请号：US12303693

申请日：2007-06-26

申请人： Yuzuru Iwasaki ,  Michiko Seyama ,  Toru Miura ,  Tsutomu Horiuchi ,  Tsuneyuki Haga ,  Serge Camou

发明人： Yuzuru Iwasaki ,  Michiko Seyama ,  Toru Miura ,  Tsutomu Horiuchi ,  Tsuneyuki Haga ,  Serge Camou

IPC分类号： G01N33/553 ,  G01N33/53 ,  G01N33/52 ,  G01N21/55 ,  G01N33/543 ,  G01N33/544

CPC分类号： G01N21/553 ,  G01N33/53 ,  G01N33/543 ,  G01N33/54373 ,  G01N33/553 ,  Y10T436/2575

摘要： An object of the present invention is to provide an element for SPR measurement without the need of a mechanical solution-sending mechanism. The scope of the present invention is defined by a sensor element for surface plasmon resonance (SPR) measurement utilizing an SPR effect, wherein the sensor element comprises a transparent substrate, a gold thin film formed on at least a part of the transparent substrate, and a thin film with affinity for a sample provided on the transparent substrate having the gold thin film formed on at least a part thereof, and the thin film with affinity for a sample has a measurement region (region A), a sample introduction section (region B) and a sample absorption section (region C) provided with the region A therebetween, the region A is provided with a sample measurement section containing a molecule-recognizing film, an introduction port is formed on the film with affinity for a sample in the region B, an absorption pad is provided on the film with affinity for a sample in the region C so that the whole region C should be covered, and a point in the region B, a point in the region A, and a point in the region C exist in one straight line on the thin film with affinity for a sample.

摘要翻译： 本发明的目的是提供一种用于SPR测量的元件，而不需要机械解决方案发送机构。 本发明的范围由用于利用SPR效应的表面等离子体共振（SPR）测量的传感器元件限定，其中传感器元件包括透明基板，形成在透明基板的至少一部分上的金薄膜，以及 对在其至少部分形成有金薄膜的透明基板上提供的样品具有亲和性的薄膜，对样品具有亲和性的薄膜具有测量区域（区域A），样品导入部（区域 B）和在其间设置有区域A的样品吸收部（区域C），区域A设置有包含分子识别膜的样品测定部，在膜上形成有对样品的亲和性的引入口 区域B中，在膜C上提供吸收垫，对区域C中的样品具有亲和性，使得应该覆盖整个区域C，并且区域B中的点，区域A中的点和 区域C中的点在样品的亲和性上存在于薄膜上的一条直线上。

公开(公告)号：US08778954B2

公开(公告)日：2014-07-15

申请号：US13394266

申请日：2010-09-29

申请人： Toru Miura ,  Seiichi Sato ,  Hajime Yamada ,  Junya Tagashira ,  Ryohei Sekimoto ,  Rie Ishida ,  Hitomi Aoki ,  Tadaaki Ohgiya

发明人： Toru Miura ,  Seiichi Sato ,  Hajime Yamada ,  Junya Tagashira ,  Ryohei Sekimoto ,  Rie Ishida ,  Hitomi Aoki ,  Tadaaki Ohgiya

IPC分类号： C07D401/14 ,  A61K31/422 ,  A61K31/4427

CPC分类号： C07D401/14 ,  A61K31/422 ,  A61K31/4427 ,  C07D413/14

摘要： Disclosed are: a novel compound which has both an antagonistic activity on an angiotensin II receptor and a PPARγ-activating activity and is therefore useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, arteriosclerosis, type-2 diabetes, diabetic complications, metabolic syndrome or the like; and a pharmaceutical composition containing the compound. Specifically disclosed are: a compound represented by general formula (I) (wherein the ring A represents a pyridine ring; the ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C—R5 or a nitrogen atom; R1 represents a C1-6 alkyl group; R2 represents a C1-6 alkyl group or a C3-8 cycloalkyl group; and R3, R4, R5 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a halo-C1-6 alkyl group, or a C1-6 alkoxy group which may have a substituent), a salt of the compound, or a solvate of the compound or the salt; and a pharmaceutical composition containing the compound, the salt or the solvate.

摘要翻译： 公开了一种对血管紧张素II受体具有拮抗作用和PPARγ活化活性的新型化合物，因此可用作高血压，心脏病，动脉硬化，2型糖尿病，糖尿病并发症的预防和/或治疗剂 ，代谢综合征等; 和含有该化合物的药物组合物。 具体公开的是：由通式（I）表示的化合物（其中环A表示吡啶环;环B表示四唑环或恶二唑-5（4H） - 酮环; X表示C-R5或氮 原子; R1表示C1-6烷基; R2表示C1-6烷基或C3-8环烷基; R3，R4，R5分别表示氢原子，卤素原子，C1-6烷基， 卤代C 1-6烷基或可具有取代基的C 1-6烷氧基），化合物的盐或化合物或其盐的溶剂合物; 和含有该化合物，该盐或溶剂化物的药物组合物。

公开(公告)号：US08664226B2

公开(公告)日：2014-03-04

申请号：US13263023

申请日：2010-04-16

申请人： Toru Miura ,  Kazuhiro Onogi ,  Seiichi Sato ,  Junya Tagashira ,  Gen Watanabe ,  Ryohei Sekimoto ,  Rie Ishida ,  Hitomi Aoki ,  Tadaaki Ohgiya

发明人： Toru Miura ,  Kazuhiro Onogi ,  Seiichi Sato ,  Junya Tagashira ,  Gen Watanabe ,  Ryohei Sekimoto ,  Rie Ishida ,  Hitomi Aoki ,  Tadaaki Ohgiya

IPC分类号： C07D401/14 ,  A61K31/506

CPC分类号： C07D401/14 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14

摘要： Disclosed is a compound which has both an angiotensin-II receptor antagonistic activity and a PPARγ activation activity and is useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, angina pectoris, cerebrovascular disorders, cerebral circulatory disorders, ischemic peripheral circulatory disorders, renal diseases, arteriosclerosis, inflammatory diseases, type-2 diabetes, diabetic complications, insulin resistance syndrome, syndrome X, metabolic syndrome and hyperinsulinemia. [In the formula, A represents a 5- to 10-membered heteroaryl group; R1 and R2 independently represent a C1-6 alkyl group; and each of R3 to R5 is absent or represents H, a halogen atom, OH, NO2, a halo-C1-6 alkyl group, a (substituted) C1-6 alkoxy group, a (substituted) C3-6 cycloalkyloxy group, or a 5- to 10-membered heteroaryl group.]

摘要翻译： 公开了具有血管紧张素-II受体拮抗作用和PPARγ活化活性的化合物，可用作高血压，心脏病，心绞痛，脑血管障碍，脑循环障碍，缺血性外周循环障碍的预防和/或治疗剂 肾脏疾病，动脉硬化，炎性疾病，2型糖尿病，糖尿病并发症，胰岛素抵抗综合征，X综合征，代谢综合征和高胰岛素血症。 [式中，A表示5至10元杂芳基; R1和R2独立地表示C1-6烷基; 并且R 3至R 5不存在或表示H，卤素原子，OH，NO 2，卤代C 1-6烷基，（取代的）C 1-6烷氧基，（取代的）C 3-6环烷氧基或 5至10元杂芳基。]

公开(公告)号：US08496859B2

公开(公告)日：2013-07-30

申请号：US13109121

申请日：2011-05-17

申请人： Toru Miura ,  Yoshimitsu Aiiso

发明人： Toru Miura ,  Yoshimitsu Aiiso

IPC分类号： B29D11/00

CPC分类号： B29D11/0073 ,  Y10T428/31565

摘要： A method of producing a plastic polarized lens with excellent processability and the like by injecting a mixture of a specified isocyanate compound and a specified active hydrogen compound into a lens-forming mold wherein a polarized film containing a thermoplastic polyester is fixed, followed by polymerization and curing.

摘要翻译： 通过将特定的异氰酸酯化合物和规定的活性氢化合物的混合物注入到其中固定含有热塑性聚酯的偏光膜的透镜成型模具中，然后进行聚合，制造具有优异加工性等的塑料偏光透镜的方法， 养护。

公开(公告)号：US20120264753A1

公开(公告)日：2012-10-18

申请号：US13511876

申请日：2010-12-22

申请人： Toru Miura ,  Hajime Yamada ,  Junya Tagashira ,  Gen Watanabe ,  Ryohei Sekimoto ,  Rie Ishida ,  Hitomi Aoki ,  Tadaaki Ohgiya

发明人： Toru Miura ,  Hajime Yamada ,  Junya Tagashira ,  Gen Watanabe ,  Ryohei Sekimoto ,  Rie Ishida ,  Hitomi Aoki ,  Tadaaki Ohgiya

IPC分类号： A61K31/4178 ,  A61K31/4245 ,  C07D413/14 ,  A61K31/506 ,  C07D403/14 ,  A61K31/5377 ,  C07D403/10 ,  A61P9/00 ,  A61P9/12 ,  A61P9/10 ,  A61P13/12 ,  A61P3/00 ,  A61P3/10 ,  A61P25/00 ,  C07D413/10

CPC分类号： C07D403/10 ,  C07D403/14 ,  C07D413/10 ,  C07D413/14

摘要： Disclosed is a novel 1-(biphenyl-4-yl-methyl)-1H-imidazole derivative represented by general formula (I), which has both angiotensin II receptor antagonist activity and PPAR-γ activating activity and is useful as a prophylactic and/or therapeutic agent for cardiovascular diseases and metabolic diseases. Also disclosed is a pharmaceutical composition which contains the novel 1-(biphenyl-4-yl-methyl)-1H-imidazole derivative. In general formula (I), ring A represents a group represented by formula (II) or (III); R1 represents a C1-6 alkyl group; R2 represents a C1-6 alkyl group which may be substituted by a hydroxy group, or a group represented by formula —CO—R4 (wherein R4 represents a hydroxy group, a C1-6 alkoxy group, an amino group, a mono(C1-6 alkyl)amino group, a di(C1-6 alkyl)amino group, a morpholino group, a piperidino group or a pyrrolidino group); R3 represents a halogen atom or a C1-6 alkoxy group; and X and Y may be the same or different and each represents a nitrogen atom or CH.

摘要翻译： 公开了由通式（I）表示的新颖的1-（联苯-4-基 - 甲基）-1H-咪唑衍生物，其具有血管紧张素II受体拮抗剂活性和PPAR-γ活化活性，可用作预防和/ 或用于心血管疾病和代谢疾病的治疗剂。 还公开了含有新的1-（联苯-4-基 - 甲基）-1H-咪唑衍生物的药物组合物。 在通式（I）中，环A表示由式（II）或（III）表示的基团; R1表示C1-6烷基; R2表示可以被羟基取代的C1-6烷基或由式-CO-R4表示的基团（其中R4表示羟基，C1-6烷氧基，氨基，单（C1 -6烷基）氨基，二（C 1-6烷基）氨基，吗啉代基，哌啶子基或吡咯烷子基）。 R3表示卤素原子或C1-6烷氧基; X和Y可以相同或不同，各自表示氮原子或CH。

公开(公告)号：US20120046308A1

公开(公告)日：2012-02-23

申请号：US13318750

申请日：2010-05-28

申请人： Toru Miura ,  Kazuhiro Onogi ,  Junya Tagashira ,  Gen Watanabe ,  Ryohei Sekimoto ,  Rie Ishida ,  Hitomi Aoki ,  Tadaaki Ohgiya

发明人： Toru Miura ,  Kazuhiro Onogi ,  Junya Tagashira ,  Gen Watanabe ,  Ryohei Sekimoto ,  Rie Ishida ,  Hitomi Aoki ,  Tadaaki Ohgiya

IPC分类号： A61K31/506 ,  C07D401/14 ,  A61P9/00 ,  A61P9/12 ,  A61P9/10 ,  C07D239/52 ,  A61P3/10

CPC分类号： C07D401/04 ,  C07D239/34 ,  C07D239/36 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D413/14

摘要： An α-phenoxybenzeneacetic acid derivative represented by general formula (I), which has both an angiotensin II receptor antagonistic activity and a PPARγ activation activity and is useful as a prophylactic and/or therapeutic agent for hypertension, metabolic syndrome or the like, a salt of the derivative, or a solvate of the derivative or the salt; and a pharmaceutical composition containing the derivative, the salt or the solvate. [In the formula, Q represents a group represented by formula (II) or (III) [wherein R1 and R1′ independently represent a C1-6 alkyl group; R2 and R2′ independently represent a substituted or unsubstituted C1-6 alkyl group; R3 represents a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group, or a group represented by formula (IV) [wherein X and Y independently represent CH or N; Z represents a C1-6 alkylene chain, or the like; R11 represents a hydrogen atom, a C6-10 aryl group, or the like; and m represents 0 or 1]; and R4 represents a substituted C1-6 alkyl group]; R5 and R6 independently represent a C1-6 alkyl group: R7 represents a carboxyl group, or the like; R8, R9 and R10 independently represent a hydrogen atom, a halogen atom, or the like; and n represents an integer of 1 to 3.]

摘要翻译： 由通式（I）表示的α-苯氧基苯乙酸衍生物，其具有血管紧张素II受体拮抗作用和PPARγ活化活性，可用作高血压，代谢综合征等的预防和/或治疗剂，盐 的衍生物，或衍生物或盐的溶剂合物; 和含有该衍生物，盐或溶剂化物的药物组合物。 [式中，Q表示由式（II）或（III）表示的基团[式中，R1和R1'独立地表示C1-6烷基; R2和R2'独立地表示取代或未取代的C1-6烷基; R3表示氢原子，取代或未取代的C1-6烷基或由式（IV）表示的基团[其中X和Y独立地表示CH或N; Z表示碳原子数1〜6的亚烷基链等。 R 11表示氢原子，C 6-10芳基等; m表示0或1]; 并且R 4表示取代的C 1-6烷基]; R5和R6独立地表示C1-6烷基：R7表示羧基等; R 8，R 9和R 10独立地表示氢原子，卤素原子等; n表示1〜3的整数。

公开(公告)号：US20110306623A1

公开(公告)日：2011-12-15

申请号：US13202052

申请日：2010-02-22

申请人： Toru Miura ,  Kazuhiro Onogi ,  Junya Tagashira ,  Gen Watanabe ,  Ryohei Sekimoto ,  Rie Ishida ,  Tadaaki Ohgiya

发明人： Toru Miura ,  Kazuhiro Onogi ,  Junya Tagashira ,  Gen Watanabe ,  Ryohei Sekimoto ,  Rie Ishida ,  Tadaaki Ohgiya

IPC分类号： A61K31/506 ,  A61P3/04 ,  A61P9/12 ,  A61P3/06 ,  C07D413/14 ,  A61P3/10

CPC分类号： A61K31/513 ,  C07D403/04 ,  C07D413/14

摘要： Provided are novel compounds that have both angiotensin II receptor-antagonist effects and PPAR-activating effects that are useful as agents for preventing and/or treating hypertension, heart disease, angina, cerebral vascular accident, cerebrovascular disorder, ischemic peripheral circulatory disorder, kidney disease, atherosclerosis, inflammatory disease, type 2 diabetes mellitus, diabetic complication, insulin resistance syndrome, Syndrome X, metabolic syndrome, and hyperinsulinemia. Disclosed are 3-(5-alkoxypyrimidin-2-yl)pyrimidin-4(3H)-one derivatives represented by the General formula (I): [wherein R represents a C1-4 alkyl group], or salts or solvates thereof (I)

摘要翻译： 提供了具有血管紧张素II受体拮抗剂作用和PPAR活化作用的新型化合物，其可用作预防和/或治疗高血压，心脏病，心绞痛，脑血管意外，脑血管障碍，缺血性外周循环障碍，肾脏疾病 ，动脉粥样硬化，炎性疾病，2型糖尿病，糖尿病并发症，胰岛素抵抗综合征，X综合征，代谢综合征和高胰岛素血症。 公开了由通式（I）表示的3-（5-烷氧基嘧啶-2-基）嘧啶-4（3H） - 酮衍生物：[其中R表示C 1-4烷基]或其​​盐或溶剂合物（I ）

公开(公告)号：US20110070655A1

公开(公告)日：2011-03-24

申请号：US12993298

申请日：2009-05-26

申请人： Tsutomu Horiuchi ,  Toru Miura ,  YUzuru Iwasaki ,  Michiko Seyama ,  Tsuyoshi Hayashi ,  Jun-Ichi Takahashi ,  Tsuneyuki Haga

发明人： Tsutomu Horiuchi ,  Toru Miura ,  YUzuru Iwasaki ,  Michiko Seyama ,  Tsuyoshi Hayashi ,  Jun-Ichi Takahashi ,  Tsuneyuki Haga

IPC分类号： G01N1/28

CPC分类号： G01N21/05 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L2200/0621 ,  B01L2200/148 ,  B01L2200/16 ,  B01L2300/0829 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0694 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2035/1039

摘要： A flow cell includes: a flow channel through which a sample solution flows; an inlet section which communicates with the flow channel and to which the sample solution is supplied; a transfer section which includes a plurality of opening sections, one end side of which communicates with the flow channel and an other side of which opens to outside air, and which communicates with the flow channel, and draws in and guides the sample solution supplied into the inlet section to the flow channel; a detecting section which faces the sample solution in the flow channel; and a sealing member which unsealably seals at least either one of the opening section or the inlet section.

摘要翻译： 流动池包括：样品溶液流过的流动通道; 入口部分，其与所述流动通道连通并且供应所述样品溶液; 转移部，其包括多个开口部，其一端侧与流路连通，另一侧与外部空气连通，与流路连通，吸入并引导供给的样品溶液 流道的入口部分; 检测部，其面向流路中的样品溶液; 以及密封构件，其不分封地密封所述开口部或所述入口部中的至少一个。

公开(公告)号：US20100296972A1

公开(公告)日：2010-11-25

申请号：US12864222

申请日：2009-01-30

申请人： Toru Miura ,  Tsutomu Horiuchi ,  Yuzuru Iwasaki ,  Michiko Seyama

发明人： Toru Miura ,  Tsutomu Horiuchi ,  Yuzuru Iwasaki ,  Michiko Seyama

IPC分类号： G01N21/05

CPC分类号： G01N21/05 ,  B01L3/502707 ,  B01L3/50273 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/086 ,  F04B19/006 ,  G01N21/553 ,  G01N2021/0346 ,  G01N2021/056 ,  Y10T137/2224 ,  Y10T137/85978 ,  Y10T436/2575

摘要： A measurement fluidic channel (17) is formed at almost the center of a flow cell (1). In general, the measurement region of a measurement apparatus is set to focus on almost the center of a measurement chip. When the flow cell (1) is mounted in the measurement apparatus, the focus of the measurement region is positioned just above the measurement fluidic channel (17). The measurement apparatus can more reliably measure a sample solution flowing through the measurement fluidic channel (17). A suction pump (18) is formed in regions around the measurement fluidic channel (17). When the flow cell has the same planar shape as a conventional one, the amount of sample solution which can be supplied can be increased, compared to a conventional structure in which components are formed in line. The time during which a sample solution flows through the fluidic channel can be prolonged, the amount of sample solution can be increased, and the measurement time can also be prolonged. A sample solution flowing through the fluidic channel can be measured more reliably.

摘要翻译： 测量流体通道（17）形成在流动池（1）的几乎中心处。 通常，测量装置的测量区域被设置为聚焦在测量芯片的几乎中心。 当流量池（1）安装在测量装置中时，测量区域的焦点位于测量流体通道（17）的正上方。 测量装置可以更可靠地测量流过测量流体通道（17）的样品溶液。 在测量流体通道（17）周围的区域中形成抽吸泵（18）。 当流动池具有与常规流动池相同的平面形状时，与其中部件形成在一起的常规结构相比，可以提高可供应的样品溶液的量。 样品溶液流过流体通道的时间可以延长，可以增加样品溶液的量，并且还可以延长测量时间。 可以更可靠地测量流过流体通道的样品溶液。