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    Immunoisolative encapsulation system
    1.
    发明申请
    Immunoisolative encapsulation system 审中-公开
    免疫隔离系统

    公开(公告)号：US20090028945A1

    公开(公告)日：2009-01-29

    申请号：US11447393

    申请日：2006-06-05

    申请人： Charles Y. Cheung ,  Kristi S. Anseth

    发明人： Charles Y. Cheung ,  Kristi S. Anseth

    IPC分类号： A61K9/00 ,  A61K39/395 ,  A61P3/10 ,  A61P37/06

    CPC分类号： A61K9/06 ,  A61K9/0019 ,  A61K47/32 ,  A61K47/6849 ,  A61K47/6903 ,  A61K2035/126 ,  C12N5/0677 ,  C12N2533/30 ,  C12N2533/50

    摘要： A fundamental deficiency with current biological cell encapsulation technology is that passive material barriers cannot protect biological cells from exposure to cytokines and other small, diffusible cytotoxic molecules produced by activated immune cells, subsequently leading to biological cell destruction. The present invention provides an immunoisolative encapsulation system that actively and locally suppresses immune response using Fas receptor binding agents.

    摘要翻译： 目前的生物细胞包封技术的根本缺陷是被动材料障碍物不能保护生物细胞免受暴露于由活化的免疫细胞产生的细胞因子和其他小的，可扩散的细胞毒性分子，随后导致生物细胞破坏。 本发明提供了使用Fas受体结合剂主动和局部抑制免疫应答的免疫分离包封系统。

    Photodegradable groups for tunable polymeric materials
    2.
    发明授权
    Photodegradable groups for tunable polymeric materials 有权
    可调谐聚合材料的可光降解组

    公开(公告)号：US08343710B1

    公开(公告)日：2013-01-01

    申请号：US11374471

    申请日：2006-03-13

    申请人： Kristi S. Anseth ,  Andrea M. Kasko

    发明人： Kristi S. Anseth ,  Andrea M. Kasko

    IPC分类号： C07C205/00 ,  C07C205/04 ,  C08F20/34 ,  G03C1/00 ,  G03F7/00

    CPC分类号： C08F220/34 ,  C08F20/34 ,  C08F222/1006 ,  C08F2222/104

    摘要： Provided is a method that provides both spatial and temporal control of a polymer degradation process using mono- and multifunctional macromolecular monomers (“macromers”) that degrade via single- and multi-photon photolysis mechanisms over a broad range of wavelengths. The macromers can form or be incorporated into networks via covalent, non-covalent and/or ionic interactions. The spatial and temporal degradation of these networks can be controlled. More specifically, provided is a photodegradable macromer, comprising: (a) a photodegradable group; (b) a backbone structure comprising one or more repeating units that may be the same or different, which backbone structure is attached to the photodegradable group directly or through a linker; (c) one or more reactive end groups at one or more ends of the macromer; and optionally, (d) one or more therapeutic agents; and optionally (e) one or more caged groups. Also provided are polymers and networks incorporating macromers of the invention and optionally other substituents such as other polymeric structures. Also provided is a method of controlled degradation of a polymer comprising: providing a photodegradable polymer as described herein and exposing the photodegradable polymer to photoradiation of the appropriate wavelength and energy to cause one or more of the photodegradable groups to photodegrade.

    摘要翻译： 提供了一种使用在宽波长范围内通过单光子和多光子光解机理降解的单功能和多功能大分子单体（大分子单体）提供聚合物降解过程的空间和时间控制的方法。 大分子单体可以通过共价，非共价和/或离子相互作用形成或并入网络。 可以控制这些网络的空间和时间退化。 更具体地，提供一种可光降解的大分子单体，其包含：（a）可光降解的基团; （b）骨架结构，其包含一个或多个可以相同或不同的重复单元，该主链结构直接或通过连接体连接到可光降解基团; （c）在大分子单体的一个或多个末端的一个或多个反应性端基; 和（d）一种或多种治疗剂; 和（e）一个或多个笼式组。 还提供了结合本发明的大分子单体和任选的其它取代基如其它聚合物结构的聚合物和网络。 还提供了聚合物受控降解的方法，其包括：提供如本文所述的光可降解聚合物，并将可光降解的聚合物暴露于适当的波长和能量的光辐射以使一个或多个可光降解基团光降解。

    Method and material for use with dental composites for improving conversion of monomers to polymers and reducing volume shrinkage
    4.
    发明授权
    Method and material for use with dental composites for improving conversion of monomers to polymers and reducing volume shrinkage 失效
    用于牙科复合材料以改善单体向聚合物转化并减少体积收缩的方法和材料

    公开(公告)号：US5730601A

    公开(公告)日：1998-03-24

    申请号：US613348

    申请日：1996-03-11

    申请人： Christopher N. Bowman ,  Kristi S. Anseth ,  Anandkumar R. Kannurpatti ,  Michael D. Goodner

    发明人： Christopher N. Bowman ,  Kristi S. Anseth ,  Anandkumar R. Kannurpatti ,  Michael D. Goodner

    IPC分类号： A61K6/083 ,  A61C5/00

    CPC分类号： A61K6/083

    摘要： A composition for use in dental treatments of damaged or diseased teeth is provided. The composition comprises a combined filler material, photoinitiator and comonomer resin mixture polymerizable upon incidence of light. The comonomer resin mixture comprises a comonomer resin blend comprising at least two monomers from the same monomer series with at least a first monomer having a first molecular weight and a second monomer having a second molecular weight with the second molecular weight being greater than the first molecular weight of the first monomer. The comonomer resin mixture further comprises a third monomer combined with the comonomer resin blend.

    摘要翻译： 提供了一种用于牙齿治疗受损或患齿的组合物。 组合物包含组合的填充材料，光引发剂和共聚单体树脂混合物在光入射时可聚合。 共聚单体树脂混合物包括共聚单体树脂混合物，其包含至少两种与至少第一分子量的第一单体相同的单体系列的单体和具有第二分子量的第二单体，第二分子量大于第一分子量 第一单体的重量。 共聚单体树脂混合物还包含与共聚单体树脂共混物组合的第三单体。

    Biodegradable polymer networks for use in orthopedic and dental applications
    6.
    发明授权
    Biodegradable polymer networks for use in orthopedic and dental applications 失效
    用于矫形和牙科应用的可生物降解聚合物网络

    公开(公告)号：US5902599A

    公开(公告)日：1999-05-11

    申请号：US603171

    申请日：1996-02-20

    申请人： Kristi S. Anseth ,  Robert Langer ,  Venkatram R. Shastri

    发明人： Kristi S. Anseth ,  Robert Langer ,  Venkatram R. Shastri

    IPC分类号： A61F2/28 ,  A61F2/30 ,  A61K47/32 ,  C08F2/46

    CPC分类号： C08F2/48 ,  A61C8/0012 ,  A61L27/16 ,  A61L27/58

    摘要： Biodegradable polymer networks are provided which are useful in a variety of dental and orthopedic applications. The biodegradable polymer networks can be formed in one embodiment by polymerizing anhydride prepolymers including crosslinkable groups, such as unsaturated moieties. The anhydride prepolymers can be crosslinked, for example in a photopolymerization reaction by irradiation of the prepolymer with light in the presence of a free radical initiator. Suitable anhydride prepolymers include dianhydrides of a dicarboxylic acid and a carboxylic acid molecule comprising a crosslinkable group. For example, methacrylic acid dianhydrides of monomers or oligomers of a diacid such as sebacic acid or 1,3-bis(p-carboxyphenoxy)-hexane can be used. The anhydride prepolymers can be applied in vivo to a site where an orthopedic implant is needed, and then may be crosslinked, for example, by irradiation with U.V. light, to form a biodegradable implant such as a rods, pin or plate. The implants advantageously provide mechanical support and also are capable of slow surface degradation to permit bone ingrowth.

    摘要翻译： 提供可生物降解的聚合物网络，其可用于各种牙科和矫形应用。 可生物降解的聚合物网络可以在一个实施方案中通过聚合包括可交联基团如不饱和部分的酸酐预聚物来形成。 酸酐预聚物可以交联，例如通过在自由基引发剂的存在下用光照射预聚物进行光聚合反应。 合适的酸酐预聚物包括二羧酸的二酸酐和包含可交联基团的羧酸分子。 例如，可以使用二酸的单体或低聚物如癸二酸或1,3-双（对羧基苯氧基） - 己烷的甲基丙烯酸二酐。 酸酐预聚物可以在体内应用于需要整形外科植入物的部位，然后可以例如通过用紫外线照射来交联。 光，以形成可生物降解的植入物，例如杆，针或板。 植入物有利地提供机械支撑并且还能够缓慢的表面退化以允许骨向内生长。