公开(公告)号：US08318684B2

公开(公告)日：2012-11-27

申请号：US12300468

申请日：2007-05-15

申请人： Keiichi Numata ,  Noriyuki Okujo ,  Siew Eim Khor ,  Lee Li Tan ,  Annie George ,  Szu Ting Ng ,  Chin Jye Tan ,  Hironobu Iinuma ,  Yasuo Fukagawa ,  Kunimoto Hotta ,  Seiji Shibahara ,  Shinichi Kondo ,  Satoshi Nimura

发明人： Keiichi Numata ,  Noriyuki Okujo ,  Siew Eim Khor ,  Lee Li Tan ,  Annie George ,  Szu Ting Ng ,  Chin Jye Tan ,  Hironobu Iinuma ,  Yasuo Fukagawa ,  Kunimoto Hotta ,  Seiji Shibahara ,  Shinichi Kondo ,  Satoshi Nimura

IPC分类号： A61K31/70 ,  C07H17/08 ,  C12P19/62

CPC分类号： C07H17/04 ,  A61K31/04 ,  A61K31/7048 ,  C12P17/08 ,  A61K2300/00

摘要： Seven novel antibiotic substances can be produced by cultivation of a microbial strain which has been isolated from a soil sample and which is designated as Microbispora sp. A 34030 (deposited under an access number FERM BP-10505 in terms of Budapest Treaty). These seven antibiotic substances are named as bispolide A1, bispolide A2, bispolide A3, bispolide B1, bispolide B2a, bispolide B2b and bispolide B3, respectively. These bispolides are each novel compounds which have a chemical structure as collectively represented by the general formula (III) shown below: These bispolides have each a high antibacterial activity against a variety of bacteria, particularly Gram-positive bacteria and their antibiotic-resistant strains, and hence these bispolides each are effective and useful for therapeutically treating bacterial infections of Gram-positive bacteria in humans and animals.

摘要翻译： 可以通过培养已经从土壤样品中分离并被称为微双歧杆菌（Microbispora sp。）的微生物菌株来生产七种新型抗生素物质。 A 34030（根据布达佩斯条约保存在访问号FERM BP-10505）。 这七种抗生素物质分别被称为双吡啶A1，双吡啶B2，双吡哆醛A3，双吡啶B1，双吡啶B2a，双吡啶B2b和双吡啶B3。 这些双吡啶衍生物是具有如以下通式（III）统称为化学结构的新型化合物：这些双酚化物对各种细菌，特别是革兰氏阳性菌及其抗生素抗性菌株具有高抗菌活性， 因此这些双吡哆醇各自对于治疗性地治疗人和动物中革兰氏阳性菌的细菌感染是有效和有用的。

公开(公告)号：US20100144658A1

公开(公告)日：2010-06-10

申请号：US12300468

申请日：2007-05-15

申请人： Keiichi Numata ,  Noriyuki Okujo ,  Siew Eim Khor ,  Lee Li Tan ,  Annie George ,  Szu Ting Ng ,  Chin Jye Tan ,  Hironobu Iinuma ,  Yasuo Fukagawa ,  Kunimoto Hotta ,  Seiji Shibahara ,  Shinichi Kondo ,  Satoshi Nimura

发明人： Keiichi Numata ,  Noriyuki Okujo ,  Siew Eim Khor ,  Lee Li Tan ,  Annie George ,  Szu Ting Ng ,  Chin Jye Tan ,  Hironobu Iinuma ,  Yasuo Fukagawa ,  Kunimoto Hotta ,  Seiji Shibahara ,  Shinichi Kondo ,  Satoshi Nimura

IPC分类号： A61K31/7048 ,  A61P31/04 ,  C07H17/08 ,  C12P19/60 ,  C12N1/20

CPC分类号： C07H17/04 ,  A61K31/04 ,  A61K31/7048 ,  C12P17/08 ,  A61K2300/00

摘要： Seven novel antibiotic substances could be produced by cultivation of a microbial strain which has been isolated from a soil sample and which is designated as Microbispora sp. A 34030 (deposited under an access number FERM BP-10505 in terms of Budapest Treaty). These seven antibiotic substances are named as bispolide A1, bispolide A2, bispolide A3, bispolide B1, bispolide B2a, bispolide B2b and bispolide B3, respectively. These bispolides are each novel compounds which have a chemical structure as collectively represented by the general formula (III) shown below. These bispolides have each a high antibacterial activity against a variety of bacteria, particularly Gram-positive bacteria and their antibiotic-resistant strains, and hence these bispolides each are effective and useful for therapeutically treating bacterial infections of Gram-positive bacteria in human and animals.The general formula (III):

摘要翻译： 可以通过培养已经从土壤样品中分离并被称为微双歧杆菌（Microbispora sp。）的微生物菌株产生七种新型抗生素物质。 A 34030（根据布达佩斯条约保存在访问号FERM BP-10505）。 这七种抗生素物质分别被称为双吡啶A1，双吡啶B2，双吡哆醛A3，双吡啶B1，双吡啶B2a，双吡啶B2b和双吡啶B3。 这些双吡啶衍生物是具有如以下通式（III）统称的化学结构的新化合物。 这些双糖苷酸各自对各种细菌，特别是革兰氏阳性菌及其抗生素抗性菌株具有高的抗菌活性，因此这些双吡啶苷各自对于治疗性地治疗人和动物中革兰氏阳性菌的细菌感染是有效和有用的。 通式（III）：