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1.发明授权Antibiotics, bispolides A1, A2, and A3 as well as bispolides B1, B2a, B2b and B3 and processes for producing said antibiotics 有权抗生素，双酚A，A2和A3以及双酚B1，B2a，B2b和B3以及生产所述抗生素的方法公开(公告)号：US08318684B2
公开(公告)日：2012-11-27
申请号：US12300468
申请日：2007-05-15
申请人： Keiichi Numata , Noriyuki Okujo , Siew Eim Khor , Lee Li Tan , Annie George , Szu Ting Ng , Chin Jye Tan , Hironobu Iinuma , Yasuo Fukagawa , Kunimoto Hotta , Seiji Shibahara , Shinichi Kondo , Satoshi Nimura
发明人： Keiichi Numata , Noriyuki Okujo , Siew Eim Khor , Lee Li Tan , Annie George , Szu Ting Ng , Chin Jye Tan , Hironobu Iinuma , Yasuo Fukagawa , Kunimoto Hotta , Seiji Shibahara , Shinichi Kondo , Satoshi Nimura
CPC分类号： C07H17/04 , A61K31/04 , A61K31/7048 , C12P17/08 , A61K2300/00
摘要： Seven novel antibiotic substances can be produced by cultivation of a microbial strain which has been isolated from a soil sample and which is designated as Microbispora sp. A 34030 (deposited under an access number FERM BP-10505 in terms of Budapest Treaty). These seven antibiotic substances are named as bispolide A1, bispolide A2, bispolide A3, bispolide B1, bispolide B2a, bispolide B2b and bispolide B3, respectively. These bispolides are each novel compounds which have a chemical structure as collectively represented by the general formula (III) shown below: These bispolides have each a high antibacterial activity against a variety of bacteria, particularly Gram-positive bacteria and their antibiotic-resistant strains, and hence these bispolides each are effective and useful for therapeutically treating bacterial infections of Gram-positive bacteria in humans and animals.
摘要翻译： 可以通过培养已经从土壤样品中分离并被称为微双歧杆菌（Microbispora sp。）的微生物菌株来生产七种新型抗生素物质。 A 34030（根据布达佩斯条约保存在访问号FERM BP-10505）。 这七种抗生素物质分别被称为双吡啶A1，双吡啶B2，双吡哆醛A3，双吡啶B1，双吡啶B2a，双吡啶B2b和双吡啶B3。 这些双吡啶衍生物是具有如以下通式（III）统称为化学结构的新型化合物：这些双酚化物对各种细菌，特别是革兰氏阳性菌及其抗生素抗性菌株具有高抗菌活性， 因此这些双吡哆醇各自对于治疗性地治疗人和动物中革兰氏阳性菌的细菌感染是有效和有用的。
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2.发明授权公开(公告)号：US07658421B2
公开(公告)日：2010-02-09
申请号：US11115353
申请日：2005-04-27
申请人： Narikazu Hashimoto , Masatoshi Yoshida , Hiroyuki Yamashita , Satoshi Nimura , Toru Hashimura , Yoshihaya Imamura , Kazumori Horiguchi
发明人： Narikazu Hashimoto , Masatoshi Yoshida , Hiroyuki Yamashita , Satoshi Nimura , Toru Hashimura , Yoshihaya Imamura , Kazumori Horiguchi
IPC分类号： B60R19/24
摘要： A target tubular member with flange, such as a bumper stay, has a flange having an outer diameter larger than the diameter of an axial section and is formed by electromagnetic forming without excessive expansion. The tubular member with flange includes an axial member made of a tubular aluminum alloy extrudate and a flange member joined to an end of the axial member. The axial member has an end flange being integrated at its end and having an area smaller than that of the flange member. The flange member has a hole, and a cylindrical hole flange at the edge of the hole. The axial member fits in the hole of the flange member, the end flange is in intimate contact with the flange member, and the outer periphery of a small-diameter portion of the axial member is in intimate contact with the inner periphery of the hole flange. The hole flange is held between the end flange and a protrusion. The tubular member with flange may be produced by inserting an untreated pipe into the hole of the flange member and expanding the untreated pipe by electromagnetic forming.
摘要翻译： 具有凸缘的目标管状构件（例如保险杠撑杆）具有外径大于轴向部分的直径的凸缘，并且通过电磁成形形成而不会过度膨胀。 具有凸缘的管状构件包括由管状铝合金挤出物制成的轴向构件和连接到轴向构件的端部的凸缘构件。 轴向构件的端部凸缘在其端部成一体，其面积小于凸缘构件的面积。 凸缘构件具有孔，并且在孔的边缘处具有圆柱形孔凸缘。 轴向构件配合在凸缘构件的孔中，端部凸缘与凸缘构件紧密接触，轴向构件的小直径部分的外周与孔凸缘的内周紧密接触 。 孔凸缘保持在端部凸缘和突起之间。 具有凸缘的管状构件可以通过将未处理的管插入凸缘构件的孔中并通过电磁成形来膨胀未处理的管而制造。
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公开(公告)号：US20090243314A1
公开(公告)日：2009-10-01
申请号：US12402174
申请日：2009-03-11
IPC分类号： B60R19/04
CPC分类号： B60R19/24
摘要： The bumper stay includes a cylindrical shaft member fit in to a hole of a bumper reinforce, a cylindrical reinforcing member fit in to the outer periphery of the shaft member in the rear side of the bumper reinforce, and a mounting flange member fit in to the outer periphery of the shaft member in its rear end. The shaft member is enlarged by electromagnetic forming and is tightly adhered to the inner peripheral surface of the hole formed in the bumper reinforce, the inner peripheral surface of the reinforcing member, and the inner peripheral surface of the hole flange formed in the mounting flange member, thereby these are joined with each other. Thin aluminum alloy extruded material can be used for the shaft member. With such configuration, when a bumper stay is fit in to the holes formed in the front and rear walls of the bumper reinforce and the bumper stay is enlarged by electromagnetic forming to join with the bumper reinforce, joining of the both can be firmly performed and sufficient strength and energy absorption quantity can be secured.
摘要翻译： 保险杠座包括配合在保险杠加强件的孔中的圆柱形轴构件，与保险杠加强件后侧的轴构件的外周配合的圆柱形加强构件，以及安装凸缘构件 轴构件的后端的外周。 轴构件通过电磁成形而扩大，并且紧密地粘附在形成于保险杠加强件的孔的内周面，加强构件的内周面和形成在安装凸缘构件中的孔凸缘的内周面 ，从而使它们彼此连接。 薄铝合金挤压材料可用于轴件。 通过这样的结构，当保险杠撑杆与保险杠加强件的前壁和后壁中形成的孔相配合时，通过电磁成形扩大保险杠撑条以与保险杠加强件相接合，可以牢固地实现两者的接合， 可以确保足够的强度和能量吸收量。
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公开(公告)号：US06481690B2
公开(公告)日：2002-11-19
申请号：US09783568
申请日：2001-02-15
IPC分类号： B60R1904
CPC分类号： B60R19/24 , B60R19/18 , B60R2019/182 , B60R2019/186
摘要： A lightweight car body energy absorber made of Al alloy which provides a high energy absorption performance. The car body energy absorber comprises a hollow shape with a rectangular sectional profile and a reinforcing shape attached to the front face of the collision plane of the hollow shape, where the hollow shape and the reinforcing shape are aluminum alloy extruded shapes. The reinforcing shape has a hat-shaped open sectional profile, which is composed of a collision wall almost parallel to the collision plane of the hollow shape, plural mutually parallel horizontal ribs which support the collision wall, and vertical flanges provided at the tips of these ribs. The reinforcing shape is joined to the collision plane of the hollow shape through the vertical flanges.
摘要翻译： 轻质车身能量吸收器，由Al合金制成，能够提供高能量吸收性能。 车身能量吸收器包括中空形状和中空形状，其中空心形状和加强形状是铝合金挤压形状，中空形状具有矩形截面轮廓和附着到中空形状的碰撞面的前表面的加强形状。 加强形状具有帽状的开口截面轮廓，其由几乎平行于中空形状的碰撞面的碰撞壁构成，支撑碰撞壁的多个相互平行的水平肋，以及设置在其顶端的垂直凸缘 肋骨。 加强形状通过垂直法兰接合到中空形状的碰撞面。
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公开(公告)号：US07896408B2
公开(公告)日：2011-03-01
申请号：US12402174
申请日：2009-03-11
IPC分类号： B60R19/04
CPC分类号： B60R19/24
摘要： The bumper stay includes a cylindrical shaft member fit in to a hole of a bumper reinforce, a cylindrical reinforcing member fit in to the outer periphery of the shaft member in the rear side of the bumper reinforce, and a mounting flange member fit in to the outer periphery of the shaft member in its rear end. The shaft member is enlarged by electromagnetic forming and is tightly adhered to the inner peripheral surface of the hole formed in the bumper reinforce, the inner peripheral surface of the reinforcing member, and the inner peripheral surface of the hole flange formed in the mounting flange member, thereby these are joined with each other. Thin aluminum alloy extruded material can be used for the shaft member. With such configuration, when a bumper stay is fit in to the holes formed in the front and rear walls of the bumper reinforce and the bumper stay is enlarged by electromagnetic forming to join with the bumper reinforce, joining of the both can be firmly performed and sufficient strength and energy absorption quantity can be secured.
摘要翻译： 保险杠座包括配合在保险杠加强件的孔中的圆柱形轴构件，与保险杠加强件后侧的轴构件的外周配合的圆柱形加强构件，以及安装凸缘构件 轴构件的后端的外周。 轴构件通过电磁成形而扩大，并且紧密地粘附在形成于保险杠加强件的孔的内周面，加强构件的内周面和形成在安装凸缘构件中的孔凸缘的内周面 ，从而使它们彼此连接。 薄铝合金挤压材料可用于轴件。 通过这样的结构，当保险杠撑杆与保险杠加强件的前壁和后壁中形成的孔相配合时，通过电磁成形扩大保险杠撑条以与保险杠加强件相接合，可以牢固地实现两者的接合， 可以确保足够的强度和能量吸收量。
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6.发明授权公开(公告)号：US07980615B2
公开(公告)日：2011-07-19
申请号：US12650146
申请日：2009-12-30
申请人： Narikazu Hashimoto , Masatoshi Yoshida , Hiroyuki Yamashita , Satoshi Nimura , Toru Hashimura , Yoshihaya Imamura , Kazumori Horiguchi
发明人： Narikazu Hashimoto , Masatoshi Yoshida , Hiroyuki Yamashita , Satoshi Nimura , Toru Hashimura , Yoshihaya Imamura , Kazumori Horiguchi
IPC分类号： B62D27/02
摘要： A target tubular member with flange, such as a bumper stay, has a flange having an outer diameter larger than the diameter of an axial section and is formed by electromagnetic forming without excessive expansion. The tubular member with flange includes an axial member made of a tubular aluminum alloy extrudate and a flange member joined to an end of the axial member. The axial member has an end flange being integrated at its end and having an area smaller than that of the flange member. The flange member has a hole, and a cylindrical hole flange at the edge of the hole. The axial member fits in the hole of the flange member, the end flange is in intimate contact with the flange member, and the outer periphery of a small-diameter portion of the axial member is in intimate contact with the inner periphery of the hole flange. The hole flange is held between the end flange and a protrusion. The tubular member with flange may be produced by inserting an untreated pipe into the hole of the flange member and expanding the untreated pipe by electromagnetic forming.
摘要翻译： 具有凸缘的目标管状构件（例如保险杠撑杆）具有外径大于轴向部分的直径的凸缘，并且通过电磁成形形成而不会过度膨胀。 具有凸缘的管状构件包括由管状铝合金挤出物制成的轴向构件和连接到轴向构件的端部的凸缘构件。 轴向构件的端部凸缘在其端部成一体，其面积小于凸缘构件的面积。 凸缘构件具有孔，并且在孔的边缘处具有圆柱形孔凸缘。 轴向构件配合在凸缘构件的孔中，端部凸缘与凸缘构件紧密接触，轴向构件的小直径部分的外周与孔凸缘的内周紧密接触 。 孔凸缘保持在端部凸缘和突起之间。 具有凸缘的管状构件可以通过将未处理的管插入凸缘构件的孔中并通过电磁成形来膨胀未处理的管而制造。
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7.发明申请NOVEL ANTIBIOTICS, BISPOLIDES A1, A2, AND A3 AS WELL AS BISPOLIDES B1, B2A, B2B AND B3 AND PROCESSES FOR PRODUCING SAID ANTIBIOTICS 有权新型抗生素，BISPOLIDES A1，A2和A3作为双酚A B1，B2A，B2B和B3以及生产抗生素的方法公开(公告)号：US20100144658A1
公开(公告)日：2010-06-10
申请号：US12300468
申请日：2007-05-15
申请人： Keiichi Numata , Noriyuki Okujo , Siew Eim Khor , Lee Li Tan , Annie George , Szu Ting Ng , Chin Jye Tan , Hironobu Iinuma , Yasuo Fukagawa , Kunimoto Hotta , Seiji Shibahara , Shinichi Kondo , Satoshi Nimura
发明人： Keiichi Numata , Noriyuki Okujo , Siew Eim Khor , Lee Li Tan , Annie George , Szu Ting Ng , Chin Jye Tan , Hironobu Iinuma , Yasuo Fukagawa , Kunimoto Hotta , Seiji Shibahara , Shinichi Kondo , Satoshi Nimura
IPC分类号： A61K31/7048 , A61P31/04 , C07H17/08 , C12P19/60 , C12N1/20
CPC分类号： C07H17/04 , A61K31/04 , A61K31/7048 , C12P17/08 , A61K2300/00
摘要： Seven novel antibiotic substances could be produced by cultivation of a microbial strain which has been isolated from a soil sample and which is designated as Microbispora sp. A 34030 (deposited under an access number FERM BP-10505 in terms of Budapest Treaty). These seven antibiotic substances are named as bispolide A1, bispolide A2, bispolide A3, bispolide B1, bispolide B2a, bispolide B2b and bispolide B3, respectively. These bispolides are each novel compounds which have a chemical structure as collectively represented by the general formula (III) shown below. These bispolides have each a high antibacterial activity against a variety of bacteria, particularly Gram-positive bacteria and their antibiotic-resistant strains, and hence these bispolides each are effective and useful for therapeutically treating bacterial infections of Gram-positive bacteria in human and animals.The general formula (III):
摘要翻译： 可以通过培养已经从土壤样品中分离并被称为微双歧杆菌（Microbispora sp。）的微生物菌株产生七种新型抗生素物质。 A 34030（根据布达佩斯条约保存在访问号FERM BP-10505）。 这七种抗生素物质分别被称为双吡啶A1，双吡啶B2，双吡哆醛A3，双吡啶B1，双吡啶B2a，双吡啶B2b和双吡啶B3。 这些双吡啶衍生物是具有如以下通式（III）统称的化学结构的新化合物。 这些双糖苷酸各自对各种细菌，特别是革兰氏阳性菌及其抗生素抗性菌株具有高的抗菌活性，因此这些双吡啶苷各自对于治疗性地治疗人和动物中革兰氏阳性菌的细菌感染是有效和有用的。 通式（III）：
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8.发明申请公开(公告)号：US20100102582A1
公开(公告)日：2010-04-29
申请号：US12650146
申请日：2009-12-30
申请人： Narikazu Hashimoto , Masatoshi Yoshida , Hiroyuki Yamashita , Satoshi Nimura , Toru Hashimura , Yoshihaya Imamura , Kazumori Horiguchi
发明人： Narikazu Hashimoto , Masatoshi Yoshida , Hiroyuki Yamashita , Satoshi Nimura , Toru Hashimura , Yoshihaya Imamura , Kazumori Horiguchi
摘要： A target tubular member with flange, such as a bumper stay, has a flange having an outer diameter larger than the diameter of an axial section and is formed by electromagnetic forming without excessive expansion. The tubular member with flange includes an axial member made of a tubular aluminum alloy extrudate and a flange member joined to an end of the axial member. The axial member has an end flange being integrated at its end and having an area smaller than that of the flange member. The flange member has a hole, and a cylindrical hole flange at the edge of the hole. The axial member fits in the hole of the flange member, the end flange is in intimate contact with the flange member, and the outer periphery of a small-diameter portion of the axial member is in intimate contact with the inner periphery of the hole flange. The hole flange is held between the end flange and a protrusion. The tubular member with flange may be produced by inserting an untreated pipe into the hole of the flange member and expanding the untreated pipe by electromagnetic forming.
摘要翻译： 具有凸缘的目标管状构件（例如保险杠撑杆）具有外径大于轴向部分的直径的凸缘，并且通过电磁成形形成而不会过度膨胀。 具有凸缘的管状构件包括由管状铝合金挤出物制成的轴向构件和连接到轴向构件的端部的凸缘构件。 轴向构件的端部凸缘在其端部成一体，其面积小于凸缘构件的面积。 凸缘构件具有孔，并且在孔的边缘处具有圆柱形孔凸缘。 轴向构件配合在凸缘构件的孔中，端部凸缘与凸缘构件紧密接触，轴向构件的小直径部分的外周与孔凸缘的内周紧密接触 。 孔凸缘保持在端部凸缘和突起之间。 具有凸缘的管状构件可以通过将未处理的管插入凸缘构件的孔中并通过电磁成形来膨胀未处理的管而制造。
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9.发明申请公开(公告)号：US20060284432A1
公开(公告)日：2006-12-21
申请号：US11115353
申请日：2005-04-27
申请人： Narikazu Hashimoto , Masatoshi Yoshida , Hiroyuki Yamashita , Satoshi Nimura , Toru Hashimura , Yoshihaya Imamura , Kazumori Horiguchi
发明人： Narikazu Hashimoto , Masatoshi Yoshida , Hiroyuki Yamashita , Satoshi Nimura , Toru Hashimura , Yoshihaya Imamura , Kazumori Horiguchi
IPC分类号： B60R19/24
摘要： A target tubular member with flange, such as a bumper stay, has a flange having an outer diameter larger than the diameter of an axial section and is formed by electromagnetic forming without excessive expansion. The tubular member with flange includes an axial member made of a tubular aluminum alloy extrudate and a flange member joined to an end of the axial member. The axial member has an end flange being integrated at its end and having an area smaller than that of the flange member. The flange member has a hole, and a cylindrical hole flange at the edge of the hole. The axial member fits in the hole of the flange member, the end flange is in intimate contact with the flange member, and the outer periphery of a small-diameter portion of the axial member is in intimate contact with the inner periphery of the hole flange. The hole flange is held between the end flange and a protrusion. The tubular member with flange may be produced by inserting an untreated pipe into the hole of the flange member and expanding the untreated pipe by electromagnetic forming.
摘要翻译： 具有凸缘的目标管状构件（例如保险杠撑杆）具有外径大于轴向部分的直径的凸缘，并且通过电磁成形形成而不会过度膨胀。 具有凸缘的管状构件包括由管状铝合金挤出物制成的轴向构件和连接到轴向构件的端部的凸缘构件。 轴向构件的端部凸缘在其端部成一体，其面积小于凸缘构件的面积。 凸缘构件具有孔，并且在孔的边缘处具有圆柱形孔凸缘。 轴向构件配合在凸缘构件的孔中，端部凸缘与凸缘构件紧密接触，轴向构件的小直径部分的外周与孔凸缘的内周紧密接触 。 孔凸缘保持在端部凸缘和突起之间。 具有凸缘的管状构件可以通过将未处理的管插入凸缘构件的孔中并通过电磁成形来膨胀未处理的管而制造。
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